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Molecular docking and molecular dynamics simulation studies of inhibitor candidates against Anopheles gambiae 3-hydroxykynurenine transaminase and implications on vector control

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Heliyon 2025年第1期11卷 e41633页

作者： Adedeji, Eunice O. Ogunlana, Olubanke O. Oduselu, Gbolahan O. Koenig, Rainer Adebiyi, Ezekiel Soremekun, Opeyemi S. Fatumo, Segun Covenant University Bioinformatics Research (CUBRe) Covenant University Ogun State Ota Nigeria Department of Biochemistry Covenant University Ogun State Ota Nigeria Department of Biology University of York York United Kingdom Covenant Applied Informatics and Communication Africa Centre of Excellence Covenant University Ota Nigeria Institute for Infectious Diseases and Infection Control (IIMK RG Systems Biology) Jena University Hospital Am Klinikum 1 Jena 07747 Germany African Center of Excellence in Bioinformatics & Data Intensive Science Makerere University Kampala 10218 Uganda Division of Applied Bioinformatics German Cancer Research Center (DKFZ) G200 Im Neuenheimer Feld 280 Heidelberg 69120 Germany The African Computational Genomics (TACG) Research Group MRC/UVRI and LSHTM Entebbe Uganda Precision Healthcare University Research Institute Queen Mary University of London United Kingdom Department of Non-Communicable Disease Epidemiology London School of Hygiene & Tropical Medicine United Kingdom

Isoxazole and oxadiazole derivatives inhibiting 3-hydroxykynurenine transaminase (3HKT) are potential larvicidal candidates. This study aims to identify more suited potential inhibitors of Anopheles gambiae 3HKT (Ag3HKT) through molecular docking and molecular dynamics simulation. A total of 958 compounds were docked against Anopheles gambiae 3HKT (PDB ID: 2CH2) using Autodock vina and Autodock4. The top three identified hits were subjected to 300 ns molecular dynamics simulation using AMBER 18 and ADMET analysis using SWISSADME predictor and ADMETSAR. Replacement of alkyl attachment on C5 of isoxazole or oxadiazole derivative with a cycloalkyl group yielded compounds with lower binding energy than their straight chain counterparts. The top three compounds were brominated compounds, 2‐[3‐(4‐bromophenyl)‐1,2‐oxazol‐5‐yl]cyclopentane‐1‐carboxylic acid, 2-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]cyclopentane-1-carboxylic acid, 3-[3-(4-bromo-2-methylphenyl)-1,2,4-oxadiazol-5-yl]cyclopentane-1-carboxylic acid, and they had binding energies of −8.58, −8.25, and −8.18 kcal/mol in virtual screening against 2CH2 protein target, respectively. These compounds were predicted to be less toxic than temephos, a standard larvicide and more biodegradable than previously reported inhibitors. The three compounds exhibited a greater stabilizing effect on 2CH2 protein target than 4-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]butanoic acid, a previously reported inhibitor candidate with good larvicidal activity on Aedes aegypti. Further thermodynamic calculations revealed that the top three compounds possessed total binding energies (ΔG_bind) of −26.64 kcal/mol, −24.26 kcal/mol and −14.11 kcal/mol, respectively, as compared to −12.02 kcal/mol for 4-[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]butanoic acid. These compounds could be better larvicides than previously reported isoxazole or oxadiazole derivatives and safer than temephos. © 2025 The Authors

关键词： 1,2,4-Oxadiazole 3HKT Isoxazoles Larvicide Mosquito Vector control

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Employing Hexahydroquinolines as PfCDPK4 Inhibitors to Combat Malaria Transmission: An Advanced Computational Approach

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Advances and Applications in bioinformatics and Chemistry 2024年 17卷 83-105页

作者： Oduselu, Gbolahan O Elebiju, Oluwadunni F. Ogunnupebi, Temitope A. Akash, Shopnil Ajani, Olayinka O. Adebiyi, Ezekiel Covenant University Bioinformatics Research (CUBRe) Covenant University OG Ota Nigeria Department of Chemistry Covenant University OG Ota Nigeria Department of Pharmacy Daffodil International University Dhaka Bangladesh African Center of Excellence in Bioinformatics & Data Intensive Science Makerere University Kampala Uganda Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany

Background: Existing antimalarial drugs primarily target blood-stage parasites, but there is a need for transmission-blocking drugs to combat malaria effectively. Plasmodium falciparum Calcium-dependent Protein Kinase 4 (CDPK4) is a promising target for such drugs. This study employed advanced in silico analyses of hexahydroquinolines (HHQ) derivatives to identify PfCDPK4 inhibitors capable of disrupting malaria transmission. Structure-based virtual screening (SBVS) was employed to discover HHQ derivatives with the highest binding affinities against the 3D structure of PfCDPK4 (PDB 1D: 4QOX). Methods: Interaction analysis of protein-ligand complexes utilized Discovery Studio Client, while druglikeness and ADMET properties were assessed using SwissADME and pkCSM web servers, respectively. Quantum mechanical calculations of the top hits were conducted using density functional theory (DFT), and GROMACS was employed to perform the molecular dynamics (MD) simulations. Binding free energy was predicted using the *** tool from the AMBER package. Results: SBVS identified ten best hits possessing docking scores within the range of −11.2 kcal/mol and −10.6 kcal/mol, surpassing the known inhibitor, BKI-1294 (−9.9 kcal/mol). Among these, 4-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-(naphthalen-2-ylmethyl)- 2-oxo-4a,5,6,7,8,8a-hexahydroquinoline-3-carbonitrile (PubChem ID: 145784778) exhibited the highest binding affinity (−11.2 kcal/ mol) against PfCDPK4. Conclusion: Comparative analysis of this compound with BKI-1294 using advanced computational approaches demonstrated competitive potential. These findings suggest the potential of 4-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-(naphthalen-2-ylmethyl)- 2-oxo-4a,5,6,7,8,8a-hexahydroquinoline-3-carbonitrile as a promising PfCDPK4 inhibitor for disrupting malaria transmission. However, further experimental studies are warranted to validate its efficacy and safety profile. © 2024 Oduselu et al.

关键词： antimalarial drugs drug design gametocidal activity malaria molecular dynamics

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The role of MLH1, MSH2 and MSH6 in the development of colorectal cancer in Uganda

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BMC Cancer 2025年第1期25卷 1-13页

作者： Wismayer, Richard Matthews, Rosie Whalley, Celina Kiwanuka, Julius Kakembo, Fredrick Elishama Thorn, Steve Wabinga, Henry Odida, Michael Tomlinson, Ian Department of Surgery Masaka Regional Referral Hospital Masaka Uganda Department of Surgery Faculty of Health Sciences Equator University of Science and Technology Masaka Uganda Department of Surgery Faculty of Health Sciences Habib Medical School IUIU University Kampala Uganda Department of Pathology School of Biomedical Sciences College of Health Sciences Makerere University Kampala Uganda Institute of Genetics and Cancer College of Medicine and Veterinary Medicine University of Edinburgh Edinburgh United Kingdom Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences University of Birmingham Birmingham United Kingdom Department of Epidemiology and Biostatistics College of Health Sciences Makerere University Kampala Uganda Department of Immunology and Molecular Biology School of Biomedical Sciences College of Health Sciences Makerere University Kampala Uganda African Centre of Excellence in Bioinformatics and Data Intensive Sciences Infectious Diseases Institute Makerere University Kampala Uganda Department of Oncology University of Oxford Oxford United Kingdom Department of Pathology Faculty of Medicine Gulu University Gulu Uganda

Introduction: In Uganda, colorectal cancer (CRC) is steadily increasing according to the Kampala Cancer Registry. In the West, microsatellite instability is detected in 90% of hereditary nonpolyposis colon cancers (HNPCC) which account for 1–2% of all CRC, and 15% of sporadic CRC. Germline mutations in MLH1 and MSH2 account for 90% of HNPCC in the West, whilst the remainder of cases are due to mutations in MSH6 and PMS2. The aim of this study was to determine the microsatellite instability (MSI) status and determine the proportions of MLH1, MSH2, and MSH6 pathological mutations in Ugandan CRC patients. Methodology: This was a cross-sectional study carried out between 1st January 2008 to 15th September 2021. Patients were recruited prospectively from 16th September 2019 to 16th September 2021, from Masaka Regional Referral Hospital, Mulago National Referral Hospital, Uganda Martyrs’ Hospital Lubaga and Mengo Hospital. From 1st January 2008 to 15th September 2019, CRC FFPE tissue blocks were obtained from the archives of the Department of Pathology, Makerere University. data was abstracted from the medical case files for demographics, topography and stage. The histopathological subtype and grade of CRC were obtained by two consultant pathologists from the H&E slides. DNA was extracted from CRC formalin-fixed paraffin-embedded (FFPE) tissue blocks. Library preparation was completed using the Qiagen custom design panel. The custom panel represented 56 genes. The MLH-1, MSH2, MSH6, BRAF and KRAS genes were sequenced using the above library preparation and NGS sequencing. The MSI status was obtained if one of the MSI genes, MLH1, MSH2 or MSH6 was pathologically mutated. If none of the genes was pathologically mutated it was considered MSI negative, microsatellite stable (MSS). Immunohistochemistry was carried out to determine whether MLH1 and PMS2 was MMR proficient or deficient. Categorical data was summarized using frequencies and proportions corresponding to each of th

