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International Conference on control and Automation (ICCA)

作者： Kunhee Ryu Jinsung Kim Minkyu Han Juhoon Back Vehicle Control Technology Development Team Division of Advanced Vehicle Platform Hyundai Motor Company Republic of Korea School of Robotics Kwangwoon University Seoul Republic of Korea

ISBN: (数字)9798350354409

ISBN: (纸本)9798350354416

This paper investigates the estimation of lateral tire forces and predictive control for vehicles equipped with intelligent tires. Motivated by the capability of intelligent tires to estimate lateral tire forces, we propose a control scheme that includes a predictor for lateral tire forces, utilizing the Gaussian Process Regression technique. In addition, a metric for online data management is proposed, which has the characteristic of retaining more data in regions where the change of the function value is relatively large. The proposed metric can be interpreted as an extension of the existing method, allowing for the control of dataset quality within its limited size. We apply the proposed control scheme to the model predictive contouring control problem. Numerical simulations demonstrate the robustness of the proposed control scheme to tire parameter uncertainty, in comparison to a baseline controller.

关键词： Measurement Uncertain systems Gaussian processes Predictive models Numerical simulation Tires Robustness

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Motion Sickness Detection and Prevention

Motion Sickness Detection and Prevention

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21st Stuttgart International Symposium on Automotive and Engine Technology, 2021

作者： Alayan, Mohamad ZF Friedrichshafen AG corp. R&D Advanced System Development Vehicle Dynamics Control Functions Friedrichshafen Germany

ISBN: (纸本)9783658335205

Autonomous vehicles are expected to push towards the evolution of mobility environment in the near future, by decreasing traffic accidents, traffic congestion and vehicle fuel consumption. One of the main limitations they face is motion sickness (MS) and it seems capable of putting in risk fully automated vehicles wide impact, as well as their acceptance by the public [1, 2]. © Springer Fachmedien Wiesbaden GmbH, ein Teil von Springer Nature 2021.

关键词： Traffic congestion

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Engineering grain boundaries in monolayer molybdenum disulfide for efficient water-ion separation

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Science (New York, N.Y.) 2025年第6735期387卷 776-782页

作者： Shen, Jie Aljarb, Areej Cai, Yichen Liu, Xing Min, Jiacheng Wang, Yingge Wang, Qingxiao Zhang, Chenhui Chen, Cailing Hakami, Mariam Fu, Jui-Han Zhang, Hui Li, Guanxing Wang, Xiaoqian Chen, Zhuo Li, Jiaqiang Dong, Xinglong Shih, Kaimin Huang, Kuo-Wei Tung, Vincent Shi, Guosheng Pinnau, Ingo Li, Lain-Jong Han, Yu Physical Sciences and Engineering Division (PSE) King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore Department of Physics King Abdulaziz University Jeddah Saudi Arabia KAUST Catalysis Center King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing China Shanghai Applied Radiation Institute Shanghai Key Laboratory of Atomic Control and Application of Inorganic 2D Supermaterials Shanghai University Shanghai China Department of Mechanical Engineering University of Hong Kong Pok Fu Lam Road Hong Kong China Department of Civil Engineering University of Hong Kong Pok Fu Lam Road Hong Kong China Imaging and Characterization Core Lab King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Department of Chemical System Engineering School of Engineering University of Tokyo Tokyo Japan Center for Electron Microscopy South China University of Technology Guangzhou China School of Emergent Soft Matter South China University of Technology Guangzhou China Catalyst Center of Excellence (CCoE) Research and Development Center Saudi Aramco Dhahran Saudi Arabia Center for Sustainability and Energy Technologies Chang Gung University Taoyuan Taiwan Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt Lakes Chinese Academy of Sciences Xining Qinghai China University of Chinese Academy of Sciences Wenzhou China

