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检索条件"机构=Advanced Methodology and Data Science"
86 条 记 录,以下是1-10 订阅
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Comparing methods to assess treatment effect heterogeneity in general parametric regression models
arXiv
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arXiv 2025年
作者: Chen, Yao Sun, Sophie Sechidis, Konstantinos Zhang, Cong Hothorn, Torsten Bornkamp, Björn Advanced Methodology and Data Science Novartis Pharmaceuticals Corporation East HanoverNJ United States Advanced Methodology and Data Science Novartis Pharmaceuticals Corporation CambridgeMA United States Advanced Methodology and Data Science Novartis Pharma AG Basel Switzerland China Novartis Institutes for Bio-Medical Research Co Shanghai China Biostatistik und Prävention Universität Zürich Switzerland
This paper reviews and compares methods to assess treatment effect heterogeneity in the context of parametric regression models. These methods include the standard likelihood ratio tests, bootstrap likelihood ratio te... 详细信息
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Using Individualized Treatment Effects to Assess Treatment Effect Heterogeneity
arXiv
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arXiv 2025年
作者: Sechidis, Konstantinos Zhang, Cong Sun, Sophie Chen, Yao Spector, Asher Bornkamp, Björn Advanced Methodology and Data Science Novartis Pharma AG Basel Switzerland China Novartis Institutes for Bio-medical Research CO. Shanghai China Advanced Methodology and Data Science Novartis Pharmaceuticals Corporation East HanoverNJ United States Department of Statistics Stanford University StanfordCA United States
Assessing treatment effect heterogeneity (TEH) in clinical trials is crucial, as it provides insights into the variability of treatment responses among patients, influencing important decisions related to drug develop... 详细信息
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Peter Krusches and Frank Bretz's contribution to the Discussion of ‘Gaussian Differential Privacy’ by Dong et al.
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Journal of the Royal Statistical Society. Series B: Statistical methodology 2022年 第1期84卷 42-43页
作者: Krusche, Peter Bretz, Frank Novartis Pharma Advanced Methodology and Data Science Basel Switzerland
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Synthetic data use: exploring use cases to optimise data utility
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Discover Artificial Intelligence 2021年 第1期1卷 1-13页
作者: James, Stefanie Harbron, Chris Branson, Janice Sundler, Mimmi Data Policy Director Data Office Data Science and Artificial Intelligence Biopharmaceuticals Research and Development AstraZeneca Academy House 136 Hills Road CambridgeCB2 8PA United Kingdom Expert Statistical Scientist Roche Pharmaceuticals Welwyn Garden City United Kingdom Global Head of Advanced Methodology and Data Science Novartis Basel Switzerland Head of Data and AI Governance and Policy R & amp D Data Office Data Science and Artificial Intelligence Biopharmaceuticals Research and Development AstraZeneca Cambridge United Kingdom
Synthetic data is a rapidly evolving field with growing interest from multiple industry stakeholders and European bodies. In particular, the pharmaceutical industry is starting to realise the value of synthetic data w... 详细信息
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Non-proportional hazards in Immuno-oncology: is an old perspective needed?
arXiv
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arXiv 2020年
作者: Magirr, Dominic Advanced Methodology and Data Science Novartis Pharma AG Basel Switzerland
A fundamental concept in two-arm non-parametric survival analysis is the comparison of observed versus expected numbers of events on one of the treatment arms (the choice of which arm is arbitrary), where the expectat... 详细信息
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Design and analysis of group-sequential clinical trials based on a Modestly-weighted log-rank test in anticipation of a delayed separation of survival curves: A practical guidance
arXiv
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arXiv 2021年
作者: Magirr, Dominic Jiménez, José L. Advanced Methodology and Data Science Novartis Pharma AG Basel Switzerland
A common feature of many recent trials evaluating the effects of immunotherapy on survival is that non-proportional hazards can be anticipated at the design stage. This raises the possibility to use a statistical meth... 详细信息
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Treatment-control comparisons in platform trials including non-concurrent controls
arXiv
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arXiv 2024年
作者: Roig, Marta Bofill Krotka, Pavla Hees, Katharina Koenig, Franz Magirr, Dominic Jacko, Peter Parke, Tom Posch, Martin Center for Medical Data Science Medical University of Vienna Vienna Austria Section of Data Science and Methods Paul-Ehrlich-Institut Germany Advanced Methodology and Data Science Novartis Pharma AG Switzerland Berry Consultants United Kingdom
Shared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to the control arm before the arm enters ... 详细信息
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Gaussian universal likelihood ratio testing
arXiv
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arXiv 2021年
作者: Dunn, Robin Ramdas, Aaditya Balakrishnan, Sivaraman Wasserman, Larry Novartis Pharmaceuticals Corporation Advanced Methodology and Data Science East HanoverNJ07936 United States Department of Statistics & Data Science Carnegie Mellon University PittsburghPA15213 United States
The classical likelihood ratio test (LRT) based on the asymptotic chi-squared distribution of the log likelihood is one of the fundamental tools of statistical inference. A recent universal LRT approach based on sampl... 详细信息
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Machine learning vs. rule-based methods for document classification of electronic health records within mental health care—A systematic literature review
Natural Language Processing Journal
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Natural Language Processing Journal 2025年 10卷
作者: Emil Rijcken Kalliopi Zervanou Pablo Mosteiro Floortje Scheepers Marco Spruit Uzay Kaymak Jheronimus Academy of Data Science Eindhoven University of Technology Sint Janssingel 92 ’s-Hertogenbosch 5211 DA The Netherlands Department of Information and Computing Sciences Utrecht University Princetonplein 5 Utrecht 3584 CC The Netherlands Department of Methodology and Statistics Utrecht University Padualaan 14 Utrecht 3584CH The Netherlands Psychiatry University Medical Center Utrecht Heidelberglaan 100 Utrecht 3584 CS The Netherlands Leiden Institute of Advanced Computer Science Niels Bohrweg 1 Leiden 2333 CA The Netherlands Public Health & Primary Care Leiden University Medical Center Albinusdreef 2 Leiden 2333 ZA The Netherlands
Document classification is a widely used task for analyzing mental healthcare texts. This systematic literature review focuses on the document classification of electronic health records in mental healthcare. Over the... 详细信息
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Optimal allocation strategies in platform trials
arXiv
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arXiv 2023年
作者: Roig, Marta Bofill Glimm, Ekkehard Mielke, Tobias Posch, Martin Section for Medical Statistics Center for Medical Data Science Medical University of Vienna Vienna Austria Advanced Methodology and Data Science Novartis Pharma AG Basel Switzerland Statistics and Decision Sciences Janssen-Cilag GmbH Germany
Platform trials are randomized clinical trials that allow simultaneous comparison of multiple interventions, usually against a common control. Arms to test experimental interventions may enter and leave the platform o... 详细信息
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