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A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy

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Bioactive Materials 2024年第12期42卷 165-177页

作者： Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung Siu Hong Dexter Wong Mo Yang School of Medicine and Pharmacy Ocean University of ChinaQingdao266003ChinaLaboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao266237China Department of Biomedical Engineering The Hong Kong Polytechnic University999077Hong KongChina The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen518000China Research Center for Nanoscience and Nanotechnology The Hong Kong Polytechnic UniversityKowloon999077Hong KongChina Joint Research Center of Biosensing and Precision Theranostics The Hong Kong Polytechnic UniversityKowloon999077Hong KongChina Department of Applied Physics The Hong Kong Polytechnic University999077Hong KongChina Key Laboratory of Sensing Technology and Biomedical Instruments(Guangdong Province) School of Biomedical EngineeringSun Yat-Sen UniversityGuangzhou510000China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou510080China

Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen species(ROS).As an antioxidant,hydrogen gas(H_(2))has the potential to mitigate AD by scavenging highly harmful ROS such as·***,conventional administration methods of H_(2) face significant challenges in controlling H_(2) release on demand and fail to achieve effective accumulation at lesion ***,we report artificial nanoreactors that mimic natural photosynthesis to realize near-infrared(NIR)light-driven photocatalytic H_(2) evolution in *** nanoreactors are constructed by biocompatible crosslinked vesicles(CVs)encapsulating ascorbic acid and two photosensitizers,chlorophyll a(Chla)and indoline dye(Ind).In addition,platinum nanoparticles(Pt NPs)serve as photocatalysts and upconversion nanoparticles(UCNP)act as light-harvesting antennas in the nanoreacting system,and both attach to the surface of *** NIR irradiation,the nanoreactors release H_(2) in situ to scavenge local excess ROS and attenuate tau hyperphosphorylation in the AD mice *** NIR-triggered nanoreactors provide a proof-of-concept design for the great potential of hydrogen therapy against AD.

关键词： Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease

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A Low-Cost Indoor Signal Redistribution Solution Based on Active Frequency Selective Surface Technique

A Low-Cost Indoor Signal Redistribution Solution Based on Ac...

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Antennas and Propagation & USNC/URSI National Radio Science Meeting

作者： Lin-Man Zhang Xiao Ding Maurizio Bozzi Institute of Applied Physics University of Electronic Science and Technology of China Chengdu China Department of Electrical Computer and Biomedical Engineering University of Pavia Pavia Italy

ISBN: (数字)9798350369908

ISBN: (纸本)9798350369915

We combine reconfigurable and active frequency selective surface (AFSS) techniques to provide a low-cost solution for indoor signal redistribution. The scheme consists of a low-cost elliptical cylindrical AFSS reconfigurable operating at 2.5 GHz/5.2 GHz and a shortcut algorithm to control its operating frequency bands and radiation beams. It is important to note that in order to meet the Wi-Fi requirements, the proposed AFSS radiation beams can be realized by independently adjusting the transmission coefficient and phase of the different frequencies of the AFSS.

关键词： Wireless communication Frequency selective surfaces Frequency modulation Channel capacity Conferences Wireless fidelity Frequency control

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Photobiomodulation Promotes Early Recovery of Olfactory Function and Modulates Neuroprotective Gene Expression in a Mouse Model of Ischemic Stroke

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Translational Stroke Research 2025年 1-10页

作者： Shalaby, Reham A. Emmanuel, Acquah Nezhad, Fatemeh Dehgan Akter, Kohinur Salam, S. M. Abdus Yi, Jawoon Kim, Sang Seong Park, Jihwan Kwon, Hyuk Sang Lee, Kyung Hwa Kim, Young Ro Chung, Euiheon Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology Gwangju South Korea School of Life Sciences Gwangju Institute of Science and Technology Gwangju South Korea Department of Pathology Hwasun Hospital and Medical School Biomedical Sciences Graduate Program (BMSGP) Chonnam National University Gwangju South Korea Department of Radiology Harvard Medical School Boston MA United States AI Graduate School Gwangju Institute of Science and Technology Gwangju South Korea Department of Physics and Photon Science Gwangju Institute of Science and Technology Gwangju South Korea Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Boston United States

