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In-vitro characterization of 3D printed PLA scaffold with hydroxyapatite-chitosan coating for mandibula reconstruction

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AIP Conference Proceedings 2020年第1期2314卷

作者： Anis Fitria Wulandari Siti Zulaihah Ika Rachmadanti Aminatun 1Biomedical Engineering Program Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia 2Physics Program Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia

The mandibula is a part of the face that determines its shape as well as a place to attach the muscles of the mouth which has functions for chewing, swallowing, talking and yawning. Similar to other body organs, the mandibular bone can experience abnormalities, such as benign and malignant tumors. The tumor can potentially cause physiological and aesthetic disorders, so it needs to be resected in order to remove the infected part. This research was conducted to find out the potentials of 3D printed PLA scaffold with hydroxyapatite-chitosan coating for mandibula reconstructing through the contact angle test, the water absorption test and the biocompatibility test by in-vitro. The scaffold was made from polylactic acid (PLA) using 3D printing method of Fused Deposition Modelling (FDM) with a pore diameter of 1000 µm. Polylactic acid (PLA) is bioactive and hydrophobic filaments that needed to be coated with a bioactive material such as hydroxyapatite as well as a hydrophilic material such as chitosan. The composition variations of hydroxyapatite-chitosan which were used as the coating include A (70:30), B (60:40), C (50:50), D (40:60) and E (30:70). To determine the characteristics of the scaffold, several characterizations were carried out, namely the contact angle tests, the absorbency tests and the biocompatibility test. The characterization result from the contact angle test showed that PLA scaffold which has been coated with hydroxyapatite-chitosan is hydrophilic with contact angles of 45.7 - 71.3° in 25 minutes. The absorption test result showed a number of 4.15 - 9.34% from the first day to 9.57 - 12.90% on the seventh day which indicated that as the concentration of the chitosan increases, the water absorption also increases. Meanwhile, the biocompatibility test proved that scaffolds are non-toxic and safe for the body because they have a cell viability of 92.74 - 111.42%.

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Collagen-chitosan scaffold - Lauric acid plasticizer for skin tissue engineering on burn cases

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AIP Conference Proceedings 2017年第1期1817卷

作者： Prihartini Widiyanti Ewing Dian Setyadi Djony Izak Rudyardjo 1Biomedical Engineering Faculty of Science and Technology Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia 2Institute of Tropical Disease Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia 3Physics Study Program Faculty of Science and Technology Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia

The prevalence of burns in the world is more than 800 cases per one million people each year and this is the second highest cause of death due to trauma after traffic accident. Many studies are turning to skin substitute methods of tissue engineering. The purpose of this study is to determine the composition of the collagen, chitosan, and lauric acid scaffold, as well as knowing the results of the characterization of the scaffold. The synthesis of chitosan collagen lauric acid scaffold as a skin tissue was engineered using freeze dried method. Results from making of collagen chitosan lauric acid scaffold was characterized physically, biologically and mechanically by SEM, cytotoxicity, biodegradation, and tensile strength. From the morphology test, the result obtained is that pore diameter size ranges from 94.11 to 140.1 µm for samples A,B,C,D, which are in the range of normal pore size 63-150 µm, while sample E has value below the standard which is about 37.87 to 47.36 µm. From cytotoxicity assay, the result obtained is the percentage value of living cells between 20.11 to 21.51%. This value is below 50% the standard value of living cells. Incompatibility is made possible because of human error mainly the replication of washing process over the standard. Degradation testing obtained values of 19.44% - 40% by weight which are degraded during the 7 days of observation. Tensile test results obtained a range of values of 0.192 - 3.53 MPa. Only sample A (3.53 MPa) and B (1.935 MPa) meet the standard values of skin tissue scaffold that is 1-24 MPa. Based on the results of the characteristics of this study, composite chitosan collagen scaffold with lauric acid plasticizer has a potential candidate for skin tissue engineering for skin burns cases.

