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Rock Climbing‑Inspired Electrohydrodynamic Cryoprinting of Micropatterned Porous Fiber Scaffolds with Improved MSC Therapy for Wound Healing

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Advanced Fiber Materials 2023年第1期5卷 312-326页

作者： Jinjian Huang Jie Wu Jiahang Wang Mengjia Xu Jiao Jiao Yuhao Qiang Feng Zhang Zongan Li Research Institute of General Surgery Jinling HospitalSchool of MedicineSoutheast UniversityNanjing 210009China Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing NARI School of Electrical and Automation EngineeringNanjing Normal UniversityNanjing 210042China Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridge 02139USA

Impaired wound healing imposes great health risks to ***,mesenchymal stem cell(MSC)therapy has shown potential to improve the healing process,but approaches to employ MSCs in the treatment of wounds remain *** this study,we reported a novel electrohydrodynamic(EHd)cyroprinting method to fabricate micropatterned fiber scaffolds with polycaprolactone(PCL)dissolved in glacial acetic acid(GAC).Cyroprinting ensured the formation of a porous struc-ture of PCL fibers by preventing the evaporation of GAC,thus increasing the surface roughness parameter Ra from 11 to 130 *** to how rough rocks facilitate easy climbing,the rough surface of fibers was able to increase the adhesion of adipose-derived MSCs(AMSCs)by providing more binding sites;therefore,the cell paracrine action of secreting growth factors and chemokines was enhanced,promoting fibroblast migration and vascular endothelial cell tube *** rat models with one-centimeter wound defects,enhanced MSC therapy based on porous PCL fiber scaffolds improved wound healing by augmenting scarless collagen deposition and angiogenesis and reducing proinflammatory ***,this study offers a new and feasible strategy to modulate the surface topography of polymeric scaffolds to strengthen MSC therapy for wound healing.

关键词： Electrohydrodynamic cryoprinting Porous fiber scaffolds Mesenchymal stem cell Wound healing

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Customized scaffolds for large bone defects using 3d‑printed modular blocks from 2d‑medical images

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Bio-design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos daskalakis Paulo Bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3d),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2d)medical images when the surgeon lacks access to a 3d printer or cannot wait for lengthy 3d imaging,modeling,and 3d printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2d medical image measurements without the need for expensive 3d medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2d data or *** algorithms are implemented,and the designed scaffold blocks are 3d printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

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Reinforcement Learning for the Optimization of Power Plane designs in Power delivery Networks 31

Reinforcement Learning for the Optimization of Power Plane D...

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IEEE 31st Conference on Electrical Performance of Electronic Packaging and Systems (EPEPS)

作者： Han, Seunghyup Bhatti, Osama Waqar Swaminathan, Madhavan School of Electrical and Computer Engineering 3D Systems Packaging Research Center (PRC) Georgia Institute of Technology Atlanta GA USA School of Material Science and Engineering 3D Systems Packaging Research Center (PRC) Georgia Institute of Technology Atlanta GA USA

ISBN: (数字)9781665450751

ISBN: (纸本)9781665450751

This paper proposes a deep deterministic policy gradient (ddPG) based method to optimize the power plane in power delivery networks (PdNs). The proposed method considers the degrees of freedom of a plane design in a layer, determining the parameters for creating a power plane. The results show that the proposed method can provide an optimized power plane design even in a plane layer with a restricted region.

关键词： deep deterministic policy gradient (ddPG) Power plane Power delivery network Reinforcement learning (RL)

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Effects of Laser Parameters on Microgrooves morphology of SiC/SiC Composites fabricated by Femtosecond Laser 3

Effects of Laser Parameters on Microgrooves morphology of Si...

