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Age at menarche by birth cohort: A pooled analysis of half a million women in Asia

Public Health 2024年 237卷 130-134页

作者： Abe, Sarah K. Nishio, Marisa Huang, Hsi-Lan Leung, Chi Yan Islam, Md Rashedul Rahman, Md Shafiur Saito, Eiko Shin, Aesun Merritt, Melissa A. Choi, Ji-Yeob Katagiri, Ryoko Mohammadi, Zahra Shu, Xiao-Ou Wakai, Kenji Sawada, Norie Ideno, Yuki Tamakoshi, Akiko Seow, Wei Jie Koh, Woon-Puay Sakata, Ritsu Hozawa, Atsushi Kim, Jeongseon Nagata, Chisato Sugawara, Yumi Park, Sue K. Kweon, Sun-Seog Azizi, Fereidoun Malekzadeh, Reza Moy, Foong-Ming Pourfarzi, Farhad Gao, Yu-Tang Kubo, Yoko Hirabayashi, Mayo Nagai, Kazue Kimura, Takashi Yuan, Jian-Min Kanemura, Seiki Wada, Keiko Kang, Daehee Shin, Min-Ho Khalili, Davood Poustchi, Hossein Rezaianzadeh, Abbas Mansour-Ghanaei, Fariborz Najafi, Farid Mohebbi, Iraj Boffetta, Paolo Lee, Jung Eun Matsuo, Keitaro Rothman, Nathaniel Qiao, You-Lin Zheng, Wei Inoue, Manami Division of Prevention National Cancer Center Institute for Cancer Control Japan Hitotsubashi Institute for Advanced Study Hitotsubashi University Japan Research Center for Child Mental Development Hamamatsu University School of Medicine Japan Sustainable Society Design Center Graduate School of Frontier Sciences the University of Tokyo Japan Department of Preventive Medicine Seoul National University College of Medicine Seoul South Korea Cancer Research Institute Seoul National University Seoul South Korea The Daffodil Centre The University of Sydney a joint venture with Cancer Council NSW Sydney NSW Australia Department of Biomedical Sciences Seoul National University Graduate School Seoul South Korea Graduate School of Informatics Faculty of Informatics Chiba University Japan Liver and Pancreatobiliary Diseases Research Center Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Division of Epidemiology Department of Medicine Vanderbilt Epidemiology Center Vanderbilt-Ingram Cancer Center Vanderbilt University Medical Center Nashville TN United States Department of Preventive Medicine Nagoya University School of Medicine Nagoya Japan Division of Cohort Research National Cancer Center Institute for Cancer Control Japan Gunma University Center for Food Science and Wellness Maebashi Japan Department of Public Health Hokkaido University Faculty of Medicine Sapporo Japan Saw Swee Hock School of Public Health and Department of Medicine National University of Singapore and National University Health System Singapore Healthy Longevity Translational Research Programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Institute for Clinical Sciences Agency for Science Technology and Research (A∗STAR) Singapore Department of Epidemiology Radiation Effects Research Foundation Hiroshima Japan Division of Epidemiology Department of Public Health and Forensic Medicine Tohoku University Graduate School

Objectives: To evaluate changes in the age at menarche in Asian populations. Study design: Retrospective cohort study. Methods: We included 548,830 women from six countries in Asia. The data were sourced from 20 cohorts participating in the Asia Cohort Consortium (ACC) and two additional cohort studies: Japan Multi-institutional Collaborative Cohorts (J-MICC), and Japan Nurse Health Study (JNHS) with data on age at menarche. Joinpoint regression was used to evaluate changes in age at menarche by birth year and by country. Results: The study includes data from cohorts in six Asian countries namely, China, Iran, Japan, Korea, Malaysia and Singapore. Birth cohorts ranged from 1873 to 1995. The mean age of menarche was 14.0 years with a standard deviation (SD) of 1.4 years, ranged from 12.6 to 15.5 years. Over 100 years age at menarche showed an overall decrease in all six countries. China showed a mixed pattern of decrease, increase, and subsequent decrease from 1926 to 1960. Iran and Malaysia experienced a sharp decline between about 1985 and 1990, with APC values of −4.48 and −1.24, respectively, while Japan, South Korea, and Singapore exhibited a nearly linear decline since the 1980s, notably with an APC of −3.41 in Singapore from 1993 to 1995. Conclusions: Overall, we observed a declining age at menarche, while the pace of the change differed by country. Additional long-term observation is needed to examine the contributing factors of differences in trend across Asian countries. The study could serve as a tool to strengthen global health campaigns. © 2024 The Royal Society for Public Health

