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Identification of Key Genes as Potential Drug Targets for Gastric Cancer

Tsinghua Science and technology 2023年第4期28卷 649-664页

作者： Md.Tofazzal Hossain Md.Selim Reza Yin Peng Shengzhong Feng Yanjie Wei Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh Guangdong Provincial Key Laboratory for Genome Stability and Disease Prevention and Regional Immunity and Diseases Department of PathologyShenzhen UniversityShenzhen 518060China

Gastric cancer(GC)is one of the most common cancers and ranks the third in cancer mortality all over the *** goal of this study was to identify potential hub-genes,highlighting their functions,signaling pathways,and candidate drugs for the treatment of GC *** used publicly available next generation sequencing(NGS)data to identify differentially expressed(DE)*** top DE genes were mapped to STRING database to construct the protein-protein interaction(PPI)network and top hub genes were selected for further *** found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in *** selected the top 400(200 upregulated and 200 downregulated)genes to construct a PPI network and extracted the top 15 hub *** gene ontology(GO)term and kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC *** survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2,COL4A1,and COL5A2 were associated with better survival of GC *** three genes might be the candidate biomarkers for the diagnosis and treatment of ***,we considered 3 key proteins(genomic biomarkers)(COL4A1,CDH2,and CO5A2)as the drug target proteins(receptors),performed their docking analysis with the 102 meta-drug agents,and found Everolimus,Docetaxel,Lanreotide,Venetoclax,Temsirolimus,and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC ***,the proposed drugs might play vital role for the treatment against GC patients.

关键词： gastric cancer hub genes candidate genes molecular docking candidate drugs

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Dynamic Formation Tracking of Multi-agent Systems with Bounded Unknown Leader Input 5th

Dynamic Formation Tracking of Multi-agent Systems with Bou...

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5th Chinese Conference on Swarm Intelligence and Cooperative Control, CCSICC 2021

作者： Su, Piaoyi Dong, Xiwang Zhao, Qin Li, Qingdong Ren, Zhang School of Automation Science and Electronic Engineering Science and Technology on Aircraft Control Laboratory Beihang University Beijing100191 China Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Beijing100191 China Beijing Institute of Control and Electronics Technology Beijing100038 China

ISBN: (纸本)9789811939976

This literature investigate the dynamic formation tracking problem of multiple Lagrange systems with linear nonautonomous leader over directed topology. In order to estimate the leader system, a distributed control scheme is proposed firstly by constructing adaptive distributed observer. Secondly, this paper design a nonlinear function to decrease the influence from the leader’s bounded unknown input. Then, the dynamic formation tracking problem of multiple Euler-Lagrange systems with nonlinear uncertainties and disturbances is solved by distributed tracking algorithm. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Multi agent systems

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Three-dimensional cooperative guidance strategy and guidance law for intercepting highly maneuvering target

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Chinese Journal of Aeronautics 2021年第5期34卷 485-495页

作者： Ziyan CHEN Jianglong YU Xiwang DONG Zhang REN School of Automation Science and Electrical Engineering Science and Technology on Aircraft Control LaboratoryBeihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Big Data cmd Brain Computing Beihang UniversityBeijing 100191China

Cooperative interception of the target with strong maneuverability by multiple missiles with weak maneuverability in the three-dimensional nonlinear model is ***,the three-dimensional nonlinear model of cooperative guidance is *** three-dimensional reachable region is represented composed of lateral acceleration and longitudinal acceleration in the two-dimensional coordinate ***,the problem of the multiple missile’s reachable coverage area is transformed into the problem of cooperative coverage.A cooperative coverage strategy is proposed and an algorithm for quickly calculating the number of required missiles is ***,the guidance law based on the cooperative coverage strategy is proposed,and it is proved that cooperative interception of the target can be achieved under the acceleration ***,the relations among the number of missiles,the initial array position of terminal guidance and the coverage area of the target’s large maneuver are *** dynamic adjustment strategy of guidance parameters is proposed to reduce the guidance ***,simulation results show that multiple missiles with low maneuverability can achieve effective interception of target with strong maneuverability through the proposed cooperative strategy and cooperative guidance method.

关键词： Acceleration constraint Cooperative interception Coverage strategy Guidance law Highly maneuvering target

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A Multi-DOF Robot System Based on LightGBM-Driven EEG Decoding Model for BCI Human-Machine Interaction 42

A Multi-DOF Robot System Based on LightGBM-Driven EEG Decodi...

