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The action of injectable nanodispersion of Bixa orellana (Chronic-in®) on arthritis in diabetic rats: pharmacological and histopathological studies

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INFLAMMOPHARMACOLOGY 2025年第4期33卷 2109-2128页

作者： Gomes, Lauana Carvalho, Helison de Oliveira Lopes, Gisele Rocha Furtado, Gabriel da Costa Goncalves, Danna Emanuelle Santos Colares, Nayara Nilcia Dias Ferreira, Adriana Maciel Furtado, Crislany da Costa da Silva, Heitor Ribeiro dos Santos, Abrahao Victor Costa do Nascimento, Aline Lopes Lage, Tamiris Marques Pedro, Irma Danielle Rodrigues Teixeira, Thiago Afonso Carvalho, Jose Carlos Tavares Univ Fed Amapa Dept Biol & Hlth Sci Lab Drug Res Km 02Jardim Marco ZeroRod Josmar Chaves Pinto BR-68903419 Macapa AP Brazil Univ Fed Amapa Dept Biol & Hlth Sci Innovat Pharmaceut Program Macapa AP Brazil Univ Fed Amapa Univ Hosp Macapa AP Brazil

Diabetic arthritis (DA) is a microvascular complication associated with diabetes mellitus (DM), necessitating the exploration of innovative therapeutic approaches. The Amazon biome, rich in bioactive compounds, offers potential treatments;notably, Bixa orellana, which contains tocotrienol and geranylgeraniol, exhibits anti-inflammatory and antioxidant properties, particularly when formulated as a nanodispersion. Objective: This study aims to investigate the pharmacological effects of an injectable nanodispersion of Bixa orellana, termed Chronic-in (R), in diabetic Wistar rats. Method: Male Wistar rats were employed in the study, and DA was induced using an intraperitoneal injection of 100 mg/kg alloxan and an intraplantar administration of Freund's complete adjuvant. The animals were divided into five groups (n = 5): CON (normal rats treated with saline solution IM), CHR SC (DA rats treated with Chronic-in SC daily), SS (DA rats treated with saline solution IM), IND (DA rats treated with indomethacin orally), and CHR IM (DA rats treated with Chronic-in IM every 3 days). Treatment outcomes were assessed through various parameters, including changes in paw edema, Arthritic Index (AI), performance in the open field and Rotarod tests, radiographic evaluations using the Eichenholtz classification, Scanning Electron Microscopy (SEM) analysis of articular morphology, and hematological and biochemical assessments. Results: Significant reductions in edema were observed in the CHR SC, CHR IM, and IND groups (p < 0.001) compared to the SSA group. The AI showed significant differences among the CON, CHR SC, and CHR IM groups. Enhanced exploratory behavior was noted in the open field test for the Chronic-in-treated groups, particularly with IM administration. The Rotarod test demonstrated marked differences between the Chronic-in-treated, CON and SS groups. Radiographic and SEM evaluations indicated fewer bone alterations in the CHR IM and SC groups compared to the SSA and IND g

关键词： Arthritis Nanocomposites Diabetes Injectable nanodispersion

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Development of chitosan-based nanoparticles encapsulating Bacillus velezensis CMRP4490 metabolites for enhanced in vitro control of Sclerotinia sclerotiorum

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CANADIAN JOURNAL OF CHEMICAL ENGINEERING 2025年第5期103卷 2191-2203页

作者： de Lima, Gesiara de Franca Silva Suzuki, Rubia Michele de Oliveira Junior, Admilton Goncalves Aranha, Ana Caroline Raimundini Defendi, Rafael Oliveira Gomes, Maria Carolina Sergi Nicoletto, Maria Luiza Abreu Sipoli, Caroline Casagrande Fed Technol Univ Parana UTFPR Postgrad Program Chem Engn PPGEQ AP Apucarana Brazil State Univ Londrina UEL Dept Microbiol Londrina Brazil State Univ Maringa UEM Dept Chem Engn Maringa Brazil

Modern agriculture seeks to control pests and diseases in the field while maintaining production, reducing the use of dangerous chemical molecules, and resorting to more sustainable solutions. One of the ways to achieve these objectives is biological control. Furthermore, combined with biological control, the use of nanoencapsulation techniques of biological control agents with materials that are bioavailable and biodegradable in the environment has proven to be an alternative to reducing the use of non-renewable materials. Therefore, the present work aimed to develop a nanoparticle system for biological control of Sclerotinia sclerotiorum. The nanoparticle system was produced using the ionotropic gelation technique using chitosan (CHI) as a polymer. The cell-free supernatant (CFS) of the microorganism Bacillus velezensis CMRP4490 was used to produce nanoparticles, as preliminary studies show that its metabolites act in biological control. The nanoparticles produced were prepared in different concentrations of CHI and CFS and their antimicrobial activity was evaluated against the fungus S. sclerotiorum. The encapsulated samples have a concentration of 20%-80% of CFS and 0.25% and 0.8% of CHI and showed a 100% inhibitory effect against S. Sclerotiorum, and the results obtained indicate a synergistic effect between CHI and CFS.

