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arXiv 2023年

作者： Kim, Seunghwi Peng, Yu-Gui Yves, Simon Alù, Andrea Photonics Initiative Advanced Science Research Center City University of New York New YorkNY10031 United States School of Physics Huazhong University of Science and Technology Wuhan430074 China Physics Program Graduate Center City University of New York New YorkNY10016 United States

Abbe diffraction limit fundamentally bounds the resolution of conventional optical imaging and spectroscopic systems. Along the years, several schemes have been introduced to overcome this limit, each offering opportunities and trade-offs. Metamaterials have been proposed as a promising platform in this context, in principle enabling superlenses capable of drastic resolution enhancements. However, their performance is severely hindered by material loss and nonlocal phenomena, which become increasingly more detrimental as we attempt to image more subwavelength details. Active metamaterials have been explored to overcome these challenges, however material gain introduces other obstacles, e.g., instabilities, nonlinearities and noise. Here, we demonstrate that the temporal excitation of passive superlenses using signals oscillating at complex frequencies compensates material loss, leading to resolution enhancement. Our results demonstrate that virtual gain stemming from tailored forms of excitation can tackle the impact of loss in superlenses. More broadly, our work opens promising avenues for loss compensation in metamaterials, with a broad range of applications extendable to optics and nanophotonic systems. © 2023, CC BY-NC-ND.

关键词： Metamaterials

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Eu2O3 doped silicoborate glasses for scintillation material application: Luminescence ability and X-ray imaging

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Optik 2023年 294卷

作者： Intachai, N. Kothan, S. Wantana, N. Kaewjaeng, S. Pakawanit, P. Vittayakorn, N. Kanjanaboos, P. Phuphathanaphong, N. Kim, H.J. Kaewkhao, J. Center of Radiation Research and Medical Imaging Department of Radiologic Technology Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai50200 Thailand Physics Program Faculty of Science and Technology Nakhon Pathom Rajabhat University Nakhon Pathom73000 Thailand Nakhon Pathom Rajabhat University Nakhon Pathom73000 Thailand Synchrotron Research and Applications Division Synchrotron Light Research Institute 111 University Avenue Muang District Nakhon Ratchasima30000 Thailand Advanced Materials Research Unit School of Science King Mongkut's Institute of Technology Ladkrabang Bangkok10520 Thailand School of Materials Science and Innovation Faculty of Science Mahidol University Nakhon Pathom73170 Thailand Department of Physics Kyungpook National University Daegu41566 Korea Republic of

The glass samples were prepared by melt quenching method and changing Eu2O3 concentrations following component of xEu2O3 - 40Na2O - 7.5Gd2O3 - 5SiO2 - (47.5-x)B2O3 (x = 0, 1, 2, 3 mol %). Density and molar volume tend to increase with increasing Eu2O3 concentrations, corresponding to the larger non-bridging oxygen. Fourier transform infrared spectra (FTIR) results point out that the majority BO3 borate group. The absorption spectra were represented in the length of UV-Vis and NIR region. The phonon energy of 3Eu:7.5Gd was 1280.54 cm−1, related to the borate glass host. The photoluminescence and X-ray-induced luminescence spectra of 3Eu:7.5Gd glass showed similar highest intensity at 613 nm (5D0→7F2). The photoluminescence quantum yield (PLQY) of 3Eu:7.5Gd glass shows the highest value at 85.70 %. The scintillation efficiency of 3Eu:7.5Gd glass was 17.51 % of bismuth germanate (BGO) crystal. The decay time owing to Eu3+ emission is 2.054 ms for 2Eu:7.5Gd glass. The highest energy transfer efficiency was 2 mol % of Eu2O3 concentrations (ηET = 70 %). The CIE chromaticity coordinates of the glasses are placed in the reddish-orange area (0.65, 0.35). The spatial resolution of X-ray imaging study was 10 lp/mm. These results suggest that 3 mol % of Eu2O3 doped silicoborate glass is capable of being a scintillator applied in the X-ray imaging system. © 2023 Elsevier GmbH

