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Scaled-up synthesis of defect-rich layered double hydroxide monolayers without organic species for efficient oxygen evolution reaction

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Green Energy & Environment 2022年第5期7卷 975-982页

作者： Haoyuan Chi Jingwen Dong Tian Li Sha Bai Ling Tan Jikang Wang Tianyang Shen Guihao Liu Lihong Liu Luyi Sun Yufei Zhao Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China College of Chemistry Key Laboratory of Theoretical&Computational Photochemistry of Ministry of EducationBeijing Normal UniversityBeijing100875China Polymer Program Institute of Materials Science and Department of Chemical&Biomolecular EngineeringUniversity of ConnecticutStorrsConnecticut06269USA Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing100029China

The scaled-up synthesis of organic-free monolayer nanomaterials is highly desirable,especially in obtaining green energy by *** this study,a method for the scaled-up synthesis of the series of monolayer layered double hydroxides(LDHs)without the addition of organic solvents is reported via the separate nucleation and aging steps *** resulting monolayer LDHs with the thicknesses of less than 1 nm showed a narrow thickness distribution.X-ray absorption fine-structure revealed that monolayer NiFe-LDH nanosheets have a number of oxygen and metal vacancies *** a practical application,monolayer NiFe-LDH nanosheets containing defects showed an enhanced electrocatalytic water oxidation activity compared with that of bulk *** functional theory calculations uncovered that excellent catalytic activity is attributed to vacancies *** proposed method is an economical and universally applicable strategy for the scaled-up production of monolayer LDHs.

关键词： process synthesis monolayer

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A targetable pathway to eliminate TRA-1-60^(+)/TRA-1-81^(+)chemoresistant cancer cells

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Journal of Molecular Cell Biology 2023年第6期15卷 25-39页

作者： Lei Tan Xiaohua Duan Pratyusha Mutyala Ting Zhou Sadaf Amin Tuo Zhang Brian Herbst Gokce Askan Tomer Itkin Zhaoying Xiang Fabrizio Michelassi Michael D.Lieberman Christine AIacobuzio-Donahue Steven DLeach Todd Evans Shuibing Chen Department of Surgery Weill Cornell MedicineNew YorkNY 10065USA Center for Energy Metabolism and Reproduction Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Genomic Health Weill Cornell MedicineNew YorkNY 10065USA The SKI Stem Cell Research Facility The Center for Stem Cell Biology and Developmental Biology ProgramMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Genomic Resource Core Facility Weill Cornell Medical CollegeNew YorkNY 10065USA Rubenstein Center for Pancreatic Cancer Research Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Division of Regenerative Medicine Hartman Institute for Therapeutic Organ RegenerationAnsary Stem Cell InstituteDepartment of MedicineWeill Cornell MedicineNew YorkNY 10065USA Dartmouth Cancer Center Darmouth CollegeHanoverNH 03755USA

Chemoresistance is a primary cause of treatment failure in pancreatic *** cell surface markers specifically expressed in chemoresistant cancer cells(CCCs)could facilitate targeted therapies to overcome *** performed an antibody-based screen and found that TRA-1-60 and TRA-1-81,two‘stemness’cell surface markers,are highly enriched in ***-more,TRA-1-60^(+)/TRA-1-81^(+)cells are chemoresistant compared to TRA-1-60^(-)/TRA-1-81^(-)*** profiling identified UGT1A10,shown to be both necessary and sufficient to maintain TRA-1-60/TRA-1-81 expression and *** a high-content chemical screen,we identified Cymarin,which downregulates UGT1A10,eliminates TRA-1-60/TRA-1-81 expression,and increases chemosensitivity both in vitro and in ***,TRA-1-60/TRA-1-81 expression is highly specific in primary cancer tissue and positively correlated with chemoresistance and short survival,which highlights their potentiality for targeted ***,we discovered a novel CCC surface marker regulated by a pathway that promotes chemoresistance,as well as a leading drug candidate to target this pathway.

