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Impact of occupational noise exposure on the hearing level in hospital staffs: a longitudinal study

Environmental science and Pollution Research 2024年第16期31卷 24129-24138页

作者： Wang, Tang-Chuan Yu, You-Cheng Hsu, Alan Lin, Jia-Yi Tsou, Yung-An Liu, Chiu-Shong Chuang, Kai-Jen Pan, Wen-Chi Yang, Chin-An Hu, Sung-Lin Ho, Chien-Yi Chen, Tzu-Liang Lin, Chia-Der Pai, Pei-Ying Chang, Ta-Yuan Department of Public Health College of Public Health China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Department of Otolaryngology – Head and Neck Surgery China Medical University Hsinchu Hospital No. 199 Section 1Xinglong Road Hsinchu County Zhubei City302056 Taiwan School of Medicine College of Medicine China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan The Ph.D. Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Department of Occupational Safety and Health College of Public Health China Medical University No. 100 Section 1Jingmao Road Beitun District Taichung City406040 Taiwan Department of Public Health School of Medicine College of Medicine Taipei Medical University No.250 Wuxing St. Xinyi Dist. Taipei City110 Taiwan Institute of Environmental and Occupational Health Sciences National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City112304 Taiwan Department of Biomedical Imaging and Radiological Science China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Division of Family Medicine Physical Examination Center Department of Medical Research China Medical University Hsinchu Hospital No. 199 Section 1Xinglong Road Hsinchu County Zhubei City302 Taiwan

The study aimed to evaluate the impact of occupational noise on hearing loss among healthcare workers using audiometry. A longitudinal study was conducted with a six-month follow-up period in a hospital with 21 participants, divided into high-noise-exposure (HNE) and low-noise-exposure (LNE) groups. Mean noise levels were higher in the HNE group (70.4 ± 4.5 dBA), and hearing loss was measured using pure-tone audiometry at baseline and follow-up. The HNE group had significantly higher mean threshold levels at frequencies of 0.25 kHz, 0.5 kHz, 4.0 kHz, and an average of 0.5, 1, 2, and 4 kHz (all p-values © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Audition

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Understanding ADC variation by fat content effect using a dual-function MRI phantom

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European Radiology Experimental 2024年第1期8卷 19页

作者： Liu, Yi-Jui Tsai, Tung-Sheng Li, Ya-Hui Peng, Jo-Hua Chang, Hing-Chiu Peng, Hsu-Hsia Lee, Ying-Chieh Lee, Tung-Yang Liou, Chang-Hsien Lin, Tz-Feng Chew, Fatt-Yang Chou, Ruey-Hwang Juan, Chun-Jung Department of Automatic Control Engineering Feng Chia University Taichung Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital 199 Sec. 1 Xinglong Rd. Hsinchu County Zhubei City 302 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Biomedical Engineering Chinese University of Hong Kong Hong Kong Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Institute of Nuclear Engineering and Science National Tsing Hua University Hsinchu Taiwan Department of Fiber and Composite Materials Feng Chia University Taichung Taiwan Department of Medical Imaging China Medical University Hospital Taichung Taiwan Department of Radiology School of Medicine China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 406 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung Taiwan Department of Medical Laboratory and Biotechnology Asia University Taichung Taiwan