关键词： agriculture antimicrobial activity biological control ionotropic gelation Sclerotinia sclerotiorum

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Analysis of the composition of Brazilian black soybean seeds and mathematical modelling of intermittent drying and extraction of antioxidant compounds using fractional calculus

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CANADIAN JOURNAL OF CHEMICAL ENGINEERING 2025年第5期103卷 2386-2405页

作者： Aranha, Ana Caroline Raimundini Defendi, Rafael Oliveira Bissaro, Camila Andressa Ferrari, Andressa Lopes Nardino, Danielli Andrea Michele Suzuki, Rubia Madrona, Grasiele Scaramal Paschoal, Sirlei Marques Carmona, Giovana Genari de Souza Matias, Gustavo de Matos Jorge, Luiz Mario State Univ Maringa UEM Chem Engn Grad Program PEQ Ave Colombo 5790Block E-46 BR-87020900 Maringa PR Brazil Fed Technol Univ Parana UTFPR Chem Engn Grad Program PPGEQ AP Apucarana Brazil State Univ Maringa UEM Chem Grad Program PQU Maringa Brazil State Univ Maringa UEM Dept Food Engn Maringa Brazil State Univ Parana UNESPAR Ind Engn Dept Paranagua Brazil

The present study aims to analyze the composition of black soybean seeds, evaluate the intermittent drying of black soybean seeds by fractional calculus, optimize the extraction conditions of the antioxidant compounds by varying the solvent ratio and the extraction time, fit traditional models of extraction kinetics, and compare with the fractional order model. Regarding the oil content, it is analyzed that black soybeans have a high lipid content (18.86%), an oil source of interest for research and industrial applications. Regarding drying, it was found that the first order model cannot be used to describe the kinetics of intermittent drying for black soybean seeds and the best kinetic fits were obtained with the Page and fractional order models, which can be applied in simulations of drying and dryer designs. Regarding the extraction process, ethanol/water 45/55 (v/v) solvent proportion obtained the highest antioxidant compound content during 1 h of extraction. So and MacDonald's and hyperbolic kinetic models presented the best fitting to experimental data. About the fractional order model, it is found that for extraction conditions with more significant amounts of water in the ethanolic solution, the alpha value obtained is less than 1, resulting in the phenomenon of subdiffusion. For the extraction condition with a low amount of water in the ethanolic solution, the alpha value was greater than 1, depicting a superdiffusion process.

关键词： antioxidants black soybean extraction kinetics mathematical model

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Combatting pesticide pollution: using liquid scintillation spectrometry to assess ¹⁴C-labeled hexachlorobenzene removal by mangrove Bacillus spp.

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BIODEGRADATION 2025年第1期36卷 1-14页

作者： Mota, Wanessa J. Santana de Jesus, Jessica R. Rego, Ana P. Justiniano da Costa, Ayslan S. P. Tornisielo, Valdemar L. Eguiluz, Katlin I. Barrios Salazar-Banda, Giancarlo R. Hernandez-Macedo, Maria L. Lopez, Jorge A. Inst Technol & Res BR-49032490 Aracaju SE Brazil Univ Tiradentes Ind Biotechnol Grad Program BR-49032490 Aracaju SE Brazil Univ Sao Paulo Ctr Nucl Energy Agr BR-13400970 Piracicaba SP Brazil Univ Tiradentes Proc Engn Grad Program PEP BR-49032490 Aracaju SE Brazil State Univ Amapa Organ Chem & Biochem Lab BR-68900070 Macapa AP Brazil

