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Rapid fabrication of modular 3d paper-basedmicrofluidic chips using projection-based 3d printing

Bio-design and Manufacturing 2024年第5期7卷 611-623页

作者： Mingjun Xie Zexin Fu Chunfei Lu Sufan Wu Lei Pan Yong He Yi Sun Ji Wang Plastic and Reconstructive Surgery Center Department of Plastic and Reconstructive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Cancer Center Zhejiang UniversityHangzhou 310058China

Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other *** study describes amethod developed to fabricate modular three-dimensional(3d)paper-based microfluidic chips based on projection-based 3d printing(PBP)technology.A series of two-dimensional(2d)paper-based microfluidic modules was designed and *** evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally ***,several 3d paper-based microfluidic chips were assembled based on the 2d ones using different methods,with good channel ***-based 2d and hydrogel-based 3d cell culture systems based on 3d paper-based microfluidic chips were verified to be ***,by combining extrusion 3d bioprinting technology and the proposed 3d paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3d hydrogel structures on 3d paperbased microfluidic chips,confirming that the prepared modular 3d paper-based microfluidic chip is potentially applicable in various biomedical applications.

关键词： Paper-based microfluidic chip Projection-based 3d printing(PBP) Modularization Cell culture

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Balancing the customization and standardization:exploration and layout surrounding the regulation of the growing field of 3d-printed medical devices in China

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Bio-design and Manufacturing 2022年第3期5卷 580-606页

作者： Zhongboyu Jin Chaofan He Jianzhong Fu Qianqian Han Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Cancer Center Zhejiang UniversityHangzhou 310058China National Institutes for Food and Drug Control Beijing 102629China

Medical devices are instruments and other tools that act on the human body to aid clinical diagnosis and disease treatment,playing an indispensable role in modern ***,the increasing demand for personalized medical devices poses a significant challenge to traditional manufacturing *** emerging manufacturing technology of three-dimensional(3d)printing as an alternative has shown exciting applications in the medical field and is an ideal method for manufacturing such personalized medical devices with complex ***,the application of this new technology has also brought new risks to medical devices,making 3d-printed devices face severe challenges due to insufficient regulation and the lack of standards to provide guidance to the *** review aims to summarize the current regulatory landscape and existing research on the standardization of 3d-printed medical devices in China,and provide ideas to address these *** focus on the aspects concerned by the regulatory authorities in 3d-printed medical devices,highlighting the quality system of such devices,and discuss the guidelines that manufacturers should follow,as well as the current limitations and the feasible path of regulation and standardization work based on this *** key points of the whole process quality control,performance evaluation methods and the concept of whole life cycle management of 3d-printed medical devices are ***,the significance of regulation and standardization is pointed ***,aspects worthy of attention and future perspectives in this field are discussed.

关键词： 3d printing Medical device Regulation Standardization

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Projection-based 3d bioprinting for hydrogel scaffold manufacturing

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Bio-design and Manufacturing 2022年第3期5卷 633-639页

作者： Yuan Sun Kang Yu Qing Gao Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Engineering for Life Group(EFL) Suzhou 215101China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Cancer Center Zhejiang UniversityHangzhou 310058China

Projection-based 3d bioprinting(PBP):a powerful method to fabricate 3d cellular structures Three-dimensional(3d)bioprinting has played an important role in tissue engineering and regenerative medicine areas over the past decade[1].different from traditional cell cultures in Petri dishes,3d bioprinting can build bionic structures with a better potential to become artificial organ substitutes[2–4].With the development of photocurable biomaterials,the projection-based 3d printing method has been successfully applied in biological research[5,6].

关键词： printing biomaterials projection

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A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting

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International Journal of Extreme Manufacturing 2023年第4期5卷 486-499页

作者： Yuanrong Li Mingjun Xie Shang Lv Yuan Sun Zhuang Li Zeming Gu Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002People’s Republic of China Plastic and Reconstructive Surgery Center Department of Plastic and Reconstructive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouZhejiang 310014People’s Republic of China

Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human ***,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently ***,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar *** BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,*** by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied ***/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung *** biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.

