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Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第1期24卷 50-63页

作者： Qiong ZHAO Luwen ZHANG Qiufen HE Hui CHANG Zhiqiang WANG Hongcui CAO Ying ZHOU Ruolang PAN Ye CHEN Department of Genetics and Department of Genetic and Metabolic DiseaseThe Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders Institute of GeneticsZhejiang UniversityHangzhou 310058China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Xiangshan Hospital of TCM Medical and Health Group Ningbo 315700China Zhejiang Provincial Key Laboratory of Cell-Based Drug and Applied Technology Development Hangzhou 311121China

Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor *** present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)***,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor *** TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen ***,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy ***,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy.

关键词： Transfer RNA(tRNA) tRNA methyltransferase 5(TRMT5) Hepatocellular carcinoma(HCC) Hypoxia-inducible factor-1α(HIF-1α)

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A 4-Channel Ultrafast Wavelength-Swept REC-DFB Laser Array for Fiber Bragg Grating Interrogation

A 4-Channel Ultrafast Wavelength-Swept REC-DFB Laser Array f...

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Asia Communications and Photonics Conference and Exhibition (ACP)

作者： Lingxin Meng Pan Dai Qilu Ban Kaichuan Xu Jiacheng Wang Zhen Li Feng Wang Jie Zeng Shaobo Li Xiang Ma Xiangfei Chen Key Laboratory of Intelligent Optical Sensing and Manipulation of the Ministry of Education & Engineering National Laboratory of Solid State Microstructures Research Center of Precision Photonics Integration and System Application of the Ministry of Education College of Engineering and Applied Sciences Nanjing University Nanjing China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and Astronautics Nanjing China Optical Communication Research and Development Center the 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang China

We present a four-channel ultrafast wavelength-swept distributed feedback (DFB) semiconductor laser array based on the reconstruction-equivalent-chirp (REC) technique using instantaneous injection current modulation. With the aid of our designed laser driving circuit system consists of the microcontroller unit (MCU), field-programmable gate array (FPGA) and negative metal-oxide-semiconductor field effect transistors (n-MOSFETs), the precise pulse driving current for the 4-channel wavelength-swept REC-DFB laser array can be generated and a fast tuning of 16.424 nm within 10 μs is achieved. To further investigate the tuning performance of the proposed wavelength-swept laser source, we then applied it to the fiber Bragg grating (FBG) interrogation system and four FBG temperature sensor arrays were successfully demodulated. The development of high-efficient optical sensing systems heavily relies on the significance of the ultrafast wavelength-swept laser source, which has the potential to greatly enhance FBG interrogator performance in the future.

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Enhanced Automatic Generation Control in Multiarea Power Systems: Crow Search Optimized Cascade FOPI-TIDDN Controller With Integrated Renewable Solar Thermal Models and HVDC Lines

Engineering Reports

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Engineering Reports 2025年第5期7卷

作者： Babu, Naladi Ram Sunitha, Pamarthi B. S. S., Ganesh Pardhu Bhagat, Sanjeev Kumar Ramesh, Adireddy Saha, Arindita Mbasso, Wulfran Fendzi Jangir, Pradeep Hossam-Eldin, Ahmed Department of Electrical and Electronics Engineering Aditya University Kakinada India Department of Electronics and Communication Engineering Aditya University Kakinada India Department of Electrical Engineering Sandip University Madhubani India Department of Electrical Engineering Regent Education and Research Foundation Group of Institutions Kolkata India Technology and Applied Sciences Laboratory U.I.T. of Douala University of Douala Douala Cameroon Department of Biosciences Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences Chennai India Applied Science Research Center Applied Science Private University Amman Jordan University Centre for Research and Development Chandigarh University Gharuan Mohali India Department of CSE Graphic Era Hill University Dehradun India Department of CSE Graphic Era Deemed to be University Dehradun India Centre for Research Impact & Outcome Chitkara University Institute of Engineering and Technology Chitkara University Punjab Rajpura India Department of Electrical and Electronics Engineering J.J. Technology Tamilnadu Tiruchirappalli India Department of Electrical Power and Machines Faculty of Engineering Alexandria University Alexandria Egypt

