检索结果-内蒙古大学图书馆

arXiv 2024年

作者： Stock, Eduardo V. Valverde, Pablo González-Avella, Juan Carlos Iglesias, José Roberto Gonçalves, Sebastián da Silva, Roberto Instituto de Física Universidade Federal do Rio Grande do Sul Caixa Postal 15051 RS Porto Alegre90501-970 Brazil Pontificia Universidad Católica del Ecuador Facultad de Ciencias Exactas y Naturales Quito170525 Ecuador Institute for Cross-Disciplinary Physics and Complex Systems UIB-CSIC Palma de Mallorca07122 Spain Advanced Programming Solutions SL Palma de Mallorca07120 Spain Instituto Nacional de Ciência e Tecnologia de Sistemas Complexos CBPF RJ Rio de Janeiro22290-180 Brazil

The Optional Public Goods Game is a three-strategy game in which an individual can play as a cooperator or defector or decide not to participate. Despite its simplicity, this model can effectively represent many human social dilemmas, such as those found in the use of public services, environmental concerns, or other activities related to society. In this contribution, we present a comprehensive analysis of the conditions under which spontaneous, sustained cooperation emerges and the characteristics of these cooperative states. Through simulations, we demonstrate the conditions leading to the coexistence of the three strategies in a steady state or the alternate dominance of each strategy in a rock-paper-scissors fashion. The results identify each of the possible scenarios in terms of two key parameters: the multiplication rate of the public good game (reward) and the size of the group of potential players. We also discuss other details of the game that may influence the appearance of cycles, along with relevant characteristics of these cycles, such as the prevalence of cooperation. Copyright © 2024, The Authors. All rights reserved.

关键词：

来源：评论

学校读者我要写书评

暂无评论

The role of 7-dehydrocholesterol in inducing ER stress and apoptosis of head and neck squamous cell carcinoma

引用

Cancer Letters 2025年 217842页

作者： Bok-Soon Lee Yea-In Park Hengtian Liu Sang Gyu Kim Hyo Jeong Kim Ji-Hye Choi Si Hyun Rho Joselyn Padilla Jin Roh Hyun Goo Woo Hae Jin Seo Man Ho Choi Yu-Jin Jeong Evan C. Lien Syed Hassan Mehdi Dongjoon Lee Donghoon Yoon Chul-Ho Kim Jiyoung Lee Department of Biochemistry and Molecular Medicine School of Medicine and Health Sciences The George Washington University Washington DC USA Department of Otolaryngology Ajou University School of Medicine Suwon Korea Department of Molecular Science and Technology Ajou University School of Medicine Suwon Korea Department of Physiology Ajou University School of Medicine Suwon Korea Department of Pathology Ajou University School of Medicine Suwon Korea Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology Seoul Korea Department of Metabolism and Nutritional Programming Van Andel Institute Grand Rapids MI USA Hematology Oncology Division Department of Internal Medicine The University of Arkansas for Medical Sciences Little Rock AR USA GW Cancer Center School of Medicine and Health Sciences The George Washington University Washington DC USA

Alterations of metabolic pathways that sustain cancer cell survival often offer promising therapeutic avenues. Here, we show that enhanced de novo cholesterol biosynthesis is crucial for the survival of head and neck squamous cell carcinoma (HNSCC). Transcriptomic analysis of HNSCC tissues identified profound dysregulation in steroid and cholesterol metabolism compared to normal tissues. Inhibition of two key enzymes, DHCR7 and DHCR24, which mediate cholesterol biosynthesis, induced apoptosis in HNSCC cells, even when cholesterol levels were restored. Metabolomic profiling revealed the accumulation of 7-dehydrocholesterol (7-DHC) upon DHCR7 or DHCR24 inhibition, triggering endoplasmic reticulum (ER) stress and promoting further cell death. These findings suggest that HNSCC cells adapt to ER stress by modulating 7-DHC levels through enhancing DHCR7 and DHCR24 levels, highlighting a metabolic vulnerability in HNSCC and demonstrating a direct link between cholesterol metabolism and ER stress in cancer cell viability.