Two-dimensional (2D) materials have long been considered as ideal platforms for developing separation membranes. However, it is difficult to generate uniform subnanometer pores over large areas on 2D materials. We report that the well-defined eight-membered ring (8-MR) pores, typically formed at the boundaries of two antiparallel grains of monolayer molybdenum disulfide (MoS2), can serve as molecular sieves for efficient water-ion separation. The density of grain boundaries and, consequently, the number of 8-MR pores can be tuned by regulating the grain size. Optimized MoS2 membranes outperformed the state-of-the-art membranes in forward osmosis tests by demonstrating both ultrahigh water/sodium chloride selectivity and exceptional water permeance. Creating precise pore structures on atomically thin films through grain boundary engineering presents a promising route for producing membranes suitable for various applications.

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development of Dynamic Wireless Power Transfer system for vehicle Logistics Robot

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IEEJ Transactions on Industry Applications 2022年第2期142卷 146-154页

作者： Shimizu, Osamu Hanabusa, Kazuyoshi Arasaki, Kota Gunji, Daisuke Sakai, Yuto Ikeda, Hiromori Matsuoka, Fuminori Graduate School of Frontier Science The University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba277-8561 Japan Development Section 1 Energy Units Development Dept. Advanced Products Development Center Technology & Intellectual Property HQ TDK Corporation 2-15-7 Higashi-Ohwada Ichikawa Chiba272-8558 Japan R&D Division System Power Supply Department WPT Development Group TDK-Lambda Corporation 2-15-7 Higashi-Ohwada Ichikawa Chiba272-8558 Japan New Product Development Department Technical Research Office NSK Ltd. 1-5-50 Kugenumashimmei Fujisawa Kanagawa251-8501 Japan BR NEXT GENERATION LOGISTICS DIV. YUTO SAKAI SHINMEI INDUSTRY CO. Ltd. 3-20 Koromogahara Aichi Toyota471-0856 Japan Central Japan Business Dept. TOYOTA T&S CONSTRUCTION CO. LTD. 65 Kamekubi-cho Kamimukaida Aichi Toyota470-0375 Japan Strategy Planning & Administration Dept. Vehicle Logistics Div. TOYOTA MOTOR CORPORATION 1 Motomachi Aichi Toyotashi471-0854 Japan

Laborsaving is a major issue in production. In an automotive production line, a yard that is used as a temporary storage for vehicles before shipping. The vehicle-loading robot that operates autonomously has been proposed to automate the alignment of vehicles in the yard instead of human driving. In this study, the dynamic wireless power transfer system that includes the structure of the roadside for the vehicle-loaded robot is proposed. It is proven that the transmitter coil has enough durability for the load of the robot weight using simulation and actual measurement. It is also shown that the reinforcement bars of the road structure cause considerable eddy current loss even with stainless steel. This is similar to loss by coil resistance. This system achieves a 1.8 kW dynamic wireless power transfer with an automated coil detection system and a frequency control system, under factory conditions. 2022 The Institute of Electrical Engineers of Japan.

关键词： Robots

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Age at menarche by birth cohort: A pooled analysis of half a million women in Asia

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Public Health 2024年 237卷 130-134页

