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Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2568-2577页

作者： Abi Maharjan Hongyu Sun Zeying Cao Ke Li Jinping Liu Jun Liu Tiqiao Xiao Guanyun Peng Junqiu Ji Peter York Balmukunda Regmi Xianzhen Yin Jiwen Zhang Li Wu Center for Drug Delivery System Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationYantai UniversityYantai 264005China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China Shanghai Synchrotron Radiation Facility/Zhangjiang Lab Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Hefei Lifeon Medication Group Hefei 230088China Center for MOST and Image Fusion Analysis Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201210China Maharajgung Medical Campus Institute of MedicineTribhuvan UniversityKathmandu 44606Nepal

Defining and visualizing the three-dimensional(3 D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanism of drug release from complex structured dosage forms, such as bilayer osmotic pump tablets, has not been investigated widely for most solid 3 D structures. In this study, bilayer osmotic pump tablets undergoing dissolution, as well as after dissolution in a desiccated solid state were examined, and visualized by synchrotron radiation micro-computed tomography(SR-μCT). In situ formed 3 D structures at different in vitro drug release states were characterized comprehensively. A distinct movement pattern of NaCl crystals from the push layer to the drug layer was observed, beneath the semi-permeable coating in the desiccated tablet samples. The 3 D structures at different dissolution time revealed that the pushing upsurge in the bilayer osmotic pump tablet was directed via peripheral“roadways”. Typically, different regions of the osmotic front, infiltration region, and dormant region were classified in the push layer during the dissolution of drug from tablet samples. According to the observed3 D microstructures, a “subterranean river model” for the drug release mechanism has been defined to explain the drug release mechanism.

关键词： Bilayer osmotic pump tablet Synchrotron radiation micro-computed tomography Three-dimensional microstructure Release kinetics Void formation Peripheral“roadways” Push-pull model Subterranean river model

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High Sensitivity Submicron Scale Temperature Sensor Based on Perovskite Nanoplatelet Lasers

SSRN

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SSRN 2024年

作者： Zhao, Ruofan Tao, Jianxun Xi, Yuying Chen, Jiangzhao Ji, Ting Wang, Wenyan Wen, Rong Cui, Yanxia Chen, Junsheng Lia, Guohui College of Physics and Optoelectronics Key Laboratory of Interface Science and Engineering in Advanced Materials Key lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan030024 China School of Materials Science and Engineering Kunming University of Science and Technology Kunming650093 China Shanxi-Zheda institute of advanced materials and chemical engineering China Nano-Science Center Department of Chemistry University of Copenhagen Universitetsparken 5 CopenhagenDK-2100 Denmark

Submicron scale temperature sensors are crucial for a range of applications, particularly in micro and nanoscale environments. One promising solution involves the use of active whispering gallery mode (WGM) microresonators. These resonators can be remotely excited and read out using free-space structures, simplifying the process of sensing. In this study, we present a submicron-scale temperature sensor with a remarkable sensitivity up to 190 pm/℃ based on a triangular CH3NH3PbI3 nanoplatelet (NPL) laser. Notably, as temperature changes, the peak wavelength of the laser line shifts linearly. This unique characteristic allows for precise temperature sensing by tracking the peak wavelength of the NPL laser. The optical modes are confined within the perovskite NPL, which measures just 85 nanometers in height, due to total internal reflection. Our NPL laser boasts several key features, including a high Q-factor of ~ 2610 and a low laser threshold of about 19.8 µJ cm−2. The combination of exceptional sensitivity and ultra-small size makes our WGM device an ideal candidate for integration into systems that demand compact temperature sensors. This advancement paves the way for significant progress in the development of ultrasmall temperature sensors, opening new possibilities across various fields. © 2024, The Authors. All rights reserved.