关键词： Age Asia Birth cohort Menarche

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COMMERCIAL APPLICATIONS OF advanced MARINE vehicleS FOR EXPRESS SHIPPING

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NAVAL ENGINEERS JOURNAL 1983年第3期95卷 283-300页

作者： LUEDEKE, G FARNHAM, RB JR. George Luedeke Jr.: received his BS degree in Mechanical Engineering from Massachusetts Institute of Technology and his MS degree in Product Design from Illinois Institute of Technology. Early in his career Mr. Luedeke joined General Motors Corporation as a designer responsible for development of people mover and rail rapid transit systems. From 1964 to 1974 he was with Hughes Aircraft Company. At Hughes he performed analyses and developed designs for a wide variety of program and proposal efforts such as: High Speed Ground Transportation (DOT) Task Force Command Center (NAVY) Panama Canal Marine Traffic Control Center (Panama Canal Co.) Royal Iranian Navy Command Center (Iran) Tactical Information Processing and Interpretation Center (Air Force) and WALLEYE CONDOR and PHOENIX Missile Systems (NAVY). He also had marketing development responsibilities related to the diversification of Hughes resources in civil business areas such as: Automatic train control (WMATA BARTD SCRTD) water/sewage treatment plant automation (Santa Clara County) Aqueduct Control (SWR) Hydrometeorological data collection (BPA WMO) and Salton Sea basin systems analysis (Dept. of the Interior). He was responsible for combat system integration for the Hughes 2000T Surface Effect Ship (SES) proposal. He also conducted detailed studies concerning ship flexure for the Improved Point Defense Target Acquisition System Program and for the definition of operational High Energy Laser weapon installations on a series of conventional monohulls (DLG DD and CVN). Since 1974 Mr. Luedeke has been employed at RMI Inc. (formerly Rohr Marine Inc.). During this time he has held several positions. His responsibilities have included directing a number of studies on advanced SES concepts managing activities defining mission/cost effectiveness of military and commercial SES's including defining the operational benefits and enhanced survivability characteristics of cargo SES's for high speed military sealiftfor NA TO and Southeast Asia

This paper will present the results of a marketing, engineering, and economic analysis of advanced marine vehicles done by IMA Resources, Inc. and RMI, Inc., in support of a Maritime Administration project to study “Multimode Express Shipping”. The study was conducted in 1981 and examined the economic benefits of using advanced marine vehicles as express cargo vessels in domestic and international service. Commodity characteristics, desirable express carrier rates, and potential high payoff service and route alternatives were identified. advanced marine vehicles were surveyed and sized to meet desirable deadweight and block speed objectives. The costs of operating these craft on a variety of trade routes were calculated using an advanced marine vehicle economic analysis program. Revenues, expenses, break-even, profit and loss, cash flow requirements, tax summary and economic indicators (i.e., cost/ton – mile, etc.) were projected over the expected life of the vehicles as was return on investment. Traffic density and market penetration considerations narrowed the field of choice to smaller sized advanced marine vehicle carriers (i.e., 50 and 250 ton deadweight) and to three international and five domestic routes.