关键词： 7-dehydrocholesterol Cholesterol metabolism DHCR24 DHCR7 ER stress head and neck cancer

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis

引用

Nature communications 2019年第1期10卷 2926页

作者： Edgar-John Vogt Keizo Tokuhiro Min Guo Ryan Dale Guanghui Yang Seung-Wook Shin Maria Jimenez Movilla Hari Shroff Jurrien Dean Laboratory of Cellular and Developmental Biology NIDDK National Institutes of Health Bethesda MD 20892 USA. Charité - Universitätsmedizin Berlin Augustenburger Platz 1 13353 Berlin Germany. Department of Genome Editing Institute of Biomedical Science Kansai Medical University 2-5-1 Shinmachi Hirakata Osaka 573-1010 Japan. Section on High Resolution Optical Imaging NIBIB National Institutes of Health Bethesda MD 20892 USA. Bioinformatics and Scientific Programming Core Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892 USA. Department of Cell Biology and Histology Medical School University of Murcia IMIB 30100 Murcia Spain. Advanced Imaging and Microscopy Resource National Institutes of Health Bethesda MD 20892 USA. Laboratory of Cellular and Developmental Biology NIDDK National Institutes of Health Bethesda MD 20892 USA. jurrien.dean@nih.gov.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Including gap junctions into distributed neuronal network simulations 1

引用

2nd International Workshop on Brain-Inspired Computing, BrainComp 2015

作者： Hahne, Jan Helias, Moritz Kunkel, Susanne Igarashi, Jun Kitayama, Itaru Wylie, Brian Bolten, Matthias Frommer, Andreas Diesmann, Markus School of Mathematics and Natural Sciences University of Wuppertal Wuppertal Germany and JARA BRAIN Institute I Jülich Research Centre Jülich Germany RIKEN Advanced Institute for Computational Science Programming Environment Research Team Kobe Japan Department of Computational Science and Technology School of Computer Science and Communication KTH Royal Institute of Technology Stockholm Sweden Simulation Laboratory Neuroscience Bernstein Facility for Simulation and Database Technology Institute for Advanced Simulation Jülich Aachen Research Alliance Jülich Research Centre Jülich Germany Okinawa Institute of Science and Technology Neural Computation Unit Okinawa Japan Laboratory for Neural Circuit Theory RIKEN Brain Science Institute Wako Japan HPC Usability Research Team RIKEN Advanced Institute for Computational Science Kobe Japan Jülich Supercomputing Centre Jülich Research Centre Jülich Germany Institut für Mathematik Universität Kassel Kassel Germany Department of Psychiatry Psychotherapy and Psychosomatics Medical Faculty RWTH Aachen University Aachen Germany Department of Physics Faculty 1 RWTH Aachen University Aachen Germany

ISBN: (数字)9783319508627

ISBN: (纸本)9783319508610

Contemporary simulation technology for neuronal networks enables the simulation of brain-scale networks using neuron models with a single or a few compartments. However, distributed simulations at full cell density are still lacking the electrical coupling between cells via so called gap junctions. This is due to the absence of efficient algorithms to simulate gap junctions on large parallel computers. The difficulty is that gap junctions require an instantaneous interaction between the coupled neurons, whereas the efficiency of simulation codes for spiking neurons relies on delayed communication. In a recent paper [15] we describe a technology to overcome this obstacle. Here, we give an overview of the challenges to include gap junctions into a distributed simulation scheme for neuronal networks and present an implementation of the new technology available in the NEural Simulation Tool (NEST 2.10.0). Subsequently we introduce the usage of gap junctions in model scripts as well as benchmarks assessing the performance and overhead of the technology on the supercomputers JUQUEEN and K computer. © Springer International Publishing AG 2016.