关键词： biomimetic air-blood barrier,composite material design,controllable mechanical stimulus structure

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deformation Behavior and Microstructure Characterization of A357 Aluminum Alloy Welding Wires Used for Wire Arc Additive Manufacturing

SSRN

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SSRN 2023年

作者： Zheng, Tao Wang, Gaosong Shi, Hanchao Chen, Bingqing Ren, Xinyu Xiong, Huaping 3D Printing Research and Engineering Technology Center Beijing Institute of Aeronautical Materials Beijing100095 China Key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern University Shenyang110819 China

Microstructure and mechanical responses of A357 aluminum alloy welding wires after different degrees of strain were studied. It is found that the grains are elongated and refined along the drawing direction, accompanying with cell structures and sub-grains with strain increasing. Meanwhile, the main contributions to the fibrous texture are Cube, Goss and Copper, i.e., and textures. With the increase of drawing strain, the volume fraction of the Copper texture first increases and then decreases, while that of the Goss texture increases monotonously. The yield strength sharply increases at low drawing strain, after reaching the maximum value of 144.7MPa at the strain of 0.32 and it decreases slightly due to dynamic recrystallization. Interestingly, the elongation of the cold-drawn wires decreases steadily from 24.4 % to 2.3 % throughout the entire drawing process. In addition to the grain boundary strengthening and dislocation strengthening, the yield strength of the cold-drawn A357 wires is also impacted by the texture. Moreover, the fracture mode of the cold-drawn wires changes from typical ductile fracture to cleavage fracture during the drawing process. © 2023, The Authors. All rights reserved.

关键词： Textures

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Rapid and mass manufacturing of soft hydrogel microstructures for cell patterns assisted by 3d printing

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Bio-design and Manufacturing 2022年第4期5卷 641-659页

作者： Chaofan He Xuechun Chen Yuan Sun Mingjun Xie Kang Yu Jing He Jinwei Lu Qing Gao Jing Nie Yi Wang Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Cancer Center Zhejiang UniversityHangzhou 310058China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300072China

Micro-/nano-patterns on hydrogels are widely used in cell ***,manufacturing molds with traditional lithography is time-consuming and *** addition,the excessive demolding force can easily damage patterns since biocompatible hydrogels are ultra-soft or ***,we presented a novel method for rapid and mass fabrication of cell ***-precision three-dimensional(3d)printing was used to manufacture a mold with a resolution of 2µm,and the gelatin-based hydrogel was cured by thermal–photo-crosslinking so that the low-concentration and low-substitutionrate hydrogel could be demolded *** found that pre-cooling before illumination made gelatin-based hydrogels resilient due to the partial regain of triple-helix *** this method,arbitrarily customized hydrogel patterns with a feature size of 6–80µm can be fabricated stably and at low *** cardiomyocytes were seeded on ultra-soft hydrogels with parallel groove structures,a consistent and spontaneous beating with 216 beats per minute(BPM)could be observed,approaching the natural beating rate of rat hearts(300 BPM).Overall,this work provides a general scheme for manufacturing cell patterns which has great potential for cell ethology and tissue repair.

关键词： 3d printing Gelatin-based hydrogel Cell pattern Cardiomyocytes beating

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Printability during projection-based 3d bioprinting

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Bioactive Materials 2022年第5期7卷 254-267页

作者： Kang Yu Xinjie Zhang Yuan Sun Qing Gao Jianzhong Fu Xiujun Cai Yong He State Key Laboratory of Fluid Power and Mechatronic Systems College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment Hangzhou310016China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058 China

Since projection-based 3d bioprinting(PBP)could provide high resolution,it is well suited for printing delicate structures for tissue ***,the low crosslinking density and low photo-crosslinking rate of photocurable bioink make it difficult to print fine ***,an in-depth understanding of the is ***,a research framework is established for the analysis of printability during *** gelatin methacryloyl(GelMA)-based bioink is used as an example,and the printability is systematically *** analyze the photo-crosslinking reactions during the PBP process and summarize the specific requirements of bioinks for *** standard quantized models are established to evaluate 2d and 3d printing ***,the better strategies for bioprinting five typical structures,including solid organs,vascular structures,nerve conduits,thin-wall scaffolds,and micro needles,are presented.

关键词： Projection-based printing(PBP) 3d bioprinting GelMA bioink Rheological analysis

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Influence of laser parameters on segregation of Nb during selective laser melting of Inconel 718

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China Foundry 2021年第4期18卷 379-388页

作者： Liang Wang Ran Cui Bin-qiang Li Xue Jia Long-hui Yao Yan-qing Su Jing-jie Guo Tong Liu School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China HIT-Chungu Joint Research Center for Additive Manufacturing Materials Anhui Chungu 3D Printing Institute of Intelligent Equipment and Industrial TechnologyWuhu 241200AnhuiChina

A transient three-dimensional powder-scale model was established for understanding the flow field and mass transfer within the molten pool during the selective laser melting(SLM)of Inconel 718 alloy by considering some important physical phenomena,such as,a transition from powder to solid,nonlinearities produced by temperature-dependent materials’properties,and fluid flow in the *** influence of laser power or scanning speed on the flow field and cooling rate was discussed in *** simulation results reveal that the motion of molten pool and higher cooling rate promote the mass transfer and benefit the solute distribution by increasing laser ***,with increasing the scanning speed,the melt flow speed and cooling rate are elevated,resulting in an agglomeration of the solute elements,which is ascribed to the shorter dwelling time of ***,the segregation of Nb can be effectively suppressed by increasing laser power or decreasing scanning speed,which can decrease the dwelling time of liquid.