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THE USE OF MAINTENANCE DATA TO IMPROVE FLEET MAINTENANCE PRACTICES

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Naval Engineers Journal 1978年第6期90卷 25-36页

作者： REINES, J. MCCORMICK, J.P. Mr. J. Reinesis a Program Manager with ARINC Research Corporation an Annapolis Md. based consulting engineering corporation where in addition to management of DDEOC development he is responsible for the acquisition and direction of the Company's work in support of operational ships and ship systems. Before joining ARINC Research he worked for the newly formed Litton Advanced Marine Technology Division. where as Manager System Engineering and Analysis and Director System Assurance he had responsibilities in a variety of areas including Reliability Maintainability Human. Engineering System Safety Operations Analysis and the operational and maintenance training of LHA I and DD 963 Class Navy crews. Mr. Reines received his BS degree from Columbia University in 1951 after his service in the U.S. Navy as an Aviation Machinist Mate/Combat Air Crewman. During his 27–year career since then he has worked in the automotive and aerospace industries and as a Consultant to industry and the military. Mr. John P. McCormickis a Principal Engineer and Group Manager in ARINC Research Corporation's Ships and Ordnance Division. He has been with ARINC Research since 1963 when he joined the Company to participate in reliability studies of NASA's SATURN Launch Vehicle. He was Project Leader of a comprehensive study of the Air Force Jet Engine Maintenance Management Program has conducted a number of studies involving the use of Army Maintenance Data and has considerable experience in the use and analysis of Navy Maintenance Data. Currently he is managing a number of projects involving the analysis of Navy Destroyer and Submarine Maintenance Information. Mr. McCormick received his BS degree in Physics from St. Bonaventure University in 1959. after which he was employed by the U.S. Naval Propellant Plant as an Internal Ballistics Specialist.

The purpose of this paper is to explain and demonstrate the value of using historical Navy maintenance data in analyses for developing improved Fleet maintenance practices. The Navy produces great volumes of maintenance and maintenance—related data on its ships, ship systems, and equipments. Analyses of these data by persons familiar with the intricacies of the data and the systems involved can provide the information and insight needed to evaluate present practices and develop improved Fleet maintenance. This paper identifies specific data elements, together with their sources, that have proven to be most useful. Capabilities of the data are highlighted, and the general analysis approach is described. A number of case studies are presented to trace the use of various data elements from their source, through analysis, to the requirements for improved maintenance practices. © 1978 American Society of Naval Engineers

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Shipboard controls of the future

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Naval Engineers Journal 1997年第3期109卷 143-153页

作者： Amy Jr., J.V. Doerry, N.H. McCoy, T.J. Zivi, E.L. Udr. John V. Amy Jr.:USN graduated from the United States Naval Academy with a B.S.E.E. degree in 1983 and then served as antisubmarine warfare officer on USS Boone (FFG 28). He then reported to M.I.T where he earned an S. M. E. E. C.S. degree Naval Engineer degree and a Ph.D. in naval electric power systems. An engineering duty oficez he was assistant project officer for aircraft carrier overhaul at Supervisw of Shipbuilding Conversion and Repail: USN Newport Nms Virginia assigned to the refueling complex overhaul of USS Enterprise (CVN 65) and her subsequent post-shakedown avail-ability. Presently he is the deputy program manager for the Integrated Power System (IPS) Program at the Naval Sea systems command. Udr. Norbert H. Doerry USN:graduated from the United States Naval Academy with a B.S.E.E. degree in 1983 and then served as gunnery and fire control officer on USS Deyo (DD 989). He then reported to M.I.T where he earned a S.M.E.E.C.S. degree Naval Engineer degree and a Ph.D. in naval electrical power systems. An engineering duty officer he was assigned to the Advanced Surfme Machinery Programs for the development athe Integrated Power System from 1992 to 1995. Presently he is assistant project officer for aircrafi carrier construction at Supervisor of Shipbuilding Conversion and Repair: USN Newport News Virginia. LCdr. Timothy J. McCoy USN:graduated from the Univer-sity of Illinois with a B.S. degree in marine engineering in 1982. He was cmnmissirmed in 1985 and served as jrst lieuten-ant and communications officer on USS John Young (DD 973). He then was assigned to Supervisor of Shipbuilding Conversion and Repair USN San Diego California as repair ship superin-tendent repair project manager and new construction ship superintendent. Subsequently he attended M.I.T earning a S.M.E.E.C.S. degree Naval Engineer degree and a Ph.D. in naval engineering. Presently he is assigned to Naval Surface Warfare Center Carderock Division Annapolis Detachment where he works as the technical manager f