关键词： Supercomputers

来源：评论

学校读者我要写书评

暂无评论

Reasoning (on) service component ensembles in rewriting logic

Lecture Notes in Computer Science (including subseries Lectu...

引用

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2014年 8373卷 188-211页

作者： Belzner, Lenz De Nicola, Rocco Vandin, Andrea Wirsing, Martin Programming and Software Engineering LMU Munich Germany IMT Institute for Advanced Studies Lucca Italy

programming autonomic systems with massive number of heterogeneous components poses a number of challenges to language designers and software engineers and requires the integration of computational tools and reasoning tools. We present a general methodology to enrich SCEL, a recently introduced language for programming systems with massive numbers of components, with reasoning capabilities that are guaranteed by external reasoners. We show how the methodology can be instantiated by considering the Maude implementation of SCEL and a specific reasoner, Pirlo, implemented in Maude as well. Moreover we show how the actual integration can benefit from the existing analytical tools of the Maude framework. In particular, we demonstrate our approach by considering a simple scenario consisting of a group of robots moving in an arena aiming at minimising the number of collisions. © 2014 Springer-Verlag Berlin Heidelberg.

关键词： Logic programming

来源：评论

学校读者我要写书评

暂无评论

LAR-CC: Large atomic regions with conditional commits

LAR-CC: Large atomic regions with conditional commits

引用

作者： Borin, Edson Wu, Youfeng Breternitz, Mauricio Wang, Cheng Institute of Computing University of Campinas Brazil Programming Systems Lab. Intel Labs. United Kingdom Advanced Software and Analytics Technology Group - AMD United Kingdom

ISBN: (纸本)9781612843551

HW/SW Co-designed systems rely on dynamic binary translation and optimizations for efficient execution of binary code. Due to memory ordering properties and other architectural constraints, most binary optimizations are applied to regions of code that are atomically executed. To ensure that the underlying hardware has enough speculative resources to execute the whole atomic region, these systems typically form short atomic regions, with only 20 to 30 instructions. However, the shorter is the atomic region the smaller is the scope for optimizations. We present LAR-CC, a novel technique that enables HW/SW co-designed systems to optimize large atomic regions and dynamically fit them into the available speculative hardware resources by means of conditional commits. The LAR-CC technique consists of two major components: 1) conditional branch instructions to conditionally skip commit operations;2) code transformations that replace commit operations by conditional commits and enable optimizations to be applied on the large atomic regions. Our experiments show that LAR-CC can effectively achieve dynamic atomic region sizes larger than 1000 instructions, providing sufficiently large scope to apply many advanced optimizations on HW/SW co-designed systems. © 2011 IEEE.

关键词： Cosine transforms

来源：评论

学校读者我要写书评

暂无评论

Muskel: A skeleton library supporting skeleton set expandability

引用

Scalable Computing 2007年第4期8卷 325-341页

作者： Aldinucci, Marco Danelutto, Marco Dazzi, Patrizio Dept. Computer Science Univ. of Pisa Italy Programming Model Institute CoreGRID United Kingdom ISTI-CNR Pisa Italy IMT-Institute for Advanced Studies Lucca Italy

programming models based on algorithmic skeletons promise to raise the level of abstraction perceived by programmers when implementing parallel applications, while guaranteeing good performance figures. At the same time, however, they restrict the freedom of programmers to implement arbitrary parallelism exploitation patterns. In fact, efficiency is achieved by restricting the parallelism exploitation patterns provided to the programmer to the useful ones for which efficient implementations, as well as useful and efficient compositions, are known. In this work we introduce muskel, a full Java library targeting workstation clusters, networks and grids and providing the programmers with a skeleton based parallel programming environment. muskel is implemented exploiting (macro) data flow technology, rather than the more usual skeleton technology relying on the use of implementation templates. Using data flow, muskel easily and efficiently implements both classical, predefined skeletons, and user-defined parallelism exploitation patterns. This provides a means to overcome some of the problems that Cole identified in his skeleton "manifesto" as the issues impairing skeleton success in the parallel programming arena. We discuss fully how user-defined skeletons are supported by exploiting a data flow implementation, experimental results and we also discuss extensions supporting the further characterization of skeletons with non-functional properties, such as security, through the use of Aspect Oriented programming and annotations. © 2007 SWPS.