关键词： Glass

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Amino-functionalized reduced graphene oxide@MoS2@CoS2 heterostructure as a high-rate anode material for ultralong lifespan sodium–sulfur batteries

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New Journal of Chemistry 2025年第24期49卷 10379-10387页

作者： Navid Aslfattahi Maryam Sadat Kiai Nilgun Baydogan Lingenthiran Samylingam Kumaran Kadirgama Chee Kuang Kok Department of Fluid Dynamics and Thermodynamics Faculty of Mechanical Engineering Czech Technical University in Prague Prague 166 07 Czech Republic Nano-Science and Nano-Engineering Program Graduate School of Science Engineering and Technology Istanbul Technical University Istanbul-34469 Turkey Energy Institute Ayazaga Campus Istanbul Technical University Maslak Istanbul Turkey Centre for Advanced Mechanical and Green Technology Center of Excellence for Robotics & Sensing Technologies Faculty of Engineering and Technology Multimedia University Jalan Ayer Keroh Lama Bukit Beruang 75450 Melaka Malaysia Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang 26600 Pekan Malaysia Centre for Research in Advanced Fluid and Process University Malaysia Pahang Al-Sultan Abdullah Lebuhraya Tun Razak Gambang Kuantan Pahang Malaysia Centre for Sustainable Materials & Surface Metamorphosis (CSMSM) Chennai Institute of Technology Chennai India

A nanocomposite comprising MoS2@CoS2 amino-functionalized graphene (En-RGO) with a two-dimensional structure has been successfully synthesized using a simple self-assembly technique. The resulting cell with a MoS2@CoS...

A nanocomposite comprising MoS₂@CoS₂ amino-functionalized graphene (En-RGO) with a two-dimensional structure has been successfully synthesized using a simple self-assembly technique. The resulting cell with a MoS₂@CoS₂@En-RGO anode and a sulfur cathode exhibits a superior hierarchical architecture that significantly facilitates ion mobility, cell conductivity, and pseudocapacitance. Consequently, this leads to improved rate performance and extended cycle stability in Na–S batteries. Micron-sized CoS₂ was synthesized by solvothermal growth of MoS₂ nanosheets on its surface. This composite material presents enhanced sodium-ion diffusion kinetics attributed to its heterogeneous interface, reduced ion diffusion pathways and increased exposure of active sites for sodium storage due to its hierarchical nanosheet structure. Additionally, amino functionalized graphene oxide with uniform nitrogen doping could improve electronic conductivity. The cell employing MoS₂@CoS₂@En-RGO with superior ion mobility and enhanced adsorption energy of Na⁺ ions achieves a cycle stability of 541.2 mA h g⁻¹ after 1800 cycles. The increased adsorption energy facilitates a more efficient sodiation process at MoS₂@CoS₂@En-RGO compared to En-RGO. Additionally, the MoS₂@CoS₂@En-RGO anode demonstrates a capacity retention of 95.8% after 1800 cycles at 1 A g⁻¹. The enhanced mobility of Na ions and the effective adsorption of polysulfide chains in MoS₂@CoS₂@En-RGO have been examined through DFT calculations, confirming its potential as a promising anode material for

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Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity

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细胞研究（英文版） 2022年第6期32卷 570-584页

作者： Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijingChina Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesPeking UniversityBeijingChina School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijingChina School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijingChina Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesTsinghua UniversityBeijingChina Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijingChina Ministry of Education Key Laboratory of Protein Science Tsinghua-Peking Joint Center for Life SciencesBeijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijingChina Neuroscience Research Institute Peking UniversityBeijingChina Beijing Advanced Innovation Center for Intelligent Robots and System Beijing Institute of TechnologyBeijingChina School of Life Sciences Tsinghua UniversityBeijingChina GHDDI BeijingChina

The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including ***-boosting agents can provide neuroprotective ***,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage *** obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active *** optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT *** effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional ***,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt *** findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline.

