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Preliminary study of the polymesoda expansa based hydroxyapatite for medical devices coating application

AIP Conference Proceedings 2020年第1期2306卷

作者： M. Riza Roslan N. F. Mohd Nasir M. A. Gilani Nur Farahiyah Mohammad E. M Cheng M. F. Abdul Khalid A. S. Zoolfakar N. A. M. Amin S. F. Khan 1Biomedical Electronic Engineering Program School of Mechatronic Engineering Universiti Malaysia Perlis Perlis Malaysia 2Microwave Research Institute (MRI) Universiti Teknologi Mara Shah Alam Malaysia 3Faculty of Electrical Engineering Universiti Teknologi Mara Shah Alam Malaysia 4Mechanical Engineering Program School of Mechatronic Engineering Universiti Malaysia Perlis Perlis Malaysia

Hydroxyapatite (HA) which is a group of calcium phosphate (CaP) is used as a medical devices coating due to its ability to increase the bioactivity and biocompatibility of the device surface. The attraction of using waste seashells products is interesting due to its sustainability and low cost solution especially in biomedical application. Polymesoda expansa or locally known as Lokan is potentially rich with calcium carbonate (CaCO3). Here, the synthesis of HA was done via precipitation method by utilizing the Polymesoda expansa (Lokan) shells as the resource of calcium precursors. Hydroxyapatite synthesized from Polymesoda expansa was carried out with different pH solution (pH 9 and 13) in alkaline environment. The effects of pH on the morphological and chemical composition properties as well as the Ca/P ratio of HA powders were analyzed through Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and Energy Dispersive X-ray Spectrometry (EDS). The finding demonstrates as the pH increases, the calcium apatite reduced and this had increases the Ca/P ratio.

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Design and implementation of multichannel EMG for upper extremity myoelectric signal acquisition using IIR filter

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AIP Conference Proceedings 2020年第1期2314卷

作者： Akif Rahmatillah Amila Sofiah Prihartini Widiyanti 1Medical Instrumentation Laboratory Biomedical Engineering Study Program Faculty of Science & Technology Universitas Airlangga Surabaya Indonesia 2Institute of Tropical Disease (ITD) Universitas Airlangga Surabaya Indonesia

This study aimed at designing and implementing a multichannel EMG based on Infinite Impulse Response (IIR) filter and then compare its performance with the standard EMG devices. Hence, the design of this multichannel EMG system consists of two parts: hardware and software. The hardware comprises instrumentation amplifier and NI DAQ USB 6009 as data acquisition device, while the software is composed of myoelectric signal processing (e.g. filtering, rectifying, and smoothing) and interface signal on personal computer (PC) using LabVIEW programming. To test the device, two procedures were performed, there were instrumentation test and performance test of the EMG device. The instrumentation test resulted in the gain value of instrumentation amplifier at 12.794 times with linearity of 0.9998. Moreover, the response of implemented Butterworth IIR filter is compatible with the design at the cut off frequency of 30-400 Hz and 50 Hz. For the performance test, quantitative and qualitative data recorded from normal male subjects aged of 20-40 were compared. The result showed that EMG prototype work as well as EMG comparison with relative error percentage for each value parameter of maximum, minimum, and average amplitude signals at 14.05885 %, 14.82683 %, and 14.0411 % respectively. Furthermore, the features of recorded signal for similar simultaneous movements using EMG prototype also share identical features with the recorded signal using standard EMG.

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PID control design and implementation for laboratory scale infant incubator temperature using FOPDT model

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AIP Conference Proceedings 2020年第1期2314卷

作者： Akif Rahmatillah Inten Fauziah Hidayat Alfian Pramudita Putra Osmalina Nur Rahma Suhariningsih 1Medical Instrumentation Laboratory Biomedical Engineering Study Program Faculty of Science & Technology Universitas Airlangga Surabaya Indonesia 2Institute of Tropical Disease (ITD) Universitas Airlangga Surabaya Indonesia