This study explored the ability of two Bacillus species isolated from mangrove sediments to degrade hexachlorobenzene (HCB), a persistent organic pollutant that affects the quality of surface water, groundwater, and soil. Hence, we analyzed bacterial growth in a medium with hexachlorobenzene as the sole carbon source. Moreover, chemical oxygen demand removal, ecotoxicity, and measured radiolabeled HCB degradation were assessed. Our results revealed that both Bacillus strains (I3 and I6) demonstrated hexachlorobenzene-degrading potential and achieved degradation rates of 11.5 +/- 1.47% and 21.1 +/- 0.84%. Additionally, the ability of these strains to mineralize HCB was confirmed by the production of radiolabeled carbon dioxide, assessed by liquid scintillation spectrometry and thin-layer chromatography. Ecotoxicity assays further demonstrated the effectiveness of bacteria treatment in degrading HCB. These findings underscore the potential of Bacillus strains from mangrove sediments to degrade and mineralize HCB, opening new perspectives for the bioremediation of aromatic compounds in contaminated environments.

关键词： Aromatic compound Recalcitrant Mangrove Microorganisms Biodegradation

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CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL

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LEUKEMIA 2025年第1期39卷 64-74页

作者： Strullu, Marion Caye-Eude, Aurelie Robert, Elie Renard, Jean-Marie Chaye, Amandine Galimand, Julie Fenneteau, Odile Arfeuille, Chloe Cuccuini, Wendy Theron, Alexandre Thouvenin, Sandrine Paillard, Catherine Petit, Arnaud Rohrlich, Pierre-Simon Cave, Helene Baruchel, Andre Lainey, Elodie Robert Debre Hosp AP HP Pediat Hematol & Immunol Dept Paris France Univ Paris Cite Paris France INSERM U1131 IUH Paris France Robert Debre Hosp AP HP Genet Dept Paris France Univ Paris Saclay INSERM PEDIAC Program U1170 Gustave Roussy Canc Campus Villejuif France Robert Debre Hosp AP HP Hematol Lab Paris France Armand Trousseau AP HP Genet Dept Paris France St Louis Hosp AP HP Hematol Lab Paris France CHU Montpellier Dept Pediat Oncol & Hematol Montpellier France CHU St Etienne Dept Pediat Oncohematol St Etienne France CHU Strasbourg Dept Pediat Hematol Oncol Strasbourg France Sorbonne Univ Armand Trousseau Hosp AP HP Dept Pediat Oncohematol Paris France Univ Cote Azur CHU Nice Pediat Hematol Oncol Dept Nice France Inst Rech St Louis URP 3518 Paris France

Genetic alterations are the cornerstone of risk stratification in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and their accurate identification is critical for optimal treatment. Most cases with ABL-class fusion are classified as high-risk yet display good responses to tyrosine kinase inhibitors (TKIs). Current clinical protocols recommend adding a TKI to chemotherapy as soon as possible, making it mandatory to rapidly identify these alterations. We investigated here whether the identification of immunophenotypic features associated with these molecular alterations could be a valuable screening tool. CD36 expression was shown to be a characteristic feature of ABL- or JAK-class kinase fusions. The main genetic subgroups clustering in the subset with Philadelphia (Ph)-like features were also found to display specific immunophenotypic characteristics. A predictive multiparameter scoring system was generated, segregating genetic subtypes with aberrant kinase activation (PAX5/CRLF2alt, BCR::ABL1, ABL/JAK-class). The most robust markers identified were the TSLPR with CD19/22/9/38/81/304 and CD49f. As TKI adjunction is currently limited to the ABL-class kinase fusions, immunophenotypes distinguishing ABL from JAK-class were also investigated. The flow cytometry method reported here, accessible to most hematology departments, is thus a new useful tool to quickly screen for Ph-like kinase fusion with a good sensitivity (95%) and specificity (96%).

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Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration

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NEURON 2025年第7期113卷 1065-1081.e13页