关键词： Neural stem cells X-ray crystallography

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Designing strategically functionalized conjugated microporous polymers with pyrene and perylenetetracarboxylic dianhydride moieties with single-walled carbon nanotubes to enhance supercapacitive energy storage efficiency

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Journal of Power Sources 2024年 608卷

作者： Osama Mousa, Aya Sharma, Santosh U. Chaganti, Swetha V. Mansoure, Tharwat Hassan Singh, Poonam Nagendra Ejaz, Moshin Chuang, Cheng-Hsin Lee, Jyh-Tsung Kuo, Shiao-Wei Mohamed, Mohamed Gamal Department of Materials and Optoelectronic Science College of Semiconductor and Advanced Technology Research Center of Crystal Research National Sun Yat-Sen University Kaohsiung804 Taiwan Institute of Medical Science and Technology College of Medicine National Sun Yat-sen University Kaohsiung804201 Taiwan Department of Chemistry National Sun Yat-Sen University Kaohsiung80424 Taiwan International PhD Program for Science National Sun Yat-sen University Kaohsiung80424 Taiwan Chemistry Department Faculty of Science Assiut University Assiut71515 Egypt Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung807 Taiwan

We utilize straightforward and traditional Sonogashira coupling reactions to synthesize two conjugated microporous polymers linked with pyrene (referred to as PyT-PTCDA and PyT-PHTD CMPs) by combining the common precursor of 1,3,6,8-tetraethynylpyrene (PyT) with 1,7-dibromo-3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA-Br2) and 3,6-dibromophenanthrene-9,10-dione (PHTD-Br2). Various analytical techniques, including spectroscopy and microscopy, are employed to characterize these two PyT-CMP materials. The PyT-PTCDA CMP exhibits notable thermal stability (with a decomposition temperature of 351 °C and a char yield of 61 wt %). We combine the PyT-PTCDA and PyT-PHTD CMPs with exceptionally conducting single-walled carbon nanotubes (SWCNTs) through π-π stacking interactions between SWCNTs and PyT unit to improve their electrical conductivity and electrochemical performance. Electrochemical evaluations reveal that the PyT-PTCDA CMP/SWCNTs nanocomposite shows an impressive capacitance of 376 F g−1 (at 0.5 A g−1) in a three-electrode system. After undergoing 5000 cycles of charging and discharging, it maintained 98 % of its original capacitance while demonstrating an energy density of 52 Wh/kg. Additionally, in a symmetric coin cell system, the energy density is 17 Wh/kg and the capacitance is 119 F g−1 for PyT-PTCDA CMP/SWCNTs. This approach presents a promising avenue for developing high-performance supercapacitors by strategically blending PyT-CMPs with highly conductive SWCNTs. © 2024 Elsevier B.V.

关键词： Capacitance

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Analyzing microbial communities and metabolic functions in estuaries affected by human activity to uncover bioelectrochemical system potential

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Environmental Advances 2024年 16卷

作者： Amin, Muhammad Hilman Fu'adil Kim, Hyun-Woo Kim, Kyunghoi Wahyudianto, Febri Eko Dianbudiyanto, Wahid Oktavitri, Nur Indradewi Advanced Tropical Biodiversity Genomics and Conservation Research Group Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia Department of Biology Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia Department of Marine Biology Pukyong National University Busan 48513 South Korea Department of Ocean Engineering Pukyong National University Busan 48513 South Korea Study Program of Environmental Engineering Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia

In the context of bioelectrochemical systems (BES), a profound understanding of the taxonomic composition within indigenous microbial communities is crucial. Their metabolic versatility assumes a foundational role in dictating the functionality of BES, yielding diverse applications for bioenergy production and bioremediation in anthropogenically impacted estuaries. Employing high-throughput sequencing of the V3-V4 region of 16S rRNA and predictive metagenomic analyses of three different estuaries samples (eutrophicated urban reservoir, mud volcano impacted river, and its river mouth), this study delves into the intricate interplay between these communities and their metabolic functions in response to human-induced perturbations, with a specific focus on their applicability to BES. Our findings illuminate remarkable distinctions among the three samples, manifesting in variations in microbial composition and functional metabolic pathways within the respective ecosystems. The mud volcano-affected river, characterized by the highest microbial diversity, exhibited the most diverse array of functional metabolic processes, prominently dominated by chemoheterotrophy (67.43%). In contrast, the river mouth displayed a distinct penchant for autotrophy (33.33%). The eutrophicated urban reservoir showcased a balanced coexistence of chemoheterotrophy (41.18%) and autotrophy (35.29%). Regarding metabolic potential for BES application, most of metabolism potential were associated with anodic activity, while cathodic activity was restricted to autotrophy and its relatives. The results suggested that the microbial communities anthropogenically impacted estuaries were potentially used for anodic and cathodic reactions in BES as electrogens to generate bioelectricity and reduce of pollutants. © 2024

