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The role of vitamin D3 supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome

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AIP Conference Proceedings 2021年第1期2353卷

作者： Susanti Susanti Krisni Subandiyah Husnul Khotimah 1Master Program of Biomedical Sciences Brawijaya University Indonesia 2Nephrology Division Department of Child Health Saiful Anwar Hospital Faculty of Medicine Brawijaya University Indonesia 3Department of Biomedical Science Faculty of Medicine Brawijaya University Indonesia

Nephrotic syndrome, the most common kidney disease in children, has been associated with transforming growth factor β1 (TGF-β1) and tumor necrosis factor a (TNF-α). This study aimed to assess the role of vitamin D3 supplementation to TGF-β1 and TNF-α levels in steroid-resistant nephrotic syndrome (SNRS). This research was an experimental study involving 32 subjects divided into two groups. Each group was given a placebo and vitamin D3 for four weeks. Peripheral blood was taken before and after treatment. In the placebo group, there were significant decrease in 25(OH)D, increase in TGF-β1, and increase in TNF-α after treatment (p < 0.05). In the vitamin D3 supplementation group, there were significant increase in 25(OH)D, decrease in TGF-β1, and decrease in TNF-α (p < 0.05). The increase in 25(OH)D had correlation with the decrease in TGF-β1 (r = -0.593; p = 0.000) and the decrease in TNF-α (r = -0.782; p = 0.000). 0ur data indicated that vitamin D3 supplementation could increase 25(OH)D, decrease TGF- β1 and TNF-α. The decrease in TGF-β1, and TNF-α was negatively correlated with the increase in 25(OH)D in SRNS.

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Theoretical study on adsorption and reaction of polymeric formic acid on the Cu(111) surface

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Physical Review Materials 2021年第7期5卷 075801-075801页

作者： Septia Eka Marsha Putra Fahdzi Muttaqien Yuji Hamamoto Kouji Inagaki Akitoshi Shiotari Jun Yoshinobu Yoshitada Morikawa Ikutaro Hamada Department of Precision Engineering Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan Department of Engineering Physics Institut Teknologi Sumatera Jalan Terusan Ryacudu Way Hui Jati Agung South Lampung 35365 Indonesia Instrumentation and Computational Physics Research Group Faculty of Mathematics and Natural Sciences Institut Teknologi Bandung Jalan Ganesha 10 Bandung West Java 40132 Indonesia Master Program in Computational Science Faculty of Mathematics and Natural Sciences Institut Teknologi Bandung Jalan Ganesha 10 Bandung West Java 40132 Indonesia Elements Strategy Initiative for Catalysts and Batteries (ESICB) Kyoto University Goryo-Ohara Nishikyou-ku Katsura Kyoto 615-8245 Japan Department of Advanced Materials Science The University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba 277-8561 Japan The Institute for Solid State Physics The University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba 277-8581 Japan Research Center for Precision Engineering Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan

We investigate the polymeric adsorption of formic acid (HCOOH) on the Cu(111) surface by means of density functional theory. We present structural models for the polymeric form of HCOOH on Cu(111) and characterize their stability, electronic, and vibrational properties. Based on the energetics and dynamics, as well as simulated scanning tunneling microscopy and atomic force microscopy images, we propose that the α polymorph is likely to be formed on the Cu(111) surface and can explain the experimental findings. We also study the initial step of the catalytic dehydrogenation of HCOOH and find that the O-H bond dissociation at the edge of the polymer is facilitated, rather than that forming hydrogen bonding, agreeing well with the experiments.

关键词： Adsorption Chemical bonding Chemical kinetics, dynamics & catalysis Electronic structure Surface & interfacial phenomena Surfaces Density functional theory First-principles calculations

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Theoretical investigation of interaction between hydroxypropyl-β-cyclodextrin and hydroxychloroquine

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AIP Conference Proceedings 2021年第1期2349卷

作者： Atthar L. Ivansyah 1Master Program in Computational Science Faculty of Mathematics and Natural Sciences Institut Teknologi Bandung Jalan Ganesha No. 10 Bandung West Java 40132 Indonesia 2Analytical Chemistry Research Group Department of Chemistry Faculty of Mathematics and Natural Sciences Institut Teknologi Bandung Jalan Ganesha No. 10 Bandung West Java 40132 Indonesia

