卒中后抑郁(post stroke depression, PSD)是脑卒中患者非常常见的并发症,其三大核心症状是:心情低落、兴趣减退及易疲劳,卒中后抑郁可发生在卒中后急性期,中期和恢复期,其发生率均在30%左右。目前卒中后抑郁的发病机制尚不清楚。犬尿氨酸代谢途径(kynurenine pathway, KP)被认为是连接神经系统免疫炎性反应等多个系统与抑郁症的主要途径。本文就犬尿氨酸代谢途径参与卒中后抑郁的病理生理学机制及其调控对抑郁症状的影响的研究做一综述,旨在为进一步研究抑郁的形成机制提供参考。Post stroke depression (PSD) is a very common complication in stroke patients, with three core symptoms: depressed mood, loss of interest and fatigue. PSD can occur in the acute, middle and recovery periods after stroke, with an incidence rate of about 30%. The pathogenesis of post-stroke depression is still unclear. The kynurenine pathway (KP) is thought to be a major pathway linking multiple systems, including the immune-inflammatory response of the nervous system, to depression. In this paper, we present a review on the pathophysiological mechanisms of kynurenine pathway involved in post-stroke depression and its modulation on depressive symptoms, with the aim of providing a reference for further research on the formation mechanisms of depression.
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