Background: A dual-function phantom designed to quantify the apparent diffusion coefficient (ADC) in different fat contents (FCs) and glass bead densities (GBDs) to simulate the human tissues has not been documented yet. We propose a dual-function phantom to quantify the FC and to measure the ADC at different FCs and different GBDs. Methods: A fat-containing diffusion phantom comprised by 30 glass-bead-containing fat-water emulsions consisting of six different FCs (0, 10, 20, 30, 40, and 50%) multiplied by five different GBDs (0, 0.1, 0.25, 0.5, and 1.0 g/50 mL). The FC and ADC were measured by the “iterative decomposition of water and fat with echo asymmetry and least squares estimation-IQ,” IDEAL-IQ, and single-shot echo-planar diffusion-weighted imaging, SS-EP-DWI, sequences, respectively. Linear regression analysis was used to evaluate the relationship among the fat fraction (FF) measured by IDEAL-IQ, GBD, and ADC. Results: The ADC was significantly, negatively, and linearly associated with the FF (the linear slope ranged from -0.005 to -0.017, R² = 0.925 to 0.986, all p < 0.001). The slope of the linear relationship between the ADC and the FF, however, varied among different GBDs (the higher the GBD, the lower the slope). ADCs among emulsions across different GBDs and FFs were overlapped. Emulsions with low GBDs plus high FFs shared a same lower ADC range with those with median or high GBDs plus median or lower FFs. Conclusions: A novel dual-function phantom simulating the human tissues allowed to quantify the influence of FC and GBD on ADC. Relevance statement: The study developed an innovative dual-function MRI phantom to explore the impact of FC on ADC variation that can affect clinical results. The results revealed the superimposed effect on FF and GBD density on ADC measurements. Key points: • A dual-function phantom made of glass bead density (GBD) and fat fraction (FF) emulsion has been developed. • Apparent diffusion coefficient (ADC) values

关键词： Adipose tissue Diffusion magnetic resonance imaging Phantoms (imaging) Quality assurance (healthcare) Quality control

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The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net

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European Radiology 2023年第9期33卷 6157-6167页

作者： Li, Ya-Hui Lin, Shao-Chieh Chung, Hsiao-Wen Chang, Chia-Ching Peng, Hsu-Hsia Huang, Teng-Yi Shen, Wu-Chung Tsai, Chon-Haw Lo, Yu-Chien Lee, Tung-Yang Juan, Cheng-Hsuan Juan, Cheng-En Chang, Hing-Chiu Liu, Yi-Jui Juan, Chun-Jung Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital No. 199 Sec. 1 Xinglong Rd. Zhubei City Hsinchu County 302 Hsinchu Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Department of Management Science National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Department of Medical Imaging Medical University Hospital Taichung Taiwan Department of Neurology China Medical University Hospital Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Automatic Control Engineering Feng Chia University No. 100 Wenhwa Rd. Seatwen Taichung 40724 Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong ERB1112 11/F William M.W. Mong Engineering Building N.T Shatin Hong Kong Multi-Scale Medical Robotics Center The Chinese University of Hong Kong N.T Shatin Hong Kong Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

Background: To evaluate the effect of the weighting of input imaging combo and ADC threshold on the performance of the U-Net and to find an optimized input imaging combo and ADC threshold in segmenting acute ischemic stroke (AIS) lesion. Methods: This study retrospectively enrolled a total of 212 patients having AIS. Four combos, including ADC-ADC-ADC (AAA), DWI-ADC-ADC (DAA), DWI-DWI-ADC (DDA), and DWI-DWI-DWI (DDD), were used as input images, respectively. Three ADC thresholds including 0.6, 0.8 and 1.8 × 10^–3 mm²/s were applied. Dice similarity coefficient (DSC) was used to evaluate the segmentation performance of U-Nets. Nonparametric Kruskal–Wallis test with Tukey–Kramer post-hoc tests were used for comparison. A p <.05 was considered statistically significant. Results: The DSC significantly varied among different combos of images and different ADC thresholds. Hybrid U-Nets outperformed uniform U-Nets at ADC thresholds of 0.6 × 10^–3 mm²/s and 0.8 × 10^–3 mm²/s (p <.001). The U-Net with imaging combo of DDD had segmentation performance similar to hybrid U-Nets at an ADC threshold of 1.8 × 10^–3 mm²/s (p =.062 to 1). The U-Net using the imaging combo of DAA at the ADC threshold of 0.6 × 10^–3 mm²/s achieved the highest DSC in the segmentation of AIS lesion. Conclusions: The segmentation performance of U-Net for AIS varies among the input imaging combos and ADC thresholds. The U-Net is optimized by choosing the imaging combo of DAA at an ADC threshold of 0.6 × 10^–3 mm²/s in segmentating AIS lesion with highest DSC. Key Points: • Segmentation performance of U-Net for AIS differs among input imaging combos. • Segmentation performance of U-Net for AIS differs among ADC thresholds. • U-Net is optimized using DAA with ADC = 0.6 × 10^–3mm²/s. © 2023, The Author(s), under exclusive licence to European Society of Radiology.

