检索结果-内蒙古大学图书馆

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

Light(Science & Applications) 2023年第12期12卷 2826-2844页

作者： Weisong Zhao Xiaoshuai Huang Jianyu Yang Liying Qu Guohua Qiu Yue Zhao Xinwei Wang Deer Su Xumin Ding Heng Mao Yaming Jiu Ying Hu Jiubin Tan Shiqun Zhao Leiting Pan Liangyi Chen Haoyu Li Innovation Photonics and Imaging Center School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbinChina Key Laboratory of Ultra-Precision Intelligent Instrumentation of Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbinChina Biomedical Engineering Department International Cancer InstitutePeking University Cancer Hospital and InstituteHealth Science CenterPeking UniversityBeijingChina The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry School of Physics and TEDA Institute of Applied PhysicsFrontiers Science Center for Cell ResponsesNankai UniversityTianjinChina State Key Laboratory of Membrane Biology Beijing Key Laboratory of Cardiometabolic Molecular MedicineInstitute of Molecular MedicineNational Biomedical Imaging CenterSchool of Future TechnologyPeking UniversityBeijingChina Department of Control Science and Engineering Harbin Institute of TechnologyHarbinChina School of Mathematical Sciences Peking UniversityBeijingChina Unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for MicrobesDevelopment and HealthKey Laboratory of Molecular Virology and ImmunologyShanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghaiChina School of Life Science and Technology Harbin Institute of TechnologyHarbinChina PKU-IDG/McGovern Institute for Brain Research BeijingChina Beijing Academy of Artificial Intelligence BeijingChina Frontiers Science Center for Matter Behave in Space Environment Harbin Institute of TechnologyHarbinChina Key Laboratory of Micro-Systems and Micro-Structures Manufacturing of Ministry of Education Harbin Institute of TechnologyHarbinChina

In fluorescence microscopy,computational algorithms have been developed to suppress noise,enhance contrast,and even enable super-resolution(SR).However,the local quality of the images may vary on multiple scales,and these differences can lead to *** mapping methods fail to finely estimate the local quality,challenging to associate the SR scale ***,we develop a rolling Fourier ring correlation(rFRC)method to evaluate the reconstruction uncertainties down to SR *** visually pinpoint regions with low reliability,a filtered rFRC is combined with a modified resolution-scaled error map(RSM),offering a comprehensive and concise map for further *** demonstrate their performances on various SR imaging modalities,and the resulting quantitative maps enable better SR images integrated from different ***,we expect that our framework can become a routinely used tool for biologists in assessing their image datasets in general and inspire further advances in the rapidly developing field of computational imaging.

关键词： resolution local enable

来源：评论

学校读者我要写书评

暂无评论

Mechanical Plasticity of Cell Membranes Enhances Epithelial Wound Closure

arXiv

引用

arXiv 2023年

作者： Ton, Andrew T. MacKeith, Arthur K. Shattuck, Mark D. O'Hern, Corey S. Department of Physics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Applied Physics Yale University New HavenCT06520 United States

During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like Drosophila. We develop deformable particle (DP) model simulations to understand how variations in cell mechanics give rise to distinct wound closure phenotypes in the Drosophila embryonic ectoderm and larval wing disc epithelium. We find that plastic deformation of the cell membrane can generate large changes in cell shape consistent with wound closure in the embryonic ectoderm. Our results show that the embryonic ectoderm is best described by cell membranes with an elasto-plastic response, whereas the larval wing disc is best described by cell membranes with an exclusively elastic response. By varying the mechanical response of cell membranes in DP simulations, we recapitulate the wound closure behavior of both the embryonic ectoderm and the larval wing disc. © 2023, CC BY-NC-ND.

关键词： Cytology

来源：评论

学校读者我要写书评

暂无评论

Classical and Quantum Phase Transitions in Multiscale Media: Universality and Critical Exponents in the Fractional Ising Model

arXiv

引用

arXiv 2025年

作者： Lewis, Joshua M. Carr, Lincoln D. Quantum Engineering Program Colorado School of Mines 1523 Illinois St. GoldenCO80401 United States Department of Physics Colorado School of Mines 1523 Illinois St. GoldenCO80401 United States Department of Applied Mathematics and Statistics Colorado School of Mines 1523 Illinois St. GoldenCO80401 United States

Until now multiscale quantum problems have appeared to be out of reach at the many-body level relevant to strongly correlated materials and current quantum information devices. In fact, they can be modeled with q-th order fractional derivatives, as we demonstrate in this work, treating classical and quantum phase transitions in a fractional Ising model for 0 D of the system tied geometrically to the anomalous dimension η. We discover that for classical systems, HD is precisely equal to the fractional order q. In contrast, for quantum systems, HD deviates from this direct equivalence, scaling more gradually, driven by additional degrees of freedom introduced by quantum fluctuations. These results reveal how fractional derivatives fundamentally modify the fractal geometry of many-body interactions, directly influencing the universal symmetries of the system and overcoming traditional dimensional restrictions on phase transitions. Specifically, we find that for q © 2025, CC BY.