关键词： Distributed computer systems

来源：评论

学校读者我要写书评

暂无评论

The design and optimisation of a UCAV wing manufactured using advanced composite materials

The design and optimisation of a UCAV wing manufactured usin...

引用

Proceedings of the Third International Conference on Engineering Computational Technology

作者： Jonson, D. Jordan, K. Centre for Advanced Materials Design and Manufacturing Programming Durban Institute of Technology Durban South Africa

ISBN: (纸本)0948749857

The results of a study aimed at investigating the conceptual design for the composite wings of the prototype UCAV-TD aircraft is presented. The work is focused on identifying an appropriate structural configuration as well as addressing the optimization of the structural design of the wing when subjected to the typical aerodynamic pressure of the structural design of the wing when subjected to the typical aerodynamic pressure loading encountered at the upper edge of the operational envelope. The results of the optimization indicated that the multi-spar arrangement of the radial configuration is more efficient in limiting the deflection of the wing, thereby allowing for a reduction in wing skin thickness.

关键词： Structural optimization

来源：评论

学校读者我要写书评

暂无评论

Implementation lessons of performance prediction tool for parallel conservative simulation 6

引用

6th International European Conference on Parallel Computing, Euro-Par 2000

作者： Lim, Chu-Cheow Low, Yoke-Hean Gan, Boon-Ping Cai, Wentong Intel Corporation SC12-305 2000 Mission College Blvd Santa ClaraCA95052-8119 United States Programming Research Group Oxford University Computing Laboratory University of Oxford OxfordOX1 3QD United Kingdom Gintic Institute of Manufacturing Technology 71 Nanyang Drive Singapore638075 Singapore Center for Advanced Information Systems School of Applied Science Nanyang Technological University Singapore639798 Singapore

ISBN: (纸本)9783540679561

Performance prediction is useful in helping parallel programmers answer questions such as speedup scalability. Performance prediction for parallel simulation requires first working out the performance analyzer algorithms for specific simulation protocols. In order for the prediction results to be close to the results from actual parallel executions, there are further considerations when implementing the analyzer. These include (a) equivalence of code between the sequential program and parallel program, and (b) system effects (e.g. cache miss rates and synchronization overheads in an actual parallel execution). This paper describes our investigations into these issues on a performance analyzer for a conservative, "super-step" (synchronous) simulation protocol. © Springer-Verlag Berlin Heidelberg 2000.

