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Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study (vol 2, pg 1.4, 2021.

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LANCET GLOBAL HEALTH 2021年第4期9卷 E408-E408页

作者： Steinmetz, Jaimie D. Vision and Eye Research Institute Anglia Ruskin University Cambridge United Kingdom Biomedical Informatics Seoul National University Hospital Seoul South Korea Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute of Health Services Research Yonsei University Seoul South Korea Department of Ophthalmology University of Washington Seattle WA United States Department of Mathematics Imperial College London London United Kingdom WHO Collaborating Centre for Public Health Education and Training Imperial College London London United Kingdom Department of Primary Care and Public Health Imperial College London London United Kingdom School of Population and Global Health University of Melbourne Carlton VIC Australia School of Optometry and Vision Science UNSW Sydney NSW Australia Brien Holden Vision Institute Sydney Australia Department of Ophthalmology University of Adelaide Adelaide SA Australia Department of Parasitology and Mycology Jahrom University of Medical Sciences Jahrom Iran Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Ophthalmology Shahid Beheshti University of Medical Sciences Tehran Iran Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic Epidemiology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Health Services Management Department Qazvin University of Medical Sciences Qazvin Iran Department of Systems Populations and Leadership University of Michigan Ann Arbor MI United States Department of Medicine Sofia Ismail Memorial Medical Centre Bogura Bangladesh The Fred Hollows Foundation Sydney NSW Australia Berhan Public Health & Eye Care Consultancy Addis A

Hospital El Salvador: a novel paradigm of intensive care in response to COVID-1. in central America. Lancet Glob Health 2021.9: e241.42?In this Comment, the conflict of interest statement should have included the following: ?By virtue of their roles within a public hospital or the Ministry of Health, MB, LC, WH, and XS are government employees. The findings and conclusions in the Comment are only those of the authors.? This correction has been made as of Feb 26, 2021.

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51. pg 659, 201.)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 1. GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 41. genic associations across 1. brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 1. did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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26th Annual Computational Neuroscience Meeting (CNS*201.): Part 3 Antwerp, Belgium. 1.-20 July 201. Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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25th Annual Computational Neuroscience Meeting CNS-201., Seogwipo City, South Korea, July 2-7, 201. Abstracts

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BMC NEUROscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1.Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1.Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1.Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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International Society for Therapeutic Ultrasound Conference 201.

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Journal of Therapeutic Ultrasound 2017年第1期5卷 1-114页