作者： Vicario, Rocio Fragkogianni, Stamatina Pokrovskii, Maria Meyer, Carina Lopez-Rodrigo, Estibaliz Hu, Yang Ogishi, Masato Alberdi, Araitz Baako, Ann Ay, Oyku Plu, Isabelle Sazdovitch, Veronique Heritier, Sebastien Cohen-Aubart, Fleur Shor, Natalia Miyara, Makoto Nguyen-Khac, Florence Viale, Agnes Idbaih, Ahmed Amoura, Zahir Rosenblum, Marc K. Zhang, Haochen Karnoub, Elias-Ramzey Sashittal, Palash Jakatdar, Akhil Iacobuzio-Donahue, Christine A. Abdel-Wahab, Omar Tabar, Viviane Socci, Nicholas D. Elemento, Olivier Diamond, Eli L. Boisson, Bertrand Casanova, Jean-Laurent Seilhean, Danielle Haroche, Julien Donadieu, Jean Geissmann, Frederic Mem Sloan Kettering Canc Ctr Sloan Kettering Inst Immunol Program New York NY 10065 USA Weill Cornell Inst Computat Biomed Dept Physiol & Biophys New York NY 10021 USA Rockefeller Univ Rockefeller Branch St Giles Lab Human Genet Infect Dis New York NY 10065 USA Sorbonne Univ Pitie Salpetriere Hosp AP HP Dept Neuropathol Paris France Trousseau Hosp AP HP Dept Pediat Hematol & Oncol French Langerhans Cell Histiocytosis Registry Paris France Sorbonne Univ Pitie Salpetriere Hosp AP HP Dept Internal Med Paris France Sorbonne Univ Pitie Salpetriere Hosp AP HP Inst E3M Paris France Sorbonne Univ Pitie Salpetriere Hosp AP HP Dept Neuroradiol Paris France Sorbonne Univ Pitie Salpetriere Hosp AP HP Ctr Immunol & Infect Dis CIMI PARIS Paris France Sorbonne Univ Pitie Salpetriere Hosp AP HP Hematol Dept Paris France Marie Josee & Henry R Kravis Ctr Mol Oncol MSKCC New York NY USA Sorbonne Univ Hop Univ La Pitie Salpetriere Charles Foix AP HP Inst Cerveau & Moelle EpiniereInsermCNRSUMR S 1 F-75013 Paris France MSKCC Dept Pathol New York NY 10065 USA MSKCC Human Oncol & Pathogenesis Program New York NY USA Princeton Univ Dept Comp Sci Princeton NJ USA MSKCC Dept Neurosurg New York NY USA MSKCC Ctr Stem Cell Biol New York NY USA MSKCC Dept Neurol New York NY USA

Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders associated with mitogen-activated protein (Map)-kinase-activating mutations and an increased risk of neurodegeneration. We found microglial mutant clones in LCH and ECD patients, whether or not they presented with clinical symptoms of neurodegeneration, associated with microgliosis, astrocytosis, and neuronal loss, predominantly in the rhombencephalon gray nuclei. Neurological symptoms were associated with PU.1+ clone size (p = 0.0003) in patients with the longest evolution of the disease, indicating a phase of subclinical incipient neurodegeneration. Genetic barcoding analysis suggests that clones may originate from definitive or yolk sac hematopoiesis, depending on the patients. In a mouse model, disease topography was attributable to a local clonal proliferative advantage, and microglia depletion by a CSF1R-inhibitor limited neuronal loss and improved survival. These studies characterize a neurodegenerative disease associated with clonal proliferation of inflammatory microglia. The long preclinical stage represents a therapeutic window before irreversible neuronal depletion.

关键词： Neurodegeneration MapK pathway microglia hippocampus brainstem resident macrophages

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Mathematical modeling of multicomponent extraction of metal ions by polymer membranes

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2025年 1-18页

作者： de Vilhena, M. B. de Matos Jr, B. C. Ferreira, J. L. Cardoso, S. de A. Viegas, B. M. Quaresma, J. N. N. Souza, J. A. da S. Macedo, E. N. Fed Univ Para Engn Nat Resources Amazon BR-66075110 Belem PA Brazil State Univ Amapa Dept Prod Engn BR-68900070 Macapa AP Brazil Fed Univ Para Fac Chem Engn BR-66075110 Belem PA Brazil Fed Univ Para Fac Biotechnol BR-66075110 Belem PA Brazil Fed Univ Para Grad Program Biotechnol BR-66075110 Belem PA Brazil Fed Univ Para Grad Program Proc Engn BR-66075110 Belem PA Brazil

Separation and recovery systems using polymeric membranes have been widely studied for the removal and extraction of metallic species, mainly because they are environmentally friendly and have significant advantages. Mathematical models have been developed to describe the mass transfer mechanism in the extraction process. However, most models are limited to the study of a single-component and do not consider selectivity and the effects of a second metal on the reaction kinetics. Therefore, the aim of this work was to propose a multi-component mathematical model capable of simulating the extraction of metals simultaneously, performing a mass transfer analysis while considering the physical-chemical effects (membrane thickness, reaction kinetics, concentration, etc.) which under real conditions can interfere in the process. The model was solved using the Coupled Integral Equations approach and validated using experimental and simulated measurements obtained by some researchers. The results demonstrated strong agreement with literature-reported data and highlighted the high reliability of the proposed model, indicating its capability to accurately describe the extraction process through polymeric membranes under different operational conditions. Additionally, the findings confirm its potential as a robust tool for multicomponent extraction simulation and optimization, providing a comprehensive and technically advanced approach for future research in multicomponent extraction processes.