Premature babies have difficulty for regulating their body temperature because weight deficiency. Infant incubator that equipped by temperature control system can support thermoregulation process in baby body. This paper explained design of temperature control system using Proportional-Integral-Derivative (PID) controller and its implementation to the laboratory scale infant incubator. The transfer function of infant incubator was obtained by step test method using First-Order and Dead Time (FOPDT) model where process gain K = 0.29, settling time Ts = 18s and dead time Td = 1. Ziegler-Nichols (ZN) and Direct Synthesis (DS) PID coefficients tuning method was used is this experiment and it resulted for ZN tunning method, proportional gain Kc = 20.14, integration time Ti = 0.2 and derivative time Td = 0.05 and DS tunning method proportional gain Kc = 5, integration time Ti = 18. PID controller was implemented to the Personal Computer (PC) with LabVIEW 2013 programing language, LabJack U3 HV data acquisition device and LM-35 temperature sensor. Set point of temperature that required was 350C with t and 250C initial temperature. The controller performance that resulted by this experiment were for ZN tunning method 38 minutes for settling time while DS tunning method resulted 12 minutes for setling time.

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Hydroxyapatite-gelatin-HPMC composite as injectable bone substitute with alendronate variation for osteoporotic bone

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AIP Conference Proceedings 2020年第1期2314卷

作者： Novita Sari Alfian Pramudita Putra Siswanto Muhammad Fajar Faliasthiunus Pradipta Dyah Hikmawati 1Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia 2Biomedical Engineering Study Program Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia

The treatment of bone with osteoporosis could be done by filling the bone defect with Injectable Bone Substitute (IBS). IBS could be functioned as drug delivery system by associating a drug inside the IBS, such as alendronate for osteoporosis case. In this study, IBS has been synthesized and characterized with the alendronate variations. The IBS was synthesized by stirring hydroxyapatite and gelatin 5% (w/v) with a ratio of 45:55. The alendronate was added to the solution with composition of 0%, 5%, 10%, 15% and 20%. The mixture was mixed with 2% (w/v) HPMC. FTIR test results indicated the formation of hydroxyapatite-gelatin bonding (Ca2+--COO−) at wavenumber of 1560.54 cm−1. The acidity test result indicated that the sample had a pH of 7 and was able to remain stable. The IBS could be set in 3 hours and 38 minutes when injected to HA substrate and capable of enveloping the surface of HA substrate. The pore size of the substrate decreased from range of 153 to 625.8 µm into 247.4 to 480.8 µm. The XRD test results indicated that degree of crystallinity decreased from 76.81% to 75.13%. The best alendronate composition in IBS was 10% compared to the mass of hydroxyapatite.

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Tuberculosis detection analysis using texture features on CXRs images

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AIP Conference Proceedings 2019年第1期2092卷

作者： Badarudin Hakim Basari 1Biomedical Engineering Course Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java Indonesia 16424 2Research Center for Biomedical Engineering Universitas Indonesia Depok 16424 West-Java Indonesia

Tuberculosis (TB) is one of the most common diseases in developing countries such as Indonesia. TB disease oftenly attacks the human lungs due to its high oxygen pressure. The basic characteristics of TB-infected lungs are in the form of wounds, which change its texture and shape. The common detection method is by comparing the X-ray thoracic image with the tuberculin skin test (TST) and fast acid staining methods. This diagnosis method is often constrained by the availability of radiologists in the health facilities. To overcome such situation, a computer-aided diagnosis (CAD) tool is required to assist the doctor read the X-ray images easily. In this paper, a complementary detection method is proposed by using a chest X-ray (CXR) image to assist the diagnosis process. In current method, the image is segmented to reduce unnecessary parts prior to preprocessing step. We use a texture-based feature approach for detection purpose because most of the common examination methods for abnormality detection on CXRs is by analyzing the change of textural (content) CXR. In our texture approach, we use texture-based statistical properties on the histogram’s intensity. Some features that are used in this approach including Mean, Standard Deviation, Smoothness, Entropy, Root Mean Square (RMS), Variance, Kurtosis, Skewness, and Inverse Difference Moment (IDM). As a result of simulation, it indicates that CXR images can be well segmented to localize the focus area, allowing to the features can be extracted from the CXR image for further detection process. The obtained accuracy is about 93.94% and 92.86%, respectively for Shenzhen-Chest X-ray dataset and Montgomery County-Chest X-ray dataset.