关键词： Perovskite

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Rapid Response and Recovery Performance of NO2 Gas Sensor Based on Gan Hexagonal Pits at Room Temperature

SSRN

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SSRN 2022年

作者： Han, Xiaomei Han, Dan Liu, Xiaoru Chen, Yi Liu, Lulu Liu, Zhihua Li, Donghui Sang, Shengbo Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Information and Computer Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System The Ministry of Education Taiyuan University of Technology Taiyuan030024 China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of Technology Ministry of Education Taiyuan030024 China

Although fantastic milestones of Gallium nitride (GaN)-based materials in optoelectronic devices had been reached, the focus on the optimization of their geometrical structure for gas-sensing applications was relatively scarce. In this work, we demonstrated NO2 gas sensor based on p-type GaN hexagonal pits (GaN-HP) with high surface-to-volume ratio by wet etching method. The fabricated NO2 gas sensor had high sensitivity, high selectivity, fast response/recovery times. The response of p-type GaN-HP with etching time for 10 min to 2 ppm NO2 gas was 6.2%, which also have quick response and recovery time at room temperature. UV light drastically enhanced the response of p-type GaN-HP sensor by 1.3 times to 100 ppm NO2 . The gas sensing mechanism of p-type GaN-HP gas sensor was explored, which provided a theoretical and experimental basis for further research and development of high-performance gas sensors based on GaN material. © 2022, The Authors. All rights reserved.

关键词： Gallium nitride

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Black Phosphorus-Organic Framework-Derived Pei/Peg Nanohybrid Prepared by a One-Pot Method for a Wide Detection Range Co2 Gas Sensor

SSRN

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SSRN 2022年

作者： Liu, Lulu Sang, Shengbo Han, Dan Liu, Zhihua Han, Xiaomei Li, Donghui Chen, Yi Liu, Dongming Liu, Xiaoru Zhuo, Kai Cheng, Yongqiang Yang, Kun Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Information and Computer Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of Technology Ministry of Education Taiyuan030024 China

In this paper, we report a hybrid PEI/PEG-BP sensor (composite material of black phosphorus-organic framework-derived PEI/PEG nanohybrid) prepared by a one-pot method, in which the existence of PEI/PEG onto BP was confirmed by SEM, EDS, XPS and UPS. The gas sensing properties of the PEI/PEG-BP sensor, including the sensor response, response/recovery times, repeatability, selectivity, and effects of humidity on the sensor, were studied by exposure to several CO 2 gas concentrations ranging from 200 ppm to 300,000 ppm at room temperature (25 ℃). The results show that the PEI/PEG-BP sensor had an extremely wide detection range, with lower and upper detection limits of 200 ppm and 160,000 ppm, respectively. The response of the PEI/PEG-BP sensor to 200 ppm, and 160,000 ppm CO 2 gas at room temperature ( RT ) was 4.48%, and 254.02%, respectively, showing fast response/recovery time, excellent repeatability and high selectivity. The gas-sensing properties of the PEI/PEG-BP sensor are better than BP, PEI, PEG, PEI-BP and PEG-BP sensors. The superior properties of the PEI/PEG-BP sensor can be attributed to the BP framework, porous structure, electron doping, and surface reactive groups such as -NH 2 and -OH. The PEI/PEG-BP sensor, with its excellent gas-sensing performance will help us to further explore the changes of CO 2 concentration in microbial growth systems, natural environments, industrial production and so on. © 2022, The Authors. All rights reserved.

关键词： Carbon dioxide

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A Novel Sensitization Mechanism of Stress-Electric-Coupled Biosensor Originated in Magnetostrictive Effect

SSRN

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SSRN 2022年

作者： Sang, Shengbo Ge, Yang Ji, Jianglong Yuan, Zhongyun Dong, Xiushan Zhou, Chuangang Xiao, Pengli Tan, Qiuyun Zhao, Dong MicroNano System Research Center Key Lab of Advanced Transducers and Intelligent Control System The Ministry of Education College of Information and Computer Taiyuan University of Technology Taiyuan030024 China School of Electrical Engineering College of Engineering Science Hanyang University Seoul04763 Korea Republic of Shanxi Bethune Hospital Taiyuan030024 China Six-dimensional Artificial Intelligence Biomedical Research Institute Taiyuan030024 China

The stress-electric coupling based on receptor functionalization provides a new paradigm for the development of biosensor. However, the gravity factor of sensitive element usually shows difficult to be avoided due to its suppression to biosensor sensitivity. Herein, a magnetic-sensitization biosensing system with multi-physical field coupling of stress, magnetism and electricity was proposed to highly detect biomolecules. The gravitational interference of sensitive membrane was conquered by doping the TbDyFe with magnetostrictive effect into polydimethylsiloxane (PDMS) and applying magnetic field, showing great contributions to magnetic sensitization. The magnetic sensitization of the biosensor was proved by the collaboration of experiment and simulation. The detections of urine protein and urine sugar associated with kidney disease were realized with limits of detection (LOD) of 0.21 ng/mL and 0.45 nM by using the magnetic-sensitization biosensor. The prepared biosensor exhibited the high specificity, selectivity, stability and repeatability. Especially, the HSA and glucose in real samples can be accurately detect, showing good practicability of the prepared biosensor. This study provides a way to improve the sensitivity of the mechanical biosensor. © 2022, The Authors. All rights reserved.