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3rd International Conference on Laser, Optics, and Optoelectronic technology, LOPET 2023

作者： Li, Xin Yuan, Yanping Chen, Lei Zhao, Tianyu Institute of Laser Engineering Faculty of Materials and Manufacturing Beijing University of Technology Beijing100124 China Ministry of Education Beijing100124 China Beijing Engineering Research Center of Laser Technology Beijing University of Technology Beijing100124 China Beijing Engineering Research Center of 3D Printing for Digital Medical Health Beijing University of Technology Beijing100124 China

ISBN: (纸本)9781510667624

Silicon carbide (SiC) fiber-reinforced SiC-matrix (SiC/SiC) composite has a wide range of applications in the aerospace field. However, SiC/SiC composite is typical difficult-to-machine materials due to their non-homogeneous and anisotropic properties, and traditional manufacturing processes cannot meet their processing requirements in aerospace applications. Femtosecond laser processing technology is expected to become the preferred choice to meet this demand, due to their ultrashort irradiation periods and ultrahigh intensities. In this study, the micro-grooving processing on the surface of SiC/SiC composites by femtosecond laser is investigated, and the effects of laser power, scanning speed and scanning frequency on the surface morphology of SiC/SiC composites are investigated. The results show that there are recast layers in the ablation zone and powdery substances in the processing zone during the laser ablation process of SiC/SiC composite. The width and depth of the micro-grooves increase with the increase of laser power and scanning times. When the ablation power is low and the scanning times are few, the grooves are non-uniformly distributed with sawtooth structure. When the ablation power is high and the scanning speed is low, the grooves are serrated. Properly increasing the scanning speed and scanning times can reduce the sawtooth structure and improve the surface quality of the ablated area. This proposed method can achieve good morphology of SiC/SiC and is expected to be applied to industrial processing of SiC/SiC. © 2023 SPIE.

关键词： Silicon carbide

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Recent research of peptide-based hydrogel in nervous regeneration

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Bioactive Materials 2024年第10期40卷 503-523页

作者： Chunmei Xie Yueyang Chen Lang Wang Kin Liao Bin Xue Yulong Han Lan Li Qing Jiang State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Advanced Digital and Additive Manufacturing Center Khalifa University of Science and TechnologyPo Box 127788Abu DhabiUnited Arab Emirates National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjingChina State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryDrum Tower Hospital Affiliated to Medical School of Nanjing UniversityNanjingChina Jiangsu Engineering Research Center for 3D Bioprinting NanjingChina Institute of Medical 3D Printing Nanjing UniversityNanjingChina

Neurological disorders exert significantly affect the quality of life for patients,necessitating effective strategies for nerve *** traditional autologous nerve transplantation and emerging therapeutic approaches encounter scientific challenges due to the complex nature of the nervous system and the unsuitability of the surrounding environment for cell *** engineering techniques offer a promising path for *** neural tissue engineering relies on modulating cell differentiation behavior and tissue repair by developing biomaterials that mimic the natural extracellular matrix(ECM)and establish a threedimensional ***-based hydrogels have emerged as a potent option among these biomaterials due to their ability to replicate the structure and complexity of the *** review aims to explore the diverse range of peptide-based hydrogels used in nerve regeneration with a specific focus on dipeptide hydrogels,tripeptide hydrogels,oligopeptide hydrogels,multidomain peptides(MdPs),and amphiphilic peptide hydrogels(PAs).Peptide-based hydrogels offer numerous advantages,including biocompatibility,structural diversity,adjustable mechanical properties,and degradation without adverse ***,hydrogels formed from self-assembled polypeptide nanofibers,derived from amino acids,show promising potential in engineering neural tissues,outperforming conventional materials like alginate,poly(ε-caprolactone),and ***,the simple design and cost-effectiveness of dipeptidebased hydrogels have enabled the creation of various functional supramolecular structures,with significant implications for nervous system *** hydrogels are expected to play a crucial role in future neural tissue engineering *** review aims to highlight the benefits and potential applications of peptidebased hydrogels,contributing to the advancement of neural tissue engineering.

关键词： Self-assembled dipeptide Cyclic dipeptide Hydrogels Nervous regeneration

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Numerical Simulation of Melting and Solidification of Alloy Phase Change Materials for Waste Heat Recovery

Numerical Simulation of Melting and Solidification of Alloy ...