Ischemic stroke often leads to neurological deficits, including olfactory dysfunction, which can significantly diminish quality of life. Photobiomodulation (PBM) has emerged as a promising therapeutic strategy for enhancing post-stroke recovery, although the molecular mechanisms, particularly regarding gene expression change, are not yet fully understood. This study investigates the long-term effects of photothrombosis (PT) on olfactory function and the olfactory bulb (OB) microenvironment, with a focus on PBM’s efficacy during both early and late phases. In a mouse OB PT stroke model, PBM therapy (808-nm laser, 40 J/cm² fluence, 325 mW/cm², 2 min daily) was applied from day 2 to day 7 post-PT. Olfactory function was monitored from pre-stroke through day 28 using the buried food test (BFT), and MRI scans were performed on days 7 and 28 to assess tissue damage. RNA sequencing (RNA-seq) and reverse transcription quantitative PCR (RT-qPCR) were conducted on day 7 to evaluate gene expression changes, with additional RT-qPCR analyses performed on day 28. PBM significantly accelerated olfactory function recovery by day 14, with full recovery maintained through day 28. Despite functional recovery, MRI results indicated persistent infarction at 28 days. RNA-seq identified upregulation of neuroprotective genes, including Gpr39 and Or4m1, following PBM treatment, suggesting enhanced gene expression related to acute-phase recovery. However, the impact of PBM on gene expression and functional recovery appeared to wane in the later stages of recovery. These findings underscore PBM’s potential to enhance early-stage recovery in ischemic stroke, though its benefits may be more limited in the chronic phase. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

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High-Selectivity Circularly Polarized Frequency Selective Surface with Ultralow Profile and Continuous Phase Modulation

High-Selectivity Circularly Polarized Frequency Selective Su...

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Antennas and Propagation & USNC/URSI National Radio Science Meeting

作者： Qing-Song Jia Shuai Ding Zhao-Jun Zhu Qiao-Li Zhang Bing-Zhong Wang Maurizio Bozzi Institute of Applied Physics University of Electronic Science and Technology of China Chengdu China Department of Electrical Computer and Biomedical Engineering University of Pavia Pavia Italy

ISBN: (数字)9798350369908

ISBN: (纸本)9798350369915

In this paper, an ultrathin circularly polarized (CP) high-selectivity frequency selective surface (FSS) with continuous phase modulation is proposed. Based on an antenna-filter-antenna (A-F -A) structure, two circular patches etched with rectangular slots and a stripline filter are cascaded to achieve high roll-off and high selectivity characteristics of FSS. On the other hand, conventional high-selectivity FSS rarely focuses on phase modulation. Continuous and precise phase modulation can be implemented by rotating the A patch in this design. An FSS element operating in the C-band is analyzed and simulated. The results show that this CP FSS, with a thickness of only 0.077 $\lambda$ , implements a high-selectivity bandpass response along with good phase modulation. The proposed design can be applied to communication systems to improve electromagnetic compatibility, effectively control interference, and optimize signal transmission.

关键词： Frequency selective surfaces Band-pass filters Slot antennas Communication systems C-band Stripline Conferences

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GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model

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Translational Neurodegeneration 2024年第1期13卷 351-355页

作者： Didio Alberto Ortiz Nuria Peregrín Miguel Valencia Rodrigo Vinueza-Gavilanes Elisa Marín-Ordovas Roberto Ferrero María Jesús Nicolás Gloria González-Aseguinolaza Montserrat Arrasate Tomás Aragón DNA and RNA Medicine Program Center for Applied Medical Research(CIMA)University of NavarraPamplonaSpain Biomedical Engineering Program Center for Applied Medical Research(CIMA)University of NavarraPamplonaSpain Institute of Data Science and Artificial Intelligence(DATAI) University of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain Neuroimmunology Department Multiple Sclerosis Center of Catalonia(Cemcat)Vall d’Hebron Research Institute(VHIR)BarcelonaSpain School of Medicine University of NavarraPamplonaSpain Brain Lab Biobizkaia Health Research InstituteBarakaldoSpain Present Address:Ikerbasque Basque Foundation for ScienceBilbaoSpain

Main text The disruption of protein folding homeostasis in motoneurons(MNs)and the accumulation of protein aggregates are some of the main molecular hallmarks of amyotrophic lateral sclerosis(ALS).Evidence from sporadic and familial ALS(fALS)patients and from ALS models suggests that protein aggregation directly participates in *** turn,the loss of MN homeostasis triggers a coping mechanism,the integrated stress response(ISR)[1].The ISR is initiated by four independent stress-sensing kinases,each of them activated by distinct stresses:protein kinase R(PKR)by double-strand RNA,protein kinase RNA-like endoplasmic reticulum kinase(PERK)by protein misfolding at the endoplasmic reticulum(ER),general control nonderepressible 2(GCN2)by nutrient starvation,and heme-regulated inhibitor(HRI)by heme deprivation.

关键词： homeostasis amyotrophic sclerosis

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Calibration free, time-resolved diffuse optical spectroscopy using combined monte-carlo and diffusion theory 11

Calibration free, time-resolved diffuse optical spectroscopy...

