Polychlorinated biphenyls (PCBs) are widespread environmental contaminants that are possible health hazards for human beings through a variety of *** the present study,50 time mated pregnant rats were divided into fiv...
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Polychlorinated biphenyls (PCBs) are widespread environmental contaminants that are possible health hazards for human beings through a variety of *** the present study,50 time mated pregnant rats were divided into five groups and injected daily from gestational days 7 to 18 with either 2,2′,4,4′- tetrachlorobiphenyl (PCB 47) or 3,3′,4,4′- tetrachlorobiphenyl (PCB 77) or seseme oil (control) to evaluate the effects of these PCBs on prenatal and postnatal *** were examined for malformations of genitalia at birth and in *** weight gains of these animals were checked every 7 days through postnatal day (PND) *** were no clinical signs of toxicity in the PCB-treated dams or their offspring throughout the *** size and sex ratio of the litters were not *** PCBs produced a significant increase in the females' anogenital distance,suggesting a modification of androgen responsiveness in females resulting from PCB exposure during *** effects were not seen with the *** proportion of individuals with eyes open by PND 15 was significantly reduced by both *** to 1 mg/kg body weight of PCB 77 significantly reduced body weight gains in male pups from PND 35 to ***,no significant differences were found in body weight gains of the pups exposed to PCB 47.
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