Recent advances in computer networking and control system technologies present an opportunity to improve the capability of naval shipboard control systems. Most existing digital machinery control systems merely replace one-for-one their analog predecessors. These recent advances motivate rethinking the basic role and architecture of shipboard controls. Traditional machinery system control has remained largely separate from combat systems and other ship information systems. Existing machinery control systems have concentrated on four functions: machinery status, control, system stability, and fault response. To implement these functions, custom systems have been designed, built and debugged for each class of ship. This lack of commonality has been expensive in terms of development costs, maintenance costs over the lifetime of the ship, and also the unrealized benefits stemming from prohibitive costs of adapting machinery controls to take advantage of emerging technologies. This paper proposes a new paradigm for developing a shipboard control system based upon a functional decomposition of ships' missions that leads to defining technology independent interface standards. Multiple vendors may be able to independently develop control system hardware and software elements adhering to such interface standards without a priori knowledge of a particular ship application, leading to the ability to develop a total ship control system with low risk by integrating proven hardware and software elements to meet specific ship design requirements. With this new concept, other functions not normally associated with machinery controls are feasible: spontaneous reconfiguration after a damage event, integrated training, condition based maintenance planning, data archiving, operator assistance, and configuration management. This new approach may also allow for the integration of machinery controls into a total ship control system with seamless support for combat systems. This new shipbo

关键词： Naval vessels

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HYBRID SATELLITE AND TERRESTRIAL NETWORKS

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INTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS 1994年第3期12卷 313-327页

作者： CHITRE, DM SHYY, DJ EPHREMIDES, A GUPTA, S COMSAT Laboratories 22300 Comsat Drive Clarksburg MD 20871–9475 USA. Received his B.Sc. from the University of Bombay India an M.A. in mathematics from the University of Cambridge U.K. and a Ph.D. in physics from the University of Maryland. He is currently an Associate Executive Director of the Network Technology Division at COMSAT Laboratories. He has been involved in research and development activities in ISDN VSAT networks data communications and network systems and architectures. Prior to his current positions Dr. Chitre was a Principal Scientist in the Network Technology Division at COMSAT Laboratories. Dr. Chitre joined COMSAT Laboratories in 1980. He has made major contributions to the analysis and architecture of data communication ISDN and BISDN via satellite. Dr. Chitre directs and participates in the international and national standards activities in ISDN BISDN and data communication as they apply to satellite communication. He was Chairman of the Working Group on Protocols and Network Timing Function of the CCIR/CCITT Joint Ad Hoc Group on ISDN/Satellite Matters during 1990–1992. Currently he is the Chairman of the Working Group on New Technologies in the ITU Intersector Coordinating Group (ICG) on Satellite Matters. Dr. Chitre was a programme manager during 1990 and 1991 on a contract from INTELSAT on systems studies on satellite communications systems architectures for ISDN and broadband ISDN systems. Currently he is the technical manager of the DoD Contract on ATM via satellite demonstration and the programme manager for the INTELSAT contract on analysis and top-level specification of INTELSAT ISDN subnetworks and SDH compatible transport network. Received the B.S. degree in electrical engineering from national Chiao-Tung University Hsin-Chu Taiwan in 1983 and the M.S. and Ph.D. degrees in electrical engineering from Georgia Institute of Technology Atlanta GA in 1986 and 1990 respectively. From June 1987 to October 1987 he worked for the Department of Neurology Emory Univers

The role of satellite communications in networks that provide new services, such as frame relay and multimedia, is investigated. Both passive and active (on-board switching/processing) satellite systems are considered. Novel techniques are developed for each system to demonstrate, via detailed analysis and simulation, how the communications bandwidth agility of multipoint/broadcast satellite channels, and the on-board switching/processing, makes it feasible to provide these new services via hybrid satellite and terrestrial networks in a resource-efficient manner.

