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54th Israel Annual Conference on Aerospace sciences, IACAS 2014

作者： Sigalov, Daniel Michaeli, Tomer Oshman, Yaakov Interdepartmental Program for Applied Mathematics Technion - Israel Institute of Technology Israel Department of Computer Science and Applied Mathematics Weizmann Institute of Science Israel Department of Aerospace Engineering Technion - Israel Institute of Technology Israel

ISBN: (纸本)9781632662651

Extended target tracking arises in situations where the resolution of the sensor is high enough to allow multiple returns from the target of interest corresponding to its different parts. Various formulations and solutions may be found in the literature. We concentrate on the data association aspect involved in the tracking problem and propose utilization of a general framework that allows reformulation of many seemingly unrelated problems in a similar way. Consequently, the extended object tracking problem is stated as a single generalized dynamical system with random coefficients and solved using a standard IMM algorithm.

关键词： Dynamical systems

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Double Noise Filtering in CT: Pre- and Post-Reconstruction

Double Noise Filtering in CT: Pre- and Post-Reconstruction

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Brazilian Symposium on computer Graphics and Image Processing (SIBGRAPI)

作者： Vinicius C. Assis Denis H.P. Salvadeo Nelson D.A. Mascarenhas Alexandre L.M. Levada Department of Statistics Applied Mathematics and Computing State University of São Paulo Rio Claro SP Brazil Faculdade Campo Limpo Paulista Graduate Program in Computer Science SP Brazil Department of Computing Federal University of São Carlos São Carlos SP Brazil

Motivated by the ALARA (As Low As Reasonably Achievable) principle, this paper proposes to denoise Computed Tomography (CT) images by using a double-filtering approach. First, projection data were filtered using methods to filter Poisson noise (pre-filtering step). Then the filtered back projection (FBP) algorithm was applied to image reconstruction. After, the reconstructed images were denoised by using suitable methods for filtering Gaussian noise (post-filtering step). Finally, known metrics of image quality evaluation (such as SSIM and PSNR) were used to compare the filtered images with the ones considered ideal images in various combinations of filters. The results lead to the conclusion that a second filtering applied on image domain can improve the CT denoising quality from pre-filtering step. Thus, CT double-filtering strategy achieved a better balance between noise reduction and details preservation.

关键词： Noise Noise measurement Computed tomography Noise reduction Image reconstruction Correlation Standards

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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Nonlinear instability for nonhomogeneous incompressible viscous fluids

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science China mathematics 2013年第4期56卷 665-686页

作者： JIANG Fei JIANG Song NI GuoXi College of Mathematics and Computer Science Fuzhou University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics

We investigate the nonlinear instability of a smooth steady density profile solution to the threedimensional nonhomogeneous incompressible Navier-Stokes equations in the presence of a uniform gravitational field,including a Rayleigh-Taylor steady-state solution with heavier density with increasing height(referred to the Rayleigh-Taylor instability).We first analyze the equations obtained from linearization around the steady density profile *** we construct solutions to the linearized problem that grow in time in the Sobolev space H k,thus leading to a global instability result for the linearized *** the help of the constructed unstable solutions and an existence theorem of classical solutions to the original nonlinear equations,we can then demonstrate the instability of the nonlinear problem in some *** analysis shows that the third component of the velocity already induces the instability,which is different from the previous known results.

关键词： nonhomogeneous Navier-Stokes equations steady density profile Rayieigh-Taylor instability incompressible viscous flows

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Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects

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Molecular Cytogenetics 2017年第2期10卷 77-94页