As renewable energy sources (RES) are increasingly unified into multiarea power systems, automatic generation control (AGC) faces challenges such as frequency instability, longer settling times, and higher overshoot. While existing optimization techniques like Firefly (FF) and gray wolf (GW) suffer from slow convergence and local optima trapping, conventional controllers like FOPI, PIDN, TIDN, and TIDDN struggle to maintain stability under fluctuating load conditions. Fractional-Order Proportional-Integral with Tilt Integral Double Derivative and Filter (FOPI-TIDDN), a novel cascade controller optimized using the crow search (CS) algorithm, is proposed in this paper to overcome these issues. Furthermore, a two-area AGC framework incorporates realistic dish-Stirling solar thermal systems (RDSTS) and parabolic trough solar thermal plants (PTSTP), and the effects of these systems are examined under different patterns of solar insolation. Additionally, the study assesses how high voltage direct current (HVDC) tie-lines contribute to increased system stability. According to simulation data, the FOPI-TIDDN controller works noticeably better than others in terms of improved frequency regulation, faster settling time, and less overshoot. Compared to FF and GW approaches, the CS algorithm guarantees faster convergence. An ideal fixed-random solar insolation method and HVDC integration also improve system performance. The suggested method enhances renewable-integrated power systems' resilience, efficiency, and stability. © 2025 The Author(s). Engineering Reports published by John Wiley & Sons Ltd.

关键词： Frequency stability

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Insights into logical method selection for modification of chitosan and alginate towards the adsorption of heavy metal ions: a review

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Environmental technology Reviews 2024年第1期13卷 398-420页

作者： Benettayeb, Asmaa Hadj Brahim, Mustapha Lal, Basant Al-Farraj, Saleh Belkacem, Mohamed John Masamvu, Malbenia Haddou, Boumediene Ali Alkahtane, Abdullah Chia, Chin-hua Sillanpaa, Mika Ghosh, Soumya Hosseini-Bandegharaei, Ahmad Laboratoire de Génie Chimique et de catalyse hétérogène département de Génie Chimique Université de Sciences et de la Technologie – Mohamed Boudiaf USTO Oran Algeria Oran Algeria Department of Chemistry Institute of Applied Science and Humanities GLA University Mathura India Department of Zoology College of Science King Saud University Riyadh Saudi Arabia Department of Applied Physics Faculty of Science and Technology Universiti Kebangsaan Malaysiaangi Bangi Malaysia Functional Materials Group Gulf University for Science and Technology Mubarak Al-Abdullah Kuwait Centre of Research Impact and Outcome Chitkara University Institute of Engineering and Technology Chitkara University Rajpura India Division of Research & Development Lovely Professional University Phagwara India Adnan Kassar School of Business Lebanese American University Beirut Lebanon Department of Chemical Engineering School of Mining Metallurgy and Chemical Engineering University of Johannesburg Doornfontein South Africa Natural & Medical Sciences Research Center University of Nizwa Nizwa Oman Faculty of Chemistry Semnan University Semnan Iran Department of Sustainable Engineering Saveetha School of Engineering SIMATS Chennai India Chitkara Centre for Research and Development Chitkara University Himachal Pradesh Baddi India

Is it necessary to modify the structure of chitosan and alginate before their use in adsorption? If yes, what type of modification can be used, and what agent should be chosen for the modification? Is there a difference between grafting and crosslinking agents and what are the benefits of each after adsorption? This review article tries to answer these questions by comparing the efficiency of biosorption of certain metals on alginate and chitosan, both before and after modification. Understanding the limitations, benefits, and drawbacks of each type of modification is essential in the field of water and wastewater treatment. Hence, this review discusses the advantages and disadvantages of using each grafting agent and the benefits of modifying the alginate and chitosan adsorbents. It tries to develop insights into the linkage between selected modification agents and types of pollutants and their bonding preferences with respect to –O, –N, and –S atoms. Thus, it highlights the contributions of each functional group added to alginate and chitosan structures through grafting, cross-linking, or both. Also, it elaborates on the corresponding benefits of each functional group (or modification) in the biosorption process. The type of contribution of each type of modification to the sorption efficiency, the way pH changes affect, reduction in adsorbent dose, the mechanisms involved in the process, the nature of adsorption, and other added properties in comparison to their natural forms, are discussed in this review, and some perspectives are suggested for future studies. Based on the concepts and ideas discussed in the current review, one can make more informed and insightful choices when selecting and modifying the studied adsorbent. © 2024 Informa UK Limited, trading as Taylor & Francis group.