关键词： HYBRID NETWORKS ON-BOARD PROCESSING FRAME RELAY

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COMPUTER-system ARCHITECTURE CONCEPTS FOR FUTURE COMBAT systemS

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NAVAL ENGINEERS JOURNAL 1990年第3期102卷 43-62页

作者： ZITZMAN, LH FALATKO, SM PAPACH, JL Dr. Lewis H. Zitzman:is the group supervisor of the Advanced Systems Design Group Fleet Systems Department The Johns Hopkins University Applied Physics Laboratory (JHU/APL). He has been employed at JHU/APL since 1972 performing applied research in computer science and in investigating and applying advanced computer technologies to Navy shipboard systems. He is currently chairman of Aegis Computer Architecture Data Bus and Fiber Optics Working Group from which many concepts for this paper were generated. Dr. Zitzman received his B.S. degree in physics from Brigham Young University in 1963 and his M.S. and Ph.D. degrees in physics from the University of Illinois in 1967 and 1972 respectively. Stephen M. Falatko:was a senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated for the majority of this effort. He is currently employed at ManTech Services Corporation. During his eight-year career first at The Johns Hopkins University Applied Physics Laboratory and currently with ManTech Mr. Falatko's work has centered around the development of requirements and specifications for future Navy systems and the application of advanced technology to Navy command and control systems. He is a member of both the Computer Architecture Fiber Optics and Data Bus Working Group and the Aegis Fiber Optics Working Group. Mr. Falatko received his B.S. degree in aerospace engineering with high distinction from the University of Virginia in 1982 and his M.S. degree in applied physics from The Johns Hopkins University in 1985. Mr. Falatko is a member of Tau Beta Pi Sigma Gamma Tau the American Society of Naval Engineers and the U.S. Naval Institute. Janet L. Papach:is a section leader and senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated. She has ten years' experience as an analyst supporting NavSea Spa War and the U.S. Department of State. She currently participates in working group efforts under Aegis Combat System Doctrin

This paper sets forth computer systems architecture concepts for the combat system of the 2010–2030 timeframe that satisfy the needs of the next generation of surface combatants. It builds upon the current Aegis computer systems architecture, expanding that architecture while preserving, and adhering to, the Aegis fundamental principle of thorough systems engineering, dedicated to maintaining a well integrated, highly reliable, and easily operable combat system. The implementation of these proposed computer systems concepts in a coherent architecture would support the future battle force capable combat system and allow the expansion necessary to accommodate evolutionary changes in both the threat environment and the technology then available to effectively counter that threat. Changes to the current Aegis computer architecture must be carefully and effectively managed such that the fleet will retain its combat readiness capability at all times. This paper describes a possible transition approach for evolving the current Aegis computer architecture to a general architecture for the future. The proposed computer systems architecture concepts encompass the use of combinations of physically distributed, microprocessor-based computers, collocated with the equipment they support or embedded within the equipment itself. They draw heavily on widely used and available industry standards, including instruction set architectures (ISAs), backplane busses, microprocessors, computer programming languages and development environments, and local area networks (LANs). In this proposal, LANs, based on fiber optics, will provide the interconnection to support system expandability, redundancy, and higher data throughput rates. A system of cross connected LANs will support a high level of combat system integration, spanning the major warfare areas, and will facilitate the coordination and development of a coherent multi-warfare tactical picture supporting the future combatant command st

关键词： Computer Architecture

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Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report

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Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2024年第4期20卷 521-530页

