The processing capability is vital for the wide applications of materials to forge structures ***-based macroscopic materials have shown excellent mechanical and functional ***,different from usual polymers and metals...
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The processing capability is vital for the wide applications of materials to forge structures ***-based macroscopic materials have shown excellent mechanical and functional ***,different from usual polymers and metals,graphene solids exhibit limited deformability and processibility for precise ***,we present a precise thermoplastic forming of graphene materials by polymer intercalation from graphene oxide(GO)*** intercalated polymer enables the thermoplasticity of GO solids by thermally activated motion of polymer *** detect a critical minimum containing of intercalated polymer that can expand the interlayer spacing exceeding 1.4 nm to activate thermoplasticity,which becomes the criteria for thermal plastic forming of GO *** thermoplastic forming,the flat GO-composite films are forged to Gaussian curved shapes and imprinted to have surface relief patterns with size precision down to 360 *** plastic-formed structures maintain the structural integration with outstanding electrical(3.07×1.^(5) S m^(−1.)and thermal conductivity(745.65 W m^(−1. K^(−1.)after removal of *** thermoplastic strategy greatly extends the forming capability of GO materials and other layered materials and promises versatile structural designs for more broad applications.
Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even *** studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in...
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Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even *** studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains *** the current study,we demonstrated that STING activation was pivotal in RA *** the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-1.6(PEI-PDA@C-1.6 NPs)for treating *** fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in ***-articular administration of PEI-PDA@C-1.6 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING *** concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA.
The design and synthesis of organic nonconventional luminescent (NL) materials with efficient emission have attracted significant attention. However, these materials usually suffer from the fact of low photoluminescen...
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Graphene,as a typical two-dimensional layered material,possesses extraordinary electronic and optical properties that render it for a wide range of potential applications including biomedicine[1..Inspired by the graph...
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Graphene,as a typical two-dimensional layered material,possesses extraordinary electronic and optical properties that render it for a wide range of potential applications including biomedicine[1..Inspired by the graphene research and development,graphene-like two-dimensional materials(2DMats)also show application potentials in biomedicine due to their unique properties[2-4].However,environmental and biological infuences of these 2DMats remain to be *** we reported the antibacterial activity of two-dimensional(2D)chemically exfoliated MoS2(ce-MoS2)sheets[5].We found that the antibacterial activity of ce-MoS2 sheets was much more potent than that of the raw MoS2 powders used for the synthesis of ce-MoS2 sheets possibly due to the 2D planar structure(high specifc surface area)and higher conductivity of the *** investigated the antibacterial mechanisms of the ce-MoS2 sheets and proposed their antibacterial *** found that the ce-MoS2 sheets could produce reactive oxygen species(ROS),different from previous report on graphenebased ***,the oxidation capacity of the ce-MoS2 sheets toward glutathione oxidation showed a time and concentration dependent trend,which is fully consistent with the antibacterial behaviour of the ce-MoS2 *** results suggest that antimicrobial behaviors were attributable to both membrane and oxidation *** antibacterial pathways include MoS2-bacteria contact induced membrane stress,superoxide anion(O2.3;–)induced ROS production by the ce-MoS2,and the ensuing superoxide anion-independent *** study thus indicates that the tailoring of dimension of nanomaterials and their electronic properties would manipulate antibacterial activity.
A negatively curved aza-nanographene (NG) containing two octagons was synthesized by a regioselective and stepwise cyclodehydrogenation procedure, in which a double aza[7]helicene was simultaneously formed as an inter...
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A negatively curved aza-nanographene (NG) containing two octagons was synthesized by a regioselective and stepwise cyclodehydrogenation procedure, in which a double aza[7]helicene was simultaneously formed as an intermediate. Their saddle-shaped structures with negative curvature were unambiguously confirmed by X-ray crystallography, thereby enabling the exploration of the structure–property relationship by photophysical, electrochemical and conformational studies. Moreover, the assembly of the octagon-embedded aza-NG with fullerenes was probed by fluorescence spectral titration, with record-high binding constants ( K a =9.5×1. 3 M −1.with C 60 , K a =3.7×1. 4 M −1.with C 70 ) found among reported negatively curved polycyclic aromatic compounds. The tight association of aza-NG with C 60 was further elucidated by X-ray diffraction analysis of their co-crystal, which showed the formation of a 1.: 1.complex with substantial concave-convex interactions.
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