The liver is frequently subject to insult because of viral infection,alcohol abuse,or toxic chemical *** research has been conducted to identify blood markers that can better discern liver damage,but little progress h...
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The liver is frequently subject to insult because of viral infection,alcohol abuse,or toxic chemical *** research has been conducted to identify blood markers that can better discern liver damage,but little progress has been achieved in clinical ***,circulating microRNAs(miRNAs) have been reported as potential biomarkers for the noninvasive diagnosis of *** this study,we investigated whether plasna miRNAs have diagnostic utility in identifying liver *** study was divided into 2 phases marker selection by real-time quantitative PCR analysis of a small set of plasma samples,and marker validation with a large set of plasma samples from patients with chronic hepatitis B viral infections and healthy *** mouse model systems. D-galactosamine- and alcoholinduced liver injury,were also developed to evaluate whether differences in miRNA concentration were associated with various liver *** the miRNA candidates identified,miR-122 presented a disease severity- dependent change in plasma concentration in the patients and animal *** with an increase in aminotransferase activity in the blood,the change in miR-122 concentration appeared ***,this change was more specific for liver injury than for other organ damage and was more reliable,because the change was correlated with liver histologic ***:Our findings suggest that circulating miR-122 has potential as a novel. predictive,and reliable blood marker for viral-,alcohol-,and chemicalinduced liver injury.
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