关键词： selective laser melting Inconel 718 alloy flow field mass transfer segregation

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Role of Co Content on densification and Microstructure of WC–Co Cemented Carbides Prepared by Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2021年第9期34卷 1245-1254页

作者： Jinyang Liu Jian Chen Li Zhou Bingyao Liu Yang Lu Shanghua Wu Xin deng Zhongliang Lu Zhipeng Xie Wei Liu Jianye Liu Zhi Qu School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China School of Electromechanical Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510635China Master Group(Guangdong)Technology Research Co LtdYunfu 527400China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Guangdong Xi’an Jiaotong University Academy Foshan 528300China State Key Laboratory of New Ceramics and Fine Processing Tsinghua UniversityBeijing 100091China Guangdong Hanbang 3D Technology Co. LtdZhongshan 528427China Guangdong Fenghua Zhuoli Technology Co. LtdFoshan 528225China

WC–Co cemented carbides, well-known as the conventional tooling materials, have not been successfully produced by one step additive manufacturing processes such as selective laser melting(SLM) yet. The microstructure evolution as well as WC grain growth behavior has rarely been investigated in detail during SLM process. In this study, the WC–Co cemented carbides with different Co contents(12–32 wt%) were prepared by optimized SLM processes for comparative investigation of densification behavior, microstructure characterization and mechanical property. The increase in Co content in feedstock carbide granules can improve the densification behavior during SLM process. The SLM processed WC-12 Co shows larger average WC grain size and higher percentage of coarser WC grains as compared with both WC-20 Co and WC-32 Co. The microstructure characterization, combined with finite element simulation, shows the WC grain growth mechanisms include agglomeration and dissolution-deposition of WC during SLM process and agglomeration of WC is an important mechanism especially for WC–Co cemented carbides with Co content as low as 12 wt%. The comparison between horizontal(perpendicular to the SLM laser beam) and vertical(parallel to the SLM laser beam) cross sections of carbides shows that SLM process introduces a certain degree of microstructure and mechanical behavior anisotropy for WC-12 Co, WC-20 Co, and WC-32 Co.

关键词： Cemented carbides Selective laser melting Microstructure densifi cation behavior Finite element simulation

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Microstructure and Mechanical Properties of Sc/Zr Modified 1460 Al-Li Alloy Fabricated by Laser Powder Bed Fusion

SSRN

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SSRN 2024年

作者： Zhang, Siyu Sun, Chu Fan, Wei Zhang, Qiang Feng, Zhe Hao, Zhiwei Tan, Hua Zhang, Fengying Lin, Xin State Key Laboratory of Solidification Processing Northwestern Polytechnical University Shaanxi Xi’an710072 China Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT China Northwestern Polytechnical University Shaanxi Xi’an710072 China Beijing Institute of Aeronautical Materials Co. Ltd Beijing100094 China Singapore Centre for 3D Printing School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore639798 Singapore Suzhou Laboratory Jiangsu Suzhou215123 China School of Material Science and Engineering Chang'an University Xi’an710064 China

The preparation of Al-Li alloy by laser powder bed fusion (LPBF) technology, especially Al-Li alloy with high Li content, is of great significance for lightweight of aerospace equipment. However, the significant susceptibility of Al-Li alloys to hot cracking during the process limits their advancement. This study starts from the two aspects of process control and composition modification, to achieve the production of crack-free and high-quality 1460 Al-Li alloys. Crack-free 1460 specimens can only be prepared at extremely low scanning velocity. The process window is markedly expanded by Sc/Zr modification. The heterogeneous nucleation of Al3(Li,Sc,Zr) results in significant grain refinement and effectively suppresses crack initiation and propagation. The unique bimodal heterogeneous microstructure endows the alloy with notable mechanical properties. After the addition of 0.6Sc-0.3Zr, the ultimate tensile strength (UTS), yield strength (YS), and elongation (δ) of 1460 alloy are increased by 104%, 158%, and 43.9%, respectively. The strength-plasticity synergism is primarily attributed to grain refinement strengthening, precipitation strengthening, and hetero-deformation induced strain hardening resulting from its unique bimodal heterogeneous microstructure. The UTS and YS of 1.2Sc-0.6Zr modified 1460 alloy increased by 156% and 279%, respectively. However, this further increase in the Sc/Zr content significantly deteriorates the plasticity of the alloy. This work establishes a foundation for advancing the use of Al-Li alloys in high-performance, lightweight, and complex aerospace structures. © 2024, The Authors. All rights reserved.

关键词： Microstructure

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