无托槽隐形矫治器施力于牙齿,使其恢复至正常的位置,最终牙齿在正确排列关系下建立平衡、稳定的咬合状态。咬合曲线是连接相关牙尖而形成的连续曲线,分为Spee曲线和Wilson曲线,是评价咬合和排齐整平效果的重要指标,但临床中缺乏准确、便捷的评价工具。近年来,口腔数字化已经覆盖了口腔诊疗的全流程,人工智能技术在信息分析中逐渐起到中流砥柱的作用,且正畸与人工智能呈现深度结合的趋势。本文将对咬合曲线的测量方法及目前无托槽隐形矫治后咬合曲线变化的研究现状进行综述。The clear aligner exerts force on the teeth, causing them to return to their normal positions, ultimately establishing a balanced and stable occlusion state for the teeth in the correct arrangement. The occlusal curve is a continuous curve formed by connecting the relevant cusps, and it is divided into the Spee curve and Wilson curve, which is an important indicator for evaluating occlusion and alignment, but there is a lack of accurate and convenient evaluation tools in clinical practice. In recent years, digitalization has covered the entire process of dental treatment, and artificial intelligence technology has played an increasingly pivotal role in information analysis, and there is a trend of deep integration between orthodontics and artificial intelligence. This paper will review the measurement methods of occlusal curves and the current research status of the changes in occlusal curves after clear aligner treatment.
间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能力受限、体内存活率低及药物递送效率不足等方面。为解决这些问题,目前出现多种工程化修饰技术,包括基因工程、表面修饰、物理化学修饰和组织工程等,以提高MSCs疗法的治疗效果和安全性。本文详细介绍了不同工程化修饰策略,并重点阐述各工程化修饰下MSCs功能化的实现和临床应用前景。Mesenchymal stem cells (MSCs) hold significant promise for the treatment of a wide range of diseases, owing to their multi-lineage differentiation potential, self-renewal capabilities, and immune regulatory properties. Although MSCs-based therapies have demonstrated safety and efficacy to some extent, their clinical application remains limited. These limitations are primarily due to challenges such as insufficient targeting of MSCs, restricted differentiation capacity, low in vivo survival rates, and poor drug delivery efficiency. To address these issues, a variety of engineering strategies, including genetic modification, surface functionalization, physicochemical modification, and tissue engineering, have been developed to enhance the therapeutic efficacy and safety of MSCs therapies. This paper provides a comprehensive overview of these engineering approaches and discusses their potential for future clinical application in MSCs-based therapies.
近年来,正畸治疗已经从简单排齐牙齿向改善面部美观发生了巨大转变,无论是患者希望通过正畸治疗达到改善面部美观的目的,还是正畸医生以颌面部软组织为治疗导向的矫治理念的产生,正畸治疗与面部软组织美观之间的关系越来越紧密。人们对面部美观的定义受主观因素影响,明确面部软组织美学的评价标准对于正畸治疗过程中不同人群目标位置的设定具有十分重要的意义,同时在制定矫治计划时关于正畸治疗前后对面部美观的改变也需要被考虑。我们不定义美貌理想值,只是希望我们的研究结果能为有美貌需求的正畸患者提供一种参考。同时,既往研究正畸治疗与面部美观的相关性大多着眼于侧貌的改变,但正面像是患者最容易观察且关注较多的部分,我们将把探索的目光放在与正畸治疗相关的面部正面像软组织的改变上,正面美学特征的研究可以作为侧貌美学的补充,丰富颜面美学分析的内容,也可以在正畸治疗前辅助医患沟通,降低因审美差异造成纠纷的风险。In recent years, orthodontic treatment has evolved significantly from merely aligning teeth to improve facial beauty. Whether it is patients’ hope to improve facial beauty through orthodontic treatment, or the emergence of the treatment concept of face soft tissue as treatment orientation, the relationship between orthodontic treatment and facial soft tissue beauty is strengthened. The perception of facial beauty is influenced by subjective factors. Making it essential to establish clear evaluation criteria for setting the target positions of different groups in the process of orthodontic treatment. At the same time, changes in facial beauty before and after orthodontic treatment should also be considered when making the treatment plan. We do not define an ideal standard of beauty, but hope that our findings can provide a reference for orthodontic patients with aesthetic concerns. At the same time, previous studies on the correlation between orthodontic treatment and facial aesthetics mostly focused on the changes of facial appearance, However, the frontal view is what patients are most likely to observe and pay attention to. We will focus our exploration on the changes of facial image soft tissue related to orthodontic treatment. The study of positive aesthetic features can complement profile aesthetics and enrich the content of facial aesthetic analysis. It can also assist doctor-patient communication before orthodontic treatment to reduce the risk of disputes caused by aesthetic differences.