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Expert system for risk prediction of cesarean section delivery with Dempster Shafer method

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AIP Conference Proceedings 2020年第1期2314卷

作者： Ismaiba Riries Rulaningtyas Katherine Ernawati 1Biomedical Engineering Program Study Faculty of Science and Technology Universitas Airlangga Campus C Zip Code: 60115 Surabaya East Java Indonesia 2Fetomaternal Division of Obstetrics and Gynecology Department Faculty of Medicine Universitas Airlangga Campus A Zip Code: 60131 Surabaya East Java Indonesia

The maternal mortality rate in Indonesia is related to the lack of knowledge of mothers regarding high-risk pregnancies, especially with cesarean delivery. In this case, the prediction system designed is done as an effort to increase the awareness of mothers or women who were preparing for high-risk pregnancies. In this article, an Android-based prediction application will be presented using an expert system with the Dempster Shafer method. This method is based on a mathematical theory which consists of a combination of belief function and plausible reasoning from the risk parameters of each labor class by representing the knowledge obtained from experts. This study uses 16 risk parameters as input based on Poejo Rochati's high-risk pregnancy card with 2 outputs, with risk or no risk of having cesarean delivery. The result obtained from this system is 85%, concludes that the prediction system is able to predict the risk of cesarean delivery.

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Characterization, differentiation, and population doubling time of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) in passage 5 and 8

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AIP Conference Proceedings 2021年第1期2344卷

作者： Rizal Rahimi Syaidah Ziyan Muhammad Aqsha Adella Josephin Vidi Miranda Pakpahan 1Biomedical Engineering program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Department of Histology Faculty of Medicine Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 3Undergraduate Program in Biomedical Engineering Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Wharton’s jelly mesenchymal stem cells (WJ-MSCs) is proposed to be the best source of mesenchymal stem cells (MSCs). It has better self-renewal and differentiation capacity compare to adult stem cells such as bone marrow- derived stem cells (BM-MSCs). However, their characteristics in different passages do not yet well described. This research aims to isolate and characterize WJ-MSCs with regard to their proliferation capacity, immunophenotypes, and differentiation capacity. The WJ-MSCs were isolated by the explant method. The cultured WJ-MSCs at P5 and P8 were then characterized using flow cytometric analysis with regard to its surface marker, which are CD44, CD90, CD105, CD73, and negative lineages. The proliferation capacity of WJ-MSCs was analyzed with the population doubling time method and the characterized cells were differentiated into three different lineages. The result revealed that the isolated cells highly express MSCs surface marker with >98% for all surface markers and 0.00% for negative lineages. Isolated WJ-MSCs also exhibited a high proliferation capacity with a range of 1.06 to 1.59 days. Both passages revealed excellent differentiation capacity into chondrocytes, adipocytes, and osteocytes.

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EEG channels reduction using PCA to increase XGBoost’s accuracy for stroke detection

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AIP Conference Proceedings 2017年第1期1862卷

作者： N. Fitriah S. K. Wijaya M. I. Fanany C. Badri M. Rezal 1Biomedical Engineering Study Program Universitas Indonesia Jl. Salemba Raya No. 4 Jakarta 10430 DKI Jakarta Indonesia 2Department of Physics Faculty of Mathematics and Natural Sciences (FMIPA) Universitas Indonesia Depok 16424 Indonesia 3Faculty of Computer Science Universitas Indonesia Depok 16424 Indonesia

In Indonesia, based on the result of Basic Health Research 2013, the number of stroke patients had increased from 8.3 ‰ (2007) to 12.1 ‰ (2013). These days, some researchers are using electroencephalography (EEG) result as another option to detect the stroke disease besides CT Scan image as the gold standard. A previous study on the data of stroke and healthy patients in National Brain Center Hospital (RS PON) used Brain Symmetry Index (BSI), Delta-Alpha Ratio (DAR), and Delta-Theta-Alpha-Beta Ratio (DTABR) as the features for classification by an Extreme Learning Machine (ELM). The study got 85% accuracy with sensitivity above 86 % for acute ischemic stroke detection. Using EEG data means dealing with many data dimensions, and it can reduce the accuracy of classifier (the curse of dimensionality). Principal Component Analysis (PCA) could reduce dimensionality and computation cost without decreasing classification accuracy. XGBoost, as the scalable tree boosting classifier, can solve real-world scale problems (Higgs Boson and Allstate dataset) with using a minimal amount of resources. This paper reuses the same data from RS PON and features from previous research, preprocessed with PCA and classified with XGBoost, to increase the accuracy with fewer electrodes. The specific fewer electrodes improved the accuracy of stroke detection. Our future work will examine the other algorithm besides PCA to get higher accuracy with less number of channels.