作者： Abe, Sarah K. Nishio, Marisa Huang, Hsi-Lan Leung, Chi Yan Islam, Md Rashedul Rahman, Md Shafiur Saito, Eiko Shin, Aesun Merritt, Melissa A. Choi, Ji-Yeob Katagiri, Ryoko Mohammadi, Zahra Shu, Xiao-Ou Wakai, Kenji Sawada, Norie Ideno, Yuki Tamakoshi, Akiko Seow, Wei Jie Koh, Woon-Puay Sakata, Ritsu Hozawa, Atsushi Kim, Jeongseon Nagata, Chisato Sugawara, Yumi Park, Sue K. Kweon, Sun-Seog Azizi, Fereidoun Malekzadeh, Reza Moy, Foong-Ming Pourfarzi, Farhad Gao, Yu-Tang Kubo, Yoko Hirabayashi, Mayo Nagai, Kazue Kimura, Takashi Yuan, Jian-Min Kanemura, Seiki Wada, Keiko Kang, Daehee Shin, Min-Ho Khalili, Davood Poustchi, Hossein Rezaianzadeh, Abbas Mansour-Ghanaei, Fariborz Najafi, Farid Mohebbi, Iraj Boffetta, Paolo Lee, Jung Eun Matsuo, Keitaro Rothman, Nathaniel Qiao, You-Lin Zheng, Wei Inoue, Manami Division of Prevention National Cancer Center Institute for Cancer Control Japan Hitotsubashi Institute for Advanced Study Hitotsubashi University Japan Research Center for Child Mental Development Hamamatsu University School of Medicine Japan Sustainable Society Design Center Graduate School of Frontier Sciences the University of Tokyo Japan Department of Preventive Medicine Seoul National University College of Medicine Seoul South Korea Cancer Research Institute Seoul National University Seoul South Korea The Daffodil Centre The University of Sydney a joint venture with Cancer Council NSW Sydney NSW Australia Department of Biomedical Sciences Seoul National University Graduate School Seoul South Korea Graduate School of Informatics Faculty of Informatics Chiba University Japan Liver and Pancreatobiliary Diseases Research Center Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Division of Epidemiology Department of Medicine Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center Vanderbilt University Medical Center Nashville TN United States Department of Preventive Medicine Nagoya University School of Medicine Nagoya Japan Division of Cohort Research National Cancer Center Institute for Cancer Control Japan Gunma University Center for Food Science and Wellness Maebashi Japan Department of Public Health Hokkaido University Faculty of Medicine Sapporo Japan Saw Swee Hock School of Public Health and Department of Medicine National University of Singapore and National University Health System Singapore Healthy Longevity Translational Research Programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Institute for Clinical Sciences Agency for Science Technology and Research (A∗STAR) Singapore Department of Epidemiology Radiation Effects Research Foundation Hiroshima Japan Division of Epidemiology Department of Public Health and Forensic Medicine Tohoku University Graduate School

Objectives: To evaluate changes in the age at menarche in Asian populations. Study design: Retrospective cohort study. Methods: We included 548,830 women from six countries in Asia. The data were sourced from 20 cohorts participating in the Asia Cohort Consortium (ACC) and two additional cohort studies: Japan Multi-institutional Collaborative Cohorts (J-MICC), and Japan Nurse Health Study (JNHS) with data on age at menarche. Joinpoint regression was used to evaluate changes in age at menarche by birth year and by country. Results: The study includes data from cohorts in six Asian countries namely, China, Iran, Japan, Korea, Malaysia and Singapore. Birth cohorts ranged from 1873 to 1995. The mean age of menarche was 14.0 years with a standard deviation (SD) of 1.4 years, ranged from 12.6 to 15.5 years. Over 100 years age at menarche showed an overall decrease in all six countries. China showed a mixed pattern of decrease, increase, and subsequent decrease from 1926 to 1960. Iran and Malaysia experienced a sharp decline between about 1985 and 1990, with APC values of −4.48 and −1.24, respectively, while Japan, South Korea, and Singapore exhibited a nearly linear decline since the 1980s, notably with an APC of −3.41 in Singapore from 1993 to 1995. Conclusions: Overall, we observed a declining age at menarche, while the pace of the change differed by country. Additional long-term observation is needed to examine the contributing factors of differences in trend across Asian countries. The study could serve as a tool to strengthen global health campaigns. © 2024 The Royal Society for Public Health

关键词： Age Asia Birth cohort Menarche

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Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report

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Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2024年第4期20卷 521-530页