At the end of 2019, there was an outbreak with symptoms similar to SARS in the People’s Republic of China caused by the SARS-CoV-2 virus. The massive spread of the virus, including in Indonesia, caused the WHO to issue a pandemic status. One alternative to reducing COVID-19 patients is to use existing drugs until a vaccine is found and ready for use. Currently, hydroxychloroquine has been widely researched as a candidate for anti-COVID-19 medicines, which has now entered the clinical trial stage. However, the solubility of hydroxychloroquine in water is so small that it impacts its low bioavailability in the human body. One way to increase hydroxychloroquine’s solubility in water is through the formation of a stable inclusion complex with hydroxypropyl-β-cyclodextrin. In this research, a molecular docking study and semiempirical quantum method were conducted to investigate the interaction between hydroxypropyl-β-cyclodextrin and hydroxychloroquine. The molecular docking study results and semiempirical quantum method show that hydroxypropyl-β-cyclodextrin and hydroxychloroquine form stable inclusion complex. The solubility of hydroxychloroquine in aqueous solution can be enhanced by forming an inclusion complex with hydroxypropyl-β-cyclodextrin.

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computational investigation of interaction between β-cyclodextrin and hydroxychloroquine

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AIP Conference Proceedings 2021年第1期2349卷

There was an outbreak with symptoms similar to SARS caused by the SARS-CoV-2 virus in the People’s Republic of China at the end of 2019. The rapid spread of the virus, even in Indonesia, led to a pandemic status being given by the WHO. The use of current medications before a vaccine is identified and ready for help is one alternative to reducing COVID-19 patients. As a candidate for anti-COVID-19 drugs, Hydroxychloroquine has been extensively studied and has now reached the clinical trial stage. Hydroxychloroquine’s solubility in water, however, is so limited that it affects its low human body bioavailability. The development of a stable inclusion complex with β-cyclodextrin is one way to increase Hydroxychloroquine’s solubility in water. This research investigated the interaction between β-cyclodextrin and Hydroxychloroquine through molecular docking analysis and a semiempirical quantum process. The results of the semiempirical quantum method and the study of molecular docking suggest that β-cyclodextrin and Hydroxychloroquine are a stable inclusion complex. Hydroxychloroquine’s solubility in aqueous solution can also be increased by forming an inclusion complex with β-cyclodextrin.

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The effect of Moringa oleifera (Lam) leaves ethanol extracts as anti-inflammatory and anti-fibrotic through TNF-α and p38-MAPK expression: In vivo model of liver fibrosis approach

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AIP Conference Proceedings 2021年第1期2353卷

作者： Lestari Kanti Wilujeng Febryana Nur Safitri Supriono Supriono Handono Kalim Sri Poeranto 1Master Program of Biomedical Science Faculty of Medicine Universitas Brawijaya Malang Indonesia 2Department of Internal Medicine Division of Gastroenterohepatology Saiful Anwar General Hospital Malang Indonesia 3Department of Internal Medicine Division of Rheumatology Saiful Anwar General Hospital Malang Indonesia 4Departement of Parasitology Faculty of Medicine University of Brawijaya Malang Indonesia

Recently, no anti-fibrotic agents work effectively to suppress fibrosis process because of its complex pathophysiology. Moringa oleifera (MO) has been shown to function as anti-inflammatory and anti-fibrotic agent through inhibition of NFĸB cascade pathway. This study was conducted to prove the anti-inflammatory and anti-fibrotic effects of MO for inhibit liver fibrosis process through an expression of TNF-α and p38-MAPK. Male Rattus norvegicus strain Wistar rat 3 months old separated randomly was conducted in this study. The liver fibrosis rat model was injected CCl4 10% 1 - 2 cc/kg BW twice a week during 14 weeks. The treatment groups which received MO ethanol extract were divided into three doses (150, 300, and 600 mg/kg BW). MO ethanol extract was injected shortly after CCl4 injection through oral gavage. Samples were analyzed for TNF-α and p38-MAPK expression using immunohistochemistry. Expression of TNF-α and p38-MAPK are decrease in all treatment groups using MO (150, 300, 600 mg/kg BW) compared to control group significantly (p<0.001). The result shows MO has anti-inflammatory and anti-fibrotic effects as expected. Moringa oleifera was proven to be able to decrease TNF-α and p38-MAPK in treatment groups compared to rat models. It could be a potential herbal as anti-inflammatory and anti-fibrotic to inhibit fibrosis process.