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Digital filter effect of the ventilator tester parameters to identify inflation phases

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AIP Conference Proceedings 2022年第1期2537卷

作者： Tomy Abuzairi Ahli Irfan Basari 1Electrical Engineering Study Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 3Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Biomedical Engineering Study Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

A ventilator is a breathing support device that serves as a therapeutic tool or treatment tool for patients with respiratory system failure caused by various health problems or diseases. On ventilators, there are crucial parameters that need to be monitored in advance, such as inspiration–expiration (I:E) ratio, respiration rate, tidal volume, peak inspiration pressure (PIP), positive end-expiratory pressure (PEEP), and oxygen concentration. To monitor those parameters, a ventilator tester is needed. In this paper, we analyzed the effect of a digital filter in the ventilator tester, COVENT-Tester, to identify the inflation phase in the ventilator parameters. The results show that the digital filter is not effective in measuring I:E ratio and respiration rate because of the delay in inspiration and expiration time. However, the digital filter is effective in measuring tidal volume, PIP, PEEP, and oxygen concentration.

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Preliminary study of the polymesoda expansa based hydroxyapatite for medical devices coating application

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AIP Conference Proceedings 2020年第1期2306卷

作者： M. Riza Roslan N. F. Mohd Nasir M. A. Gilani Nur Farahiyah Mohammad E. M Cheng M. F. Abdul Khalid A. S. Zoolfakar N. A. M. Amin S. F. Khan 1Biomedical Electronic Engineering Program School of Mechatronic Engineering Universiti Malaysia Perlis Perlis Malaysia 2Microwave Research Institute (MRI) Universiti Teknologi Mara Shah Alam Malaysia 3Faculty of Electrical Engineering Universiti Teknologi Mara Shah Alam Malaysia 4Mechanical Engineering Program School of Mechatronic Engineering Universiti Malaysia Perlis Perlis Malaysia

Hydroxyapatite (HA) which is a group of calcium phosphate (CaP) is used as a medical devices coating due to its ability to increase the bioactivity and biocompatibility of the device surface. The attraction of using waste seashells products is interesting due to its sustainability and low cost solution especially in biomedical application. Polymesoda expansa or locally known as Lokan is potentially rich with calcium carbonate (CaCO3). Here, the synthesis of HA was done via precipitation method by utilizing the Polymesoda expansa (Lokan) shells as the resource of calcium precursors. Hydroxyapatite synthesized from Polymesoda expansa was carried out with different pH solution (pH 9 and 13) in alkaline environment. The effects of pH on the morphological and chemical composition properties as well as the Ca/P ratio of HA powders were analyzed through Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and Energy Dispersive X-ray Spectrometry (EDS). The finding demonstrates as the pH increases, the calcium apatite reduced and this had increases the Ca/P ratio.

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Nonlinear Geometric Effects in Mechanical Bistable Morphing Structures

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Physical Review Letters 2012年第11期109卷 114302-114302页

作者： Zi Chen Qiaohang Guo Carmel Majidi Wenzhe Chen David J. Srolovitz Mikko P. Haataja Department of Mechanical and Aerospace Engineering Princeton University Princeton New Jersey 08544 USA Princeton Institute for the Science and Technology of Materials (PRISM) Princeton University Princeton New Jersey 08544 USA Department of Biomedical Engineering Washington University St. Louis Missouri 63130 USA College of Materials Science and Engineering Fuzhou University Fuzhou Fujian 350108 China Department of Mathematics and Physics Fujian University of Technology Fuzhou Fujian 350108 China Department of Mechanical Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Department of Materials Science and Engineering Fujian University of Technology Fuzhou Fujian 350108 China Institute for High Performance Computing 1 Fusionopolis Way Singapore 138632 Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 USA School of Mathematics Institute for Advanced Study Princeton New Jersey 08540 USA