关键词： Silicones

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Real-world Robot Reaching Skill Learning Based on Deep Reinforcement Learning

Real-world Robot Reaching Skill Learning Based on Deep Reinf...

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第32届中国控制与决策会议

作者： Naijun Liu Tao Lu Yinghao Cai Rui Wang Shuo Wang State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences University of Chinese Academy of Sciences Guangdong Provincial Key Lab of Robotics and Intelligent System Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences

Traditional programming method can achieve certain manipulation tasks with the assumption that robot environment is known and ***,with robots gradually applied in more domains,robots often encounter working scenes which are complicated,unpredictable,and *** overcome the limitation of traditional programming method,in this paper,we apply deep reinforcement learning(DRL) method to train robot agent to obtain skill *** policy trained with DRL on real-world robot is time-consuming and costly,we propose a novel and simple learning paradigm with the aim of training physical robot ***,our method train a virtual agent in an simulated environment to reach random target position from random initial ***,virtual agent trajectory sequence obtained with the trained policy,is transformed to real-world robot command with coordinate transformation to control robot performing reaching *** show that the proposed method can obtain self-adaptive reaching policy with low training cost,which is of great benefits for developing intelligent and robust robot manipulation skill system.

关键词： Robot reaching skill learning deep reinforcement learning

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A robust controller based on advance model-free adaptive method for linear motion systems

A robust controller based on advance model-free adaptive met...

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World Congress on Intelligent control and Automation (WCICA)

作者： Rongmin Cao Huixing Zhou Zhongsheng Hou Junru Wang Beijing Key Laboratory of High Dynamic Navigation Technology Beijing Information Science & Technology University Beijing China The school of engineering China Agricultural University Beijing China Advanced Control System Lab Beijing Jiaotong University Beijing China School of Automation Beijing Information Science & Technology University Beijing China

The proposed advance model-free adaptive control algorithm is able to regain the control performance when some undesirable situations occur in linear motion system. A case study is employed in the development which involves the control of a linear motor setup using two control algorithms: a nominal control algorithm based on PID tuned for high performance, and the robust accommodating control based on advanced model free adaptive control (AMFAC). Compared with PID control, AMFAC is more robust to disturbances such as vibrations for fast time-varying systems. Simulation results based on the model of a real linear motion system setup are provided to show the effectiveness of the approach.

关键词： Adaptation models Adaptive control Semiconductor process modeling control systems Robustness Educational institutions Real-time systems

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Far-field three-dimensional deep-subwavelength focal spot with azimuthal polarization

arXiv

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arXiv 2019年

作者： Nie, Zhongquan Liu, Jiawei Liu, Xiaofei Yan, Weichao Zhang, Yanxiang Tian, Yanting Liu, Shaoding Jia, Baohua Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan030024 Department of Physics Harbin Institute of Technology Harbin150001 China Centre for Micro-Photonics Faculty of Science Engineering and Technology Swinburne University of Technology HawthornVIC3122 Australia

This work focuses on the generation of far-field super-resolved pure-azimuthal focal field based on the fast Fourier transform. A self-designed differential filter is first pioneered to robustly reconfigure a doughnut-shaped azimuthal focal field into a bright one with a sub-wavelength lateral scale (∼0.392λ), which offers a 27.3% reduction ratio relative to that of tightly focused azimuthal polarization modulated by a spiral phase plate. By further uniting the versatile differential filter with spatially shifted beam approach, in addition to allowing for an extremely sharper focal spot, whose size is in turn reduced to 0.228λ and 0.286λ in the transverse as well as axial directions, the parasitic sidelobes are also lowered to an inessential level (3/128). The relevant phase profiles are further exhibited to unravel the annihilation of field singularity and locally linear (i.e. azimuthal) polarization. Our scheme opens a promising route toward efficiently steer and tailor the redistribution of the focal field. Copyright © 2019, The Authors. All rights reserved.