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Subsurface characterization of Diwak-Derekan geothermal field by HVSR analysis method based on mictrotremor data

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AIP Conference Proceedings 2020年第1期2296卷

作者： Vithya Arintalofa Gatot Yuliyanto Udi Harmoko 1Master Program of Energy School of Postgraduate Studies Diponegoro University Jl. Imam Bard}o SH No.5 Pleburan Semarang 50241 Indonesia 2Department of Physics Faculty of Science and Mathematics Diponegoro University Jl. Prof. Soedharto SH Tembalang Semarang 50275 Semarang Indonesia

The research aims to analyze the subsurface structures that are manifested in geothermal represented by using the Horizontal to Vertical Spectral Ratio (HVSR) method. The data is obtained by microtremor recording, which obtains the dominant frequency value and amplification factor that will give the value of the wave velocity P (Vp) and the wave velocity S (Vs). The results of the study at 52 measurement points were processed using Geopsy and Surfer 13. The results of microtremor data processing using the HVSR method obtained the distribution of dominant frequency values around 0.08 to 9.29 Hz, the distribution of amplification factor values around 0.03 to 7.07, the distribution of Vp values around 390 m/s to 4993 m/s and the distribution of Vs values around 190 m/s to 3054 m/s. Manifestation area of Diwak- Derekan is located on the weak zone, based on the subsurface structural analysis, a possibility of normal fault is also identified, it causes manifestation of hot water springs on the surface. The Poisson's Ratio shows subsurface lithology mostly in the form of sandy loam, and a small portion of silt and saturated clay. The analysis of Poisson's Ratio shows the geothermal manifestation area is possibly a geothermal system that the fluid type is dominated by vapor/steam. The result explains that microtremor analysis by HVSR method can be utilized to subsurface interpretation for characterization purpose of the study area.

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7,12-dimethylbenz(a)anthracene induced breast cancer in Sprague Dawley rats proved by ultrasound imaging

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AIP Conference Proceedings 2019年第1期2108卷

作者： Mutmainnah Arif Padlianah Ika Yustisia 1Master Program of Biomedical Science on Pharmacology Sekolah Pascasarjana Universitas Hasanuddin Makassar Indonesia 2Master Program of Biomedical Science on Biochemistry and Molecular Biology Sekolah Pascasarjana Universitas Hasanuddin Makassar Indonesia 3Department of Biochemistry Faculty of Medicine Universitas Hasanuddin Makassar Indonesia

Many studies have shown that some of cancer animal models have been established to study various aspects of cancer biology, including breast cancer. Substantial evidence has shown that administration of 7,12-dimethylbenz(a)anthracene (DMBA) in animal models can mimic human breast cancer in many ways. This preliminary research aimed to develop rat breast cancer models that will be used for a further study on phytotherapy as the alternative medicine for breast cancer. Four young Sprague Dawley female rats, aged 60 days, received a single subcutaneous injection of 25 mg DMBA mixed with 0.5 mL sunflower oil and 0.5 mL sodium chloride 0.9%. Control group received 0.5 ml of sunflower oil and 0.5 ml of saline only. Tumor detection by palpation and rats’ body weight measurement were performed every week after DMBA induction. At 10-weeks after DMBA induction, the tumor development was examined by ultrasound imaging. No significant differences were observed in the body weight between DMBA-induced rats and non-induced rats during 8-weeks after induction. Starting from week ninth, the body weight of the DMBA group significantly decreased (p=0.02) compared to the counterpart. A solid mass on the breast area was firstly detected at week seventh in one rat. Three weeks later the solid masses were detected in all DMBA-induced rats that proved by the ultrasound images showing hypoechoic lesions with irregular margin and calcification indicating malignancies. DMBA induced malignant lesions in female rats that demonstrated by ultrasound imaging.

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Blood chemistry profiles of DMBA-induced mammary tumor in female sprague dawley rats

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AIP Conference Proceedings 2019年第1期2108卷

作者： Padlianah Mutmainnah Arif Ika Yustisia 1Master Program of Biomedical Science on Biochemistry and Molecular Biology Sekolah Pascasarjana Universitas Hasanuddin Makassar Indonesia 2Master Program of Biomedical Science on Pharmacology Sekolah Pascasarjana Universitas Hasanuddin Makassar Indonesia 3Departement of Biochemistry Faculty of Medicine Universitas Hasanuddin Makassar Indonesia

