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Small P values may not yield robust findings:an example using REST-meta-PD

Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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Dense sampling of bird diversity increases power of comparative genomics (vol 587, pg 252, 2020)

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NATURE 2021年第7856期592卷 E24-E24页

作者： Feng, Shaohong Stiller, Josefin Deng, Yuan Armstrong, Joel Fang, Qi Reeve, Andrew Hart Xie, Duo Chen, Guangji Guo, Chunxue Faircloth, Brant C. Petersen, Bent Wang, Zongji Zhou, Qi Diekhans, Mark Chen, Wanjun Andreu-Sanchez, Sergio Margaryan, Ashot Howard, Jason Travis Parent, Carole Pacheco, George Sinding, Mikkel-Holger S. Puetz, Lara Cavill, Emily Ribeiro, Angela M. Eckhart, Leopold Fjeldsa, Jon Hosner, Peter A. Brumfield, Robb T. Christidis, Les Bertelsen, Mads F. Sicheritz-Ponten, Thomas Tietze, Dieter Thomas Robertson, Bruce C. Song, Gang Borgia, Gerald Claramunt, Santiago Lovette, Irby J. Cowen, Saul J. Njoroge, Peter Dumbacher, John Philip Ryder, Oliver A. Fuchs, Jerome Bunce, Michael Burt, David W. Cracraft, Joel Meng, Guanliang Hackett, Shannon J. Ryan, Peter G. Jonsson, Knud Andreas Jamieson, Ian G. da Fonseca, Rute R. Braun, Edward L. Houde, Peter Mirarab, Siavash Suh, Alexander Hansson, Bengt Ponnikas, Suvi Sigeman, Hanna Stervander, Martin Frandsen, Paul B. van der Zwan, Henriette van der Sluis, Rencia Visser, Carina Balakrishnan, Christopher N. Clark, Andrew G. Fitzpatrick, John W. Bowman, Reed Chen, Nancy Cloutier, Alison Sackton, Timothy B. Edwards, Scott V. Foote, Dustin J. Shakya, Subir B. Sheldon, Frederick H. Vignal, Alain Soares, Andre E. R. Shapiro, Beth Gonzalez-Solis, Jacob Ferrer-Obiol, Joan Rozas, Julio Riutort, Marta Tigano, Anna Friesen, Vicki Dalen, Love Urrutia, Araxi O. Szekely, Tamas Liu, Yang Campana, Michael G. Corvelo, Andre Fleischer, Robert C. Rutherford, Kim M. Gemmell, Neil J. Dussex, Nicolas Mouritsen, Henrik Thiele, Nadine Delmore, Kira Liedvogel, Miriam Franke, Andre Hoeppner, Marc P. Krone, Oliver Fudickar, Adam M. Mila, Borja Ketterson, Ellen D. Fidler, Andrew Eric Friis, Guillermo Parody-Merino, Angela M. Battley, Phil F. Cox, Murray P. Lima, Nicholas Costa Barroso Prosdocimi, Francisco Parchman, Thomas Lee Schlinger, Barney A. Loiselle, Bette A. Blake, John G. Lim, Haw Chuan Day, Lainy B. Fuxjager, Matthew J. Baldwin, Maude W. Braun, Michael J. Wirthlin, Morgan Dikow, China National GeneBank BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China BGI-Shenzhen Shenzhen China Villum Centre for Biodiversity Genomics Section for Ecology and Evolution Department of Biology University of Copenhagen Copenhagen Denmark BGI Education Center University of Chinese Academy of Sciences Shenzhen China MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute Zhejiang University Hangzhou China Department of Neuroscience and Developmental Biology University of Vienna Vienna Austria Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China James D. Watson Institute of Genome Sciences Hangzhou China UC Santa Cruz Genomics Institute UC Santa Cruz Santa Cruz CA USA Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark Center for Macroecology Evolution and Climate GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Biological Sciences Louisiana State University Baton Rouge LA USA Museum of Natural Science Louisiana State University Baton Rouge LA USA Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) Faculty of Applied Sciences AIMST University Kedah Malaysia Section for Evolutionary Genomics The GLOBE Institute Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Institute of Molecular Biology National Academy of Sciences Yerevan Armenia University Museum Norwegian University of Science and Technology Trondheim Norway Center for Reproductive Medicine The 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Novogene Durham NC USA Duke University Medical Center Durham NC USA The Rockefeller University New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA Department of Dermatology Medical University of Vienna Vienna Austria