关键词： Fast Fourier transforms

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A New Staining Method Using Different Targeted Fluorescent Carbon Dots For Tissue Sections Analysis and Diagnosis

SSRN

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SSRN 2024年

作者： Duan, Qianqian Guo, Qingxia Xi, Yanfeng Su, Hong Xue, Juanjuan Zhang, Qi Guo, Xing Han, Haixuan Zhou, Yangming Sang, Shengbo Wang, Xiaojuan Shanxi Key Laboratory of Artificial Intelligence & Micro Nano Sensors College of Integrated Circuits Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education Taiyuan University of Technology Taiyuan030024 China Department of Pathology Shanxi Tumour Hospital Shanxi Taiyuan030024 China

Visualization imaging of tissue sections is a crucial method for pathological diagnosis of tumour. Carbon dots (CDs) targeting specific organelles have attracted a lot of attention due to their inexpensive raw materials and excellent luminescent property, and they are expected to be used for labeling of nuclei and cytoplasm in tissue sections. In this paper, nuclear targeting carbon dots (N-CDs) with green fluorescence and cytoplasmic targeting carbon dots (C-CDs) with red fluorescence were prepared to achieve co-staining imaging of tissue sections. The two CDs had good fluorescent stability, and their targeting performance and mechanism were studied by cells co-staining and digestion experiments. The section staining method with N-CDs&C-CDs were developed, which is low-cost, simple operation, and time saving. The stained tissues structure distribution were very clear and the information of nucleus and cytoplasm could be extracted. The morphology features and statistic nucleus-cytoplasmic ratio were significantly different and consistent with the results of H&E staining. Therefore, N-CDs&C-CDs are expected to be potential alternative dyes to H&E, and a new method of tissue section staining by dual channel imaging of N-CDs&C-CDs has been developed. These results provide an important research idea for exploring the morphological differences between different cells on tissue sections, quickly and more accurately identifying sections, quantifying the ratio nucleus-cytoplasmic on sections, and then improving the efficiency of clinical diagnosis. © 2024, The Authors. All rights reserved.

关键词： Fluorescence imaging

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Multi-Objective Design Optimization and Sensitivity Analysis of Field Emission Electric Propulsion for Cubesat Platforms

SSRN

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SSRN 2024年

作者： Yeo, Suk Hyun Dinaol, Gadisa Ogawa, Hideaki Bang, Hyo-Choong Department of Aeronautics and Astronautics Graduate School of Engineering Kyushu University 744 Motooka Nishi-ku Fukuoka819-0395 Japan Department of Aerospace Engineering The Korea Advanced Institute of Science and Technology KAIST 291 Daejoen34141 Korea Republic of Space Systems Engineering Japan Aerospace System and Control Lab Korea Republic of

Field-emission electric propulsion is an electrostatic space electric propulsion technology that offers various advantageous features including efficient design, high specific impulse, and versatile thrust capabilities ranging from micro-Newton to milli-Newton levels. These characteristics make FEEP a promising technology for small satellite platforms, enabling precise attitude control, orbit maintenance, and de-orbiting through ionization and acceleration of a liquid metal propellant. The growing demand for small propulsion systems in CubeSat platforms has spurred significant progress in modeling and characterizing FEEP thrusters with the aim to enhance their overall performance. However, little study has been conducted to investigate the effect of geometric configurations on electric fields or expelled ion trajectories for design optimization. In this study, multi-objective design optimization is performed by incorporating electrostatic simulation coupled with an analytical performance model into evolutionary algorithms based on prediction from surrogate modeling, aiming to optimize the thruster emission design to maximize thruster performance. Physical insights into the key design factors influencing the performance of FEEP have been gained by probing into the interaction between ion particles and electric field behavior within the thruster. It has been found that the length of the emitter tip has a significant effect on plume divergence, \textit{i.e.,} a longer emitter tip under the influence of electric field at higher emitter current tends to result in lower initial acceleration of emitted ions and subsequently wider spread or divergence of the ion beam. A shorter emitter tip, on the other hand, generates a sharper E-field gradient, resulting in a more focused and narrower ion beam. Additionally, sensitivity analysis has identified the mass flow rate and potential distributions as the most influential design factors on performance due to the active roles they

关键词： Sensitivity analysis

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