Background Lead(Pb),as a widespread environmental pollutant,is known to cause a wide range of neurotoxic effects,including decreased intelligence quotient,cognitive deficits,poor attention span,and increased *** has l...
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Background Lead(Pb),as a widespread environmental pollutant,is known to cause a wide range of neurotoxic effects,including decreased intelligence quotient,cognitive deficits,poor attention span,and increased *** has long been recognized as a neurodevelopmental *** blood-brain barrier(BBB) and blood-cerebrospinal fluid barrier(BCB) are known to be targets of Pb neurotoxicity. Brain capillary endothelial cells with tight junctions(TJs) between adjacent cells, astrocyte end feet, and pericytes within the capillary basement constitute the structural basis of the BBB. Choroid plexus epithelial cells with tight junctions(TJs) between adjacent cells constitute the structural basis of the ***, the underlying mechanisms of Pb-induced reduction of TJ proteins of BBB and BCB are still *** way Pb enters into the brain parenchyma or cerebrospinal fluid can be classified into two categories: intercellular regions after breakdown TJ proteins and Pb transporter in the endothelial/epithelial cell bodies. Recently, hemichannels of Connexin 43(Cx43), the most ubiquitously expressed gap junction proteins in the BBB and BCB, were found to be important pathways for many substances. In previous study, Cx43 expression was enhanced in the hippocampus, a major target of Pb-induced neurotoxicity, implying that Pb may accumulate in the hippocampus via Cx43 *** is nonreceptor protein tyrosine kinases that mediates the integrin signaling on the focal adhesion complex at the cell-toextracellular matrix interface. Src kinase activity is required for both assembly and disassembly of TJ proteins in different epithelial cells. In addition, Src has long been known to interact with and phosphorylate Cx43 to promote downregulation of GJ communication and cause GJ disassembly,even channel closure. Src phosphorylation was found to increase greater than other kinases in brain microvessels after Pb exposure by using a phosphoprotein antibody *** This
Long noncoding RNA (lncRNA) highly up-regulated in liver can-cer (HULC) is the first identified IncRNA highly expressed in hepatocellular carcinoma and acts as an oncogenic IncRNA. However, the significance of HULC in...
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Long noncoding RNA (lncRNA) highly up-regulated in liver can-cer (HULC) is the first identified IncRNA highly expressed in hepatocellular carcinoma and acts as an oncogenic IncRNA. However, the significance of HULC in triple-negative breast cancer (TNBC) is still unclear. Our purpose is to explore the clinical significance and biological function ofHULC in *** of HULC in TNBC tissues and cell lines was measured and the as-sociation between HULC expression and clinicopathological factors was analyzed. Cell proliferation, migration, and invasion assays were executed by using TNBC cell lines transfected with si-HULC or si-NC. The potential mechanism of HULC was explored by Western blot.
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