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All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO and Advanced Virgo O3 data

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Physical Review D 2022年第10期106卷 102008-102008页

作者： R. Abbott H. Abe F. Acernese K. Ackley N. Adhikari R. X. Adhikari V. K. Adkins V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu S. Albanesi R. A. Alfaidi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres M. Andrés-Carcasona T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier T. Apostolatos E. Z. Appavuravther S. Appert S. K. Apple K. Arai A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud M. Arogeti S. M. Aronson H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. Assis de Souza Melo S. M. Aston P. Astone F. Aubin K. AultONeal C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai J. Baird R. Bajpai T. Baka M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri B. Banerjee D. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos S. Basak R. Bassiri A. Basti M. Bawaj J. C. Bayley M. Bazzan B. R. Becher B. Bécsy V. M. Bedakihale F. Beirnaert M. Bejger I. Belahcene V. Benedetto D. Beniwal M. G. Benjamin T. F. Bennett J. D. Bentley M. BenYaala S. Bera M. Berbel F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser D. Beveridge R. Bhandare A. V. Bhandari U. Bhardwaj R. Bhatt D. Bhattacharjee S. Bhaumik A. Bianchi I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boër G. Bogaert M. Boldrini G. N. Bolingbroke L. D. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Graduate School of Science Tokyo Institute of Technology Meguro-ku Tokyo 152-8551 Japan Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics and Astronomy Monash University Clayton 3800 Victoria Australia University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA Louisiana State University Baton Rouge Louisiana 70803 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Dipartimento di Fisica Università degli Studi di Torino I-10125 Torino Italy INFN Sezione di Torino I-10125 Torino Italy SUPA University of Glasgow Glasgow G12 8QQ United Kingdom Università di Napoli “Federico II ” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1

We present results of an all-sky search for continuous gravitational waves which can be produced by spinning neutron stars with an asymmetry around their rotation axis, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. Four different analysis methods are used to search in a gravitational-wave frequency band from 10 to 2048 Hz and a first frequency derivative from −10−8 to 10−9 Hz/s. No statistically significant periodic gravitational-wave signal is observed by any of the four searches. As a result, upper limits on the gravitational-wave strain amplitude h0 are calculated. The best upper limits are obtained in the frequency range of 100 to 200 Hz and they are ∼1.1×10−25 at 95% confidence level. The minimum upper limit of 1.10×10−25 is achieved at a frequency 111.5 Hz. We also place constraints on the rates and abundances of nearby planetary- and asteroid-mass primordial black holes that could give rise to continuous gravitational-wave signals.

关键词： Gravitational wave sources Neutron stars & pulsars Gravitational wave detection

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Search for continuous gravitational wave emission from the Milky Way center in O3 LIGO-Virgo data

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Physical Review D 2022年第4期106卷 042003-042003页

作者： R. Abbott H. Abe F. Acernese K. Ackley N. Adhikari R. X. Adhikari V. K. Adkins V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu S. Albanesi R. A. Alfaidi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres M. Andrés-Carcasona T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier T. Apostolatos E. Z. Appavuravther S. Appert S. K. Apple K. Arai A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud M. Arogeti S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. Assis de Souza Melo S. M. Aston P. Astone F. Aubin K. AultONeal C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai J. Baird R. Bajpai T. Baka M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri B. Banerjee D. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos S. Basak R. Bassiri A. Basti M. Bawaj J. C. Bayley M. Bazzan B. R. Becher B. Bécsy V. M. Bedakihale F. Beirnaert M. Bejger I. Belahcene V. Benedetto D. Beniwal M. G. Benjamin T. F. Bennett J. D. Bentley M. BenYaala S. Bera M. Berbel F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser D. Beveridge R. Bhandare A. V. Bhandari U. Bhardwaj R. Bhatt D. Bhattacharjee S. Bhaumik A. Bianchi I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boër G. Bogaert M. Boldrini G. N. Bolingbroke L. D. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Graduate School of Science Tokyo Institute of Technology Meguro-ku Tokyo 152-8551 Japan Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics and Astronomy Monash University Clayton 3800 Victoria Australia University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA Louisiana State University Baton Rouge Louisiana 70803 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 Sáo José dos Campos São Paulo Brazil Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Dipartimento di Fisica Università degli Studi di Torino I-10125 Torino Italy INFN Sezione di Torino I-10125 Torino Italy SUPA University of Glasgow Glasgow G12 8QQ United Kingdom Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1