关键词： pancreatic cancer TRA-1-60/TRA-1-81 chemoresistance UGT1A10 Cymarin

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Critical Review on the Abatement Of Endocrine Disrupting Compounds In Iron-Based Materials Catalyzed Persulfate Systems: Reactive Species, Reaction Mechanisms, and Perspectives

SSRN

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SSRN 2024年

作者： Sun, Ye Huang, Ying Zheng, Shujie Chen, Haojia Yang, Yan Ji, Hongbing Han, Changseok School of Chemical Engineering and Light Industry School of Environmental Science and Engineering Guangdong University of Technology Guangzhou510006 China School of Environment Hangzhou Institute for Advanced Study UCAS Hangzhou310024 China School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology Guangxi University Nanning530004 China Synergy Innovation Institute of Guangdong University of Technology Shantou515041 China Department of Environmental Engineering INHA University Incheon22212 Korea Republic of Program in Environmental and Polymer Engineering Graduate School of INHA University Incheon22212 Korea Republic of

Persulfate-based advanced oxidation processes have emerged as promising technologies for mitigating endocrine-disrupting compounds (EDCs) in wastewater treatment. Economically viable Fe-based materials with tailored properties have demonstrated significant efficacy in activating persulfate for the decomposition of EDCs through both radical-routes (•OH, SO4•−, and O2•−) and non-radical routes (1O2, surface activated PS complex, and high-valent Fe species). This review summarized the latest advancements in the persulfate activation mechanisms mediated by Fe-based materials, categorized by Fe valence states and the types of reactive species. Furthermore, it critically assesses the influence of active sites of Fe-based catalysts on persulfate activation pathways and summarizes the selective reaction of reactive species towards EDCs. Despite these advancements, several challenges persist in non-radical route-dominated persulfate activation, particularly regarding the impact of Fe-Fe distance on the reactive species and the catalytic role of Fe-based materials for reactions between inorganic ions and persulfate. This review proposes prospective research directions, provides design strategies, and expands the application of Fe-based materials in PS activation for effective EDC abatement in real situations. © 2024, The Authors. All rights reserved.

关键词： Endocrine disrupters

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Whole transcriptomic analysis reveals structure-activity relationships of cinnamoylquinic acid derivatives in human amniotic stem cells

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Biochemical pharmacology 2025年 239卷 117029页

作者： Yu Jia Chen Farhana Ferdousi Kazunori Sasaki Aprill Kee Oliva Mizushima Hiroko Isoda Tsukuba Life Science Innovation Program (T-LSI) University of Tsukuba Tsukuba Ibaraki 305-8572 Japan. Tsukuba Life Science Innovation Program (T-LSI) University of Tsukuba Tsukuba Ibaraki 305-8572 Japan Institute of Life and Environmental Sciences University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba Tsukuba Ibaraki 305-8572 Japan. Alliance for Research on the Mediterranean and North Africa (ARENA) University of Tsukuba Tsukuba Ibaraki 305-8572 Japan Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba 305-8577 Japan. Research and & Development Center for Tailor-made QOL Program University of Tsukuba Tsukuba Japan. Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL) National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba 305-8577 Japan Research and & Development Center for Tailor-made QOL Program University of Tsukuba Tsukuba Japan. Electronic address: isoda.hiroko.ga@u.tsukuba.ac.jp.

Cinnamoylquinic acids constitute a class of polyphenolic compounds with a quinic acid core and with diverse quinic acid esterification result in distinctive beneficial biological effects. Naturally present in many foods, these compounds exhibit properties such as antioxidant, antibacterial, anti-inflammatory, and anticancer effects. Transcriptomic analysis was performed on human amniotic epithelial stem cells (hAESCs) treated with ten cinnamoylquinic acid derivatives. These multipotent stem cells, previously recognized as a physiologically relevant model for studying the bioactivities of natural compounds, revealed distinct transcriptomic differences associated with eight of the structural variations. The structure-functionality relationship was distinguished through cell specific tissue, functional enrichment, and developmental stem cell marker genes analysis. Structural characteristics were explored to assess the druggability potential of the derivative. Certain moieties showed pronounced effects, notably methyl tetraferuloylquinate, with four ferulic acid side substitutions and one carboxymethyl group. Overall, while structure-activity analyses identified key molecular components driving bioactivity suggesting optimal compound modifications. The utilization of big data with statistical analysis underscores the therapeutic and preventative medicine potential of Cinnamoylquinic acids.