关键词： Degrees of freedom (mechanics)

来源：评论

学校读者我要写书评

暂无评论

Orbit symmetry breaking in MXene implements enhanced soft bioelectronic implants

arXiv

引用

arXiv 2024年

作者： Wu, Yizhang Li, Yuan Liu, Yihan Zhu, Dashuai Xing, Sicheng Lambert, Noah Weisbecker, Hannah Liu, Siyuan Davis, Brayden Zhang, Lin Wang, Meixiang Yuan, Gongkai You, Chris Zhoufan Zhang, Anran Duncan, Cate Xie, Wanrong Wang, Yihang Wang, Yong Kanamurlapudi, Sreya Evert, Garcia-Guzman Putcha, Arjun Dickey, Michael D. Huang, Ke Bai, Wubin Department of Applied Physical Sciences University of North Carolina Chapel HillNC27514 United States Joint Department of Biomedical Engineering North Carolina State University University of North Carolina at Chapel Hill RaleighNC27607 United States Department of Molecular Biomedical Sciences North Carolina State University RaleighNC27607 United States Department of Chemical and Biomolecular Engineering North Carolina State University RaleighNC27606 United States Chapel Hill High School Chapel HillNC27516 United States Department of Physics Nanjing University Jiangsu Nanjing210000 China

Bioelectronic implants with soft mechanics, biocompatibility, and excellent electrical performance enable biomedical implants to record electrophysiological signals and execute interventions within internal organs, promising to revolutionize the diagnosing, monitoring, and treatment of various pathological conditions. However, challenges remain in improving excessive impedance at the bioelectronic-tissue interface and thus the efficacy of electrophysiological signaling and intervention. Here, we devise orbit symmetry breaking in MXene (a low-cost scalability, biocompatible, and conductive 2D layered material, that we refer to as OBXene), that exhibits low bioelectronic-tissue impedance, originating from the out-of-plane charge transfer. Furthermore, the Schottky-induced piezoelectricity stemming from the asymmetric orbital configuration of OBXene facilitates interlayered charge transport in the device. In this study, we report an OBXene-based cardiac patch applied on the left ventricular epicardium of both rodent and porcine models to enable spatiotemporal epicardium mapping and pacing, while coupling the wireless and battery-free operation for long-term real-time recording and closed-loop stimulation. Copyright © 2024, The Authors. All rights reserved.

关键词： Charge transfer

来源：评论

学校读者我要写书评

暂无评论

Designing the pressure-dependent shear modulus using tessellated granular metamaterials

arXiv

引用

arXiv 2023年

作者： Zhang, Jerry Wang, Dong Jin, Weiwei Xia, Annie Pashine, Nidhi Kramer-Bottiglio, Rebecca Shattuck, Mark D. O’Hern, Corey S. Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States

Jammed packings of granular materials display complex mechanical response. For example, the ensemble-averaged shear modulus 〈G〉 increases as a power-law in pressure p for static packings of soft spherical particles that can rearrange during compression. We seek to design granular materials with shear moduli that can either increase or decrease with pressure without particle rearrangements even in the large-system limit. To do this, we construct tessellated granular metamaterials by joining multiple particle-filled cells together. We focus on cells that contain a small number of bidisperse disks in two dimensions. We first study the mechanical properties of individual disk-filled cells with three types of boundaries: periodic boundary conditions (PBC), fixed-length walls (FXW), and flexible walls (FLW). Hypostatic jammed packings are found for cells with FLW, but not in cells with PBC and FXW, and they are stabilized by quartic modes of the dynamical matrix. The shear modulus of a single cell depends linearly on p. We find that the slope of the shear modulus with pressure, λc c > 0, as well as λc © 2023, CC BY.

关键词： Elastic moduli

来源：评论

学校读者我要写书评

暂无评论

Surface-enhanced Raman spectroscopy for the identification of a non-enveloped virus

Surface-enhanced Raman spectroscopy for the identification o...