着色牙是常见的口腔疾病,根据其病因可以分为外源性着色牙和内源性着色牙两类。随着人们生活水平和经济水平的提高,牙齿变色与美观问题引起越来越多患者的关注,而漂白治疗,作为一种微创性高,对牙齿硬组织损伤较小的治疗方式被越来越多地应用于变色牙的治疗。漂白治疗已经被大量的研究证实其有效性,但漂白治疗的效果受多种因素的影响,本文将就影响漂白治疗效果的因素进行综述。Discolored teeth are common oral diseases, which can be divided into exogenous and endogenous discolored teeth according to their etiology. With the improvement of people’s living standards and economic level, the discoloration and aesthetic problems of teeth have attracted more and more patients’ attention. Bleaching treatment, as a minimally invasive treatment with less damage to the hard tissue of teeth, has been more and more applied in the treatment of discoloration of teeth. Bleaching treatment has been proved effective by a large number of studies, but the effect of bleaching treatment is affected by many factors. This paper reviews the factors influencing the therapeutic effect of tooth bleaching.
牙髓炎是发生于牙髓组织的炎性病变,持续发展会导致根尖周炎及骨组织缺损,严重破坏牙齿功能,影响患者的口腔健康及日常生活,造成时间、经济损失。细胞凋亡是基因控制的一种程序性细胞死亡,其表观遗传调节主要包括非编码RNA (non-coding RNA, ncRNA)转录调控、DNA甲基化和组蛋白修饰等。本文通过对表观遗传在牙髓炎进展中对细胞凋亡的调控机制和潜在作用作一综述,旨在丰富牙髓炎症的机制背景,为研究牙髓炎症的防治提供参考。Pulpitis is an inflammatory disease that occurs in the pulp tissue. Continued development can lead to periapical periodontitis and bone tissue defect, seriously damage dental function, affect patients’ oral health and daily life, and cause time and economic losses. Apoptosis is a programmed cell death controlled by genes. Its epigenetic regulation mainly includes non-coding RNA (ncRNA) transcriptional regulation, DNA methylation and histone modification. This article reviews the regulatory mechanism and potential role of epigenetic on apoptosis in the progression of pulpitis, aiming to enrich the mechanism background of pulpitis and provide reference for the study of pulp inflammation prevention and treatment.
微/纳米马达在生物医学中的应用在近年来引起了广泛的研究,结合囊泡的微/纳米马达在生物医学领域具有极大的应用潜力,由于微/纳米马达的自驱动力以及囊泡本身具有的良好的生物相容性使其在药物递送、光热疗法、解毒等领域均有所应用。本文回顾了结合囊泡的微/纳米马达的制备方式,以及结合不同类型囊泡的微纳米马达的驱动力、结合方式及应用。总而言之,结合囊泡的微/纳米马达有望推进微/纳米马达在生物医学领域的应用,并促进其临床转化。The application of micro/nanomotors in biomedicine has garnered widespread attention in recent years. The integration of vesicles with micro/nanomotors holds significant potential in the biomedical field. Due to the self-propelling nature of micro/nanomotors and the excellent biocompatibility of vesicles, they have been applied in areas such as drug delivery, photothermal therapy, and detoxification. This article reviews the preparation methods of micro/nanomotors combined with vesicles, as well as the driving forces, coupling methods, and applications of micro/nanomotors integrated with different types of vesicles. In summary, micro/nanomotors combined with vesicles are expected to advance the application of micro/nanomotors in biomedicine and promote their clinical translation.
暂无评论