关键词： ADME Cinnamoylquinic acid Human Amniotic Epithelial Stem Cells Structure-Activity Relationship Transcriptomics

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Sea Surface Wind Structure in the Outer Region of Tropical Cyclones Observed by Wave Gliders

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Journal of Geophysical Research: Atmospheres 2023年第3期128卷 e2022JD037235-e2022JD037235页

作者： Tian, Di Zhang, Han Wang, Shuai Zhang, Wenyan Sun, Xiujun Zhou, Ying Zheng, Gang Jiang, Han Yang, Shili Zhou, Feng State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography Ministry of Natural Resources Hangzhou China Observation and Research Station of Yangtze River Delta Marine Ecosystems Ministry of Natural Resources Zhoushan China Key Laboratory of Ocean Space Resource Management Technology Ministry of Damage the Coastal Ecosystem Natural Resources Marine Academy of Zhejiang Province Hangzhou China Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Zhuhai China Program in Atmospheric and Oceanic Sciences Princeton University Princeton NJ United States Institute of Coastal Systems - Analysis and Modeling Helmholtz-Zentrum Hereon Geesthacht Germany Physical Oceanography Laboratory Ocean University of China Qingdao China Institute for Advanced Ocean Study Ocean University of China Qingdao China Beijing Meteorological Observation Centre Beijing Meteorological Bureau Beijing China Ocean College Zhejiang University Zhoushan China

Understanding the sea surface wind structure during tropical cyclones (TCs) is the key for study of ocean response and parameterization of air-sea surface in numerical simulation. However, field observations are scarce. In 2019, three wave gliders were deployed in the South China Sea and the adjacent Western Pacific region, which acquired sea surface wind structure of eight TCs. Analysis of the field data suggests that the wave glider-observed surface winds are consistent with most analysis/reanalysis data (i.e., ERA5, Cross-Calibrated Multi-Platform, and National Centers for Environmental Prediction-Global Data Assimilation System) and Soil Moisture Active Passive. Both wave glider observations and analysis/reanalysis data indicate that TC wind fields induce an obvious increase in speed toward the sea surface together with a sharp change in direction, showing an asymmetric wind structure which is sensitive to TC translation speed and intensity. Larger mean values of wind speed and inflow angle are located on the right side along TC tracks. The inflow angle shows a highly dynamic dependence on the radial distance from the TC center, the TC intensity, as well as the TC-relative azimuth. Comparisons between field observations and theoretical models indicate that the most widely used, ideal TC wind profile models can largely represent the observed sea surface wind structure, but generally underestimate the wind speed due to lack of consideration of background wind. Moreover, simple ideal models (e.g., the modified Rankine vortex model) may outperform complex models when accurate information of TCs is limited. Wave glider observations have potential for better understanding of air-sea exchanges and for improvements of the corresponding parameterization schemes. © 2023. American Geophysical Union. All Rights Reserved.

关键词： ideal wind model inflow angle sea surface wind tropical cyclone wave glider

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Decline of Fossil Fuels in Electricity Required for 1.5°C Target Has Historical Precedents except in Asia

SSRN

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SSRN 2020年

作者： Vinichenko, Vadim Cherp, Aleh Jewell, Jessica Centre for Climate and Energy Transformations University of Bergen Bergen Norway Department of Geography Faculty of Social Sciences University of Bergen Bergen Norway Vienna Austria International Institute for Industrial Environmental Economics Lund University Lund Sweden Division of Physical Resource Theory Department of Space Earth and Environment Chalmers University of Technology Gothenburg Sweden Advanced Systems Analysis Program International Institute for Applied Systems Analysis Laxenburg Austria