Bistable structures associated with nonlinear deformation behavior, exemplified by the Venus flytrap and slap bracelet, can switch between different functional shapes upon actuation. Despite numerous efforts in modeling such large deformation behavior of shells, the roles of mechanical and nonlinear geometric effects on bistability remain elusive. We demonstrate, through both theoretical analysis and tabletop experiments, that two dimensionless parameters control bistability. Our work classifies the conditions for bistability, and extends the large deformation theory of plates and shells.

关键词： NONLINEAR theories DEFORMATIONS (Mechanics) PARAMETER estimation OPTICAL bistability STRUCTURAL shells PLATES (engineering) CRYSTAL structure

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Finite element analysis of posterior leaf spring ankle-foot orthosis for tibialis anterior atrophy case

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AIP Conference Proceedings 2022年第1期2663卷

作者： Alfian Pramudita Putra Arief Sofian Hidayat Akif Rahmatillah Pujiyanto Pujiyanto Dinda Cyberputri I. Putu Alit Pawana 1Biomedical Engineering Study Program Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 2Biomedical Signals and Systems Research Group Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 3Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 4Department of Rehabilitation and Physical Medicine Dr. Soetomo General Academic Hospital Surabaya Indonesia

Stroke is a neurological disease and is a significant cause of disability throughout the world. Patients with stroke or post-stroke usually still experience interference in walking in the form of a drop foot caused by atrophy of the anterior tibialis muscle, so they cannot perform dorsiflexion. Drop foot disorders can be treated by rehabilitation using Posterior Leaf Spring Ankle-Foot Orthosis (PLS AFO). PLS AFO has the advantage of a higher level of flexibility compared to other AFO types. The primary purpose of this research is to observe the level of resilience based on the influence of AFO thickness. This study uses the finite element analysis of three model variations in the initial contact, midstance, terminal stance, and calf loading phases. The material used in this study was carbon fiber. The simulation will result in the distribution of stress, strain, and deformation values in each AFO model. The simulation results show that AFO resistance is affected by variations in AFO thickness where the increase in strength is proportional to the increase in AFO thickness. The AFO with a thickness of 10 mm is the most suitable for the tibialis anterior atrophy case.

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Design and implementation of multichannel EMG for upper extremity myoelectric signal acquisition using IIR filter

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AIP Conference Proceedings 2020年第1期2314卷

作者： Akif Rahmatillah Amila Sofiah Prihartini Widiyanti 1Medical Instrumentation Laboratory Biomedical Engineering Study Program Faculty of Science & Technology Universitas Airlangga Surabaya Indonesia 2Institute of Tropical Disease (ITD) Universitas Airlangga Surabaya Indonesia

This study aimed at designing and implementing a multichannel EMG based on Infinite Impulse Response (IIR) filter and then compare its performance with the standard EMG devices. Hence, the design of this multichannel EMG system consists of two parts: hardware and software. The hardware comprises instrumentation amplifier and NI DAQ USB 6009 as data acquisition device, while the software is composed of myoelectric signal processing (e.g. filtering, rectifying, and smoothing) and interface signal on personal computer (PC) using LabVIEW programming. To test the device, two procedures were performed, there were instrumentation test and performance test of the EMG device. The instrumentation test resulted in the gain value of instrumentation amplifier at 12.794 times with linearity of 0.9998. Moreover, the response of implemented Butterworth IIR filter is compatible with the design at the cut off frequency of 30-400 Hz and 50 Hz. For the performance test, quantitative and qualitative data recorded from normal male subjects aged of 20-40 were compared. The result showed that EMG prototype work as well as EMG comparison with relative error percentage for each value parameter of maximum, minimum, and average amplitude signals at 14.05885 %, 14.82683 %, and 14.0411 % respectively. Furthermore, the features of recorded signal for similar simultaneous movements using EMG prototype also share identical features with the recorded signal using standard EMG.

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