关键词： Colorectal cancer Immunohistochemistry Microsatellite instability (MSI) Microsatellite stable (MSS) Uganda

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369 Precision education and generative AI in surgery utilization study: A framework for global surgical education

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Journal of Clinical and Translational science 2025年第s1期9卷 114-114页

作者： Timothy Kintu Mike Nsubuga Allan Bakesiga Helen Please Kelsey Stewart Sergio M Navarro African Centre of Excellence in Bioinformatics and Data Intensive Sciences The Infectious Diseases Institute Makerere University P. O. Box 22418 Kampala Uganda The Infectious Diseases Institute Makerere University P. O. Box 22418 Kampala Uganda Faculty of Health Sciences University of Bristol Bristol BS40 5DU UK The African Center of Excellence in Bioinformatics and Data Intensive Sciences Kampala Uganda Makerere University Department of Surgery Kampala Uganda Duke University Department of Surgery Durham NC Oxford University Hospitals NHS Foundation Trust Oxford UK Harris Manchester College University of Oxford Oxford UK Mayo Clinic Department of Obstetrics and Gynecology Rochester MN US Mayo Clinic Department of Surgery Rochester MN US University of Minnesota Department of Surgery Minneapolis MN US

Objectives/Goals: Global surgical education is largely driven by high-income countries (HICs), with curricula not tailored to the needs of low- and middle-income countries (LMICs). This study assessed country-specific needs for global surgical curricula and used generative AI to develop tailored curricula. Methods/Study Population: A curriculum framework was developed using expert opinion. Using a focused needs assessment survey, we evaluated international medical students’ and trainees’ needs for structured global surgery curricula, covering research, education, data and develop tailored curriculum templates for each country, ensuring alignment with the distinct needs of respective LMIC and HIC respondents. The AI-generated curricula were then compared across countries to identify variations in content and focus areas. Results/Anticipated Results: A total of 145 respondents from 18 countries and 6 continents participated, with 94 from LMICs and 51 from HICs. Four countries [Uganda (n = 31), Nigeria (n = 34), the USA (n = 23), and the UK (n = 23)] had more than 10 respondents, with the creation of a country specific global surgery curriculum. Curricula developed by HIC trainees focused on access to resources and infrastructure, future directions of global surgical research, and the role of medical students and early career development with a decreased focus on the history of global surgery. LMIC country-based curriculum focused on introducing the concepts of global surgery, quantifying the burden and epidemiology of surgical disease and had a greater emphasis on case studies and use cases, with decreased focus on resources and collaboration. Discussion/Significance of Impact: The research introduces a “precision education” approach that could help close the surgical education access gap globally. Further pilot and qualitative studies are necessary to validate the feasibility of AI-generated needs-based curricula.

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FedMonitor: An Implementation Architecture for Monitoring of Resources and Events'Notifications on Federated Cloud Computing Infrastructures 4

FedMonitor: An Implementation Architecture for Monitoring of...