作者： Batel Blechter Chao Agnes Hsiung Xiaoyu Wang Haoyu Zhang Wei Jie Seow Jianxin Shi Nilanjan Chatterjee Hee Nam Kim Maria Pik Wong Yun-Chul Hong Jason Yy Wong Juncheng Dai H Dean Hosgood Zhaoming Wang I-Shou Chang Jiyeon Choi Jiucun Wang Minsun Song Wei Hu Wei Zheng Jin Hee Kim Baosen Zhou Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Roel C H Vermeulen Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Yukihide Momozawa Yoichiro Kamatani Takayuki Honda Hideo Kunitoh Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Hsien-Chih Lin Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Tzu-Yu Chen Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Junwen Wang Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Chung-Hsing Chen Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jun Suk Kim Ho-Il Yoon Qiuyin Cai In Kyu Park Ping Xu Qincheng He Chih-Yi Chen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Joseph F Fraumeni Jie Liu Maria Teresa Landi Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Hongxia Ma Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Motoki Iwasaki Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Fang-Yu Tsai Jinming Yu Victoria L Stevens Pan-Chyr Yang Dongxin Lin Kexin Chen Yi-Long Wu Keitaro Matsuo Nathaniel Rothman Kouya Shiraishi Hongbing Shen Stephen J Chanock Takashi Kohno Qing Lan Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore. Department of Oncology School of Medicine Johns Hopkins University Baltimore MD USA Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology Queen Mary Hospital Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Epidemiology and Community Health Branch National Heart Lung and Blood Institute Bethesda MD USA. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Epidemiology and Population Health Albert Einstein College of Medicine New York USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Department of Statistics & Research Institute of Natural Sciences Sookmyung Women's University Seoul 04310 Korea. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Environmental Health

We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the epidermal growth factor receptor (EGFR) gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4,544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared to EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (OR=8.63, 95% CI:5.67, 13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (OR=3.50, 95% CI: 2.44, 5.00) (p-heterogeneity=3.66x10). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.

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THE CALLING(SM) NETWORK - A GLOBAL WIRELESS COMMUNICATION-system

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INTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS 1994年第1期12卷 45-61页

作者： TUCK, EF PATTERSON, DP STUART, JR LAWRENCE, MH Calling Communications Corporation. 1900 West Garvey Ave South. Suite 200 West Covina CA 91790 USA. Chairman of Calling Communications Corporation. He is also the Managing Director of Kinship Venture Management Inc. the general partner of Kinship Partners 11 and a General Partner of Boundary the general partner of The Boundary Fund. As a venture capitalist he has founded or participated in founding several telecommunications companies including Calling Communications Corporation Magellan Systems Corporation manufactures of Global Positioning System receivers Applied Digital Access manufacturer of DS-3 test access and network performance monitoring equipment Endgate Technology Corporation specialists in satellite phased array antennas and Poynting Systems Corporation. now a division of Reliance Corporation manufacturers of fibre optic transport equipment. He was a founder of Kebby Microwave Corporation where he invented the first solid-state. frequency-modulated commercial microwave link system. The company was acquired by ITT Corporation where he rose to the position of V.P. and Technical Director of ITT North America Telecommunications Inc. Subsequently he was V.P. of Marketing and Engineering at American Telecommunications Inc. (ATC). He was founding Director of American Telecom Inc. a joint venture between ATC and Fujitsu and has served on more than 20 boards of directors including those of three public companies. He has authored articles on microwave engineering and telephone signalling and was a contributor to Reference Data For Radio Engineers. He is a graduate of the University of Missouri at Rolla where he was later awarded an honorary Professional degree and serves on its Academy of Electrical Engineering. Mr Tuck is a Senior Member of the IEEE a Fellow of the Institution of Engineers (Australia) a Professional Member of the AIAA and a registered professional engineer in three states. More than 25 years of experience in the telecommunications industry where he has been responsibl

