This article analyzes different methods for modeling a buck regulator among the variety of voltage regulator modules from the perspective of power integrity and assesses the accuracy of power supply induced jitter (PS...
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In this paper, a newly developed 3rd Gen. rC-IGBT is presented. To reduce the power loss and improve the heat dissipation of rC-IGBTs, we introduced four approaches, controlling Gate-capacitances, thin wafer technique...
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Current drugs for treating human cytomegalovirus(HCMV)infections are limited by resistance and treatment-associated *** developing mechanistically novel HCMV antivirals,we discovered an N-benzyl hydroxypyridone carbox...
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Current drugs for treating human cytomegalovirus(HCMV)infections are limited by resistance and treatment-associated *** developing mechanistically novel HCMV antivirals,we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit(8a)inhibiting HCMV in submicromolar *** describe herein the structure–activity relationship(SAr)for 8a,and the characterization of potent analogs for cytotoxicity/cytostatic property,the preliminary mechanism of action,and the absorption,distribution,metabolism and excretion(AdME)*** SArrevealed a few pharmacophore features conferring optimal antiviral profile,including the 5-OH,the N-1 benzyl,at least one–CH_(2)−in the linker,and a di-halogen substituted phenyl ring in the amide *** the end,we identified numerous analogs with sub-micromolar antiviral potency and good selectivity *** preliminary mechanism of action characterization used a pUL89-C biochemical endonuclease assay,a virus entry assay,a time-of-addition assay,and a compound withdrawal *** profiling measuring aqueous solubility,plasma and liver microsomal stability,and parallel artificial membrane permeability assay(PAMPA)permeability demonstrated largely favorable drug-like ***,these studies validate the N-benzyl hydroxypyridone carboxamide as a viable chemotype for potent and mechanistically distinct antivirals against HCMV.
Thermal management of microprocessor chips has emerged as a critical issue to ensure high-power operation, especially in high-performance computing (HPC) applications such as artificial intelligence (AI). To effective...
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driver fatigue detection serves as an essential tool in the process of human-machine co-driving, capable of promptly alerting intelligent systems to assume control of the vehicle. The detection of driver fatigue based...
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The EMU plug sliding door system's security loop relies on two crucial components: the lock limit switch and the lock sensing limit switch, wired in series. Any malfunction in either switch during operation can di...
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The separation and purification of methane from natural gas are crucial chemical processes. Herein, we report a Zn-cluster-based MOF (SdMOF-3), enabling the efficient separation of mixed low-carbon alkanes. The unique...
In North American railway industry, the truck design generally takes into consideration of several factors, e.g. the axle load, maximum operating anddesign speed, new and worn wheel diameter, arrangement of journal b...
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The bendability of extruded Al-4.4Zn-1.4Mg (mass%) alloy flat bars with 1.4 mm thickness having two types of microstructures which are fibrous andrecrystallized is evaluated by a Verbandder Automobilindustrie (VdA) ...
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developing fluorescence probes with multiple responses has vital significance but remains ***,for the first time,we present a mitochondrial dNA(mtdNA)-triggered pH response signalamplified fluorescent probe(QCY-dBT)fo...
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developing fluorescence probes with multiple responses has vital significance but remains ***,for the first time,we present a mitochondrial dNA(mtdNA)-triggered pH response signalamplified fluorescent probe(QCY-dBT)for multiple cell *** probe exhibited a large stokes shift(229 nm),excellent dNA selectivity overrNA,and ultrasensitivity of detection limit(dL;74.0 ng/mL).Thus,QCY-dBT was successfully applied to analyze multiple human peripheral blood cells and visualize mtdNA in healthy and apoptotic *** the tumor acidic environment(pH 6.0–7.0),the absorbance of QCY-dBT at 436 nm increased,and the fluorescence signal(665 nm)was amplified by mtdNA,which enabled the direct observation of tumor *** study provides help in designing smart probes with multiple responses for efficient abnormal cell detection.
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