Recurrent genome copy number aberrations are known to be a common feature of many cancers,including hepatocellular carcinoma(HCC),and their analysis is expected to reveal genes involved in *** copy number variation(CN...
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Recurrent genome copy number aberrations are known to be a common feature of many cancers,including hepatocellular carcinoma(HCC),and their analysis is expected to reveal genes involved in *** copy number variation(CNV)is one of the mechanisms to regulate the expression level of genes which contributes to the development and progression of ***,in many regions with high frequency copy number variations(CNVs),the aberrantly expressed protein-coding genes is unable to make a sense,which suggests that the mechanisms underlying carcinogenesis may be partly contributed to the differently expression of long non-coding RNAs(IncRNAs).We carried out an association analysis of lncRNAs expression microarray and genome copy number variations data in HCC was and identified a set of lncRNAs whose expression levels correlated with common chromosomal *** we examined the relative copy number and expression levels of the related lncRNAs at candidate regions in 42 pairs HBV-related HCC and paired adjacent nontumor tissues via real-time quantitative PCR *** these lncRNA-PRAL(P53 Regulatory Associated LncRNA)is consistently decreased(p<0.001,n=42)with a significant correlation with the copy number variations(R=0.537,p=0.006).We further found that IncRNA-PRAL could promote the tumor cell apoptosis and suppress the progress of carcinogenesis in ***,lncRNA-PRAL can participate in HSP90-p53 protein complex formation to help facilitate the nuclear transportation of p53.A large amount of regions of high frequent copy number variations can be ascribed to the lncRNAs genome *** lncRNA-PRAL can promotes the tumor cell apoptosis through p53 and it presents this functional copy-number variation as a potential therapeutic target for HCC.
A new class of non-coding RNAs,designated long non-coding RNAs(lncRNAs),was recently found to be frequently deregulated in various *** previous data suggested that lncRNAs are likely to have biological effects,this po...
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A new class of non-coding RNAs,designated long non-coding RNAs(lncRNAs),was recently found to be frequently deregulated in various *** previous data suggested that lncRNAs are likely to have biological effects,this possibility needs to be confirmed by specific hypothesis-driven *** the precise molecular mechanisms by which lncRNAs function in various diseases will be critical for exploring new potential strategies for early diagnosis and *** the past several years,multiple studies have demonstrated that nearly every step in the life cycle of a gene can be regulated by lncRNAs.
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