There is a very large demand for basic telephone service in developing nations, and remote parts of industrialized nations, which cannot be met by conventional wireline and cellular systems. This is the world's largest unserved market. We describe a system which uses recent advances in active phased arrays, fast-packet switching technology, adaptive routeing, and light spacecraft technology, in part based on the work of the Jet Propulsion Laboratory and on recently-declassified work done on the Strategic Defense Initiative, to make it possible to address this market with a global telephone network based on a large low-Earth-orbit constellation of identical satellites. A telephone utility can use such a network to provide the same modern basic and enhanced telephone services offered by telephone utilities in the urban centres of fully-industrialized nations. Economies of scale permit capital and operating costs per subscriber low enough to provide a service to all subscribers, regardless of location, at prices comparable to the same services in urban areas of industrialized nations, while generating operating profits great enough to attract the capital needed for its construction. The bandwidth needed to support the capacity needed to gain these economies of scale requires that the system use K(alpha)-band frequencies. This choice of frequencies places unusual constraints on the network design, and in particular forces the use of a large number of satellites. Global demand for basic and enhanced telephone service is great enough to support at least three networks of the size described herein. The volume of advanced components, and services such as launch services, required to construct and replace these networks is sufficient to propel certain industries to market leadership positions in the early 21st Century.

关键词： LOW EARTH ORBIT SATELLITE COMMUNICATIONS FAST PACKET SWITCHING EARTH FIXED CELLS ADAPTIVE ROUTEING LIGHT SPACECRAFT K(A) BAND PHASED-ARRAY ANTENNAS

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Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

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Nature communications 2025年第1期16卷 4235-4235页

作者： Cecilia Anza-Ramirez J. Jaime Miranda Benedetta Armocida Jorge César Correia Harriette Gillian Christine Van Spall David Beran Amirali Aali Kalkidan Hassen Abate Semagn Mekonnen Abate Cristiana Abbafati Mohsen Abbasi-Kangevari Zeinab Abbasi-Kangevari Zahra Aryan Sina Azadnajafabad Mohammadreza Azangou-Khyavy Seyyed-Hadi Ghamari Mohammad Keykhaei Javad Khanali Sara Momtazmanesh Fateme Montazeri Shayan Rahmani Mohammad-Mahdi Rashidi Nazila Rezaei Negar Rezaei Sahar Saeedi Moghaddam Hossein Hassanian-Moghaddam Ali-Asghar Kolahi Ali Nikoobar Hedayat Abbastabar Ahmed M. Abdel-Azeem Michael Abdelmasseh Juan Sanabria Sherief Abd-Elsalam Ahmed Abdelwahab Gholamreza Abdoli Mohammad Abdollahi Meriem Abdoun Deldar Morad Abdulah Abu Yousuf Md Abdullah Ame Mehadi Abdurehman Getachew Abebe Aidin Abedi Chirag P. Doshi Vida Abedi Hassan Abidi Richard Gyan Aboagye Hassan Abolhassani Nima Rezaei Lucas Guimarães Abreu Michael R. M. Abrigo Yonas Derso Abtew Hiwa Abubaker Ali Eman Abu-Gharbieh Hiba Jawdat Barqawi Rabih Halwani Maha Mohamed Saber-Ayad Iman M. Talaat Ahmed Abu-Zaid Manfred Mario Kokou Accrombessi Juan Manuel Acuna Denberu Eshetie Adane Tigist Demssew Adane Isaac Yeboah Addo Giovanni Addolorato Oluwafemi Atanda Adeagbo Victor Adekanmbi Miracle Ayomikun Adesina Isaac Iyinoluwa Olufadewa Olatunji O. Adetokunboh Daniel Adedayo Adeyinka Qorinah Estiningtyas Sakilah Adnani Aanuoluwapo Adeyimika Afolabi Olayinka Stephen Ilesanmi Muhammad Sohail Afzal Saira Afzal Gina Agarwal Prerna Agarwal Pradyumna Agasthi Anurag Agrawal Marcela Agudelo-Botero Adolfo Martinez-Valle Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Sohail Ahmad Tauseef Ahmad Ali Ahmadi Siamak Sabour Keivan Ahmadi Sanjay Basu Sepideh Ahmadi Ali Ahmed Shaun Wen Huey Lee Ayman Ahmed Haroon Ahmed Jivan Qasim Ahmed Gahin Abdulraheem Tayib Yahya Yahya Luai A. Ahmed Iffat Elbarazi Syed Mahboob Shah Janardhana P. Aithala Marjan Ajami Budi Aji Hossein Akbarialiabad Yibeltal Akelew Meisam Akhlaghdoust Elham Jamshidi Addis Aklilu Azene Tesfaye Melat Woldemariam Maxwell Ak CRONICAS Center of Excellence in Chronic Diseases Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Peruana Cayetano Heredia Lima Peru Sydney School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine London UK Division of Tropical and Humanitarian Medicine University of Geneva Geneva Switzerland Department of Cardiovascular Endocrine-metabolic Diseases and Aging Istituto Superiore di Sanità Rome Italy Division of Endocrinology Diabetology Nutrition and Therapeutic Patient Education Department of Medicine Geneva University Hospitals Geneva Switzerland Department of Medicine and Department of Health Research Evidence and Impact McMaster University Hamilton ON Canada Research Institute of St. Joe’s Hamilton ON Canada Population Health Research Institute Hamilton Canada Geneva University Hospitals Geneva Switzerland Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Nutrition and Dietetics Jimma University Jimma Ethiopia Anesthesiology Department Dilla University Addis Ababa Ethiopia Department of Juridical and Economic Studies La Sapienza University Rome Italy Non-Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Brigham and Women’s Hospital Harvard University Boston MA USA Students’ Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Institute Tehran University of Medical Sciences Tehran Iran Chapter of Addiction Medicine University of Sydney Sydney NSW Australia Advanced Diagnostic and Intervent