关键词： Polymer inclusion membranes Multicomponent extraction Mathematical modeling Mass transfer Metal ion recovery

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Evaluation of an automated laminar cartilage T2 relaxation time analysis method in an early osteoarthritis model

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SKELETAL RADIOLOGY 2025年第3期54卷 571-584页

作者： Wirth, Wolfgang Maschek, Susanne Wisser, Anna Eder, Jana Baumgartner, Christian F. Chaudhari, Akshay Berenbaum, Francis Eckstein, Felix Chondrometrics GmbH Freilassing Germany Paracelsus Med Univ Inst Imaging & Funct Musculoskeletal Res Ctr Anat & Cell Biol Res Program Musculoskeletal Imaging Strubergasse 21 A-5020 Salzburg Austria Paracelsus Med Univ Ludwig Boltzmann Inst Arthrit & Rehabil LBIAR Strubergasse 21 A-5020 Salzburg Austria Univ Tubingen Tubingen Germany Stanford Univ Dept Radiol Stanford CA USA 4Moving Biotech Lille France St Antoine Hosp AP HP Dept Rheumatol Paris France Sorbonne Univ St Antoine Hosp AP HP INSERM Paris France

ObjectiveA fully automated laminar cartilage composition (MRI-based T2) analysis method was technically and clinically validated by comparing radiographically normal knees with (CL-JSN) and without contra-lateral joint space narrowing or other signs of radiographic osteoarthritis (OA, CL-noROA).Materials and methods2D U-Nets were trained from manually segmented femorotibial cartilages (n = 72) from all 7 echoes (AllE), or from the 1st echo only (1stE) of multi-echo-spin-echo (MESE) MRIs acquired by the Osteoarthritis Initiative (OAI). Because of its greater accuracy, only the AllE U-Net was then applied to knees from the OAI healthy reference cohort (n = 10), CL-JSN (n = 39), and (1:1) matched CL-noROA knees (n = 39) that all had manual expert segmentation, and to 982 non-matched CL-noROA knees without expert *** agreement (Dice similarity coefficient) between automated vs. manual expert cartilage segmentation was between 0.82 +/- 0.05/0.79 +/- 0.06 (AllE/1stE) and 0.88 +/- 0.03/0.88 +/- 0.03 (AllE/1stE) across femorotibial cartilage plates. The deviation between automated vs. manually derived laminar T2 reached up to - 2.2 +/- 2.6 ms/ + 4.1 +/- 10.2 ms (AllE/1stE). The AllE U-Net showed a similar sensitivity to cross-sectional laminar T2 differences between CL-JSN and CL-noROA knees in the matched (Cohen's D <= 0.54) and the non-matched (D <= 0.54) comparison as the matched manual analyses (D <= 0.48). Longitudinally, the AllE U-Net also showed a similar sensitivity to CL-JSN vs. CS-noROA differences in the matched (D <= 0.51) and the non-matched (D <= 0.43) comparison as matched manual analyses (D <= 0.41).ConclusionThe fully automated T2 analysis showed a high agreement, acceptable accuracy, and similar sensitivity to cross-sectional and longitudinal laminar T2 differences in an early OA model, compared with manual expert *** *** identification: NCT00080171.

关键词： Osteoarthritis Cartilage T2 Knee MRI Deep learning U-Net

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Effects of copper foliar fertilization on growth, gas exchange and chlorophyll a fluorescence in green dwarf coconut seedlings

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JOURNAL OF PLANT NUTRITION 2025年第8期48卷 1326-1343页

作者： de Moraes, Ana Renata Abreu Araujo, Suzana Romeiro da Silva Junior, Mario Lopes Lins, Paulo Manoel Pontes Gomes, Maynara Santos Gomes, Mila Facanha Marques, Jonathan Dias Dias, Victor Henrique Rodrigues Fed Rural Univ Amazonia Grad Program Agron Belem Para Brazil Fed Rural Univ Amazonia Socio Environm Inst Water Resources Belem PA Brazil Fed Rural Univ Amazonia Inst Agr Sci Belem PA Brazil Empresa Sococo SA Agroind Amazonia Reunidas Farm Santa Isabel Do Para PA Brazil State Univ Amapa Av Presidente Getulio Vargas 650 BR-68900070 Macapa AP Brazil Fed Rural Univ Amazonia Grad Program Forest Sci Belem PA Brazil