关键词： Deep Learning Diffusion Magnetic Resonance Imaging Ischemic Stroke Neural Networks, Computer Retrospective Study

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Enhancement of student critical thinking ability and environmental awareness through e-module based on SETS-Edutainment: A need analysis

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AIP Conference Proceedings 2023年第1期2540卷

作者： Rizka Ayu Mujiningtyas Maridi Nurma Yunita Indriyanti 1Master Program of Science Education Faculty of Teacher Training And Education Sebelas Maret University Indonesia Jl. Ir. Sutami No. 36A Kentingan Surakarta Indonesia

A need analysis in this research were carried out to determine the use of teaching methods and materials in science learning used by teachers, difficulties in science teaching and learning activities and to measure critical thinking skills and environmental awareness of students in Balerejo District Junior High School. The method used in this research is quantitative by collecting, processing and concluding based on a survey using a questionnaire. The research subjects were science teachers and seventh grade students of SMPN 1 Balerejo, SMPN 2 Balerejo and SMPS Wisma-Wisnu located in the Balerejo sub-district with a total of 60 students in each school. Based on survey the teachers using handbook and worksheet with lecture method. Teaching difficulties experienced by teachers in the lack of appropriate media facilities and the ability to develop teaching materials in accordance with appropriate learning methods. Based on the test of critical thinking skills at the observation stage through HOTS (Higher Order Thinking Skill) questions regarding environmental problems, it was found that about 80% did not understand the impact of environmental damage and had not maximally found real solutions that were useful for the surrounding environment in accordance with current developments and technology. Based on a need analysis, the environmental awareness of students in the Balerejo District Junior High School showed that 70% were not used to throwing garbage in its place, 85% did not know the benefits of planting trees around the riverbanks in Balerejo District and almost 90% did not know the cause of flooding in Balerejo District in 2019 ago. Empowerment of critical thinking can be done by teachers with learning that has the potential to empower critical thinking skills, such as using the SETS-Edutainment approach. SETS-Edutainment provides science, Environment, Technology and Society-oriented learning that combines science with environmentally friendly technology and is exp

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Landsat 8 OLI imagery based mapping of agricultural land change in 2014 to 2020 in Karawang Regency

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AIP Conference Proceedings 2023年第1期2654卷

作者： Samsudin A. Hafid Bowo Susilo Iswari Nur Hidayati 1Master Program of Remote Sensing Faculty of Geography Universitas Gadjah Mada Yogyakarta Indonesia 2Department of Geographic Information Science Faculty of Geography Universitas Gadjah Mada Yogyakarta Indonesia

Land use change is a phenomenon that needs special attention, especially concerning the planning and development of a region. Agricultural land is the most vulnerable form of land use to change. Agricultural land was transformed or converted into other forms of land use for the industrial zone. Changes in agricultural land occur in various regions even in areas known for their rice productions, namely Karawang Regency. Information about changes or conversion of agricultural land, especially information with spatial references, is very important and needs to be kept up to date. This information is very useful as input in regional development planning. This study aims to map and analyze changes in agricultural lands in Karawang Regency. The study period was between 2014 and 2020. The method used was a combination of remote sensing image interpretation and spatial analysis. Interpretation of imagery was done using multispectral classification methods called maximum likelihood. The results showed that during the 2014-2020 period, agricultural land in Karawang Regency decreased by 27,659.57 hectares.