关键词： Forecasting

来源：评论

学校读者我要写书评

暂无评论

Symposia lectures

引用

Journal of Biosciences 1999年第1期24卷 5-31页

作者： F. Parak A. Ostermann G. U. Nienhaus Nobuo Niimura William A. Eaton Stephen J. Hagen Eric R. Henry James Hofrichter Gouri Jas Lisa Lapidus Victor Muñoz Chih-chen Wang Abani Bhuyan Javant Udgaonkar Heinz Rüterians Derek N. Woolfson M. D. Finucane J. H. Lees M. J. Pandya G. Spooner M. Tuna Wilma K. Olson K. V. R. Chary E. Westhof I. G. Wool C. C. Correll V. I. Ivanov S. A. Bondarenko E. M. Zdobnov A. D. Beniaminov E. E. Minyat N. B. Ulyanov Dale B. Wigley Nobuo Shimamoto Takashi Kinebuchi Hiroyuki Kabata Osamu Kurosawa Masao Washizu Barbara Baird David Holowka H. Belrhali P. Nollert A. Royant J. P. Rosenbusch E. M. Landau E. Pebav-Peyroula Anil K. Lala Patrick R. D’Silva Daniela Pietrobon Paolo Pinton Paulo Magalhaes Anna Chiesa Marisa Brini Tullio Pozzan Rosario Rizzuto M. Montai Shu-Rong Wang José L. Carrascosa B. Bhattacharyya Ian A. Wilson Dinakar M. Salunke Kurt Drickamer Anne Imberty A. Surolia Louise N. Johnson Michal Neeman S. M. Prince K. McLuskey R. J. Cogdell K. McAuley N. W. Isaacs G. Venturoli F. Drepper J. C. Williams J. P. Allen X. Lin P. Mathis R. van Grondelle Wolfgang Junge T. Tsukihara K. Shinzawa-Itoh R. Nakashima E. Yamashita M. J. Fei N. Inoue T. Tomizaki C. Peters Libeu S. Yoshikawa Patrick Chaussepied Keiichi Namba Marie-France Carlier Fariza Ressacl Valerie Laurent Thomas Loisel Coumaran Egile Philippe Sansonetti Dominique Pantaloni Manju Bansal E. W. Knapp M. G. Ullmann A. Amadei B. L. de Groot M. A. Ceruso M. Paci H. J. C. Berendsen A. Di Nola V. Di Francesco P. J. Munson J. Garnier Sung-Hou Kim Jean-Michel Claverie Ian C. P. Smith P. T. Callaghan Bruce Cornell Ratna S. Phadke Kazuhiko Kinosita D. Goldfarb I. Qromov C. Shutter I. Pecht P. Manikandan R. Carmieli T. Shane David S. Moss Clare E. Sansom Jeremy K. Cockcroft Ian J. Tickle Huub C. P. Driessen J. Raul Grigera Ramen K. Poddar Charles R. Cantor Barry Robson Jean Garnier John Helliwell Sunney I. Chan Ronald Rock Physik-Department El7 Technische Universität München Garching Abteilung Biophysik Universität Ulm Ulm Advanced Science Research Center Japan Atomic Energy Research Institute Japan Laboratory of Chemical Physics NIDDK National Institutes of Health Bethesda USA National Lab of Biomacromolecules Institute of Biophysics Beijing China National Centre for Biological Sciences Bangalore Institute of Biophysical Chemistry University of Frankfurt Frankfurt/Main Germany Centre for Biomolecular Design and Drug Development University of Sussex UK Rutgers University Piscataway USA Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India IBMC-CNRS Strasbourg France Department of Biochemistry and Molecular Biology The University of Chicago Chicago USA Engelhardt Institute of Molecular Biology RAS Moscow Russia Sir William Dunn School of Pathology University of Oxford Oxford UK Structural Biology Center National Institute of Genetics Japan Faculty of Engineering Kyoto University Kyoto Advance Co. Tokyo Japan Department of Chemistry and Chemical Biology Cornell University Ithaca Institute de Biologie Structurale Joseph Fourier Grenoble Cedex 1 France Biomembrane Lab Department of Chemistry and Biotechnology CenterIndian Institute of Technology Bombay Powai Mumbai India Dept of Biomedical Sciences Univ. of Padova Italy Dept. Exp. Diagn. Med. Sect. Gen. Pathol Ferrara Italy Department of Biology University of California San Diego La Jolla USA Chinese Academy of Sciences Institute of Biophysics Beijing China Centra Nacional de Biotecnología CSIC. Campus de la Universidad Autónoma de Madrid Cantoblanco Spain Dept.of Biochemistry Bose Institute Calcutta-54 India The Scripps Research Institute La Jolla National Institute of Immunology New Delhi India Glycobiology Institute Department of Biochemistry University of Oxford Oxford UK Centre de Recherches sur les Macromolécules Végétales-CNRS Grenoble cedex 9 France Molecular Biophysics Uni

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：