作者： Brian Fowlkes Pejman Ghanouni Narendra Sanghvi Constantin Coussios Paul C. Lyon Michael Gray Christophoros Mannaris Marie de Saint Victor Eleanor Stride Robin Cleveland Robert Carlisle Feng Wu Mark Middleton Fergus Gleeson Jean-Franҫois Aubry Kim Butts Pauly Chrit Moonen Jacob Vortman Shirley Sharabi Dianne Daniels David Last David Guez Yoav Levy Alexander Volovick Javier Grinfeld Itay Rachmilevich Talia Amar Zion Zibly Yael Mardor Sagi Harnof Michael Plaksin Yoni Weissler Shy Shoham Eitan Kimmel Omer Naor Nairouz Farah Dong-Guk Paeng Zhiyuan Xu John Snell Anders H. Quigg Matthew Eames Changzhu Jin Ashli C. Everstine Jason P. Sheehan Beatriz S. Lopes Neal Kassell Thomas Looi Vera Khokhlova Charles Mougenot Kullervo Hynynen James Drake Michael Slayton Richard C. Amodei Keegan Compton Ashley McNelly Daniel Latt John Kearney David Melodelima Aurelien Dupre Yao Chen David Perol Jeremy Vincenot Jean-Yves Chapelon Michel Rivoire Wei Guo Guoxin Ren Guofeng Shen Michael Neidrauer Leonid Zubkov Michael S. Weingarten David J. Margolis Peter A. Lewin Nathan McDannold Jonathan Sutton Natalia Vykhodtseva Margaret Livingstone Thiele Kobus Yong-Zhi Zhang Michael Schwartz Yuexi Huang Nir Lipsman Jennifer Jain Martin Chapman Tejas Sankar Andres Lozano Robert Yeung Christakis Damianou Nikolaos Papadopoulos Omer Brokman Eyal Zadicario Ori Brenner David Castel Shih-Ying Wu Julien Grondin Wenlan Zheng Marc Heidmann Maria Eleni Karakatsani Carlos J. Sierra Sánchez Vincent Ferrera Elisa E. Konofagou Marinos Yiannakou HongSeok Cho Hwayoun Lee Mun Han Jong-Ryul Choi Taekwan Lee Sanghyun Ahn Yongmin Chang Juyoung Park Nicholas Ellens Ari Partanen Keyvan Farahani Raag Airan Alexandre Carpentier Michael Canney Alexandre Vignot Cyril Lafon Jean-yves Delattre Ahmed Idbaih Henrik Odéen Bradley Bolster Eun Kee Jeong Dennis L. Parker Pooja Gaur Xue Feng Samuel Fielden Craig Meyer Beat Werner William Grissom Michael Marx Hans Weber Valentina Taviani Brian Hargreaves Jun Tanaka Kentaro Kikuchi Ayumu Ishijima Takashi Azuma Kosuke Minamihata Satoshi Basic Radiological Sciences Division Department of Radiology University of Michigan Ann Arbor USA Stanford School of Medicine Stanford USA SonaCare Medical Indianapolis USA Institute of Biomedical Engineering University of Oxford Oxford UK HIFU Unit Churchill Hospital Oxford UK Department of Oncology University of Oxford Oxford UK Department of Radiology Churchill Hospital Oxford UK Institut Langevin Paris France Center for Imaging Sciences Imaging Division University Medical Center Utrecht The Netherlands InSighTec Haifa Israel Sheba Medical Center Ramat-Gan Israel Tel-Aviv University Tel-Aviv Israel Faculty of Biomedical Engineering & Russell Berrie Nanotechnology Institute Technion – Israel Institute of Technology Haifa Israel ELSC Center for Brain Sciences Hebrew University Jerusalem Israel Biomedical Engineering Technion- Israel Institute of Technology Haifa Israel Faculty of Life Sciences Bar Ilan University Ramat Gan Israel Focused Ultrasound Foundation Charlottesville USA Ocean System Engineering Jeju National University Jeju Republic of Korea Neurosurgery University of Virginia Charlottesville USA Biology University of Virginia Charlottesville USA Pathology University of Virginia Charlottesville USA Hospital for Sick Children Toronto Canada University of Toronto Toronto Canada University of Washington Seattle USA Philips Healthcare Markham Canada Sunnybrook Research Institute Toronto Canada Guided Therapy Systems LLC Mesa USA School of Medicine University of Arizona Tucson USA The CORE Institute Phoenix USA LabTAU - U1032 INSERM Lyon France Centre Leon Berard Lyon France Department of Oral Maxillofacial and Head Neck Oncology Shanghai 9th People’s Hospital Shanghai China The School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia USA Department of Surgery College of Medicine Drexel University Philadelphia USA Biostatistics and Epidemiology University of Pennsylvania Philadelphi

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G′ band in double- and triple-walled carbon nanotubes: A Raman study

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Physical Review B 2015年第7期91卷 075402-075402页

作者： Thomas Ch. Hirschmann Mildred S. Dresselhaus Hiroyuki Muramatsu Max Seifert Ursula Wurstbauer Eric Parzinger Kornelius Nielsch Yoong Ahm Kim Paulo T. Araujo Institute of Applied Physics University of Hamburg Jungiusstrasse 11 20355 Hamburg Germany Department of Electrical Engineering and Computer Science Cambridge Massachusetts 02139-4307 USA Department of Physics Massachusetts Institute of Technology Cambridge Massachusetts 02139-4307 USA Faculty of Engineering Shinshu University 4-17-1 Wakasato Nagano 380-8553 Japan Walter Schottky Institut and Physik Department Technische Universität München 85748 Garching Germany Polymer and Fiber System Engineering Chonnam National University 77 Yongbong-ro buk-gu Gwangju 500-757 Korea Department of Physics and Astronomy University of Alabama Tuscaloosa Alabama 35401 USA

Double- and triple-walled carbon nanotubes are studied in detail by laser energy-dependent Raman spectroscopy in order to get a deeper understanding about the second-order G′ band Raman process, general nanotube properties, such as electronic and vibrational properties, and the growth method itself. In this work, the inner nanotubes from the double- and triple-walled carbon nanotubes are produced through the encapsulation of fullerene peapods with high-temperature thermal treatments. We find that the spectral features of the G′ band, such as the intensity, frequency, linewidth, and line shape are highly sensitive to the annealing temperature variations. We also discuss the triple-peak structure of the G′ band observed in an individual triple-walled carbon nanotube taken at several laser energies connecting its Raman spectra with that for the G′ band spectra obtained for bundled triple-walled carbon nanotubes.

关键词： CARBON nanotubes RAMAN spectroscopy ANNEALING of metals TEMPERATURE effect ELECTRIC fields

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Color image modification based on visual saliency for guiding visual attention

Color image modification based on visual saliency for guidin...

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22nd IEEE International Symposium on Robot and Human Interactive Communication: "Living Together, Enjoying Together, and Working Together with Robots!", IEEE RO-MAN 201.