We present a directed search for continuous gravitational wave (CW) signals emitted by spinning neutron stars located in the inner parsecs of the Galactic Center (GC). Compelling evidence for the presence of a numerous population of neutron stars has been reported in the literature, turning this region into a very interesting place to look for CWs. In this search, data from the full O3 LIGO-Virgo run in the detector frequency band [10,2000] Hz have been used. No significant detection was found and 95% confidence level upper limits on the signal strain amplitude were computed, over the full search band, with the deepest limit of about 7.6×10−26 at ≃142 Hz. These results are significantly more constraining than those reported in previous searches. We use these limits to put constraints on the fiducial neutron star ellipticity and r-mode amplitude. These limits can be also translated into constraints in the black hole mass–boson mass plane for a hypothetical population of boson clouds around spinning black holes located in the GC.

关键词： Cosmic rays & astroparticles Dark matter General relativity Gravitational waves

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All-sky search for gravitational wave emission from scalar boson clouds around spinning black holes in LIGO O3 data

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Physical Review D 2022年第10期105卷 102001-102001页

作者： R. Abbott H. Abe F. Acernese K. Ackley N. Adhikari R. X. Adhikari V. K. Adkins V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu S. Albanesi R. A. Alfaidi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres M. Andrés-Carcasona T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier T. Apostolatos E. Z. Appavuravther S. Appert S. K. Apple K. Arai A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud M. Arogeti S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. Assis de Souza Melo S. M. Aston P. Astone F. Aubin K. AultONeal C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai J. Baird R. Bajpai T. Baka M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri B. Banerjee D. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos S. Basak R. Bassiri A. Basti M. Bawaj J. C. Bayley M. Bazzan B. R. Becher B. Bécsy V. M. Bedakihale F. Beirnaert M. Bejger I. Belahcene V. Benedetto D. Beniwal M. G. Benjamin T. F. Bennett J. D. Bentley M. BenYaala S. Bera M. Berbel F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser D. Beveridge R. Bhandare A. V. Bhandari U. Bhardwaj R. Bhatt D. Bhattacharjee S. Bhaumik A. Bianchi I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boër G. Bogaert M. Boldrini G. N. Bolingbroke L. D. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Graduate School of Science Tokyo Institute of Technology Meguro-ku Tokyo 152-8551 Japan Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics and Astronomy Monash University Clayton 3800 Victoria Australia University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA Louisiana State University Baton Rouge Louisiana 70803 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Dipartimento di Fisica Università degli Studi di Torino I-10125 Torino Italy INFN Sezione di Torino I-10125 Torino Italy SUPA University of Glasgow Glasgow G12 8QQ United Kingdom Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1

This paper describes the first all-sky search for long-duration, quasimonochromatic gravitational-wave signals emitted by ultralight scalar boson clouds around spinning black holes using data from the third observing run of Advanced LIGO. We analyze the frequency range from 20 to 610 Hz, over a small frequency derivative range around zero, and use multiple frequency resolutions to be robust towards possible signal frequency wanderings. Outliers from this search are followed up using two different methods, one more suitable for nearly monochromatic signals, and the other more robust towards frequency fluctuations. We do not find any evidence for such signals and set upper limits on the signal strain amplitude, the most stringent being ≈10−25 at around 130 Hz. We interpret these upper limits as both an “exclusion region” in the boson mass/black hole mass plane and the maximum detectable distance for a given boson mass, based on an assumption of the age of the black hole/boson cloud system.

