Though analyzing a single scalar field using Morse complexes is well studied, there are few techniques for visualizing a collection of Morse complexes. We focus on analyses that are enabled by looking at a Morse compl...
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The identification of topics in Social Networks has become an important research task when dealing with event detection, particularly when global communities are affected. Text processing techniques and machine learni...
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The identification of topics in Social Networks has become an important research task when dealing with event detection, particularly when global communities are affected. Text processing techniques and machine learning algorithms have been extensively used to solve this problem. In this paper we compare three clustering algorithms - k-means, k-medoids and NMF (Non-negative Matrix Factorization) - in order to detect topics related to textual messages obtained from Twitter. The algorithms were applied to a database composed by tweets, having as initial context hashtags that are related to the recent scandal of corruption involving FIFA (International Federation of Football Association). Obtained results suggest that the NMF presents better results, since it provides providing clusters that are easier to interpret.
IT systems design and architecture have many similarities with the design of organisations and institutions. Both pay attention to social concepts such as rules, norms, and values. Justice is one of the key concepts t...
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Accurate and flexible representations of music data are paramount to addressing MIR tasks, yet many of the existing approaches are difficult to interpret or rigid in nature. This work introduces two new song represent...
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Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiati...
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiation toward alternative fates remains unclear. We employed in vivo CRISPR-Cas9-based perturbation sequencing to assess the role of ~40 transcription factors (TFs) and epigenetic modulators in T cell fate decisions. Unexpectedly, we found that knockout of the TF Klf2 resulted in aberrant differentiation to exhausted-like CD8 T cells during acute infection. KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a polyfunctional tumor-specific progenitor state. Thus, KLF2 provides effector CD8 T cell lineage fidelity and suppresses the exhaustion program.
IT is the purpose of this letter first to point out that several independent lines of evidence seem to indicate that the ‘intercloud medium’ does not exist in its usually quoted state with density≳0.1 cm−3and temper...
IT is the purpose of this letter first to point out that several independent lines of evidence seem to indicate that the ‘intercloud medium’ does not exist in its usually quoted state with density≳0.1 cm−3and temperatureT∼104K. Rather, a hot, tenuous medium (n≲10−2cm−3,T∼106K) seems more consistent with observations in the neighbourhood of the Sun. That such might be the situation has been previously suggested (see refs 1 and 2). A mechanism for producing such a medium has been proposed by Cox and Smith3. Second, this letter points out several implications of such a “missing intercloud medium” on the large-scale structure of spiral galaxies.
Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(SNR)r...
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Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(SNR)recovery of material chemistry at nano-and atomic-resolution by coupling correlated information encoded within both elastic scattering(high-angle annular dark-field(HAADF))and inelastic spectroscopic signals(electron energy loss(EELS)or energy-dispersive x-ray(EDX)).By linking these simultaneously acquired signals,or modalities,the chemical distribution within nanomaterials can be imaged at significantly lower doses with existing detector *** many cases,the dose requirements can be reduced by over one order of *** high SNR recovery of chemistry is tested against simulated and experimental atomic resolution data of heterogeneous nanomaterials.
The purpose of this research was to develop a power consumer service support system, a case study of the Provincial Electricity Authority, Chumphon Province. By applying the ITIL version 3 operating framework to be ap...
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