Although aerobic glycolysis (Warburg effect) in cancers had been accepted as a significant characteristic of cancer, changes in metabolic state in each stage of tumorigenesis remain to be explored. In this preliminary study, we analyzed the changes of several blood chemistry parameters intending to describe the general metabolic state of the early and advanced stages of tumorigenesis in rat mammary tumor models. The mammary tumor was induced in female Sprague Dawley (SD) rats by subcutaneous injection of 7, 12-dimethylbenz[a]anthracene (DMBA). The rats were palpated on the breast every week after DMBA induction to detect tumor development. Blood chemistry examinations including blood glucose, triglyceride, cholesterol, HDL-cholesterol, urea, and creatinine, were performed at 8-weeks and 12-weeks after DMBA induction. Rats were fasted 12-14 hours before retro-orbital blood collection. The spectrophotometer measured all the parameters. The palpable mammary tumor was firstly detected at 7-weeks on 1 of 4 DMBA induced rats. At three weeks later all rats had palpable tumors that also confirmed by ultrasound imaging. The blood chemistry measurements revealed that DMBA-induced rats had a significantly higher level of triglyceride (p=0.001) and creatinine (p=0.018); and glucose (p=0.007) at 8-weeks and 10-weeks after DMBA induction compared to the non-induced rats, respectively while not in the other parameters. The stages of tumor development may have a different profile of blood chemistry parameters. Further research should be performed to elucidate whether the profile could describe the metabolic reprogramming during tumorigenesis.

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Performance of biofoam polyurethane-urea/rice straw waste (Oryza Sativa) as a noise reducer

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AIP Conference Proceedings 2020年第1期2296卷

作者： Romy Dyah Rahmawati Mohammad Masykuri Yulia Lanti Retno Dewi 1Master of Environmental Science Study Program Postgraduate Sebelas Maret University Jl. Ir. Sutami 36A Surakarta Indonesia 2Chemistry Education Study Program Faculty of Teacher Training and Education Sebelas Maret University Jl. Ir. Sutami 36A Surakarta Indonesia 3Medical Education Study Program Faculty of Medicine Sebelas Maret University Jl. Ir. Sutami 36A Surakarta Indonesia

Noise is one of the common problems found in the metal processing industry. The noise that continuously occurs can influence the health of workers. The large number of workers who do not use Personal Protective Equipment (PPE) and pay less attention to work safety, resulting in them being exposed to high noise, for example, parts of production units that have an average noise intensity of 102.9 dBA/8 hours. The need of noise reduction materials for the metal processing industry is still very potent. Utilization of eco-friendly noise reduction materials in a wide frequency range cannot be fulfilled by the existing materials. This research aims to synthesize polyurethane-urea/rice straw waste (PUU/RSW) foam and to measure its performance as a noise reducer. Rice straw waste is used as an additive in a mixture of polyurethane-urea foam. The one-step method is used for the synthesis of PUU/RSW biofoam using with the composition of maleic anhydric (MAH) 0.1% (w/w), ethylene diamine (EDA) 1% (w/w), variations of polyethylene glycol/methylene diamine (PEG/MDI) (1/1), and rice straw waste with the variations from 0, 1, 2, 3, 4, to 5% (w/w). The characterization of biofoam structures was carried out using FTIR. The effectiveness of the foam in sound absorption is tested by using the two-microphone technique according to the ASTM E-1050 procedure. The results show that physically biofoam products are medium-textured (soft to hard), porous and brown with chemical groups identified C-H, C-O, O-H. Noise absorption test results show that PUU/RSW biofoam is effective as a noise-reducing material as it has a high absorption coefficient in the wide frequency range.

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Microplastic in Gonggong snails (Laevistrombus turturella) and sediment of Bintan Island, Kepulauan Riau Province, Indonesia

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AIP Conference Proceedings 2019年第1期2202卷

作者： Ainul J. Al Hamra Mufti P. Patria 1Master Program of Marine Science Faculty of Mathematics and Natural Science Universitas Indonesia Depok Jawa Barat 16424 Indonesia 2Department of Biology Faculty of Mathematics and Natural Science Universitas Indonesia Depok Jawa Barat 16424 Indonesia

Microplastics (1 um - 5 mm) had been pollutants in marine habitat and can be consumed by fauna. This study aims to determine the number of microplastic particles found in sediments and Gonggong snails Laevistrombus turturella in four station at coastal areas of Bintan Island. Ten snails were taken, and its sediment collected at a depth of 1-2 cm from the surface as much as ± 250 gr. The tissue of gonggong snails were destructed on HNO3 for 24 hours and diluted 10 times with 50% NaCl solution before observed under a light microscope. Our findings at four stations showed the average number of microplastics concentration in the snail presence at Madong Village (492 ± 107.68 particles/ind.), Pengudang Village (476 ± 171.34 particles/ind.), Busung Village (360 ± 118.43 particles/ind) and Kawal Village (628 ± 191.93 particles/ind) wet weight. Microplastics concentration in the sediment at Madong Village (956 ± 171.18 particles/kg), Pengudang Village (928 ± 118.58 particles/kg), Busung Village (604 ± 119.26 particles/kg) and Kawal Village (1,136 ± 154.75 Particles/kg). Our observations also showed many plastics waste on the coastal area.

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