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Energy Technologies and CO2 Management symposium, 2025, held as part of the TMS Annual Meeting and Exhibition, TMS 2025

作者： Hu, Hang Yang, Lingzhi Chen, Weizhen Yi, Fang School of Minerals Processing and Bioengineering Central South University Changsha410083 China Xiangya Stomatological Hospital and Xiangya School of Stomatology Center South University Changsha410008 China Hunan 3D Printing Engineering Research Center of Oral Care Changsha410008 China

ISBN: (纸本)9783031806872

Iron and steel production process (ISPP) emits massive high-temperature flue gas, resulting in vast energyEnergy consumption and waste. Waste heat recoveryWaste heat recovery (WHR) is better for improving energy efficiencyEnergy efficiency, and energyEnergy-saving and emission reduction effect. Phase change materials (PCM) play an important role in energyEnergy storage, conversion, saving and utilization. In this paper, the Al-Cu-Si alloy PCM is selected for WHR. The numerical calculation models and boundary conditions of WHR are established. The liquid phase, temperature and velocity field distributions during the melting and solidificationMelting and solidification are further researched and analyzed by ANSYS Fluent 2023 R1 software. The results reveal that the Al-Cu-Si alloy PCM possesses the shorter melting time of 353.6 s than the solidification time of 450.4 s, and great WHR effect. The thermal conduction and natural convection result in the different velocity and temperature field in different stages. Based on the simulation results, a laboratory WHR scheme is designed. © The Minerals, Metals & Materials Society 2025.

关键词： Silicon alloys

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design and development of a mitochondrial-targeted photosensitizer for two-photon fluorescence imaging and photodynamic therapy

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Journal of Materials Science & technology 2023年第10期141卷 135-148页

作者： Yu Chen Sheng Zhang Tianjiao Cheng Wei Lin Linlin Mao Zhonghui Chen Yang Yang Hanqing Huang Jinqiu Li Zhiyong Ke Zhong-Kai Cui Institute of Cancer Affiliated Hospital of Putian UniversityPutian UniversityPutian 351100China Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Affiliated Putian Hospital of Southern Medical University Putian 351100China Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangzhou 510515China

Mitochondria are well-acknowledged as ideal targets for tumor therapy due to their important role in energy supply and cellular signal ***-specific photosensitizers have been reported to be critical for inducing cell ***-photon fluorescence imaging provides a new technique for delineating biological structures and activities in deep ***,we developed a new aggregation-induced emission(AIE)active photosensitizer by attaching a pyridinium group for mitochondrial *** rationally designed photosensitizer(TTTP)exhibited excellent photophysical properties,good biocompatibility,reactive oxygen species(ROS)stimulation ability,anticancer efficacy,and two-photon imaging *** was highly taken up by cells and accumulated specifically in mitochondria but was selectively cytotoxic to cancer *** light irradiation,the generation of ROS was significantly boosted,leading to actively induced *** in vivo tumor photodynamic therapeutic efficacy of TTTP showed significant inhibition of tumor ***,the underlying mechanism of TTTP tu-mor suppression revealed that the apoptosis agonist Bax was markedly up-regulated while the antagonist Bcl-xL was *** research provides a potential mitochondrial-targeted phototherapeutic agent for effective therapy and two-photon fluorescence imaging.

关键词： Mitochondrial-targeting Two-photon fluorescence imaging Photodynamic therapy Apoptosis Reactive oxygen species(ROS)

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Real-time porosity reduction during metal directed energy deposition using a pulse laser

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Journal of Materials Science & technology 2022年第21期116卷 214-223页

作者： Hoon Sohn Peipei Liu Hansol Yoon Kiyoon Yi Liu Yang Sangjun Kim Department of Civil and Environmental Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Center for 3D Printing Nondestructive Testing Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Global R&D Center SQ EngineeringSeoul 05818Republic of Korea Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Porosity is a challenging issue in additive manufacturing and is detrimental to the quality of the additively manufactured *** this study,a real-time porosity reduction technique was developed by incorporating a pulse laser into a laser metal powder directed energy deposition(dEd)*** incorporated pulse laser can accelerate fluid flow within the melt pool and facilitate the escape of pores before complete *** achieves this real-time porosity reduction by inducing accelerated and turbulent Marangoni flow,ultrasonic waves,and shock waves into the melt *** uniqueness and advantages of the proposed technique include the following:(1)For a laser metal powder dEd process,this study proposed a noncontact,nondestructive,and real-time porosity reduction technique at the melt pool level.(2)It was experimentally and numerically validated that the developed technique did not alter the geometry and the grain structure of the manufactured Ti-6Al-4V samples.(3)Because the porosity reduction is accomplished at the melt pool level,its application is not limited by the size,shape,or complexity of the printing target.(4)The developed technique can be readily incorporated into the existing dEd systems without any modification of the original tool-path *** experimental results showed that the pore volume fraction decreased from 0.132%to 0.005%,no pores larger than 6×10^(4)μm^(3) were observed,and a 91%reduction in the total pore number was achieved when the pulse laser energy reached 11.5 mJ.