作者： Batel Blechter Chao Agnes Hsiung Xiaoyu Wang Haoyu Zhang Wei Jie Seow Jianxin Shi Nilanjan Chatterjee Hee Nam Kim Maria Pik Wong Yun-Chul Hong Jason Yy Wong Juncheng Dai H Dean Hosgood Zhaoming Wang I-Shou Chang Jiyeon Choi Jiucun Wang Minsun Song Wei Hu Wei Zheng Jin Hee Kim Baosen Zhou Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Roel C H Vermeulen Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Yukihide Momozawa Yoichiro Kamatani Takayuki Honda Hideo Kunitoh Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Hsien-Chih Lin Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Tzu-Yu Chen Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Junwen Wang Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Chung-Hsing Chen Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jun Suk Kim Ho-Il Yoon Qiuyin Cai In Kyu Park Ping Xu Qincheng He Chih-Yi Chen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Joseph F Fraumeni Jie Liu Maria Teresa Landi Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Hongxia Ma Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Motoki Iwasaki Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Fang-Yu Tsai Jinming Yu Victoria L Stevens Pan-Chyr Yang Dongxin Lin Kexin Chen Yi-Long Wu Keitaro Matsuo Nathaniel Rothman Kouya Shiraishi Hongbing Shen Stephen J Chanock Takashi Kohno Qing Lan Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore. Department of Oncology School of Medicine Johns Hopkins University Baltimore MD USA Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology Queen Mary Hospital Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Epidemiology and Community Health Branch National Heart Lung and Blood Institute Bethesda MD USA. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Epidemiology and Population Health Albert Einstein College of Medicine New York USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Department of Statistics & Research Institute of Natural Sciences Sookmyung Women's University Seoul 04310 Korea. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Environmental Health

We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the epidermal growth factor receptor (EGFR) gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4,544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared to EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (OR=8.63, 95% CI:5.67, 13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (OR=3.50, 95% CI: 2.44, 5.00) (p-heterogeneity=3.66x10). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.

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Potential of wheel-individual brake interventions as a backup for steering system failures during automated driving

Potential of wheel-individual brake interventions as a backu...

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7th International Munich Chassis Symposium, IMCS 2016

作者： Gauger, Andreas Kern, Alexander Feinauer, Jochen Kanngießer, Stefan Greul, Roland System Development Vehicle Motion Control Actuator Management Robert Bosch GmbH Chassis Systems Control Heilbronn74003 Germany Advanced Engineering Vehicle Dynamics System Interconnection Robert Bosch GmbH Automotive Steering Schwabisch Gm und73522 Germany

ISBN: (纸本)9783658142186

Wheel individual brake interventions have been applied in order to influence vehicle lateral dynamics within the Electronic Stability Program (ESP®) and its predecessors. Traditionally, the main focus is to ensure stability and improve agility for vehicles con- trolled by a human driver. Within the recent years, these use cases where extended by driver assistance functions like side wind or lane departure prevention assists, which still require the driver within the loop and a faultless overall system. A better utilization of the potentials within the actuator network and reduction of the complexity for an increasing number of functions becomes more and more important. Therefore, there is a strong trend to decouple the driving task determination from the vehicle and actuator properties by introducing dedicated control and coordination layers. An exemplary name for such a layer is vehicle Motion control. A possible new use case for vehicle Motion control arises within the context of automated driving. Taking the driver out of the vehicle control loop for a certain time period requires an increased availability of the actuator systems compared to today's fail-safe systems. Here, wheel individual brake interventions could be used as a redundancy level in case that the electromechanic power steering (EPS) as fail-safe component is no more avail- able. The potential of asymmetric brake interventions for vehicle guidance is strongly depending on the vehicle parameters and the behaviour of the steering system during passive state. Within the following examination, these variables are examined both analytically and experimentally. Finally, a rating of the suitability for series introduction of wheel individual brake interventions as a backup for a passive steering system is given. © Springer Fachmedien Wiesbaden 2017.

