Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been...
详细信息
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been *** previous study has demonstrated that theα7nAChR-mediated cholinergic anti-inflammatory pathway is impaired systemically in the genetic model of *** this work,we investigated the changes ofα7nAChR expression in a model of secondary *** The 2-kidney 1-clip(2K1C)hypertensive rat model was *** pressure,vagus nerve function,serum tumor necrosis factor-α(TNF-αand both the mRNA and protein levels ofα7nAChR in tissues from heart,kidney and aorta were measured at 4,8 and 20 weeks after *** Compared with age-matched control,it was found that vagus nerve function was significantly decreased in 2K1C rats with the development of *** levels of TNF-αwere greater in 2K1C rats than in age-matched control at 4,8 and 20 weeks.α7nAChR mRNA in the heart was not altered in 2K1C *** the kidney of 2K 1 C rats,α7nAChR expression was significantly decreased at 8 and 20 weeks,but markedly increased at 4 weeks.α7nAChR mRNA was less in aorta of 2K1C rats than in age-matched control at 4.8 and *** findings were confirmed at the protein levels ofα*** Our results suggested that secondary hypertension may induceα7nAChR downregulation,and the decreased expression ofα7nAChR may contribute to inflammation in2K1 C hypertension.
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence s...
详细信息
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence suggests that stimulation ofα7 nicotinic acetylcholine receptor(α7nAChR) prevents cell death by inhibition of *** this study,we demonstrated that a single dose of PNU282987(100μg/kg,i.p.),a selectiveα7nAChR agonist,protected mice from intestinal injury and significantly improved survival when administered prior to lethal 8 Gy total body *** vitro,PNU282987protected against 8 Gy radiation-induced cell death in human umbilical venous endothelial cells by inhibiting *** conclude that activation ofα7nAChR may provide a new therapeutic pathway for the treatment of radiation-induced damage and mortality.
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been...
详细信息
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been *** previous study has demonstrated that the α7nAChR-mediated cholinergic anti-inflammatory pathway is impaired systemically in the genetic model of *** this work,we investigated the changes ofα7nAChR expression in a model of secondary *** The 2-kidney 1-clip(2K1C)hypertensive rat model was *** pressure,vagus nerve function,serum tumor necrosis factor-α(TNF-α)and both the mRNA and protein levels of α7nAChR in tissues from heart,kidney and aorta were measured at 4,8 and 20 weeks after *** Compared with age-matched control,it was found that vagus nerve function was significantly decreased in 2K1C rats with the development of *** levels of TNF-α were greater in 2K1C rats than in age-matched control at 4,8 and 20 weeks.α7nAChR mRNA in the heart was not altered in 2K1C *** the kidney of 2K1C rats,α7nAChR expression was significantly decreased at 8 and 20 weeks,but markedly increased at 4 weeks.α7nAChR mRNA was less in aorta of 2K1C rats than in age-matched control at 4,8 and 20 *** findings were confirmed at the protein levels of α*** Our results suggested that secondary hypertension may induce α7nAChR downregulation,and the decreased expression of α7nAChR may contribute to inflammation in 2K1C hypertension.
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence s...
详细信息
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence suggests that stimulation of α7 nicotinic acetylcholine receptor(α7nAChR)prevents cell death by inhibition of *** this study,we demonstrated that a single dose of PNU282987(100 μg/kg,i.p.),a selective α7nAChR agonist,protected mice from intestinal injury and significantly improved survival when administered prior to lethal 8 Gy total body *** vitro,PNU282987 protected against 8 Gy radiation-induced cell death in human umbilical venous endothelial cells by inhibiting *** conclude that activation of a7nAChR may provide a new therapeutic pathway for the treatment of radiation-induced damage and mortality.
1.药物长期致癌试验的必要性IARC公布的对人肯定致癌物(group 1)中药物及其治疗方法(Medical drugs and treatments)共24种,位于各类物资之首;21世纪化学致癌的特点是多种暴露的联合效应。通过遗传毒性评价致癌性有局限性,只能检出遗传...
详细信息
1.药物长期致癌试验的必要性IARC公布的对人肯定致癌物(group 1)中药物及其治疗方法(Medical drugs and treatments)共24种,位于各类物资之首;21世纪化学致癌的特点是多种暴露的联合效应。通过遗传毒性评价致癌性有局限性,只能检出遗传毒性致癌物。ICH和很多国家管理机构都制定了药物致癌试验的指导原则,要求在遗传毒性筛选的基础上对某些药物进行长期致癌试验。2010年04月01日我国SFDA制定发布了《药物致癌试验必要性的技术指导原则》。
暂无评论