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Evaluation on requirements of nuclear medicine facility building

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AIP Conference Proceedings 2019年第1期2180卷

作者： Anita Nur Mayani Basari 1Biomedical Engineering Course Program Departement of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Nuclear medicine is one of medical fields that uses ionizing radiation sources for therapeutic and diagnostic imaging for cancer. The number of nuclear medicine services in Indonesia is 17 hospitals, which only 10 is active in conducting nuclear medicine services because it doesn’t meet the requirements. Regulations about the standards of nuclear medicine services Indonesia are regulated by KMK number 008/MENKES/SK/I/2009 but it have not yet been discussed the requirements in details for building design and layout design as reference. For this reason, the author did study about the requirements of a nuclear medical service facility referring to KMK number 008/MENKES/SK/I/2009 and the International Health Facility Guidelines to create layout design of nuclear medicine facility. This study is done by comparing national and international regulation for planning criteria and construct layout design of nuclear medicine facility as recommendation to accomplish the regulations in Ministry of Health decree, Republic of Indonesia number 008/MENKES/SK/I/2009 regarding nuclear medical requirements.

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Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2022年第6期117卷 1-272页

作者： Ruvishika S.Jayawardena Kevin D.Hyde Song Wang Ya‑Ru Sun Nakarin Suwannarach Phongeun Sysouphanthong Mohamed A.Abdel‑Wahab Faten A.Abdel‑Aziz Pranami D.Abeywickrama Vanessa P.Abreu Alireza Armand AndréAptroot Dan‑Feng Bao Dominik Begerow Jean‑Michel Bellanger Jadson D.P.Bezerra Digvijayini Bundhun Mark S.Calabon Ting Cao Taimy Cantillo João LVRCarvalho Napalai Chaiwan Che‑Chih Chen Régis Courtecuisse Bao‑Kai Cui Ulrike Damm Cvetomir M.Denchev Teodor T.Denchev Chun Y.Deng Bandarupalli Devadatha Nimali Ide Silva Lidiane Ados Santos Nawal K.Dubey Sylvain Dumez Himashi SFerdinandez André L.Firmino Yusufon Gaforov Achala J.Gajanayake Deecksha Gomdola Sugantha Gunaseelan Shucheng‑He Zin H.Htet Malarvizhi Kaliyaperumal Martin Kemler Kezhocuyi Kezo Nuwan DKularathnage Marco Leonardi Ji‑Peng Li Chunfang Liao Shun Liu Michael Loizides Thatsanee Luangharn Jian Ma Hugo Madrid S.Mahadevakumar Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda María P.Martín Niranjan Mekala Pierre‑Arthur Moreau Yan‑Hong Mu Pasouvang Pahoua Dhandevi Pem Olinto L.Pereira Wiphawanee Phonrob Chayanard Phukhamsakda Mubashar Raza Guang‑Cong Ren Andrea C.Rinaldi Walter Rossi Binu C.Samarakoon Milan CSamarakoon Vemuri V.Sarma Indunil C.Senanayake Archana Singh Maria F.Souza Cristina M.Souza‑Motta Adriano A.Spielmann Wenxin Su Xia Tang XingGuo Tian Kasun M.Thambugala Naritsada Thongklang Danushka S.Tennakoon Nopparat Wannathes DingPeng Wei Stéphane Welti Subodini N.Wijesinghe Hongde Yang Yunhui Yang Hai‑Sheng Yuan Huang Zhang Jingyi Zhang Abhaya Balasuriya Chitrabhanu SBhunjun Timur S.Bulgakov Lei Cai Erio Camporesi Putarak Chomnunti Y.S.Deepika Mingkwan Doilom Wei‑Jun Duan Shi‑Ling Han Naruemon Huanraluek EBGareth Jones NLakshmidevi Yu Li Saisamorn Lumyong Zong‑Long Luo Surapong Khuna Jaturong Kumla Ishara S.Manawasinghe Ausana Mapook Wilawan Punyaboon Saowaluck Tibpromma Yong‑Zhong Lu JiYe Yan Yong Wang Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouChina Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Biotechnology and Ecology Institute Ministry of Agriculture and ForestryP.O.Box:811Vientiane CapitalLao PDR Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Beijing Key Laboratory of Environment-Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Departamento de Fitopatologia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMato Grosso do Sul CEP 79070-900Brazil College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanChina Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Institute of Plant Science and Microbiology Universität HamburgOrganismic Botany and MycologyOhnhorststr.1822609 HamburgGermany CEFE CNRSUniv.MontpellierEPHEIRDINSERM1919Route de Mende34293 Montpellier Cedex 5France Setor de Micologia Departamento de Biociências e TecnologiaInstituto de Patologia Tropical e Saúde PúblicaUniversidade Federal de GoiásRua 235S/NSetor UniversitárioGoiâniaGO CEP:74605-050Brazil Division of Biological Sciences College of Arts and SciencesUniversity of the Philippines Visayas5023 MiagaoIloiloPhilippines CA

