Arteriovenous(AV) grafts are commonly created to relieve angina or function as an access for *** of these grafts is characterized by hyperplasia of venous smooth muscle cells(SMCs),neointima formation and *** proc...
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Arteriovenous(AV) grafts are commonly created to relieve angina or function as an access for *** of these grafts is characterized by hyperplasia of venous smooth muscle cells(SMCs),neointima formation and *** processes including endothelial dysfunction and neointima cell hyperplasia are present in failed vein *** pathogenesis of this lesion is incompletely *** this study we sought to identify the molecular and cellular signalings causing neointimal formation in AV *** have identified that bone marrow(BM)-derived fibroblast specific protein -1(FSP-1) cells are major components of remodeled AV ***-derived,FSP-1 cells are attracted to the graft via a SDF-lα-dependent mechanism and induce transendothelial invasion of inflammatory cells into the *** are several novel discoveries in this study:1) we found that after creation of a vein graft,there is rapid loss of endothelial cells followed by deposition of platelets on the denuded *** platelets secrete the chemokine stromal cell-derived factor-la(SDF-lα). It recruits bone marrow(BM)-derived cells that express the SDF-lαreceptor CXCR4;2) we found that homing of FSP-1cells was dependent on platelete-derived SDF-lα.We also found that the FSP-1cells migrated into the vein graft media and secreted FSP-1;3)co-culture and manipulation of FSP-1 expression in vivo were found to stimulate proliferation of SMC and SMC hyperplasia leads to vein graft failure.
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