Background and Objectives: Toll-like receptor 4 (TLR4) links human innate and adaptive immunity via bacterial endotoxin recognition, and has a considerable role in the pathogenesis of *** some genetic association stud...
Background and Objectives: Toll-like receptor 4 (TLR4) links human innate and adaptive immunity via bacterial endotoxin recognition, and has a considerable role in the pathogenesis of *** some genetic association studies on TLR4 and asthma have been performed, the effects of the genetic variants of TLR4 on asthma are still largely *** study aimed to evaluate the effects of polymorphisms in TLR4 on asthma risk and asthma-related phenotypes in a Chinese Han ***: We consecutively recruited 318 unrelated adult asthmatic patients and 352 healthy *** tagging single nucleotide polymorphisms (SNPs) in TLR4 gene were detected using GenomeLab SNPstream or TaqMans *** conducted case-control and case-only association studies between the selected tagging SNPs in TLR4 and asthma or asthma-related ***: We found no evidence to support a significant association between TLR4 SNPs and asthma ***, our results revealed that TT homozygote of rs1927914 was associated with lower FEV1% and FEV1/FVC in asthmatic *** evidently positive association was found between the TT genotype of rs1927914, or the GG genotype ofrs10983755 and rs1927907, and asthma severity (P=0.008, 0.002, 0.004, respectively), which indicated that C allele of rs 1927914, and A allele of rs 10983755 and rs 1927907 had a protective effect on asthma *** between genetic variants in TLR4 and other asthma-related phenotypes, such as eosinophil counts, serum high-sensitivity C reactive protein and total serum immunoglobulin E levels, were not ***: TLR4 polymorphisms do not contribute to asthma susceptibility, but may influence the severity of asthma.
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