作者： Athel Cornish-Bowden David Rasnick Henry H. Heng Steven Horne Batoul Abdallah Guo Liu Christine J. Ye Mathew Bloomfield Mark D. Vincent C. Marcelo Aldaz Jenny Karlsson Anders Valind Caroline Jansson David Gisselsson Jennifer A. Marshall Graves Aleksei A. Stepanenko Svitlana V. Andreieva Kateryna V. Korets Dmytro O. Mykytenko Stanislav S. Avdieiev Nataliya L. Huleyuk Vladimir P. Baklaushev Oksana A. Kovaleva Vladimir P. Chekhonin Yegor S. Vassetzky Bjorn Bakker Aaron S. Taudt Mirjam E. Belderbos David Porubsky Diana C. J. Spierings Tristan V. de Jong Nancy Halsema Hinke G. Kazemier Karina Hoekstra-Wakker Victor Guryev Peter M. Lansdorp Maria Colomé Tatché Floris Foijer Allan Bradley Eveline S. J. M. de Bont Anke van den Berg Thomas Liehr Nicolaas C. Baudoin Joshua M. Nicholson Kimberly Soto Daniela Cimini Isabel Quintanilla Jordi Camps M. Dürrbaum N. Donnelly V. Passerini C. Kruse Z. Storchová B. Habermann Daniele Mandrioli Fiorella Belpoggi Ellen K Silbergeld Melissa J Perry Rolf I. Skotheim Marthe Løvf Bjarne Johannessen Andreas M. Hoff Sen Zhao Jonas M. SveeStrømme Anita Sveen Ragnhild A. Lothe R. Hehlmann A. Voskanyan A. Fabarius Alfred Böcking Stefan Biesterfeld Leonid Berynskyy Christof Börgermann Rainer Engers Josef Dietz A. Fritz N. Page C. Tye G. Stein J. Stein N. Sehgal R. Berezney J. Vecerova B. Stojkovicz H. Ding J. Xu S. Bhattacharya Xue Gong Sarah Grasedieck Julian Swoboda Jonathan R. Pollack Frank G. Rücker Lars Bullinger Fani-Marlen Roumelioti Maria Chiourea Christina Raftopoulou Sarantis Gagos Peter Duesberg Mat Bloomfield Sunyoung Hwang Hans Tobias Gustafsson Ciara O’Sullivan Aracelli Acevedo-Colina Eduardo M. Torres Xinhe Huang Robert C. Dickson Christian Klose Andrej Schevchenko Paola Cavaliere Noah Dephoure Martha R. Stampfer Mark A. LaBarge James C. Garbe Lukas Vrba Bernard Futscher Yi-Hong Zhou Andrew L. Trinh Michelle Digman Directeur de Recherche (Émérite) Centre National de la Recherche Scientifique (CNRS) Marseilles France 549 Fairbanks Ave. Oakland California 94610 USA Wayne State University School of Medicine Detroit MI USA University of Michigan School of Medicine Ann Arbor MI USA Department of Molecular and Cell Biology UC Berkeley Donner Lab Berkeley CA USA Department of Natural Sciences and Mathematics Dominican University of California San Rafael CA USA Department of Medical Oncology London Regional Cancer Program London Ontario N6A 4L6 Canada Department of Epigenetics and Molecular Carcinogenesis University of Texas M.D. Anderson Cancer Center Science Park Smithville TX 78957 USA Department of Laboratory Medicine Division of Clinical Genetics Lund University Lund SE221 84 Sweden Department of Clinical Sciences Division of Oncology and Pathology Lund University Lund SE221 85 Sweden Skåne Regional and Univeristy Laboratories Department of Pathology Lund SE221 85 Sweden School of Life Sciences La Trobe University Melbourne Vic 3168 Australia Department of Functional Genomics Institute of Molecular Biology and Genetics Kyiv 03680 Ukraine Institute of Hereditary Pathology National Academy of Medical Sciences of Ukraine Lviv 79008 Ukraine Federal Research and Clinical Center FMBA of Russia Moscow 115682 Russia R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology Kyiv 03022 Ukraine V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology Ministry of Health of the Russian Federation Moscow 119034 Russia Department of Medicinal Nanobiotechnology Pirogov Russian State Medical University Moscow 117997 Russia CNRS UMR8126 Université Paris-Sud 11 Institut de Cancérologie Gustave Roussy Villejuif 94805 France European Research Institute for the Biology of Ageing University of Groningen University Medical Center Groningen A. Deusinglaan 1 NL-9713 AV Groningen The Netherlands Department of Paediatrics University

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High-order continuum kinetic method for modeling plasma dynamics in phase space

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AIP Conference Proceedings 2014年第1期1639卷 146-149页

作者： G. V. Vogman P. Colella U. Shumlak Applied Science & Technology Program University of California Berkeley Berkeley CA 94720 USA Computational Research Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA and Department of Electrical Engineering & Computer Science University of California Berkeley CA 94720 USA Aerospace & Energetic Research Program University of Washington Seattle WA 98195 USA

Continuum methods offer a high-fidelity means of simulating plasma kinetics. While computationally intensive, these methods are advantageous because they can be cast in conservation-law form, are not susceptible to noise, and can be implemented using high-order numerical methods. Advances in continuum method capabilities for modeling kinetic phenomena in plasmas require the development of validation tools in higher dimensional phase space and an ability to handle non-cartesian geometries. To that end, a new benchmark for validating Vlasov-Poisson simulations in 3D (x,vx,vy) is presented [1]. The benchmark is based on the Dory-Guest-Harris instability and is successfully used to validate a continuum finite volume algorithm. To address challenges associated with non-cartesian geometries, unique features of cylindrical phase space coordinates are described. Preliminary results of continuum kinetic simulations in 4D (r,z,vr,vz) phase space are presented.

