Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence s...
详细信息
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence suggests that stimulation ofα7 nicotinic acetylcholine receptor(α7nAChR) prevents cell death by inhibition of *** this study,we demonstrated that a single dose of PNU282987(100μg/kg,i.p.),a selectiveα7nAChR agonist,protected mice from intestinal injury and significantly improved survival when administered prior to lethal 8 Gy total body *** vitro,PNU282987protected against 8 Gy radiation-induced cell death in human umbilical venous endothelial cells by inhibiting *** conclude that activation ofα7nAChR may provide a new therapeutic pathway for the treatment of radiation-induced damage and mortality.
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been...
详细信息
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been *** previous study has demonstrated that the α7nAChR-mediated cholinergic anti-inflammatory pathway is impaired systemically in the genetic model of *** this work,we investigated the changes ofα7nAChR expression in a model of secondary *** The 2-kidney 1-clip(2K1C)hypertensive rat model was *** pressure,vagus nerve function,serum tumor necrosis factor-α(TNF-α)and both the mRNA and protein levels of α7nAChR in tissues from heart,kidney and aorta were measured at 4,8 and 20 weeks after *** Compared with age-matched control,it was found that vagus nerve function was significantly decreased in 2K1C rats with the development of *** levels of TNF-α were greater in 2K1C rats than in age-matched control at 4,8 and 20 weeks.α7nAChR mRNA in the heart was not altered in 2K1C *** the kidney of 2K1C rats,α7nAChR expression was significantly decreased at 8 and 20 weeks,but markedly increased at 4 weeks.α7nAChR mRNA was less in aorta of 2K1C rats than in age-matched control at 4,8 and 20 *** findings were confirmed at the protein levels of α*** Our results suggested that secondary hypertension may induce α7nAChR downregulation,and the decreased expression of α7nAChR may contribute to inflammation in 2K1C hypertension.
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been...
详细信息
Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular *** role of the alpha7 nicotinic acetylcholine receptor(α7nAChR)in inflammation has recently been *** previous study has demonstrated that theα7nAChR-mediated cholinergic anti-inflammatory pathway is impaired systemically in the genetic model of *** this work,we investigated the changes ofα7nAChR expression in a model of secondary *** The 2-kidney 1-clip(2K1C)hypertensive rat model was *** pressure,vagus nerve function,serum tumor necrosis factor-α(TNF-αand both the mRNA and protein levels ofα7nAChR in tissues from heart,kidney and aorta were measured at 4,8 and 20 weeks after *** Compared with age-matched control,it was found that vagus nerve function was significantly decreased in 2K1C rats with the development of *** levels of TNF-αwere greater in 2K1C rats than in age-matched control at 4,8 and 20 weeks.α7nAChR mRNA in the heart was not altered in 2K1C *** the kidney of 2K 1 C rats,α7nAChR expression was significantly decreased at 8 and 20 weeks,but markedly increased at 4 weeks.α7nAChR mRNA was less in aorta of 2K1C rats than in age-matched control at 4.8 and *** findings were confirmed at the protein levels ofα*** Our results suggested that secondary hypertension may induceα7nAChR downregulation,and the decreased expression ofα7nAChR may contribute to inflammation in2K1 C hypertension.
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence s...
详细信息
Radiation-induced gastrointestinal syndrome occurs when the body is exposed to a high dose of ***,safe and effective radioprotectants are not *** was reported to play a primary role in radiation-induced *** evidence suggests that stimulation of α7 nicotinic acetylcholine receptor(α7nAChR)prevents cell death by inhibition of *** this study,we demonstrated that a single dose of PNU282987(100 μg/kg,i.p.),a selective α7nAChR agonist,protected mice from intestinal injury and significantly improved survival when administered prior to lethal 8 Gy total body *** vitro,PNU282987 protected against 8 Gy radiation-induced cell death in human umbilical venous endothelial cells by inhibiting *** conclude that activation of a7nAChR may provide a new therapeutic pathway for the treatment of radiation-induced damage and mortality.
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