Advanced dressings play a key role in accelerating wound healing velocity and enhancing quality According to the development of new dressings,I express my personal opinion and expectation of the dressings in wound rep...
Advanced dressings play a key role in accelerating wound healing velocity and enhancing quality According to the development of new dressings,I express my personal opinion and expectation of the dressings in wound repair and regeneration
目的探索A型肉毒毒索(botulinum toxin type A, BTXA)治疗挛缩性瘢痕的疗效。方法选取26例挛缩性瘢痕患者,随机分为A型肉毒毒素组(BTXA组)和曲安奈德组(TAC组,对照组),注射药物治疗前测量各组患者瘢痕长轴长度.并于注射后再...
详细信息
目的探索A型肉毒毒索(botulinum toxin type A, BTXA)治疗挛缩性瘢痕的疗效。方法选取26例挛缩性瘢痕患者,随机分为A型肉毒毒素组(BTXA组)和曲安奈德组(TAC组,对照组),注射药物治疗前测量各组患者瘢痕长轴长度.并于注射后再次测量其长度,1次/月,共6次,通过比较治疗前后差值评价药物疗效。切取各组瘢痕组织行免疫组织化学检测,观察α平滑肌肌动蛋白(α-SMA)及肌球蛋白-Ⅱ的表达情况。结果药物作用1个月后,BTXA组较TAC组瘢痕挛缩程度明显减轻(P〈0.05),尤以6个月时差异最明显,BTXA组和TAC组瘢痕长轴长度差值分别为(1.23±0.42)cm和(0.56±0.33)cm。免疫组织化学结果显示,BTXA组瘢痕内α-SMA及肌球蛋白-Ⅱ表达较TAC组明显减少(P〈0.05)。结论A型肉毒毒素治疗挛缩性瘢痕操作简单、效果明显,值得推广应用。
暂无评论