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11th German Conference on Chemoinformatics (GCC 2015) Abstracts

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JOURNAL OF CHEMINFORMATICS 2016年第SUPPL 1期8卷 1-27页

作者： [Anonymous] GDCh-CIC Division Associated Board Member Beilstein-Institut zur Förderung der Chemischen Wissenschaften Trakehner Str. 7-9 60487 Frankfurt Germany. ufechner@beilstein-institut.de. Division Medicinal Chemistry Amsterdam Institute for Molecules Medicines and Systems (AIMMS) VU University Amsterdam The Netherlands. Centre for Bioinformatics Uni Hamburg Bundesstr. 43 20146 Hamburg Germany. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. stefan.guessregen@***. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. GlaxoSmithKline Stevenage SG1 2NY UK. nicola.j.richmond@***. Discngine Paris 75011 France. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. marwin.segler@wwu.de. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. Bundeskriminalamt Wiesbaden Central Analytics II 65173 Wiesbaden Germany. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. shea@chem.ucsb.edu. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. Chemistry Department Ludwig-Maximilians-Universität München Butenandtstr. 7 81377 Munich Germany. Inorganic Chemistry and Center for Nanointegration University of Duisburg-Essen Essen Germany. CAM-D Technologies Essen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. achim.zielesny@w-hs.de. Leiden University Leiden Netherlands. j.fraaije@chem.leidenuniv.nl. Culgi BV Berlin Germany. Physikalische Chemie III TU Dortmund 44227 Dortmund Germany. stefan.kast@tu-dortmund.de. Centre for Molecular Informatics Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW United Kingdom. kcb27@cam.ac.uk. Centre for Molecular Informatics Department of Chemistry

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An independent set approach for the communication network of the GPS III system

An independent set approach for the communication network of...

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作者： Brinkmann, Gunnar Crevals, Simon Frye, John Applied Mathematics and Computer Science Ghent University Krijgslaan 281 S9 9000 Ghent Belgium Lockheed Martin GPS III Program 100 Campus Drive Newtown PA 18940 United States

In this article, we describe an algorithm to find the optimal communication network for the new GPS III satellite system. Finding a possible network will be translated to a maximum clique problem and an efficient algorithm for finding all maximum cliques under these special circumstances is described. © 2011 Elsevier B.V. All rights reserved.

关键词： Network security

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AMUSE: Empowering Users for Cost-Aware Offloading with Throughput-Delay Tradeoffs

AMUSE: Empowering Users for Cost-Aware Offloading with Throu...

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IEEE INFOCOM Conference

作者： Youngbin Im Carlee Joe-Wong Sangtae Ha Soumya Sen Ted "Taekyoung" Kwon Mung Chiang School of Computer Science and Engineering Seoul National University Seoul Korea Program in Applied and Computational Mathematics Princeton University Princeton NJ USA Department of Electrical Engineering Princeton University Princeton NJ USA

ISBN: (纸本)9781467359443

Mobile users face a tradeoff between cost, through-put, and delay in making their offloading decisions. To navigate this tradeoff, we propose AMUSE (Adaptive bandwidth Management through USer-Empowerment), a practical, cost-aware WiFi offloading system that takes into account a user's throughput-delay tradeoffs and cellular budget constraint. Based on predicted future usage and WiFi availability, AMUSE decides which applications to offload to what times of the day. To practically enforce the assigned rate of each TCP application, we introduce a receiver-side TCP bandwidth control algorithm that adjusts the rate by controlling the TCP advertisement window from the user side. We implement AMUSE on Windows 7 tablets and evaluate its effectiveness with 3G and WiFi usage data obtained from a trial with 25 mobile users. Our results show that AMUSE improves user utility.

关键词： tradeoffs UNLOADING Wi-Fi third generation rate control

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