NOD样受体家族胱天蛋白酶激活和募集结构域蛋白3(NOD-like receptor family with a caspase activation and recruitment domain containing 3,NLRC3)作为NOD样受体中的负向调控分子,在免疫应答的抗原识别提呈阶段、淋巴细胞增殖活化阶...
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NOD样受体家族胱天蛋白酶激活和募集结构域蛋白3(NOD-like receptor family with a caspase activation and recruitment domain containing 3,NLRC3)作为NOD样受体中的负向调控分子,在免疫应答的抗原识别提呈阶段、淋巴细胞增殖活化阶段以及免疫效应阶段通过p38信号分子、NF-κB-活化T细胞核因子5复合物(NF-κB-nuclear factor of activated T cells 5 complex,NF-κB-NFAT5)和丝裂原活化蛋白激酶/细胞外调节蛋白激酶(mitogen-activated protein kinase/extracellular regulated protein kinase,MEK/ERK)信号通路等多种机制发挥抑制作用,在诸多免疫相关疾病,包括感染性疾病、自身免疫性疾病和肿瘤等疾病进程中具有重要调控作用。本文综述了NLRC3分子在不同免疫应答阶段和免疫相关疾病中的作用及机制。
目的:通过对铜绿假单胞菌合并曲霉菌感染的患者进行分析,了解铜绿假单胞菌合并曲霉菌感染在临床患者中的流行情况及患者的临床特征,了解铜绿假单胞菌合并曲霉菌感染的临床现状,并且通过对合并感染的患者进行预后不佳危险因素的单因素、多因素分析,为铜绿假单胞菌合并曲霉菌感染的临床治疗提供参考,以期制定合理的诊疗策略,改善患者预后。方法:回顾性收集2013年2月至2022年10月青岛大学附属医院铜绿假单胞菌及曲霉菌培养阳性标本60例,总结临床特征,筛选出单因素危险因素,分析预后良好组和预后不佳组的临床资料,再对单因素危险因素中有统计学意义的因素采用Logistic多因素回归分析,导致预后不良的影响因素,按检验水准P Objective: This study aims to analyze patients with Pseudomonas aeruginosa co-infected with Aspergillus to understand the epidemiological characteristics and clinical features of such infections. By investigating the clinical status of co-infections and conducting univariate and multivariate analyses of risk factors associated with poor prognosis, the study seeks to provide clinical insights for the treatment of Pseudomonas aeruginosa and Aspergillus co-infections. The ultimate goal is to formulate rational diagnostic and therapeutic strategies to improve patient outcomes. Methods: A retrospective analysis was conducted on 60 cases of Pseudomonas aeruginosa and Aspergillus co-infection at the Affiliated Hospital of Qingdao University between February 2013 and October 2022. Clinical characteristics were summarized. Univariate analysis was used to identify risk factors for poor prognosis, and clinical data of the good prognosis group and the poor prognosis group were compared. Factors with statistical significance in univariate analysis were further analyzed using multivariate logistic regression to determine independent risk and protective factors associated with poor prognosis. Statistical significance was set at P < 0.05. Results: The use of antifungal drugs, neutrophil percentage, platelet count, and C-reactive protein (CRP) levels were identified as univariate risk factors for poor prognosis in patients with Pseudomonas aeruginosa co-infected with Aspergillus. The administration of antifungal drugs and platelet count emerged as independent protective factors for prognosis in these co-infected cases. Specifically, C-reactive protein (CRP) levels were determined to b
目的总结间质性肺疾病患者呼吸困难管理的相关证据。方法计算机检索UpToDate、BMJ Best Practice、美国胸科协会、英国国家卫生与临床优化研究所、乔安娜布里格斯研究所循证卫生保健中心数据库、Cochrane Library、PubMed、Embase、Web ...
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目的总结间质性肺疾病患者呼吸困难管理的相关证据。方法计算机检索UpToDate、BMJ Best Practice、美国胸科协会、英国国家卫生与临床优化研究所、乔安娜布里格斯研究所循证卫生保健中心数据库、Cochrane Library、PubMed、Embase、Web of Science、中国知网、中国生物医学文献数据库、万方数据库等数据库和网站中关于间质性肺疾病患者呼吸困难管理的相关文献,检索时限为建库至2024年4月30日。采用文献相应的质量评价标准对纳入文献进行质量评价,并提取资料。结果共纳入18篇文献,包括3篇临床决策、9篇指南、3篇专家共识、2篇系统评价和1篇证据总结。最终从呼吸困难评估、氧气治疗、肺康复、药物治疗、其他5个方面汇总了24条证据。结论本研究总结了间质性肺疾病患者呼吸困难管理的最佳证据,可以为医护人员制订相应的干预措施提供参考。医护人员需结合文化背景、临床情境及患者意愿制订呼吸困难管理策略。
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