引用

2023 IEEE applied Imagery Pattern Recognition Workshop, AIPR 2023

作者： Ricker, Ryeanne Yeh, Yin-Ting Monaco, Maria Chiara Fletcher, Anita Jacobson, Steven Loew, Murray Ghedin, Elodie National Institute of Allergy and Infectious Disease National Institutes of Health System Genomics Section Laboratory of Parasitic Diseases BethesdaMD United States Pennsylvania State University Department of Physics University ParkPA United States National Institute of Neurological Disorders and Stroke National Institutes of Health Neuroimmunology Branch Viral Immunology Section BethesdaMD United States National Institute of Neurological Disorders and Stroke National Institutes of Health Viral Immunology Section Neuroimmunology and Neuroimmunology Division BethesdaMD United States School of Engineering and Applied Science George Washington University Department of Biomedical Engineering WashingtonDC United States

ISBN: (纸本)9798350359527

Direct antigen and antibody detection tests dominate viral diagnostics. However, these types of assays rely on the detection of specific targets, limiting their use in virus discovery or in the diagnosis of infections of unknown etiology. Problems with these methods also arise when a pathogen presents atypically or during instances of coinfection. In this study, we set out to demonstrate that a platform of carbon nanotubes used for virus capture and Raman spectroscopy can be applied to the detection of non-enveloped viruses grown in cell culture. Non-enveloped viruses lack a lipid bilayer surrounding the nucleocapsid. The carbon nanotube platform consists of carbon nanotubes (CNT) grown on a glass substrate with an average intertubular distance similar to the diameter of viruses, creating a matrix into which the virus particles settle upon drop-casting. Raman spectra of the CNT forest onto which viruses were deposited were collected and machine learning models were constructed to differentiate cell culture samples containing JC polyomavirus (JCPyV), a non-enveloped human polyomavirus, from blank culture. The spectra of media containing virus significantly differed from the blank spectra, forming class clusters on a t-distributed Stochastic Neighbor Embedding (t-SNE) plot. Given that there were significant spectral differences between the culture containing virus and the blank culture, this provides evidence that the virus particles are being detected on the CNT forest. The convolutional neural networks trained to identify JCPyV achieved a 5-fold cross-validated classification accuracy of 97%. This further demonstrates the ability of Raman spectroscopy coupled with machine learning to recognize Raman spectral patterns of viruses, including non-enveloped viruses, for identification purposes. © 2023 IEEE.

关键词： Viruses

来源：评论

学校读者我要写书评

暂无评论

Large Exciton Binding Energy in the Bulk van der Waals Magnet CrSBr

arXiv

引用

arXiv 2024年

作者： Smolenski, Shane Wen, Ming Li, Qiuyang Downey, Eoghan Alfrey, Adam Liu, Wenhao Kondusamy, Aswin L.N. Bostwick, Aaron Jozwiak, Chris Rotenberg, Eli Zhao, Liuyan Deng, Hui Lv, Bing Zgid, Dominika Gull, Emanuel Jo, Na Hyun Department of Physics University of Michigan Ann ArborMI48109 United States Department of Chemistry University of Michigan Ann ArborMI48109 United States Applied Physics Program University of Michigan Ann ArborMI48109 United States Department of Physics University of Texas at Dallas RichardsonTX75080 United States Department of Materials Science and Engineering University of Texas at Dallas RichardsonTX75080 United States Advanced Light Source Lawrence Berkeley National Laboratory BerkeleyCA94720 United States

Excitons, bound electron-hole pairs, influence the optical properties in strongly interacting solid state systems. Excitons and their associated many-body physics are typically most stable and pronounced in monolayer materials. Bulk systems with large exciton binding energies, on the other hand, are rare and the mechanisms driving their stability are still relatively unexplored. Here, we report an exceptionally large exciton binding energy in single crystals of the bulk van der Waals antiferromagnet CrSBr. Utilizing state-of-the-art angle-resolved photoemission spectroscopy and self-consistent ab-initio GW calculations, we present direct spectroscopic evidence that robust electronic and structural anisotropy can significantly amplify the exciton binding energy within bulk crystals. Furthermore, the application of a vertical electric field enables broad tunability of the optical and electronic properties. Our results indicate that CrSBr is a promising material for the study of the role of anisotropy in strongly interacting bulk systems and for the development of exciton-based optoelectronics. Copyright © 2024, The Authors. All rights reserved.