作者： Kokui, Tatsuhiko Takimoto, Hironori Mitsukura, Yasue Kishihara, Mitsuyoshi Okubo, Kensuke Graduate School of Systems Engineering Okayama Prefectural University 111 Kuboki Soja Okayama 719-1197 Japan Faculty of Computer Science and System Engineering Okayama Prefectural University 111 Kuboki Soja Okayama 719-1197 Japan Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Kohoku-ku Yokohama-city Kanagawa 223-8522 Japan

ISBN: (纸本)9781479905072

In this paper, we propose a modification method of color image, for a given region in the image, to obtain the image in which the region shows the highest saliency. Generally, it is thought that the most important part of an information system that assists human activities is a natural interface with human. In addition, eye-gaze information strongly reflects the human interest or their attention. Therefore, a gaze-based interface is promising for future practical applications. In particular, if we can smoothly guide the user's visual attention toward a target without interrupting their current visual attention, the usefulness of the gaze-based interface will be highly enhanced. In order to realize a novel interface based on visual attention, we propose a modification method for color image based on visual saliency map. The proposed method iteratively modifies the intensity and color so that the saliency inside the specified region increases while that outside the region decreases. This iteration is carried out until we obtain the image in which the specified region is most salient over the entire image. With the image obtained in this way, we can smoothly attract the user's visual attention to the specified region, without any interruption to the user's gaze. We evaluated the proposed method by a gaze measurement system and subjective experiments. As a result, we confirmed that the user's visual attention is indeed attracted toward our specified region without uncomfortable feeling. © 201. IEEE.

关键词： Color

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Chip-size structure for continuous microwave irradiation using post-wall waveguide

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IEEJ Transactions on Sensors and Micromachines 2013年第12期133卷 365-371页

作者： Kishihara, Mitsuyoshi Yamashima, Masa Utsumi, Yuichi Faculty of Computer Science and System Engineering Okayama Prefectural University 111 Kuboki Soja-shi Okayama 719-1197 Japan Laboratory of Advanced Science and Technology for Industry University of Hyogo 3-1-2 Koto Kamigori Ako Hyogo 678-1205 Japan

Microwave application technologies such as microwave heating, microwave assisted chemistry, etc. are of the innovative green technologies. This paper proposes a chip-size structure for continuous microwave irradiation. It consists of a post-wall waveguide and a micro channel arranged among the metallic posts (pillars), and utilizes the 24.1.5GHz ISM band instead of the commonly used 2.45GHz ISM band to realize miniaturization. The micro channel can be embedded easily by using the gaps between the metallic posts of the post-wall waveguide, simultaneously keeping the microwave energy confined. For the input of microwave power, two types of the irradiation structure are designed. One is a structure with coaxial transmission line to post-wall waveguide transformer. The other is a structure with microstrip feed line. The temperaturetime profiles of some solvents under microwave irradiation are examined numerically and experimentally with microwave power sources of about 1.. © 201. The Institute of Electrical Engineers of Japan.

关键词： Microwave irradiation

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VMckpt:lightweight and live virtual machine checkpointing

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science China(Information sciences) 2012年第12期55卷 2865-2880页

作者： LIU HaiKun 1.JIN Hai 1.LIAO XiaoFei 1.MA Bo 1.& XU ChengZhong 2 1.Services Computing Technology and system Lab,Cluster and Grid Computing Lab,School of {1. science and Technology,Huazhong University of science and Technology,Wuhan 430074,China 2 Department of Electrical and {1. engineering,Wayne State University,Detroit,MI 48202,USA 1. Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China2. Department of Electrical and Computer Engineering Wayne State University Detroit MI [48202 USA

Recent advance of virtualization technology provides a new approach to check-point/restart at the virtual machine(VM) *** contrast to traditional process-level checkpointing,checkpointing at the virtualization layer brings up several advantages,such as compatibility,transparence,flexibility and ***,because the virtualization layer has little semantic knowledge about the operation system and the applications running atop,VM-layer checkpointing requires saving the entire operating system state rather than a single *** overhead may render the approach *** reduce the size of VM checkpoint,in this paper we propose a page eviction scheme and an incremental checkpointing mechanism to avoid saving unnecessary VM pages in the *** keep the system online transparently,we propose a live checkpointing mechanism by saving the memory image in a copy-on-write(COW) *** implement the performance optimization mechanisms in a prototype system,called *** results with a group of representative applications show that our page eviction scheme and incremental checkpointing can significantly reduce the checkpoint file size by up to 87% and shorten the total checkpointing/restart time by a factor of up to 71.,in comparison with the Xens default checkpointing *** observed application downtimes due to checkpointing can be reduced to as small as 300 ms.

关键词： checkpoint/restart copy-on-write page eviction virtual machine

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Human genome meeting 201. : Houston, TX, USA. 28 February - 2 March 201.

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1.The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21.and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O1. A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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