关键词： Classical black holes Gravitational wave detection Gravitational wave sources Particle astrophysics Particle dark matter

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Search for gravitational waves from Scorpius X-1 with a hidden Markov model in O3 LIGO data

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Physical Review D 2022年第6期106卷 062002-062002页

Results are presented for a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to allow for spin wandering. This search improves on previous HMM-based searches of Laser Interferometer Gravitational-Wave Observatory data by including the orbital period in the search template grid, and by analyzing data from the latest (third) observing run. In the frequency range searched, from 60 to 500 Hz, we find no evidence of gravitational radiation. This is the most sensitive search for Scorpius X-1 using a HMM to date. For the most sensitive subband, starting at 256.06 Hz, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=6.16×10−26, assuming the orbital inclination angle takes its electromagnetically restricted value ι=44°. The upper limits on gravitational wave strain reported here are on average a factor of ∼3 lower than in the second observing run HMM search. This is the first Scorpius X-1 HMM search with upper limits that reach below the indirect torque-balance limit for certain subbands, assuming ι=44°.

关键词： Gravitational waves Binary stars Neutron stars & pulsars

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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Promoting resilience for food, energy, and water interdependencies

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Journal of Environmental Studies and Sciences 2016年第1期6卷 50-61页

作者： Zimmerman, Rae Zhu, Quanyan Dimitri, Carolyn Institute for Civil Infrastructure Systems (www.nyu.edu/icis) Robert F. Wagner Graduate School of Public Service New York University 295 Lafayette Street–2nd Floor New York 10012 NY United States Department of Electrical and Computer Engineering Tandon School of Engineering New York University 5 MetroTech Center-LC200A Brooklyn 11201 NY United States Departments of Nutrition Food Studies and Public Health Steinhardt School New York University New York 10003 NY United States

This paper presents relationships among food, energy, and water (FEW) systems, reflecting the interconnections among the energy/water, water/energy, water/food, and energy/food sectors. First, a unique approach uses metrics and quantification to reflect interdependencies among these sectors. Next, changes in food technology and practices are put forth in terms of impacts changes are likely to produce for a set of FEW system relationships. Organic farming or shifts in food consumption patterns, such as reduced meat consumption, are two examples of changes in food technology and practices that could affect water and energy use. From a policy perspective, changes in energy and water policy can potentially facilitate increased water conservation and greater use of renewable energy sources;such policy shifts are addressed in terms of changes to metrics and/or their values. The purpose of this work is to establish a network model that quantifies interdependencies among different sectors in terms of resource usage. The model is flexible and can accommodate other factors such as cyberphysical and logical interdependencies. The established model that these metrics provide inputs for enables analysis and design of the resilience mechanisms for FEW complex systems. Examples are used to illustrate the concepts developed in this work. © 2016, AESS.

关键词： Food-energy-water production tradeoffs Infrastructure interdependencies Network analysis Organic agriculture Resilience

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Corrigendum to: More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

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Chemical senses 2021年第46期46卷 bjab050页