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biomedical Applications of Light Scattering XI 2021

作者： Helton, Michael McMaster, Carter Mycek, Mary-Ann Vishwanath, Karthik Applied Physics Program University of Michigan Ann Arbor United States Department of Physics Miami University OxfordOH45056 United States Biomedical Engineering Department University of Michigan Ann Arbor United States

ISBN: (数字)9781510641501

ISBN: (纸本)9781510641495

Near-infrared spectroscopy has been widely employed in biophotonics to study and quantify the optical properties of biological tissues. Unlike steady-state approaches, time-resolved spectroscopic techniques enable optical absorption and scattering properties of the medium to be separated, allowing for quantitation of depth-dependent absolute tissue optical properties. However, robust analysis of time-resolved signals requires careful consideration of calibration techniques and computational models. Here, we consider the effect of the time window employed when fitting a diffusion theory model to Monte-Carlo simulations. Next, we describe the impact of the temporal position of the instrument response function (IRF) in recovery of the optical properties. Finally, we discuss a technique to analyze time-resolved measurements without knowledge of the timescale of the IRF or the time-resolved measurement byfitting the relative shape of the photons' distribution time-of-flight (DTOF). © 2021 SPIE. All rights reserved.

关键词： Near infrared spectroscopy

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Mathematical modelling of haemorrhagic transformation in the human brain

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applied Mathematical Modelling 2023年第1期121卷 96-110页

作者： Chen, Xi Wang, Jiayu van Kranendonk, Katinka R. Józsa, Tamas.I. El-Bouri, Wahbi K. Kappelhof, Manon van der Sluijs, Matthijs Dippel, Diederik Roos, Yvo B.W.M. Marquering, Henk A Majoie, Charles B.L.M. Payne, Stephen J. Institute of Biomedical Engineering Department of Engineering Science University of Oxford Oxford United Kingdom Department of Radiology and Nuclear Medicine Amsterdam University Medical Centers Iocation Amsterdam Neurosciences University of Amsterdam Amsterdam Netherlands Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart & Chest Hospital Liverpool United Kingdom Department of Cardiovascular and Metabolic Medicine University of Liverpool United Kingdom Department of Radiology & Nuclear Medicine Erasmus MC-University Medical Center Rotterdam Rotterdam Netherlands Department of Neurology Erasmus MC-University Medical Center Rotterdam Rotterdam Netherlands Department of Neurology Amsterdam UMC Location AMC University of Amsterdam Amsterdam Netherlands Department of Biomedical Engineering and Physics Amsterdam UMC Location AMC University of Amsterdam Amsterdam Netherlands Institute of Applied Mechanics National Taiwan University Taiwan

Objective: Haemorrhagic transformation (HT) is one of the most common complications after ischaemic stroke. HT can be the result of stroke progression or a complication of reperfusion treatment for stroke. The aim of this study is to apply a previously proposed HT mathematical model within a computational whole brain model to determine the factors that affect the severity of HT. In addition, these simulations are directly compared with neuroimaging data. Approach: The MR CLEAN–NO IV trial assessed the effect of endovascular therapy (EVT) alone compared with intravenous alteplase treatment (IVT) followed by EVT for patients with acute ischaemic stroke due to anterior circulation large vessel occlusion. We included imaging data of 15 HT patients from the MR CLEAN–NO IV trial, 5 patients suffered from haemorrhagic infarction type 1, 5 from haemorrhagic infarction type 2 and 5 had parenchymal haematoma type 1. The comparison of simulations with patient image data is carried out by comparing the haematoma locations and haematoma volume. The parameters of the model are then optimised to improve agreement with clinical data. Finally, the model is used to investigate the factors that affect the severity of HT. Main results: Based on the computational whole brain model, we found that perfusion reduced by 5–16% after HT onset. The results are in good agreement with the clinical data. We then showed that 1% increase of blood viscosity reduces perfusion by 0.04% and increases haematoma volume by 10.35% from baseline, and 1% increase of blood pressure reduces perfusion by 0.80% and increases haematoma volume by 4.73% from baseline. These results indicate that increased blood glucose and hypertension (among other factors) both appear to lead to a higher severity of HT. Significance: This model, by enabling us to bridge the gap between the mathematical HT model and clinical imaging data, provides the first whole brain prediction model for HT severity assessment. © 2023

关键词： Finite element method

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Prediction of Retina Damage in Optical Coherence Tomography Image Using Xception Architecture Model 5

Prediction of Retina Damage in Optical Coherence Tomography ...