关键词： Real-time porosity reduction Pulse laser Melt pool directed energy deposition Ti-6Al-4V

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Evaluation of the Performance of Reinforced Concrete Beams with 3d-Printed Permanent Formwork

Journal of Intelligent Construction

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Journal of Intelligent Construction 2025年第4期2卷 1-17页

作者： Jingyuan Guan Li Wang Yimiao Huang Guowei Ma Yaxin Tao School of Civil and Transportation Engineering Hebei University of Technology Tianjin China Hebei Engineering Research Center of Construction 3D Printing Hebei University of Technology Tianjin China Institute for Building Materials ETH Zurich Zurich Switzerland

Understanding the advantages of combining traditional construction methods and 3d concrete printing is the gateway to the general structural applicability of three-dimensional concrete printing (3dCP) technology. To further this ob-jective, in this study, 3d-printed concrete is used as permanent formwork for the manufacture of reinforced concrete beams. different treatment methods for the interfaces between the printed formwork and the cast core concrete, including embedding of shear connectors, entraining of micro-cables, and inclusion of ribs in the 3d printing of the formwork, are explored to improve the integral mechanical capacities of so-called 3d-printed and cast-in-place composite beams. Specifically, flexural behaviors are studied experimentally through ob-servation of damage and failure processes via visualization with the digital image correlation (dIC) method. The mesoscale architecture at the interface between 3d-printed permanent formwork and cast-in-place concrete is investigated through computed tomography (CT) scanning to infer the cooperative bonding mechanisms of different bonding treatment methods. The stress-transfer mech-anism is thus elucidated. The applicability of 3d-printed concrete as permanent formwork is validated in view of a 14.3% increase in the bending capacity from a composite beam with bottom ribs compared to that of a completely cast counterpart. From the experiments, incorporation of shear connectors contributes most to the bonding performance of the formwork-concrete interfaces. Mean-while, interfacial bonding can be enhanced by increasing the roughness of the 3d-printed formwork, interlocking of the formwork with the inner aggregated concrete, or improving the consistency of the elastic and shear moduli of the formwork and cast concrete. In particular, the appropriate thickness of both the formwork and the aggregated concrete as a cover to yield the optimal inte-grated bending capacity of composite beams is derived from the cur

关键词： Connectors deformation Computed tomography Bending Three-dimensional printing Concrete Structural beams Bonding Ribs Surface treatment

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VP-HOT: Visual Prompt for Hyperspectral Object Tracking 13

VP-HOT: Visual Prompt for Hyperspectral Object Tracking

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13th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing, WHISPERS 2023

作者： Xie, Shaoxiong Li, Jia Zhao, Lin Hu, WenJing Zhang, Guoyun Wu, Jianhui Li, Xinpin Hunan Institute of Science and Technology School of Information Science and Engineering Yueyang414006 China Hunan Institute of Science and Technology Hunan Engineering Technology Research Center for 3D Reconstruction and Intelligent Application Yueyang China

ISBN: (纸本)9798350395570

Hyperspectral object tracking (HOT) has received increasing attention due to the property of hyperspectral Image (HSI) underlying material information of background and foreground, and it shows the potential to outperform conventional RGB-based tracking methods, especially in complex scenarios. However, it is difficult to train a powerful hyperspectral object tracker due to the lack of large-scale HSI-based datasets. To address this problem, we develop visual prompt hyperspectral object tracking (VP-HOT). In order to leverage the knowledge of the fundamental RGB model, our methodology involves the freezing of pre-trained model parameters and the incorporation of hyperspectral images (HSIs) as visual prompts, with only 1.7 million trainable parameters. This adaptation improves the suitability of the model for HOT tasks. Extensive experiments demonstrate the potential of visual prompt learning in HOT, and VP-HOT achieves outstanding performance across diverse downstream tasks, spanning VIS (16 bands), RedNIR (15 bands), and NIR (25 bands). © 2023 IEEE.

关键词： Large datasets

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