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4th International Conference on Emerging Trends in Networks and Computer Communications, ETNCC 2024

作者： Adetiba, Emmanuel Nnaji, Uche Wejin, John S. Ojesanmi, Festus Akanle, Matthew B. Ajayi, Priscilla O. Sweetwiliams, Faith O. Thakur, Surendra C. Adebiyi, Ezekiel F. Department of Electrical and Information Engineering and Covenant Applied Ota Nigeria HRA Institute for Systems Science Durban University of Technology Durban South Africa Covenant University Department of Computer and Information Science & CApIC-ACE Ota Nigeria Covenant University Department of Electrical and Information Engineering & CApIC-ACE Jalingo Nigeria Tareba State University Department of Computer Science Jalingo Nigeria Ota Nigeria Covenant University & CApIC-ACE Covenant University Department of Electrical and Information Engineering Ota Nigeria Covenant University Center for Systems and Information Services & CApIC-ACE Ota Nigeria Durban University of Technology e-Skills Co-Laboratory Department of Information Technology and KZN Durban4001 South Africa Covenant University Ogun State Ota Nigeria Makerere University African Center of Excellence in Bioinformatics & Data Intensive Science Kampala10218 Uganda

ISBN: (纸本)9798350353266

In the evolving landscape of cloud computing, federated cloud infrastructures present unique challenges and opportunities for resource and application monitoring. Monitoring the diverse array of cloud resources and applications within a federated cloud environment is crucial for delivering consistent Quality of Service (QoS) and continuous oversight across various cloud applications and infrastructure. Despite the various successes documented in the literature on multi-cloud monitoring, existing frameworks have not fully explored or provided enough insights into centralized monitoring of resources, applications, and network devices in a federated cloud environment. This paper introduces FedMonitor, an implementation architecture designed to enhance the monitoring and notification capabilities in federated cloud environments by building on the theoretical ideals in our earlier work (i.e. FEDARGOS-V1). FedMonitor leverages Prometheus and Grafana to crawl, manage and visualize metrics from diverse software services, hardware resources, and network devices within a federated cloud environment. The results demonstrate hat FedMonitor improves the effectiveness of resource and application monitoring in federated cloud environments. © 2024 IEEE.

关键词： Cloud platforms

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Docking of Human Band 3 Anion Transporter Proteins with Their Plasmodium falciparum Interactors Based on Short Linear Motifs

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American Journal of Molecular Biology 2024年第4期14卷 187-200页

作者： Fatoumata Gniné Fofana Ayoub Ksouri Cheickna Cisse Oussema Souiai Alia Benkahla Hedmon Okella Mamadou Sangare Jeffrey G. Shaffer Seydou Doumbia Mamadou Wele African Center of Excellence in Bioinformatics University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Laboratory of BioInformatics BioMathematics and BioStatistics (BIMS) Institut Pasteur de Tunis University of Tunis El Manar Tunis Tunisia School of Veterinary Medicine University of California Davis Tulare USA Department of Biostatistics and Data Science Tulane University School of Public Health and Tropical Medicine New Orleans USA University Clinical Research Centre (UCRC) USTTB Bamako Mali

Plasmodium (P.) falciparum is a pathogen that causes severe forms of malaria. Protein interactions have been shown to occur between P. falciparum and human erythrocytes in human blood. The Band 3 Anion Transporter (B3AT) protein is considered the main invasive pathway for the parasite in erythrocytes that causes clinical symptoms for malaria in humans. The interactions between P. falciparum parasites and erythrocytes along this receptor have previously been explored. Short linear motifs (SLIMs) are short linear mediator sequences that involve several biological processes, acting as mediators of protein interactions identifiable by computational tools such as SLiMFinder. For a given protein, the identification of SLIMs allows predicting its interactors. Using the SLIMs approach, protein-protein interaction network analyses between P. falciparum and its human host, were used to identify a tryptophan-rich protein, A5K5E5_PLAVS as an essential interactor of B3AT. To better understand the interaction mechanism, a guided protein-protein docking approach based on SLIM motifs was performed for human B3AT and A5K5E5_PLAVS. The highlights of this important interaction between P. falciparum and its human host have the potential to pave the way to identify new therapeutic candidates.

关键词： Malaria Protein-Protein Docking Protein-Protein Interaction Short Linear Motifs

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FedMonitor: An Implementation Architecture for Monitoring of Resources and Events'Notifications on Federated Cloud Computing Infrastructures

FedMonitor: An Implementation Architecture for Monitoring of...