Stopping global warming requires a rapid decline in the use of fossil fuels but the feasibility of such decline is unknown. Here we identify and analyse whether there are historical precedents for the decline of fossil fuels in electricity necessary to meet climate targets. We find that the maximum rates of decline were historically lower in larger electricity systems. In continental-scale systems, the use of specific fuels declined up to 20% of total electricity supply over a decade. These precedents occurred under trade embargoes, post-Communist transitions, or, recently, in wealthy countries with stagnating electricity demand. The speed of decline needed for reaching climate targets does not generally exceed these historically observed rates with the exception of coal power in Asia between 2020-2030 (IQR: 18-34%). Thus, the rates of fossils decline in many climate mitigation pathways are not unprecedented, though their feasibility under growing electricity demand and in younger power fleets is still questionable. © 2020, The Authors. All rights reserved.

关键词： Fossil fuels

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Root microbiota regulates tiller number in rice

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Cell 2025年第12期188卷 3152-3166.e16页

作者： Zhang, Jingying Wang, Bing Xu, Haoran Liu, Weidong Yu, Jingwei Wang, Qiuxia Yu, Hong Wei, Jin-Wei Dai, Rui Zhou, Jinghang He, Yuhang Zou, Di Yang, Jinhua Ban, Xinwei Hu, Qingliang Meng, Xiangbing Liu, Yong-Xin Wang, Binglei Hu, Bin Wang, Mingyu Xin, Peiyong Chu, Jinfang Li, Changsheng Garrido-Oter, Ruben Yu, Peng van Dijk, Aalt Dirk Jan Dong, Lemeng Bouwmeester, Harro Gao, Song Huang, Ancheng Chu, Chengcai Li, Jiayang Bai, Yang Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Peking-Tsinghua Center for Life Sciences State Key Laboratory of Gene Function and Modulation Research Peking-Tsinghua-NIBS Graduate Program School of Life Sciences Peking University Beijing 100871 China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China College of Advanced Agricultural Sciences University of Chinese Academy of Sciences Beijing 100101 China Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design Institute of Plant and Food Science School of Life Sciences Southern University of Science and Technology Shenzhen 518055 China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Integrated Traditional Chinese and Western Medicine Research Center Sun Yat-sen University Cancer Center Guangzhou 510060 China Yazhouwan National Laboratory Sanya 572024 China School of Life Sciences Yunnan University Kunming 650504 China Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops and Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University Guangzhou 510642 China Key Laboratory for Enhancing Resource Use Efficiency of Crops in South China Ministry of Agriculture and Rural Affairs South China Agricultural University Guangzhou 510642 China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biology Hunan University Changsha 410082 China Department of Plant-Microbe Interactions Max Planck Institute for Plant Breeding Research Cologne 50829 Germany Cluster of Excellence on Plant Sciences (CEPLAS) Düsseldorf 40225 Germany Plant Genetics TUM School of Life Sciences Technical University of Munich Freising 85354 Germany Swammerdam Institute for Life Sciences University of Amsterdam Amsterdam 1098 XH Netherlands

Rice tillering is an important agronomic trait regulated by plant genetic and environmental factors. However, the role and mechanism of the root microbiota in modulating rice tillering have not been explored. Here, we examined the root microbiota composition and tiller numbers of 182 genome-sequenced rice varieties grown under field conditions and uncovered a significant correlation between root microbiota composition and rice tiller number. Using cultivated bacterial isolates, we demonstrated that various members of the root microbiota can regulate rice tillering in both laboratory and field conditions. Genetic, biochemical, and structural analyses revealed that cyclo(Leu-Pro), produced by the tiller-inhibiting bacterium Exiguobacterium R2567, activates the rice strigolactone (SL) signaling pathway by binding to the SL receptor OsD14, thus regulating tillering. The present work provides insight into how the root microbiota regulates key agronomic traits and offers a promising strategy for optimizing crop growth by harnessing the root microbiota in sustainable agriculture. © 2025 The Authors

关键词： cyclo(Leu-Pro) dipeptide field trial microbial cultivation rice root microbiome root microbiota strigolactone pathway tiller number