Copper (Cu) is a micronutrient involved in the formation of several metalloproteins, which play critical roles in plant metabolism. Due to its natural presence in soils, fertilization with copper and other micronutrients is commonly neglected. Proper Cu nutrition is crucial for the yield of economically significant crops, as coconut. Thus, the objective of this study was to determine the ideal dose of Cu applied via foliar fertilization and evaluate its effects on nutritional status, growth attributes, gas exchange and chlorophyll a fluorescence in Brazilian green dwarf coconut seedlings. An experiment was conducted in a greenhouse in the state of Par & aacute;, Brazil. The experimental design was randomized blocks, and the treatments consisted of Cu doses (0, 4, 8, 12, 16 and 20 g plant-1), with five replicates. Cu fertilization had a positive influence on the evaluated attributes. In the nutritional status, the lowest Cu doses resulted in higher contents of nitrogen and phosphorus. Regarding growth, fertilization with Cu at lower doses promoted increments in leaf area, height, shoot dry mass and total dry mass. Regarding gas exchange, the lowest Cu doses promoted improvements in photosynthesis rate, transpiration, and stomatal conductance. In addition, Cu at lower contents improved the efficiency of photosystem II. Thus, the recommended dose of Cu for each plant is 5 g, which is considered the ideal dose to improve the growth and functioning of the photosynthetic system in green dwarf coconut seedlings, as higher doses negatively affected the metabolic and physiological processes of the plants evaluated.

关键词： Cocos nucifera L foliar fertilization micronutrient photosystem II

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Probing the Physicochemical, Nanomorphological, and Antimicrobial Attributes of Sustainable Silk Fibroin/Copaiba Oleoresin-Loaded PVA Films for Food Packaging applications

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POLYMERS 2025年第3期17卷 375页

作者： Santos, Daniel S. Matos, Robert S. Pinto, Erveton P. Santos, Samuel B. da Fonseca Filho, Henrique D. Prioli, Rodrigo Ferreira, Irlon M. Souza, Tiago M. Fed Univ Amapa UNIFAP Postgrad Program Biodivers & Biotechnol BIONORTE BR-68903419 Macapa AP Brazil Univ Fed Amapa Phys Dept Amazonian Mat Grp BR-68903419 Macapa AP Brazil Univ Fed Amapa Dept Phys BR-68903419 Macapa AP Brazil Univ Fed Sergipe Postgrad Program Physiol Sci BR-49107230 Sao Cristovao SE Brazil Univ Fed Amazonas Dept Mat Phys Lab Desenvolvimento & Aplicacoes Nanomat Amazonia BR-69067005 Manaus AM Brazil Pontif Univ Catolica Rio Janeiro Dept Fis BR-22541041 Rio De Janeiro Brazil Univ Fed Amapa Biocatalysis & Appl Organ Synth Lab BR-68903419 Macapa AP Brazil State Univ Amapa Dept Chem Engn BR-68900070 Macapa AP Brazil

We explore the development of biodegradable poly(vinyl alcohol) (PVA) films loaded with silk fibroin (SF) functionalized with copaiba oleoresin (SFCO) for potential use in active food packaging. The films were characterized, showing significant improvements in both their physicochemical and nanomorphological properties. Films containing 10% SFCO exhibited superior mechanical strength, with a Young modulus of 145 MPa and an elongation at break of 385%, compared to the control film with 42 MPa and 314%, respectively. The films also demonstrated barrier properties, with water vapor transmission rates (WVTRs) as low as 25.95 g/hm2. Antimicrobial activity against Staphylococcus aureus and Escherichia coli was significantly improved, showing inhibition zones of up to 10 +/- 1 mm and a minimum inhibitory concentration (MIC) of 100 mu g center dot mL-1. Three-dimensional nanomorphological analysis via atomic force microscopy (AFM) showed increased roughness in films with higher SFCO content, with root mean square (RMS) roughness values ranging from 2.70 nm to 11.5 nm. These results highlight the potential of SFCO-loaded PVA films as robust, eco-friendly alternatives to conventional packaging materials. They provide improved mechanical and antimicrobial properties, essential for extending the shelf life of perishable foods and advancing sustainability in the packaging industry.

关键词： PVA films silk fibroin copaiba oleoresin physicochemical properties nanomorphology antimicrobial activity

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