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International Conference on Emerging Trends in Networks and Computer Communications (ETNCC)

作者： Emmanuel Adetiba Uche Nnaji John S. Wejin Festus Ojesanmi Matthew B. Akanle Priscilla O. Ajayi Faith O. Sweetwiliams Surendra C. Thakur Ezekiel F. Adebiyi Department of Electrical and Information Engineering and Covenant Applied Informatics & Communication African Center of Excellene(CApIC-ACE) Covenant University Ota Nigeria HRA Institute for Systems Science Durban University of Technology Durban South Africa Department of Computer and Information Science & CApIC-ACE Covenant University Ota Nigeria Department of Electrical and Information Engineering & CApIC-ACE Covenant University Jalingo Nigeria Department of Computer Science Tareba State University Jalingo Nigeria Covenant Applied Informatics & Communication African Center of Excellene(CApIC-ACE) Covenant University Ota Nigeria Department of Electrical and Information Engineering Covenant University & CApIC-ACE Covenant University Ota Nigeria Center for Systems and Information Services & CApIC-ACE Covenant University Ota Nigeria Department of Information Technology and KZN e-Skills Co-Laboratory Durban University of Technology Durban South Africa Covenant University Bioinformatics Research (CUBRe) Covenant University Ota Ogun State Nigeria African Center of Excellence in Bioinformatics & Data Intensive Science Makerere University Kampala Uganda

ISBN: (数字)9798350353266

ISBN: (纸本)9798350353273

关键词： Measurement Cloud computing Visualization Computer architecture Quality of service Production Software Real-time systems Stakeholders Monitoring

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Author Correction: Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans

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Nature communications 2025年第1期16卷 2510页

作者： Katrina M Jackson Thomas J Y Kono Jovany J Betancourt Yina Wang Kisakye D Kabbale Minna Ding Perry Kezh Grace Ha J Marina Yoder Sophie R Fulton Liliane Mukaremera Peter Tiffin Asiya Gusa David B Meya R Blake Billmyre Chaoyang Xue Kirsten Nielsen Department of Microbiology and Immunology University of Minnesota Minneapolis MN USA. Pathogen and Microbiome Institute Northern Arizona University Flagstaff AZ USA. Minnesota Supercomputing Institute University of Minnesota Minneapolis MN USA. Institute of Computational Cancer Biology at the University Hospital of Cologne University of Cologne Cologne Germany. Public Health Research Institute and Department of Microbiology Biochemistry and Molecular Genetics New Jersey Medical School Rutgers University Newark NJ USA. Infectious Diseases Institute and School of Medicine College of Health Sciences Makerere University Kampala Uganda. The African Center of Excellence in Bioinformatics and Data Intensive Sciences Kampala Uganda. Center for One Health Research Department of Biomedical Sciences and Pathology Virginia Tech University Blacksburg VA USA. Department of Biosciences Faculty of Health and Life Sciences Medical Research Council Centre for Medical Mycology at the University of Exeter Exeter UK. Department of Plant and Microbial Biology University of Minnesota St. Paul MN USA. Department of Molecular Genetics and Microbiology Duke University Durham NC USA. Division of Infectious Diseases and International Medicine University of Minnesota Minneapolis MN USA. Departments of Pharmaceutical and Biomedical Sciences/Infectious Disease College of Pharmacy/College of Veterinary Medicine University of Georgia Athens GA USA. Department of Microbiology and Immunology University of Minnesota Minneapolis MN USA. kirstennielsen@vt.edu. Center for One Health Research Department of Biomedical Sciences and Pathology Virginia Tech University Blacksburg VA USA. kirstennielsen@vt.edu.

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Killer cell immunoglobulin receptor diversity and its relevance in the human host’s response to HIV infection in african populations

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Translational Medicine Communications 2023年第1期8卷 1-9页

作者： John Mukisa Marion Amujal Obondo J. Sande Moses L. Joloba David P. Kateete Daudi Jjingo Graeme Mardon Neil Hanchard Mogomotsi Matshaba Jill A. Hollenbach Department of Immunology and Molecular Biology College of Health Sciences Makerere University P.O.BOX 7072 Kampala Uganda College of Computing and Information Sciences Makerere University Kampala Uganda African Center of Excellence in Bioinformatics and Data Science Infectious Diseases Institute (IDI) Makerere University Kampala Uganda Department of Molecular and Human Genetics and Department of Pathology and Immunology Baylor College of Medicine Houston TX USA National Human Genome Research Institute Bethesda MD USA Botswana-Baylor Children’s Clinical Centre of Excellence P/Bag BR 129 Gaborone Botswana Department of Neurology and Department of Epidemiology and Biostatistics University of California San Francisco San Francisco California 94158 USA