关键词： 16S rDNA Estuaries Microbial communities Pollution Predictive metagenomic Renewable energy

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Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation

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National science Open 2023年第3期2卷 64-82页

作者： Haiqing Xiong Runyu Wang Aibin He State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Peking University-Tsinghua University-National Institute of Biological Science Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Institute of Molecular Medicine College of Future TechnologyPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China

The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies,providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the *** advances in single-cell multimodality epigenomic technologies facilitate directly interrogating the reg-ulatory relationship between multi-layer molecular information in the same *** this review,we discuss recent progress in development of single-cell multimodality epigenomic technologies and applications in elucidating cellular diversifications in development and diseases,with a focus on protein-DNA interactomics and regulatory links between epigenome and ***,we provide perspective on the future direction of single-cell multiomics tool development as well as challenges facing ahead.

关键词： single-cell protein-DNA interaction single-cell multiomics single-cell epigenomics epigenome genome regulation

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High‑Performance Thick Cathode Based on Polyhydroxyalkanoate Binder for Li Metal Batteries

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advanced Fiber Materials 2024年第1期6卷 214-228页

作者： Dong Hyuk Kang Minhyuck Park Jeonghun Lee Chan Yeol Kim Jimin Park Youn‑Ki Lee Jong Chan Hyun Son Ha Jin Hwan Kwak Juhee Yoon Hyemin Kim Hyun Soo Kim Do Hyun Kim Sangmin Kim Ji Yong Park Robin Jang Seung Jae Yang Hee‑Dae Lim Se Youn Cho Hyoung‑Joon Jin Seungjin Lee Yunil Hwang Young Soo Yun KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841South Korea Carbon Composite Materials Research Center Korea Institute of Science and Technology(KIST)92 Chundong‑roBongdong‑eupWanju‑gunJeollabuk‑do 55324South Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)514‑gil Hwaraong‑roSeoul 02792South Korea Program in Environmental and Polymer Engineering Inha University100 Inha‑ro Michuhol‑guIncheon 22212South Korea Advanced Analysis Data Center Korea Institute of Science and Technology(KIST)514‑gil Hwaraong‑roSeoul 02792South Korea Advanced Nanohybrids Laboratory Department of Chemistry and Chemical EngineeringInha University100 Inha‑roMichuhol‑guIncheon 22212South Korea CJ CheilJedang Corporation 55 Gwanggyo‑ro 42Beon‑gilYeongtong‑guSuwon 16495South Korea Department of Chemical Engineering Hanyang University222 Wangsimni‑roSeongdong‑guSeoul 04763South Korea Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841South Korea

Thick cathodes can overcome the low capacity issues,which mostly hamper the performance of the conventional active cathode materials,used in rechargeable Li ***,the typical slurry-based method induces cracking and flaking during the fabrication of thick *** addition,a significant increase in the charge-transfer resistance and local cur-rent overload results in poor rate capabilities and cycling stabilities,thereby limiting electrode *** this study,a synergistic dual-network combination strategy based on a conductive nanofibrillar network(CNN)and a nano-bridging amor-phous polyhydroxyalkanoate(aPHA)binder is used to demonstrate the feasibility of constructing a high-performance thick *** CNN and aPHA dual network facilitates the fabrication of a thick cathode(≥250μm thickness and≥90 wt%active cathode material)by a mass-producible slurry *** thick cathode exhibited a high rate capability and excel-lent cycling *** addition,the thick cathode and thin Li metal anode pair(Li//t-NCM)exhibited an optimal energy performance,affording high-performance Li metal batteries with a high areal energy of~25.3 mW h cm^(-2),a high volumetric power density of~1720 W L^(-1),and an outstanding specific energy of~470 W h kg^(-1)at only 6 mA h cm^(-2).