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International Society for Extracellular Vesicles workshop. QuantitatEVs: Multiscale analyses, from bulk to single extracellular vesicle

Journal of Extracellular Biology

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Journal of Extracellular Biology 2024年第1期3卷 e137页

作者： Basso, Manuela Gori, Alessandro Nardella, Caterina Palviainen, Mari Holcar, Marija Sotiropoulos, Ioannis Bobis-Wozowicz, Sylwia Casarotto, Elena Ciani, Yari Suetsugu, Shiro Gualerzi, Alice Martin-Jaular, Lorena Boselli, Daniela Kashkanova, Anna Parisse, Pietro Lippens, Lien Pagliuca, Martina Blessing, Martin Frigerio, Roberto Fourniols, Thibaut Meliciano, Ana Fietta, Anna Fioretti, Paolo Vincenzo Soroczyńska, Karolina Picciolini, Silvia Salviano-Silva, Amanda Bergese, Paolo Zocco, Davide Chiari, Marcella Jenster, Guido Waldron, Levi Milosavljevic, Aleksandar Nolan, John Monopoli, Marco P. Witwer, Kenneth W. Bussolati, Benedetta Di Vizio, Dolores Falcon Perez, Juan Lenassi, Metka Cretich, Marina Demichelis, Francesca Department of Cellular Computational and Integrative Biology (CIBIO) University of Trento Trento Italy National Research Council of Italy Istituto di Scienze e Tecnologie Chimiche (SCITEC-CNR) Milan Italy EV group Molecular and Integrative Biosciences Research Program Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland Institute of Biochemistry and Molecular Genetics Faculty of Medicine University of Ljubljana Ljubljana Slovenia Institute of Biosciences & Applications National Center for Scientific Research (NCSR) Demokritos Paraskevi Greece Faculty of Biochemistry Biophysics and Biotechnology Department of Cell Biology Jagiellonian University Krakow Poland Dipartimento di Scienze Farmacologiche e Biomolecolari “Rodolfo Paoletti” (DiSFeB) Dipartimento di Eccellenza Università degli Studi di Milano Milan Italy Division of Biological Science Graduate School of Science and Technology Nara Institute of Science and Technology Ikoma Japan IRCCS Fondazione Don Carlo Gnocchi Milan Italy Institut Curie PSL University Inserm U932 Immunity and Cancer Paris France FRACTAL (Flow Cytometry Resource Advanced Cytometry Technical Applications Laboratory) San Raffaele Scientific Institute Milan Italy Max Planck Institute for the Science of Light Erlangen Germany National Research Council of Italy Istituto Officina dei Materiali (IOM-CNR) Trieste Italy Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium Cancer Research Institute Ghent Ghent Belgium Molecular Predictors and New Targets in Oncology Gustave Roussy Villejuif France Clinical and Translational Oncology Scuola Superiore Meridionale Naples Italy EverZom Paris France iBET-Instituto de Biologia Experimental e Tecnológica Oeiras Portugal Department of Biomedical Sciences (DSB) University of Padua Padua Italy Fondazione Istituto di Ricerca Pediatrica Città della Speranza (IRP) Padua Italy Medical University of

The “QuantitatEVs: multiscale analyses, from bulk to single vesicle” workshop aimed to discuss quantitative strategies and harmonized wet and computational approaches toward the comprehensive analysis of extracellular vesicles (EVs) from bulk to single vesicle analyses with a special focus on emerging technologies. The workshop covered the key issues in the quantitative analysis of different EV-associated molecular components and EV biophysical features, which are considered the core of EV-associated biomarker discovery and validation for their clinical translation. The in-person-only workshop was held in Trento, Italy, from January 31^st to February 2^nd, 2023, and continued in Milan on February 3^rd with “Next Generation EVs,” a satellite event dedicated to early career researchers (ECR). This report summarizes the main topics and outcomes of the workshop. © 2024 The Authors. Journal of Extracellular Biology published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.