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Analysis of students' self-regulated learning in terms of gender using blended learning-based laboratory inquiry teaching materials

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AIP Conference Proceedings 2022年第1期2600卷

作者： Agus Ramdani I. Putu Artayasa Ezha Vandia Sulawanti M. Yustiqvar 1Master of Science Education Program Postgraduate Studies University of Mataram Mataram Indonesia 2Biology Education Program FKIP University of Mataram Mataram Indonesia

The Covid-19 pandemic has affected the way students learn from face-to-face to online learning. This condition is a challenge for educators to provide online teaching materials. Teaching materials developed to facilitate students to learn independently. The characteristics of the teaching materials developed give students the freedom to learn and facilitate the development of their abilities and skills. This study aimed to analyze the effectiveness of blended learning-based laboratory inquiry teaching materials in improving students' self-regulated learning in terms of gender. This type of research is a quasi-experimental research. The test subjects in this study were class XI in one of the public high schools in Mataram City, which consisted of two classes, namely the experimental class and the control class, which consisted of 67 students. There are 34 male students and 33 female students. The data collection technique used a self-regulated learning questionnaire instrument. The instrument refers to seven indicators of self-regulated learning. Data analysis was carried out using N-gain and T-test. The results showed that blended learning-based laboratory inquiry teaching materials could increase students' self-regulated learning. Based on the results of the T test, there was a significant difference between the control class and the experimental class. The third self-regulated learning indicator, namely goal setting and planning, got the highest increase compared to other indicators. The second indicator, namely organization and information, obtained the lowest increase compared to other indicators. Self-regulated learning of male students is higher than female students. With the availability of online class media in the blended learning learning model that can be accessed anytime and anywhere by students, it can increase the readiness of students themselves before face-to-face learning in class takes place. Student activity also increases because by providing mat

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Prediction of the Binding Mechanism of a Selective DNA Methyltransferase 3A Inhibitor by Molecular Simulation

SSRN

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SSRN 2023年

作者： Kudo, Genki Hirao, Takumi Harada, Ryuhei Hirokawa, Takatsugu Shigeta, Yasuteru Yoshino, Ryunosuke Physics Department Graduate School of Pure and Applied Sciences University of Tsukuba 1-1-1 Tennodai Ibaraki Tsukuba305-8571 Japan Master’s Program in Medical Sciences Graduate School of Comprehensive Human Sciences University of Tsukuba Ibaraki Tsukuba305-8575 Japan Division of Biomedical Science Faculty of Medicine University of Tsukuba 1-1-1 Tennodai Ibaraki Tsukuba305-8575 Japan Center for Computational Sciences University of Tsukuba 1-1-1 Tennodai Ibaraki Tsukuba305-8577 Japan Transborder Medical Research Center University of Tsukuba 1-1-1 Tennodai Ibaraki Tsukuba305-8575 Japan Japan

DNA methylation is an epigenetic mechanism that introduces a methyl group at the C5 position of cytosine. This reaction is catalyzed by DNA methyltransferases (DNMTs) and is essential for the regulation of gene transcription. The DNMT1 and DNMT3A or -3B family proteins are known targets for the inhibition of DNA hypermethylation in cancer cells. A selective non-nucleoside DNMT3A inhibitor that mimics S-adenosyl-l-methionine and deoxycytidine has been developed;however, its selectivity mechanism is unclear because the structure of the inhibitor–protein complex has not yet been determined. Therefore, we performed docking and molecular dynamics simulations to predict the structure of the complex formed by the association between DNMT3A and the selective inhibitor. Through our simulations, binding free energy decomposition analysis, structural isoform comparison, and residue scanning revealed that Arg688 of DNMT3A is involved in the interaction with this inhibitor, as seen by its significant contribution to the binding free energy. The presence of Asn1192 at the corresponding residues in DNMT1 results in a loss of affinity for the inhibitor, suggesting that the interactions mediated by Arg688 in DNMT3A are essential for selectivity. Our study findings can be applied in the design of DNMT-selective inhibitors and methylation-specific drug optimization procedures. © 2023, The Authors. All rights reserved.

关键词： Molecular dynamics

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Antibacterial effect of Coffea canephora ethanolic extract through potassium and magnesium efflux mechanism

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AIP Conference Proceedings 2023年第1期2634卷

作者： Ibnu Diptya Prawatya Daniel Winatakusuma Ferdian Tanaka Dwi Yuni Nur Hidayati Hidayat Sujuti 1Master Program of Biomedical Sciences Faculty of Medicine Universitas Brawijaya Malang Indonesia 2Department of Microbiology Faculty of Medicine Universitas Brawijaya Malang Indonesia 3Department of Ophthalmology Saiful Anwar General Hospital Malang Indonesia