Host response to the human immune deficiency virus (HIV) involves both the innate and adaptive immune systems. As part of the innate immune system, the killer cell immunoglobulin-like receptors (KIRs) found on natural killer cells and some T-lymphocytes are genetically diverse and play key functions in the host response against viral pathogens. In the last decade, there has been substantial growth in sequencing technologies and bioinformatics capacity to understand human host genetics, including KIR. However, there is limited literature on how the KIR diversity informs the perspectives on HIV disease states in understudied african settings. A better understanding of the effects of KIRs on the host’s immune response to HIV in african settings is essential to inform strategies to develop more effective therapies and vaccines to improve health among people living with HIV (PLWH). In this paper, we review KIR diversity, the role of KIR immunogenetic variation in the human host response to HIV, discuss current perspectives on the studies to assess the relationship between KIR diversity and the HIV disease continuum, and suggest future research prospects.

关键词： Killer cell immunoglobulin-like receptors ( ) Diversity Human immune deficiency virus (HIV) bioinformatics

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Climate-influenced vector-borne diseases in Africa:a call to empower the next generation of african researchers for sustainable solutions

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Infectious Diseases of Poverty 2024年第2期13卷 83-92页

作者： Judicaël Obame-Nkoghe Adjoavi Esse Agossou Gerald Mboowa Basile Kamgang Cyril Caminade Dawn C.Duke Andrew Karanja Githeko Obed M.Ogega Nestor Engone Elloué Fatou Bintou Sarr DieudonnéNkoghe Pierre Kengne Nicaise T.Ndam Christophe Paupy Moses Bockarie Patricks Voua Otomo Molecular and Cellular Biology Laboratory(LabMC) Biology DepartmentUniversity of Science and Technology of MasukuBP 901FrancevilleGabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of FrancevilleBP 769FrancevilleGabon Department of Zoology and Entomology Faculty of Natural and Agricultural SciencesUniversity of the Free StatePrivate Bag x13Phuthaditjhaba 9866Republic of South Africa Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal PhysiologyFaculty of Science and TechnologyUniversity of Abomey-CalaviBP 526CotonouBenin The African Center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases InstituteCollege of Health SciencesMakerere UniversityP.O Box 22418KampalaUganda Africa Centers for Disease Control and Prevention African Union CommissionRoosevelt StreetP.O.Box 3243W21 K19 Addis AbabaEthiopia Centre for Research in Infectious Diseases P.O.Box 13591YaoundéCameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical PhysicsTriesteItaly Africa Research Excellence Fund 99 Charterhouse StreetLondon EC1M 6HRUK Community Health Support Program P.O.Box 872Kisumu 40100Kenya The African Academy of Sciences NairobiKenya Center for Phylosophical Studies and Research(CERP) Omar Bongo University(UOB)BP 13131LibrevilleGabon UMRED Health Training and Research UnitUniversity of Iba Der Thiam of ThièsBP 967ThièsSenegal National Parasitic Diseases Control Program Ministry of HealthLibrevilleGabon MIVEGEC Univ.MontpellierCNRSIRDMontpellierFrance MERIT IRDParis CitéUniversity75006 ParisFrance Department of Parasitology Noguchi Memorial Institute for Medical ResearchUniversity of GhanaLG 54AccraGhana School of Community Health Sciences Njala UniversityBoSierra Leone

We look at the link between climate change and vector-borne diseases in low-and middle-income countries in *** large endemicity and escalating threat of diseases such as malaria and arboviral diseases,intensified by climate change,disproportionately affects vulnerable communities *** highlight the urgency of prioritizing research and development,advocating for robust scientific inquiry to promote adaptation strategies,and the vital role that the next generation of african research leaders will play in addressing these *** significant challenges such as funding shortages within countries,various pan-african-oriented funding bodies such as the african Academy of sciences,the Africa Research excellence Fund,the Wellcome Trust,the *** Institutes of Health,and the Bill and Melinda Gates Foundation as well as initiatives such as the african Research Initiative for Scientific excellence and the Pan-african Mosquito Control Association,have empowered(or are empowering)these researchers by supporting capacity building activities,including continental and global networking,skill development,mentoring,and african-led *** article underscores the urgency of increased national investment in research,proposing the establishment of research government agencies to drive evidence-based *** between governments and scientific communities,sustained by pan-african funding bodies,is *** these efforts,african nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively,fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-african funding initiatives

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