This article is the 14th in the Fungal Diversity Notes series,wherein we report 98 taxa distributed in two phyla,seven classes,26 orders and 50 families which are described and *** in this study were collected from Australia,Brazil,Burkina Faso,Chile,China,Cyprus,Egypt,France,French Guiana,India,Indonesia,Italy,Laos,Mexico,Russia,Sri Lanka,Thailand,and *** are 59 new taxa,39 new hosts and new geographical distributions with one new *** 59 new species comprise Angustimassarina kunmingense,Asterina lopi,Asterina brigadeirensis,Bartalinia bidenticola,Bartalinia caryotae,Buellia pruinocalcarea,Coltricia insularis,Colletotrichum fexuosum,Colletotrichum thasutense,Coniochaeta caraganae,Coniothyrium yuccicola,Dematipyriforma aquatic,Dematipyriforma globispora,Dematipyriforma nilotica,Distoseptispora bambusicola,Fulvifomes jawadhuvensis,Fulvifomes malaiyanurensis,Fulvifomes thiruvannamalaiensis,Fusarium purpurea,Gerronema atrovirens,Gerronema favum,Gerronema keralense,Gerronema kuruvense,Grammothele taiwanensis,Hongkongmyces changchunensis,Hypoxylon inaequale,Kirschsteiniothelia acutisporum,Kirschsteiniothelia crustaceum,Kirschsteiniothelia extensum,Kirschsteiniothelia septemseptatum,Kirschsteiniothelia spatiosum,Lecanora immersocalcarea,Lepiota subthailandica,Lindgomyces guizhouensis,Marthe asmius pallidoaurantiacus,Marasmius tangerinus,Neovaginatispora mangiferae,Pararamichloridium aquisubtropicum,Pestalotiopsis piraubensis,Phacidium chinaum,Phaeoisaria goiasensis,Phaeoseptum thailandicum,Pleurothecium aquisubtropicum,Pseudocercospora vernoniae,Pyrenophora verruculosa,Rhachomyces cruralis,Rhachomyces hyperommae,Rhachomyces magrinii,Rhachomyces platyprosophi,Rhizomarasmius cunninghamietorum,Skeletocutis cangshanensis,Skeletocutis subchrysella,Sporisorium anadelphiae-leptocomae,Tetraploa dashaoensis,Tomentella exiguelata,Tomentella fuscoaraneosa,Tricholomopsis lechatii,Vaginatispora favispora and Wetmoreana *** new combin

关键词： 59 New taxa 39 New records Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Sordariomycetes Ustilaginomycotina

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Effects of variation of chitosan concentration on the characteristics of membrane cellulose bacteria-chitosan biocomposites as candidates for artificial dura mater

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AIP Conference Proceedings 2017年第1期1817卷

作者： Prihartini Widiyanti Hajria Jabbar Djony Izak Rudyardjo 1Biomedical Engineering Study Program Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia 2Institute of Tropical Disease Universitas Airlangga Surabaya 60115 Indonesia 3Physics Study Program Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia

This study was conducted to determine the effect of variation in concentration of chitosan on the physical and biological characteristics of the membrane of bacterial cellulose-chitosan biocomposites through immersion precipitation method. Bacterial cellulose membrane was soaked in a solution of chitosan whose concentration variation are 0.1%; 0.3%; 0.5% and 0.7%. The characterization tests which were conducted included the analysis of functional groups (FTIR), tensile strength test, morphology test (SEM), and cytotoxicity assay using MTT Assay method. Based on the cluster analysis test, the results of FTIR spectra indicate changes in the physical bond which means that there is interaction between the bacterial cellulose membrane with chitosan on each sample. The bacteria produced cellulose membrane with tensile strength of 10.53 ± 0.19 MPa while the microbial cellulose membrane by adding 0.5% chitosan concentration had tensile strength value of 8:58 ± 0.19 MPa. It shows that with the addition of chitosan it would decrease the tensile strength in microbial cellulose membrane. This was shown by 496.2 nm - 2,032 µm pore size with a thickness (mm) of 0:35 ± 0.33 to 0.81 ± 0.26. Based on the test results of the analysis of functional groups, tensile strength test, and morphology test, membrane microbial cellulose-chitosan biocomposites have the potential to be used as artificial dura mater candidate.