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © 2025. The Author(s).

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BOTTOM BOUNCE ARRAY SONAR SUBMARINE (BBASS)

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NAVAL ENGINEERS JOURNAL 1989年第5期101卷 59-72页

作者： JACKSON, HA NEEDHAM, WD SIGMAN, DE USN (RET.) Capt. Harry A. Jackson USN (Ret.) is a graduate of the University of Michigan in naval architecture and marine engineering and completed the General Electric Company's 3-year advanced engineering course in nuclear engineering. He has been an independent consulting engineer and participated in projects involving deep submergence waste disposal water purification and submarine design both commercial and government. Cdr. William D. Needham USN is currently assigned as the repair officer of USS Hunley (AS-31) in Norfolk Virginia. He received a regular commission through NROTC at Duke University where he graduated magna cum laude in mechanical engineering. Selected for the Nuclear Power Program he served as a division officer on the USS Grayling (SSN-646) as the production training assistant at the MARE Prototype Reactor in New York and as blue crew engineer of the USS Nathan Hale (SSBN-623) where he completed the requirements to be designated qualified for command of submarines. Following line transfer to the EDO community in 1981 he completed a tour as nuclear repair officer (Code 310) at Norfolk Naval Shipyard and earned master of science in materials science and ocean engineer's degrees at MIT. His awards include the Meritorius Service Medal Navy Commendation Medal Navy Achievement Medal Spear Foundation Award and the Vice Admiral C.R. Bryan Award. Cdr. Needham also holds a master of arts degree in business management from Central Michigan University. Capt. Jackson was technical director of Scorpion Search Phase II. The on-site investigation included descending over 12 000 feet to the bottom of the ocean. He was also supervisor of one of the Navy's largest peacetime shipbuilding and repair programs. His responsibilities included supervision of design production and contract administration. Capt. Jackson was third from the top in managaement of a major shipyard and responsible for design material procurement work order and financial control of two major surface ship prototypes as well a

Anticipated technological advances in the quieting of potential adversary submarines mandate the use of increasingly effective detection systems for U.S. ASW forces. Based on the assumptions that sonar will continue to be the primary means of detection and that the effectiveness of each individual sonar element will not change markedly, one must increase the projected area of the sonar array to improve its capability. The primary SSN mission of anti-submarine warfare will hence require increasing the hull area devoted to the primary sonar detection system. A revolutionary hull form is proposed that maximizes the area available for this purpose. The advantages and disadvantages of this hull form are discussed and feasibility study level design parameters and arrangements presented.

关键词： Submarines

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