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5th IEEE Eurasia Conference on biomedical engineering, Healthcare and Sustainability, ECBIOS 2023

作者： Do, Minh Thanh Huynh, Hoang Nhut Tran, Trung Nghia Hoang, Thuy Linh VNU-HCM Faculty of Applied Science Department of Biomedical Engineering Physics Ho Chi Minh City Viet Nam VNU-HCM Laboratory of Laser Technology Faculty of Applied Science Ho Chi Minh City Viet Nam Industrial University of Ho Chi Minh City Ho Chi Minh City Viet Nam

ISBN: (纸本)9798350320978

One of the most vital human organs is the retina. Most of the data is gathered via our eyesight. Thus, maintaining good eye health is crucial for happy and healthy life and eyes. Unfortunately, hazardous eye conditions, including choroidal neovascularization (CNV), Drusen, and diabetic macular edema (DME), directly harm the retina. They are typically discovered late, making it frequently impossible to cure and restore vision. Significant vision loss or even complete blindness may result from this. Ophthalmologists can view the inner structure of the retina using the sophisticated medical imaging technology known as noninvasive retinal optical coherent tomography (OCT), which relies on the visual reflection of the tissues inside the eye. However, in practice, errors continue to occur in diagnosing illnesses in general and eye ailments in particular. Thus, we develop a deep learning model to help physicians diagnose CNV, Drusen, and DME more correctly and lessen medical examination and treatment mistakes. About 8,000 images from the Large Dataset of Labeled Optical Coherence Tomography (OCT) Images were used to train with the Xception's architecture model. The result of this classification study for three types of DME, CNV, and Drusen diseases showed an accuracy of 93%. © 2023 IEEE.

关键词： Optical tomography

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Opening long-time investigation window of living matter by nonbleaching phase intensity nanoscope: PINE

arXiv

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arXiv 2023年

作者： Cui, Guangjie Liu, Yunbo Zu, Di Zhao, Xintao Zhang, Zhijia Kim, Do Young Senaratne, Pramith Fox, Aaron Sept, David Park, Younggeun Lee, Somin Eunice Department of Electrical & Computer Engineering Biomedical Engineering Applied Physics Biointerfaces Institute Macromolecular Science & Engineering University of Michigan United States Department of Biomedical Engineering University of Michigan United States Department of Mechanical Engineering University of Michigan United States

Fundamental to all living organisms and living soft matter are emergent processes in which the reorganization of individual constituents at the nanoscale drives group-level movements and shape changes at the macroscale over time. However, light-induced degradation of fluorophores, photobleaching, is a significant problem in extended live cell imaging in life science, and excellent prior arts of STED, MINSTED, or MINFLUX intentionally apply photobleaching optics for super-resolution, yet lack extended live-cell imaging capability as fluorophores reach an irreversible photobleaching limit. Here, we report an innovative way of opening a long-time investigation window of living matter by a nonbleaching phase intensity nanoscope: PINE. We accomplish phase-intensity separation to obtain phase differences between electric field components, such that nanoprobes within a diffraction limited region are distinguished from one another by an integrated phase-intensity multilayer thin film (polyvinyl alcohol/liquid crystal). We obtain distributional patterns of precisely localized nanoprobes to overcome a physical limit to resolve sub-10 nm cellular architectures, and achieve the first dynamic imaging of nanoscopic reorganization over 250 hours using nonbleaching PINE. Since PINE allows a long-time investigation window, we discover nanoscopic rearrangements synchronized with the emergence of group-level movements and shape changes at the macroscale according to a set of interaction rules. We believe that PINE and its application presented here provide a mechanistic understanding of emergent dynamics important in cellular and soft matter reorganization, self-organization, and pattern formation. Copyright © 2023, The Authors. All rights reserved.

关键词： Fluorophores

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Increased light-emission efficiency in disordered (In,Ga)N through the correlated reduction of recombination rates

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Physical Review applied 2023年第6期20卷 064049-064049页

作者： Nick Pant Emmanouil Kioupakis Applied Physics Program University of Michigan Ann Arbor Michigan 48109 USA Department of Materials Science & Engineering University of Michigan Ann Arbor Michigan 48109 USA

Experiments have shown that the light-emission efficiency of indium gallium nitride [(In,Ga)N] light-emitting diodes improves with increasing indium concentration. It is widely thought that compositional fluctuations due to indium incorporation suppress diffusion of carriers to nonradiative centers, thus leading to defect-insensitive emission. However, recent experiments have challenged this hypothesis by revealing unexpectedly long diffusion lengths at room temperature. Here, we demonstrate an alternative mechanism involving the correlated reduction in radiative and nonradiative recombination rates that explains the increase in light-emission efficiency of (In,Ga)N with increasing indium concentration, without invoking the suppression of carrier diffusion. Our analysis challenges the notion that carrier localization gives rise to defect tolerance in (In,Ga)N.

关键词： Carrier generation & recombination Optoelectronics Weak localization Disordered alloys III-V semiconductors LEDs Density functional calculations Schroedinger equation

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