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42nd Chinese Control Conference, CCC 2023

作者： Yan, Weidong Xu, Zhaoliang Li, Yang Beihang University The Department of Automation Science and Electrical Engineering Beijing100191 China The Beijing Advanced Innovation Center for Big Data and Brain Computing Beijing100191 China Beihang University State Key Laboratory of Virtual Reality Technology and Systems Beijing100191 China Advanced Institute of Information Technology Peking University Hangzhou310000 China

ISBN: (纸本)9789887581543

In this study, a multi-degree-of-freedom (Multi-DOF) robot (MDR) system based on a LightGBM-driven electroencephalogram (EEG) decoding model is designed and developed to assist subjects with hand motor dysfunction in their daily activities and neurorehabilitation. The system mainly consists of a motor imagery electroencephalogram (MI-EEG) evoking layer, an intention decoding layer, and an interaction executive layer. The MI-EEG evoking layer initially displays a virtual reality (VR) motion imagination scenario, instructing the subjects to imagine a real hand gripping movement, simultaneously collecting the electrical EEG signals and preprocessing the EEG signals. Secondly, in the intention decoding layer, a network combining temporal-spectral feature fusion and LightGBM (TSFF-LightGBM) for MI-BCI classification is used to more effectively boost brain decoding accuracy and decrease decoding time. Finally, in the interaction executive layer, the Multi-DOF wearable robot is developed to offer hand grasp motion kinesthetic feedback and visual feedback synced with MI. The following are the key benefits of the proposed MDR system: (1) We propose a new lightweight network structure more suitable for brain computer interface (BCI) interaction systems, achieving more accurate decoding and shorter identification time in different data sets, which helps to improve the practicability of the system and promote the practical clinical application of BCI rehabilitation technology. (2) We integrate BCI, VR, a wearable Multi-DOF robot, motion kinesthetic feedback, and visual feedback to improve human-machine interaction. Compared to the most recent investigations, the average accuracy of the MDR system on the publicly accessible datasets BCI IV 2a and HGD reached 75.89% and 93.53%, respectively. © 2023 Technical Committee on Control Theory, Chinese Association of Automation.

关键词： Brain computer interface

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A Multi-Head Convolution Network with Attention Consistency for Facial Expression Recognition 42

A Multi-Head Convolution Network with Attention Consistency ...

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42nd Chinese Control Conference, CCC 2023

作者： Liu, Wenkang Sun, Mingyi Li, Yang Beihang University The Department of Automation Science and Electrical Engineering Beijing100191 China The Beijing Advanced Innovation Center for Big Data and Brain Computing Beijing100191 China Beihang University State Key Laboratory of Virtual Reality Technology and Systems Beijing100191 China Peking University Advanced Institute of Information Technology Hangzhou310000 China

ISBN: (纸本)9789887581543

In recent years, the demand for facial expression recognition applications has increased rapidly, and its research has received extensive attention from researchers. However, the current recognition methods based on deep learning ignore the idea of multiple head attention and semantic consistency, resulting in the model only paying attention to the local area of the feature map. In addition, the model's inconsistent attention to the images before and after the flip, resulting the poor robustness, poor interpretation, and other shortcomings in the model. To address the above problems, we propose an Affinity Separation Loss (ASLoss), which improves the separability of samples through clustering. Moreover, a Separate Multi-head Attention block (SMA), and a Zonal Loss (ZLoss) are also designed to decentralize the model's attention. Experimental results demonstrate that our proposed MACNet method achieves competitive recognition performance on two public datasets RAF-DB and FERPlus. © 2023 Technical Committee on Control Theory, Chinese Association of Automation.

关键词： Face recognition

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Low-loss Zero-index Waveguides and Devices

Low-loss Zero-index Waveguides and Devices

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

作者： Dong, Tian Dai, Tianxiang Chen, Ye Liu, Yueyang Liu, Hancheng Wang, Yiting Ma, Anqi Hu, Haifeng Xu, Lihua Zhao, Le Chu, Weiguo Peng, Chao Wang, Jianwei Li, Yang State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision Instrument Tsinghua University Beijing100084 China State Key Laboratory for Mesoscopic Physics School of Physics Peking University Beijing100871 China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronics and Frontiers Science Center for Nano-optoelectronics Peking University Beijing100871 China Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Beijing100191 China Nanofabrication Laboratory National Center for Nanoscience and Technology Beijing100190 China

We report flexible zero-index waveguides and devices whose loss is two orders of magnitude lower than the state of the art, enabling phase-error-free high-dense photonic integrated circuits for classical and quantum i... 详细信息

ISBN: (纸本)9781957171395

关键词： Photonic integrated circuits

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Low-loss Zero-index Waveguides and Devices

Low-loss Zero-index Waveguides and Devices

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CLEO: Science and Innovations in CLEO 2024, CLEO: S and I 2024 - Part of Conference on Lasers and Electro-Optics

作者： Dong, Tian Dai, Tianxiang Chen, Ye Liu, Yueyang Liu, Hancheng Wang, Yiting Ma, Anqi Hu, Haifeng Xu, Lihua Zhao, Le Chu, Weiguo Peng, Chao Wang, Jianwei Li, Yang State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision Instrument Tsinghua University Beijing100084 China State Key Laboratory for Mesoscopic Physics School of Physics Peking University Beijing100871 China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronics Frontiers Science Center for Nano-optoelectronics Peking University Beijing100871 China Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Beijing100191 China Nanofabrication Laboratory National Center for Nanoscience and Technology Beijing100190 China

