牙髓炎是发生于牙髓组织的炎性病变,持续发展会导致根尖周炎及骨组织缺损,严重破坏牙齿功能,影响患者的口腔健康及日常生活,造成时间、经济损失。细胞凋亡是基因控制的一种程序性细胞死亡,其表观遗传调节主要包括非编码RNA (non-coding RNA, ncRNA)转录调控、DNA甲基化和组蛋白修饰等。本文通过对表观遗传在牙髓炎进展中对细胞凋亡的调控机制和潜在作用作一综述,旨在丰富牙髓炎症的机制背景,为研究牙髓炎症的防治提供参考。Pulpitis is an inflammatory disease that occurs in the pulp tissue. Continued development can lead to periapical periodontitis and bone tissue defect, seriously damage dental function, affect patients’ oral health and daily life, and cause time and economic losses. Apoptosis is a programmed cell death controlled by genes. Its epigenetic regulation mainly includes non-coding RNA (ncRNA) transcriptional regulation, DNA methylation and histone modification. This article reviews the regulatory mechanism and potential role of epigenetic on apoptosis in the progression of pulpitis, aiming to enrich the mechanism background of pulpitis and provide reference for the study of pulp inflammation prevention and treatment.
肠道炎症性疾患(Inflammatory Bowel Disease)是一种慢性全身性炎症疾病,主要包括溃疡性结肠炎(Ulcerative Colitis, UC)以及克罗恩病(Crohn’s Disease, CD)特征是肠道黏膜受到广泛的炎症破坏。此外,其可涉及全身各个系统,形成系统性合并症,骨骼系统便是其中之一。肠道炎症患者或各式各样的动物模型中均可观察到骨质破坏以及骨量丧失的现象,而这其中的病因机制却涉及各个方面,包括营养状况、炎症因子、肠道激素类信号分子以及肠道菌群等。总的来说骨代谢的平衡主要依赖于成骨与破骨作用之间的平衡,外界或内部因素倘若打破这一平衡,便会引起宏观方面的骨骼系统的变化,肠道炎症状态下亦是如此。本文将从肠道炎症状态出发,对这一病理环境下骨代谢异常的表现以及病因机制以及相关治疗策略做一综述。Inflammatory Bowel Disease, as a chronic systemic inflammatory disease that includes Ulcerative Colitis (UC) and Crohn’s disease (CD), is characterized by extensive inflammatory destruction of the intestinal mucosa. In addition, it involves various systems throughout the body, leading to systemic comorbidities, especially the skeletal system. Bone destruction and bone loss have been observed in patients with intestinal inflammation or in various animal models, and the etiological mechanism of this phenomenon involves various aspects, including nutritional status, inflammatory factors, intestinal hormone signaling molecules, and intestinal flora. In general, the balance of bone metabolism mainly depends on the balance between osteogenesis and osteoclastogenesis. If external or internal factors break this balance, it would cause changes in the skeletal system in the macro aspect, and this is also the case in the state of intestinal inflammation. Starting from the state of intestinal inflammation, this article will review the manifestations, etiological mechanisms and related treatment strategies of abnormal bone metabolism in this pathological environment.
暂无评论