Capsaicin and(E)-4-hydroxy-3-methoxybenzyl-8-methylnon-6-enoate were important intermediate of *** research proposed a new method for synthesizing them from 6-bromohexanoic ester by Wittig reaction to give(Z)-8-methyl...
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Capsaicin and(E)-4-hydroxy-3-methoxybenzyl-8-methylnon-6-enoate were important intermediate of *** research proposed a new method for synthesizing them from 6-bromohexanoic ester by Wittig reaction to give(Z)-8-methyl-6-nonenoic acid(4),then treated by nitrous acid and NaNO2 to induce Z→E isomerization reaction of the carbon-carbon double bond,then followed by condensation reaction to give product in an overall yield of 31%.The method is more convenient than traditional methods.
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