关键词： Photonic integrated circuits

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PediaBench: A Comprehensive Chinese Pediatric dataset for Benchmarking Large Language Models

arXiv

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arXiv 2024年

作者： Zhang, Qian Chen, Panfeng Li, Jiali Feng, Linkun Liu, Shuyu Zhao, Heng Chen, Mei Li, Hui Wang, Yanhao State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University Guiyang China Guizhou Engineering Laboratory for Advanced Computing and Medical Information Services Guiyang China College of Big Data and Internet Shenzhen Technology University Shenzhen China School of Data Science and Engineering East China Normal University Shanghai China

The emergence of Large Language Models (LLMs) in the medical domain has stressed a compelling need for standard datasets to evaluate their question-answering (QA) performance. Although there have been several benchmark datasets for medical QA, they either cover common knowledge across different departments or are specific to another department rather than pediatrics. Moreover, some of them are limited to objective questions and do not measure the generation capacity of LLMs. Therefore, they cannot comprehensively assess the QA ability of LLMs in pediatrics. To fill this gap, we construct PediaBench, the first Chinese pediatric dataset for LLM evaluation. Specifically, it contains 4,117 objective questions and 1,632 subjective questions spanning 12 pediatric disease groups. It adopts an integrated scoring criterion based on different difficulty levels to thoroughly assess the proficiency of an LLM in instruction following, knowledge understanding, clinical case analysis, etc. Finally, we validate the effectiveness of PediaBench with extensive experiments on 20 open-source and commercial LLMs. Through an in-depth analysis of experimental results, we offer insights into the ability of LLMs to answer pediatric questions in the Chinese context, highlighting their limitations for further improvements. Our code and data are published anonymously at https://***/ACMISLab/PediaBench. © 2024, CC BY-SA.

关键词： Question answering

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Super-Resolution of Diffusion-Weighted Images via TDI-Conditioned Diffusion Model 15th

Super-Resolution of Diffusion-Weighted Images via TDI-Cond...

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15th International Workshop on Computational Diffusion MRI, CDMRI 2024, held in conjunction with 27th International Conference on Medical Image computing and Computer-Assisted Intervention, MICCAI 2024

作者： Ma, Jiquan Teng, Yujun Chen, Geng Jiang, Haotian Zhang, Kai Liu, Feihong Rekik, Islem Shen, Dinggang School of Computer Science and Technology Heilongjiang University Harbin China National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology School of Computer Science and Engineering Northwestern Polytechnical University Xi’an China School of Biomedical Engineering and State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech University Shanghai China School of Information Science and Technology Northwest University Xi’an China BASIRA Lab Imperial-X and Department of Computing Imperial College London London United Kingdom

ISBN: (纸本)9783031869198

Diffusion-Weighted Imaging (DWI) is a significant technique for studying white matter. However, it suffers from low-resolution obstacles in clinical settings. Post-acquisition Super-Resolution (SR) can enhance the resolution of DWIs and has gained increasing research interest in recent years. An advanced generative model, the Diffusion Model (DM), exhibits particularly promising performance in image SR. However, effective conditions are required to bootstrap the DM for DWI SR. To this end, we proposed the first DM-based DWI SR model with two effective conditions based on low-solution DWIs and Track Density Imaging (TDI) maps, which possess rich high-resolution prior knowledge Additionally, we consider another condition based on features from low-resolution DWIs. These two conditions are integrated into our model, which comprises three components: DWI Resolution Enhancer (DRE), DWI Feature Extractor (DFE), and TDI Feature Extractor (TFE). DRE combines low-resolution DWI features from DFE with TDI features from TFE to progressively generate high-resolution DWIs. We performed extensive experiments on DWIs of normal subjects from human connectome projects and patients with Parkinson’s disease. The results demonstrate that our model outperforms existing DWI SR models, both qualitatively and quantitatively. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Neurodegenerative diseases

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Synthesis of Decoherence-Free Modes in Linear Quantum Passive Systems via Robust Pole Placement

Synthesis of Decoherence-Free Modes in Linear Quantum Passiv...

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2024 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2024

作者： Miao, Zibo Pan, Yu Gao, Qing School of Mechanical Engineering and Automation Adaptive Robotics Harbin Institute of Technology Guangdong Key Laboratory of Intelligent Morphing Mechanisms Shenzhen518055 China The Institute of Cyber-Systems and Control College of Control Science and Engineering Zhejiang University State Key Laboratory of Industrial Control Technology Hangzhou310027 China The School of Automation Science and Electrical Engineering Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Beijing100191 China

ISBN: (纸本)9781665410205

In this paper we extend our previous research on coherent observer-based pole placement approach to study the synthesis of robust decoherence-free (DF) modes for linear quantum passive systems, which is aimed at preservation of quantum information. In particular, DF modes can be generated by placing the poles on the imaginary axis via a coherent feedback design scheme, and these modes can further be simultaneously made robust against perturbations to the system parameters by minimizing the condition number associated with imaginary poles. We develop explicit algebraic conditions for the existence of such a coherent quantum controller, with the corresponding deign procedure provided. Examples are given to illustrate the process of tuning the DF modes towards perfect robustness via the proposed pole placement technique. © 2024 IEEE.

关键词： Poles

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