关键词： multiomics analysis multiscale analysis quantitative biology single vesicle

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Community-developed checklists for publishing images and image analyses

arXiv

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arXiv 2023年

作者： Schmied, Christopher Nelson, Michael S. Avilov, Sergiy Bakker, Gert-Jan Bertocchi, Cristina Bischof, Johanna Boehm, Ulrike Brocher, Jan Carvalho, Mariana Chiritescu, Catalin Christopher, Jana Cimini, Beth A. Conde-Sousa, Eduardo Ebner, Michael Ecker, Rupert Eliceiri, Kevin Fernandez-Rodriguez, Julia Gaudreault, Nathalie Gelman, Laurent Grunwald, David Gu, Tingting Halidi, Nadia Hammer, Mathias Hartley, Matthew Held, Marie Jug, Florian Kapoor, Varun Koksoy, Ayse Aslihan Lacoste, Judith Le Dévédec, Sylvia Le Guyader, Sylvie Liu, Penghuan Martins, Gabriel G. Mathur, Aastha Miura, Kota Llopis, Paula Montero Nitschke, Roland North, Alison Parslow, Adam C. Payne-Dwyer, Alex Plantard, Laure Ali, Rizwan Schroth-Diez, Britta Schütz, Lucas Scott, Ryan T. Seitz, Arne Selchow, Olaf Sharma, Ved P. Spitaler, Martin Srinivasan, Sathya Strambio-De-Castillia, Caterina Taatjes, Douglas Tischer, Christian Jambor, HelenaKlara Fondazione Human Technopole Viale Rita Levi-Montalcini 1 Milano20157 Italy Department of Biomedical Engineering University of Wisconsin-Madison MadisonWI53706 United States Max Planck Institute of Immunobiology and Epigenetics Freiburg79108 Germany Medical BioSciences department Radboud University Medical Centre Nijmegen Netherlands Laboratory for Molecular mechanics of cell adhesions Pontificia Universidad Católica de Chile Santiago Chile Osaka University Graduate School of Engineering Science Japan Euro-BioImaging ERIC Bio-Hub Meyerhofstr. 1 Heidelberg69117 Germany Carl Zeiss AG Carl-Zeiss-Straße 22 Oberkochen73447 Germany BioVoxxel Scientific Image Processing and Analysis Eugen-Roth-Strasse 8 Ludwigshafen67071 Germany Nanophotonics and BioImaging Facility at INL International Iberian Nanotechnology Laboratory 4715-330 Portugal Phi Optics Inc. 1800 S. Oak St Ste 106 ChampaignIL61820 United States Biochemistry Center Heidelberg Heidelberg University Germany Imaging Platform Broad Institute CambridgeMA02142 United States i3S Instituto de Investigação e Inovação Em Saúde and INEB Instituto de Engenharia Biomédica Universidade do Porto Porto Portugal Translational Research Institute Queensland University of Technology 37 Kent Street WoolloongabbaQLD4102 Australia School of Biomedical Sciences Faculty of Health Queensland University of Technology BrisbaneQLD4059 Australia TissueGnostics GmbH Vienna1020 Austria Department of Medical Physics and Biomedical Engineering University of Wisconsin-Madison MadisonWI53706 United States Centre for Cellular Imaging Core Facility Sahlgrenska Academy University of Gothenburg Sweden Allen Institute for Cell Science SeattleWA United States Friedrich Miescher Institute for Biomedical Research Basel Switzerland RNA Therapeutics Institute University of Massachusetts Chan Medical School WorcesterMA01605 United States University of Oklahoma NormanOK United States Advanced Light Microscopy Unit Ce

Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained images and image analyses results, there are to date no unified guidelines. Consequently, microscopy images and image data in publications may be unclear or difficult to interpret. Here we present community-developed checklists for preparing light microscopy images and image analysis for publications. These checklists offer authors, readers, and publishers key recommendations for image formatting and annotation, color selection, data availability, and for reporting image analysis workflows. The goal of our guidelines is to increase the clarity and reproducibility of image figures and thereby heighten the quality and explanatory power of microscopy data is in publications. © 2023, CC BY-SA.

关键词： Image analysis

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