关键词： Bromine compounds

来源：评论

学校读者我要写书评

暂无评论

Computational modeling of the physical features that influence breast cancer invasion into adipose tissue

arXiv

引用

arXiv 2024年

作者： Zheng, Yitong Wang, Dong Beeghly, Garrett Fischbach, Claudia Shattuck, Mark D. O’Hern, Corey S. Department of Mechanical Engineering & Materials Science Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Nancy E. and Peter C. Meinig School of Biomedical Engineering Cornell University IthacaNY14853 United States Benjamin Levich Institute Physics Department City College of New York New YorkNY10031 United States Department of Physics Yale University New HavenCT06520 United States

Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on numerous biochemical and physical properties of cancer cells, adipocytes, and other key components of adipose tissue. We model breast cancer invasion into adipose tissue as a physical process by carrying out simulations of active, cohesive spherical particles (cancer cells) invading into confluent packings of deformable polyhedra (adipocytes). We quantify the degree of invasion by calculating the interfacial area At between cancer cells and adipocytes. We determine the long-time value of At versus the activity and strength of the cohesion between cancer cells, as well as mechanical properties of the adipocytes and extracellular matrix (ECM) in which the adipocytes are embedded. We show that the degree of invasion collapses onto a master curve by plotting it versus a dimensionless energy scale Ec, which grows linearly with mean-square fluctuations and persistence time of the cancer cell velocities, is inversely proportional to the pressure of the system, and has an offset that increases with the cancer cell cohesive energy. The condition, Ec 1, indicates that cancer cells will invade the adipose tissue, whereas for Ec 1, the cancer cells and adipocytes remain demixed. We also show that constraints on adipocyte positions by the ECM decrease At relative to that obtained for unconstrained adipocytes. Finally, spatial heterogeneity in structural and mechanical properties of the adipocytes in the presence of ECM impedes invasion relative to adipose tissue with uniform properties. © 2024, CC BY-NC-ND.

关键词： Cancer cells

来源：评论

学校读者我要写书评

暂无评论

Perturbation-induced electromyographic activity is predictive of flexion synergy expression and a sensitive measure of post-stroke motor impairment

Perturbation-induced electromyographic activity is predictiv...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Nirvik Sinha Julius P.A. Dewald Yuan Yang Interdepartmental Neuroscience Program Northwestern University Chicago Illinois USA Edmond and Lily Safra Center for Brain Sciences Hebrew University Jerusalem Israel Department of Physical Therapy and Human Movement Sciences Feinberg School of Medicine Northwestern University Chicago Illinois USA Department of Biomedical Engineering McCormick School of Engineering and Applied Sciences Northwestern University Chicago Illinois USA Department of Bioengineering Grainger College of Engineering University of Illinois Urbana-Champaign Urbana Illinois USA Carle Foundation Hospital Urbana Illinois USA

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

The goal of this study was to explore whether the stretch reflex-induced muscle activity is correlated with the expression of the flexion synergy and, therefore, can serve as a quantitative indicator of post-stroke motor impairment. Eleven stroke participants stroke were recruited for this study. Their forearm was connected to a robotic device that applied continuous position perturbations to the paretic elbow joint. The magnitude of EMG activity of the spastic biceps brachii was measured. The expression of the flexion synergy was determined using the increase of synergistic elbow flexion torque when subjects were gradually lifting their paretic arm with two derived measures: normalized flexion synergy area (NFSA) and the mean slope of the expression of flexion synergy (ΔFS). Significant positive correlations were found between spastic biceps EMG (predictor variable) and the flexion synergy expression (response variables), i.e., NFSA (ρ = 0.89, p < 0.001) and ΔFS (ρ = 0.73, p = 0.01). This result indicates that the perturbation-induced EMG activity can serve as a sensitive indicator of post-stroke motor impairments related to the expression of spasticity and flexion synergy and demonstrates that these motor impairments may be mechanistically linked.

关键词： Torque Perturbation methods Muscles Motors Particle measurements Electromyography Torque measurement Elbow engineering in medicine and biology Robots

来源：评论

学校读者我要写书评

暂无评论

Full-Duplex Beamforming in the Sub-Terahertz Regime

Full-Duplex Beamforming in the Sub-Terahertz Regime

引用

International Conference on Infrared and Millimeter Waves

作者： Subhajit Karmakar Atsutse Kludze Jacques Doumani Andrey Baydin Junichiro Kono Yasaman Ghasempour Department of Electrical and Computer Engineering Princeton University Princeton NJ USA Department of Electrical and Computer Engineering Rice University Houston TX USA Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston TX USA Smalley-Curl Institute Rice University Houston TX USA Department of Physics and Astronomy Rice University Houston TX USA Department of Material Science and NanoEngineering Rice University Houston TX USA

We propose a novel architecture that realizes full-duplex directional beamforming in the sub-terahertz regime. Our architecture leverages the frequency-controlled beam steering of leaky-wave antenna together with the polarization-dependent response of aligned single-wall carbon nanotubes. We evaluate the performance of this architecture via preliminary experiments.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：