目的分析社区脑卒中患者生活质量现状,探讨社区脑卒中患者抑郁、日常生活活动能力与生活质量之间的关系。方法随机抽取郑州市5个社区的脑卒中患者146例,分别用抑郁自评量表(self-rating depression scale,SDS)、Barthel指数评定量表、简明健康状况问卷(short form 36,SF-36)测评脑卒中患者的抑郁水平、日常生活活动能力(activity of dailyliving,ADL)及生活质量。描述生活质量现状,分析抑郁、ADL与生活质量的相关性。结果社区脑卒中患者生活质量水平低于中国常模水平;抑郁与生活质量8个维度均呈负相关;ADL与生活质量除社会功能外的其余7个维度均呈正相关。结论脑卒中发病后生活质量显著下降,尤其是生理功能、职能及情感方面;脑卒中后抑郁发生、ADL水平下降都会影响患者生活质量。
[Objective] This study aimed to establish Balb/c mice model for food allergy caused by Chinese lobsters through using intraperitoneal injection for sensitization and explore methods for in vitro identification and eva...
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[Objective] This study aimed to establish Balb/c mice model for food allergy caused by Chinese lobsters through using intraperitoneal injection for sensitization and explore methods for in vitro identification and evaluation of food allergy caused by Chinese lobsters. [Method] The 40 male Bal/c mice were divided into ovalbumin（OVA） positive control group, Coca＇s solution negative control group, blank control group and model group. Balb/c mice model was established by intraperitoneally injection of immunized Balb/c mice with OVA or Chinese lobster crude protein with aluminum hydroxide adjuvant. IgE and histamine levels in serum after the second challenge were determined by ELISA method, and the specific IgE antibody titer was determined by passive cutaneous anaphylaxis test（PCA）; additionally, spleen index and histological changes in the small intestine, as well as food allergy symptoms after challenge were also calculated or observed. [Results] After the last challenge, IgE content was（236.75 ±73.39） μg/L in the Chinese lobster crude protein group, revealing no difference with that in the OVA group, but significantly higher than that in either the Coca＇s solution group or the blank control group（P 0.01）;histamine content in serum in the Chinese lobster crude protein group was（406.55±232.79）, significantly higher than that in the blank control group（P0.01）. In the passive cutaneous anaphylaxis test, IgE antibody titer reached 1/16 after the last challenge in the Chinese lobster crude protein group. Spleen index in both Chinese lobster crude protein group and OVA group was significantly greater than that in either the Coca＇s solution group or the blank control group（P0.01）. What＇s more, infiltration of inflammatory cells like lymphocytes and eosnophils at the lamina propria of intestinal mucosa was also observed both Chinese lobster crude protein group and OVA group. [Conclusion] This study established Balb/c mice model for food allergy caused by Chinese lobsters; ser
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