Understanding the mechanism controlling erythrocyte enucleation may provide new insights into therapeutic approaches for related diseases and the generation of red blood cells(RBCs)in vitro might meet the deficiency i...
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Understanding the mechanism controlling erythrocyte enucleation may provide new insights into therapeutic approaches for related diseases and the generation of red blood cells(RBCs)in vitro might meet the deficiency in blood cell ***,the low erythrocyte enucleation rate remains the bottle neck of this *** are small RNA molecules binding to partially complementary sites in the 3'-UTR of target transcripts and repressing their *** have been shown as important regulators in stem cell commitment,cell proliferation and *** now,only a few miRNAs have been reported involved in erythroid differentiation,maturation,fetal globin genes expression and enucleation,including miR-15a,miR-16-1,miR-126,miR-144,miR-191,miR-451 and ***,it remains unclear how mammalian erythrocytes extrude their nucleus.
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