关键词： Steering

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SiO 2 @ [email protected] 2 catalyst with improved thermal stability: Effect of interaction between Pd and CeO 2 on activity for CO oxidation

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Molecular Catalysis 2020年 492卷

作者： Hyun Jae Kim Jae Hwan Lee Min Woo Lee Yaeun Seo Jin Woo Choung Chang Hwan Kim Kwan-Young Lee Department of Chemical and Biological Engineering Korea University 145 Anam-Ro Seongbuk-Gu Seoul 02841 Republic of Korea Advanced Catalysts and Emission-Control Research Lab Research & Development Division Hyundai Motor Group Hyundaiyeonguso-Ro Namyang-Eup Hwaseong-Si Gyeonggi-Do 18280 Republic of Korea Graduate School of Energy and Environment (KU-KIST Green School) Korea University 145 Anam-Ro Seongbuk-Gu Seoul 02841 Republic of Korea Super Ultra Low Energy and Emission Vehicle (SULEEV) Center Korea University 145 Anam-Ro Seongbuk-Gu Seoul 02841 Republic of Korea

In this study, SiO 2 -supported Pd catalyst (Pd/SiO 2 ) and CeO 2 -encapsulated Pd/SiO 2 core-shell catalysts (SiO 2 @ [email protected] 2 ) were prepared and examined for CO oxidation. After aging at 700 ℃, the thermal stability of SiO 2 @ [email protected] 2 catalyst was improved in comparison to Pd/SiO 2 because the CeO 2 shell increased the structural stability and effectively inhibited the sintering of Pd particles on SiO 2 . Moreover, the differences in activity and properties of the catalysts were investigated through various characterization methods. The CeO 2 shell induced changes in the chemical properties of the Pd particles adjacent to CeO 2 due to the strong interaction between Pd and CeO 2 (Pd x Ce 1-x O 2 solid solution), and the interaction improved the activity of the SiO 2 @ [email protected] 2 catalysts. As a result, the SiO 2 @ [email protected] 2 core-shell catalysts have an enhanced thermal stability and catalytic activity resulting from both a morphology effect and a synergistic effect between Pd and CeO 2 .

关键词： CO oxidation Palladium Ceria Core-shell structure Thermal stability

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Optimal control of Integrated Starter and Generator for Maximum Energy Recovery during Engine Stop Transition in Hybrid Electric vehicles

Optimal Control of Integrated Starter and Generator for Maxi...

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SAE 2016 World Congress and Exhibition

作者： Kim, Sangjoon Chung, Kwang Sik Kim, Sungdeok Jo, Kyuhwan ECO-Vehicle Control System Development Team Reasearch and Development Division Hyundai Motor Co. Korea Republic of Korea National Open University Korea Republic of

An integrated starter and generator (ISG) is a type of electric machine which is mechanically connected to an internal combustion engine (ICE). The ISG is intended to conduct important roles in the hybrid electric vehicle (HEV) such as engine start and stop. Since the HEV has frequent electric vehicle (EV)/HEV mode transition, rapid engine cranking and vibration-free engine stop controls are necessary. In the case of the engine stop, the ISG provides the negative torque output to the ICE which can rapidly escape from its resonance speed. However, the ISG torque is determined by engineering intuition, the amount of energy recovery is hardly considered. Dynamic programming (DP) is an effective solution to find optimal ISG control strategy to maximize energy recovery during engine stop transition. Even though DP is an offline algorithm, the result can be used as a reference to evaluate and improve an existing on-line algorithm. In this paper, the procedures for applying DP to ISG control during engine stop transition are explained. Simplified powertrain model, which consists of mechanical and electrical parts of HEV powertrain, is given. Then DP is applied to this model in order to verify the effect of cost function on maximizing energy recovery. In the simulation, the amount of energy recovery using DP is about 70kJ for 40 engine stop events over FTP 4-bag cycle. In addition, based on the DP result, a look-up table based real-time control is developed in the small size HEV. This experiment results in an improvement of 0.7 % better mileage in FTP 4-bag cycle. Copyright © 2016 SAE International.

关键词： Dynamic programming

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