微/纳米马达在生物医学中的应用在近年来引起了广泛的研究,结合囊泡的微/纳米马达在生物医学领域具有极大的应用潜力,由于微/纳米马达的自驱动力以及囊泡本身具有的良好的生物相容性使其在药物递送、光热疗法、解毒等领域均有所应用。本文回顾了结合囊泡的微/纳米马达的制备方式,以及结合不同类型囊泡的微纳米马达的驱动力、结合方式及应用。总而言之,结合囊泡的微/纳米马达有望推进微/纳米马达在生物医学领域的应用,并促进其临床转化。The application of micro/nanomotors in biomedicine has garnered widespread attention in recent years. The integration of vesicles with micro/nanomotors holds significant potential in the biomedical field. Due to the self-propelling nature of micro/nanomotors and the excellent biocompatibility of vesicles, they have been applied in areas such as drug delivery, photothermal therapy, and detoxification. This article reviews the preparation methods of micro/nanomotors combined with vesicles, as well as the driving forces, coupling methods, and applications of micro/nanomotors integrated with different types of vesicles. In summary, micro/nanomotors combined with vesicles are expected to advance the application of micro/nanomotors in biomedicine and promote their clinical translation.
牙髓炎是发生于牙髓组织的炎性病变,持续发展会导致根尖周炎及骨组织缺损,严重破坏牙齿功能,影响患者的口腔健康及日常生活,造成时间、经济损失。细胞凋亡是基因控制的一种程序性细胞死亡,其表观遗传调节主要包括非编码RNA (non-coding RNA, ncRNA)转录调控、DNA甲基化和组蛋白修饰等。本文通过对表观遗传在牙髓炎进展中对细胞凋亡的调控机制和潜在作用作一综述,旨在丰富牙髓炎症的机制背景,为研究牙髓炎症的防治提供参考。Pulpitis is an inflammatory disease that occurs in the pulp tissue. Continued development can lead to periapical periodontitis and bone tissue defect, seriously damage dental function, affect patients’ oral health and daily life, and cause time and economic losses. Apoptosis is a programmed cell death controlled by genes. Its epigenetic regulation mainly includes non-coding RNA (ncRNA) transcriptional regulation, DNA methylation and histone modification. This article reviews the regulatory mechanism and potential role of epigenetic on apoptosis in the progression of pulpitis, aiming to enrich the mechanism background of pulpitis and provide reference for the study of pulp inflammation prevention and treatment.
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