The resistance of some bacteria towards current antibiotics calls for a new development of antibiotics. Robusta coffee (Coffea canephora) contains active compounds with antibacterial effects such as chlorogenic acid, caffeine, caffeic acid, and quinic acid. Intracellular ions such as potassium and magnesium have important roles in bacterial life. This study aims to investigate the potential antibacterial effect of Coffea canephora and its possibility in damaging bacterial cell walls and membranes through efflux of potassium and magnesium ions. This experimental study used three types of bacteria Methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, and Pseudomonas aeruginosa, each divided into a control group and an experimental group with different concentrations. Efflux of potassium and magnesium ions in bacteria was measured using an atomic absorption spectrophotometer (AAS), while changes in bacterial cell wall morphology were observed using a scanning electron microscope (SEM). Coffea canephora is found to significantly increase the magnesium efflux of all bacteria compared to the control group (p < 0.05), while the potassium efflux only significantly increases in MRSA and Klebsiella pneumoniae. In observations using SEM, changes in the morphology of bacterial cell walls are found in the experimental group, indicating a damaging effect caused by Coffea canephora.

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Effect of exogenous insulin injection on hematological status in rats (Rattus norvegicus L.)

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AIP Conference Proceedings 2022年第1期2391卷

作者： Aisha Dian Kusuma Tyas Rini Saraswati Teguh Suprihatin 1Master Biology Program Department of Biology Faculty of Science and Mathematics Diponegoro University Indonesia 2Department of Biology Faculty of Science and Mathematics Diponegoro University Indonesia

Long-term exogenous insulin injection can cause hematopoietic disorders that can affect hematological status. This study aimed to examine the effect of exogenous insulin injection on hematological status in rats (Rattus norvegicus L.). This study uses a completely randomized design with 3 groups and not similar replications. The groups were P0 : control, P1 and P2 : rats were injected with exogenous insulin at a dose of 2 IU/Kg body weight for 14 days and 28 days subcutaneously in the abdomen. Hematological status was observed at the end of treatment, namely erythrocytes, hemoglobin concentration, hematocrit value, erythrocyte index, total and differential leukocytes, number of platelets. Data were analyzed using one-way ANOVA and LSD post hoc test. The results show that insulin injection at dose 2 IU/Kg did not have a significant effect on erythrocytes, hemoglobin concentration, hematocrit value, mean corpuscular volume, mean corpuscular hemoglobin concentration, number of leukocytes, number of neutrophils, number of lymphocytes, and number of platelets (p > 0.05), but had a significant effect on mean corpuscular hemoglobin and number of monocytes (p < 0.05). It can be concluded that exogenous insulin injection for 14 days can cause disturbances in hematological status in the form of a decrease in mean corpuscular hemoglobin and an increase in the number of monocytes.

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Development of antibacterial chitosan film modified by various Dioscorea sp. starches enriched with garlic essential oil: Optimal formulation by response surface methodology

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AIP Conference Proceedings 2022年第1期2553卷

作者： Annisa Istiqomah Maulidan Firdaus Venty Suryanti Triana Kusumaningsih 1Master Program Faculty of Mathematics and Natural Science Universitas Sebelas Maret Indonesia 2Chemistry Department Faculty of Mathematics and Natural Science Universitas Sebelas Maret Indonesia

Food packaging based on chitosan film modified with starches and enriched with garlic essential oil has been successfully developed optimally. Three types of starch from Dioscorea sp. i.e., Dioscorea alata, Dioscorea esculenta and Dioscorea hispida were used in this study, and their optimum formulations were successfully performed, respectively. Box-behnken simulation by response surface methodology, designed a study with three independent variables; chitosan (1-2% (w/v)), starches (1-2% (w/v)) and garlic essential oil (0.1-0.5% (v/v)), with the dependent variable were inhibitor zone of Salmonella typhi and Staphylococcus aureus. Both parameters have significant effect (p<0.05) on antibacterial activity of the films. An in-depth analysis of the effect of different types of starch on the optimal formulation was observed. Herein, optimal formulations are proposed for smart packaging fabrication in the food industry.

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