关键词： Thick cathode Polyhydroxyalkanoate binder Nano-bridging Conductive nano-fibrillar network Lithium metal battery

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CNEReg Interprets Ruminant-specific Conserved Non-coding Elements by Developmental Gene Regulatory Network

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Genomics, Proteomics & Bioinformatics 2023年第3期21卷 632-648页

作者： Xiangyu Pan Zhaoxia Ma Xinqi Sun Hui Li Tingting Zhang Chen Zhao Nini Wang Rasmus Heller Wing Hung Wong Wen Wang Yu Jiang Yong Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematics University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Animal Science and TechnologyGuangxi UniversityNanning 530005China Section for Computational and RNA Biology Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Department of Statistics Department of Biomedical Data ScienceBio-X ProgramStanford UniversityStanfordCA 94305USA Center for Ecological and Environmental Sciences Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

The genetic information coded in DNA leads to trait innovation via a gene regulatory network(GRN)in ***,we developed a conserved non-coding element interpretation method to integrate multi-omics data into gene regulatory network(CNEReg)to investigate the ruminant multi-chambered stomach *** generated paired expression and chromatin accessibility data during rumen and esophagus development in sheep,and revealed 1601 active ruminantspecific conserved non-coding elements(active-RSCNEs).To interpret the function of these activeRSCNEs,we defined toolkit transcription factors(TTFs)and modeled their regulation on rumenspecific genes via batteries of active-RSCNEs during *** developmental GRN revealed 18 TTFs and 313 active-RSCNEs regulating 7 rumen functional ***,6 TTFs(OTX1,SOX21,HOXC8,SOX2,TP63,and PPARG),as well as 16 active-RSCNEs,functionally distinguished the rumen from the *** study provides a systematic approach to understanding how gene regulation evolves and shapes complex traits by putting evo-devo concepts into practice with developmental multi-omics data.

关键词： Trait innovation Gene regulatory network Conserved non-coding element Toolkit transcription factor Ruminant

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The growing memristor industry

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Nature 2025年第8059期640卷 613-622页

作者： Lanza, Mario Pazos, Sebastian Aguirre, Fernando Sebastian, Abu Le Gallo, Manuel Alam, Syed M. Ikegawa, Sumio Yang, J. Joshua Vianello, Elisa Chang, Meng-Fan Molas, Gabriel Naveh, Ishai Ielmini, Daniele Liu, Ming Roldan, Juan B. Department of Materials Science and Engineering National University of Singapore Singapore Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore Singapore Centre for Advanced 2D Materials (CA2DM) National University of Singapore Singapore Singapore Materials Science and Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Intrinsic Semiconductor Technologies London United Kingdom IBM Research – Zurich Rüschlikon Switzerland Everspin Technologies Chandler AZ United States Department of Electrical and Computer Engineering University of Southern California Los Angeles CA United States CEA-Leti Université Grenoble Alpes Grenoble France Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Weebit Nano Hod Hasharon Israel Dipartimento di Elettronica Informazione e Bioingegneria (DEIB) Politecnico di Milano and *** Milano Italy Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing China Departamento de Electrónica y Tecnología de Computadores Universidad de Granada Facultad de Ciencias Granada Spain

The semiconductor industry is experiencing an accelerated transformation to overcome the scaling limits of the transistor and to adapt to new requirements in terms of data storage and computation, especially driven by artificial intelligence applications and the Internet of Things. In this process, new materials, devices, integration strategies and system architectures are being developed and optimized. Among them, memristive devices and circuits—memristors are two-terminal memory devices that can also mimic some basic bioelectronic functions—offer a potential approach to create more compact, energy-efficient or better-performing systems. The memristor industry is growing quickly, raising abundant capital investment, creating new jobs and placing advanced products in the market. Here we analyse the status and prospects of the memristor industry, focusing on memristor-based products that are already commercially available, prototypes with a high technological readiness level that might affect the market in the near future, and discuss obstacles and pathways to their implementation. © Springer Nature Limited 2025.

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