作者： Valentina Parma Kathrin Ohla Maria G Veldhuizen Masha Y Niv Christine E Kelly Alyssa J Bakke Keiland W Cooper Cédric Bouysset Nicola Pirastu Michele Dibattista Rishemjit Kaur Marco Tullio Liuzza Marta Y Pepino Veronika Schöpf Veronica Pereda-Loth Shannon B Olsson Richard C Gerkin Paloma Rohlfs Domínguez Javier Albayay Michael C Farruggia Surabhi Bhutani Alexander W Fjaeldstad Ritesh Kumar Anna Menini Moustafa Bensafi Mari Sandell Iordanis Konstantinidis Antonella Di Pizio Federica Genovese Lina Öztürk Thierry Thomas-Danguin Johannes Frasnelli Sanne Boesveldt Özlem Saatci Luis R Saraiva Cailu Lin Jérôme Golebiowski Liang-Dar Hwang Mehmet Hakan Ozdener Maria Dolors Guàrdia Christophe Laudamiel Marina Ritchie Jan Havlícek Denis Pierron Eugeni Roura Marta Navarro Alissa A Nolden Juyun Lim Katherine L Whitcroft Lauren R Colquitt Camille Ferdenzi Evelyn V Brindha Aytug Altundag Alberto Macchi Alexia Nunez-Parra Zara M Patel Sébastien Fiorucci Carl M Philpott Barry C Smith Johan N Lundström Carla Mucignat Jane K Parker Mirjam van den Brink Michael Schmuker Florian Ph S Fischmeister Thomas Heinbockel Vonnie D C Shields Farhoud Faraji Enrique Santamaría William E A Fredborg Gabriella Morini Jonas K Olofsson Maryam Jalessi Noam Karni Anna D'Errico Rafieh Alizadeh Robert Pellegrino Pablo Meyer Caroline Huart Ben Chen Graciela M Soler Mohammed K Alwashahi Antje Welge-Lüssen Jessica Freiherr Jasper H B de Groot Hadar Klein Masako Okamoto Preet Bano Singh Julien W Hsieh Danielle R Reed Thomas Hummel Steven D Munger John E Hayes Department of Psychology Temple University Philadelphia PA USA. Institute of Neuroscience and Medicine (INM-3) Research Center Jülich Wilhelm-Johnen-Straße Jülich Germany. Department of Anatomy Faculty of Medicine Mersin University Çiftlikköy Campus Yenişehir Mersin Turkey. Institute of Biochemistry Food Science and Nutrition The Hebrew University of Jerusalem Rehovot Israel. AbScent Andover Hampshire UK. Department of Food Science The Pennsylvania State University Erickson Food Science Building University Park PA USA. Center for the Neurobiology of Learning and Memory University of California and Qureshey Research Laboratory Irvine CA USA. Institut de Chimie de Nice UMR CNRS 7272 Université Côte d'Azur Avenue Valrose Nice France. Centre for Global Health Research Usher Institute The University of Edinburgh Old Medical School Teviot Place Edinburgh UK. Department of Basic Medical Sciences Neuroscience and Sensory Organs Università degli Studi di Bari A. Moro P.zza G. Cesare Bari Italy. CSIR-Central Scientific Instruments Organisation Chandigarh India. Department of Medical and Surgical Sciences "Magna Graecia" University of Catanzaro Viale Europa (Loc. Germaneto) Catanzaro Italy. Department of Food Science and Human Nutrition and Division of Nutritional Sciences University of Illinois at Urbana Champaign Urbana IL USA. Department of Biomedical Imaging and Image-guided Therapy Medical University of Vienna Währinger Gürtel Vienna Austria. Laboratoire d'Anthropologie Moléculaire et Imagerie de Synthese UMR 5288 CNRS Universitéde Toulouse Toulouse France. National Centre for Biological Sciences Tata Institute of Fundamental Research GKVK Campus Bengaluru India. School of Life Sciences Arizona State University Tempe AZ USA. Department of Psychology and Anthropology University of Extremadura Avenida de la Universidad s/n Cáceres Spain. Department of General Psychology University of Padova Via Venezia Padova Italy. Department of Psychiatry

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Comparative analysis and exprimental results of advanced control strategies for vibration suppression in aircraft wings

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Journal of Physics: Conference Series 2017年第1期783卷

作者： Isabela R. Birs Silviu Folea Dana Copot Ovidiu Prodan Cristina-I. Muresan Department of Automation Technical University of Cluj-Napoca Memorandumului St. No. 28 Cluj-Napoca Romania Department of Electrical energy Systems and Automation Research group on Dynamical Systems and Control Ghent University Technologiepark 914 2nd floor 9052 Ghent Belgium Department of Civil Engineering Technical University of Cluj-Napoca Memorandumului St. No. 28 Cluj-Napoca Romania

The smart beam is widely used as a means of studying the dynamics and active vibration suppression possibilities in aircraft wings. The advantages obtained through this approach are numerous, among them being aircraft stability and manoeuvrability, turbulence immunity, passenger safety and reduced fatigue damage. The paper presents the tuning of two controllers: Linear Quadratic Regulator and Fractional Order Proportional Derivative controller. The active vibration control methods were tested on a smart beam, vibrations being mitigated through piezoelectric patches. The obtained experimental results are compared in terms of settling time and control effort, experimentally proving that both types of controllers can be successfully used to reduce oscillations. The analysis in this paper provides for a necessary premise regarding the tuning of a fractional order enhanced Linear Quadratic Regulator, by combining the advantages of both control strategies.

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