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Echo decorrelation imaging of ex vivo HIFU and bulk ultrasound ablation using image-treat arrays

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AIP Conference Proceedings 2017年第1期1821卷

作者： Tyler R. Fosnight Fong Ming Hooi Sadie B. Colbert Ryan D. Keil Peter G. Barthe T. Douglas Mast 1Biomedical Engineering Program University of Cincinnati Cincinnati Ohio UNITED STATES 2Guided Therapy Systems/Ardent Sound Mesa Arizona UNITED STATES

In this study, the ability of ultrasound echo decorrelation imaging to map and predict heat-induced cell death was tested using bulk ultrasound thermal ablation, high intensity focused ultrasound (HIFU) thermal ablation, and pulse-echo imaging of ex vivo liver tissue by a custom image-treat array. Tissue was sonicated at 5.0 MHz using either pulses of unfocused ultrasound (N=12) (7.5 s, 50.9-101.8 W/cm2 in situ spatial-peak, temporal-peak intensity) for bulk ablation or focused ultrasound (N=21) (1 s, 284-769 W/cm2 in situ spatial-peak, temporal-peak intensity and focus depth of 10 mm) for HIFU ablation. Echo decorrelation and integrated backscatter (IBS) maps were formed from radiofrequency pulse-echo images captured at 118 frames per second during 5.0 s rest periods, beginning 1.1 s after each sonication pulse. Tissue samples were frozen at −80˚C, sectioned, vitally stained, imaged, and semi-automatically segmented for receiver operating characteristic (ROC) analysis. ROC curves were constructed to assess prediction performance for echo decorrelation and IBS. Logarithmically scaled mean echo decorrelation in non-ablated and ablated tissue regions before and after electronic noise and motion correction were compared. Ablation prediction by echo decorrelation and IBS was significant for both focused and bulk ultrasound ablation. The log10-scaled mean echo decorrelation was significantly greater in regions of ablation for both HIFU and bulk ultrasound ablation. Echo decorrelation due to electronic noise and motion was significantly reduced by correction. These results suggest that ultrasound echo decorrelation imaging is a promising approach for real-time prediction of heat-induced cell death for guidance and monitoring of clinical thermal ablation, including radiofrequency ablation and HIFU.

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Collagen-chitosan scaffold - Lauric acid plasticizer for skin tissue engineering on burn cases

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AIP Conference Proceedings 2017年第1期1817卷

作者： Prihartini Widiyanti Ewing Dian Setyadi Djony Izak Rudyardjo 1Biomedical Engineering Faculty of Science and Technology Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia 2Institute of Tropical Disease Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia 3Physics Study Program Faculty of Science and Technology Universitas Airlangga Mulyorejo Surabaya 60115 Indonesia

The prevalence of burns in the world is more than 800 cases per one million people each year and this is the second highest cause of death due to trauma after traffic accident. Many studies are turning to skin substitute methods of tissue engineering. The purpose of this study is to determine the composition of the collagen, chitosan, and lauric acid scaffold, as well as knowing the results of the characterization of the scaffold. The synthesis of chitosan collagen lauric acid scaffold as a skin tissue was engineered using freeze dried method. Results from making of collagen chitosan lauric acid scaffold was characterized physically, biologically and mechanically by SEM, cytotoxicity, biodegradation, and tensile strength. From the morphology test, the result obtained is that pore diameter size ranges from 94.11 to 140.1 µm for samples A,B,C,D, which are in the range of normal pore size 63-150 µm, while sample E has value below the standard which is about 37.87 to 47.36 µm. From cytotoxicity assay, the result obtained is the percentage value of living cells between 20.11 to 21.51%. This value is below 50% the standard value of living cells. Incompatibility is made possible because of human error mainly the replication of washing process over the standard. Degradation testing obtained values of 19.44% - 40% by weight which are degraded during the 7 days of observation. Tensile test results obtained a range of values of 0.192 - 3.53 MPa. Only sample A (3.53 MPa) and B (1.935 MPa) meet the standard values of skin tissue scaffold that is 1-24 MPa. Based on the results of the characteristics of this study, composite chitosan collagen scaffold with lauric acid plasticizer has a potential candidate for skin tissue engineering for skin burns cases.

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