Through transcriptome microarray analysis,we found that thioredoxin interacting protein(TXNIP)up-regulated in Huh7 cells after HCV *** down TXNIP through siRNA reduced HCVcc *** mRNA level up-regulation in Huh7 cells ...
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Through transcriptome microarray analysis,we found that thioredoxin interacting protein(TXNIP)up-regulated in Huh7 cells after HCV *** down TXNIP through siRNA reduced HCVcc *** mRNA level up-regulation in Huh7 cells could be observed 1d after HCV infection and peaked at 2d with more than 2 fold *** treated the cells with IFN-a,IFN-b,and IFN-l and detected TXNIP level *** level increases at least 2 folds after 12h of
Objective To study the mechanism and the exact target of Schizandronic acid(SZA)and Anwuweizic acid(AWA),two members of tetracyclic triterpenoid acid family,on hepatitis C virus(HCV).Methods The two compounds were scr...
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Objective To study the mechanism and the exact target of Schizandronic acid(SZA)and Anwuweizic acid(AWA),two members of tetracyclic triterpenoid acid family,on hepatitis C virus(HCV).Methods The two compounds were screened out through cell culture-derived HCV(HCVcc)from hundreds of natural pharmaceutical plants,and were confirmed to have antiviral activities against
MiR-221 was reported to be upregulated and play roles in tumorigenesis of hepatitis C virus(HCV)associated hepatocellular carcinoma(HCC).However,the role of miR-221 in HCV infection remains *** this study,it was found...
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MiR-221 was reported to be upregulated and play roles in tumorigenesis of hepatitis C virus(HCV)associated hepatocellular carcinoma(HCC).However,the role of miR-221 in HCV infection remains *** this study,it was found that miR-221 was upregulated in serum of HCV chronic hepatitis patients and Huh7.5.1 cells infected with *** studys indicated that miR-221 mimic could accentuate anti-HCV effect of IFN-a in HCVcc model,miR-221 mimic could
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