关键词： Chitosan

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Water consumption and biodiversity:Responses to global emergency events

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Science Bulletin 2024年第16期69卷 2632-2646页

作者： Dandan Zhao Junguo Liu Laixiang Sun Klaus Hubacek Stephan Pfister Kuishuang Feng Heran Zheng Xu Peng Daoping Wang Hong Yang Lei Shen Fei Lun Xu Zhao Bin Chen Marko Keskinen Shaohui Zhang Jialiang Cai Olli Varis Water&Development Research Group Department of Built EnvironmentAalto UniversityEspoo 15200Finland School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou 450046China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Geographical Sciences University of MarylandCollege Park 20742USA School of Finance and Management SOASUniversity of LondonLondon WC1H0XGUK Integrated Research on Energy Environment and SocietyEnergy and Sustainability Research Institute GroningenUniversity of GroningenGroningen 9747AGthe Netherlands ETH Zurich Institute of Environmental EngineeringZurich 8093Switzerland The Bartlett School of Sustainable Construction University College LondonLondon WC1E6BTUK School of Business Jiangnan UniversityWuxi 214122China Department of Computer Science and Technology University of CambridgeCambridge CB21TNUK w2e Environmental Consulting GmbH Duebendorf 8600Switzerland Key Laboratory for Resource Use and Environmental Remediation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Land Science and Technology China Agricultural UniversityBeijing 100083China Institute of Blue and Green Development Shandong UniversityWeihai 264209China Fudan Tyndall Center Department of Environmental Science and EngineeringFudan UniversityShanghai 200438China School of Economics and Management Beihang UniversityBeijing 100191China International Institute for Applied Systems Analysis Laxenburg A-2361Austria

Given that it was a once-in-a-century emergency event,the confinement measures related to the coronavirus disease 2019(COVID-19)pandemic caused diverse disruptions and changes in life and work *** changes significantly affected water consumption both during and after the pandemic,with direct and indirect consequences on ***,there has been a lack of holistic evaluation of these ***,we propose a novel framework to study the impacts of this unique global emergency event by embedding an environmentally extended supply-constrained global multi-regional input-output model(MRIO)into the drivers-pressure-state-impact-response(DPSIR)*** framework allowed us to develop scenarios related to COVID-19 confinement measures to quantify country-sector-specific changes in freshwater consumption and the associated changes in biodiversity for the period of *** results suggest progressively diminishing impacts due to the implementation of COVID-19 vaccines and the socio-economic system’s self-adjustment to the new *** 2020,the confinement measures were estimated to decrease global water consumption by about 5.7% on average across all scenarios when compared with the baseline level with no confinement ***,such a decrease is estimated to lead to a reduction of around 5% in the related pressure on *** the interdependencies and interactions across global supply chains,even those countries and sectors that were not directly affected by the COVID-19 shocks experienced significant impacts:Our results indicate that the supply chain propagations contributed to 79% of the total estimated decrease in water consumption and 84%of the reduction in biodiversity loss on *** study demonstrates that the MRIO-enhanced DSPIR framework can help quantify resource pressures and the resultant environmental impacts across supply chains when facing a global emergency ***,we recommend the development o

关键词： Global emergency events Water-biodiversity causal effect COVID-19 Biodiversity MRIO-enhanced DPSIR framework Supply-chain network High-resolution water consumption dataset Supply-constrained multi-regional input-output(mixed MRIO)model

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Modeling Households’ Behavior, Energy System Operation, and Interaction in the Energy Community

SSRN

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SSRN 2024年

作者： Yu, Songmin Mascherbauer, Philipp Haupt, Thomas Rickmann, Hannah Kochański, Maksymilian Skorna, Kevan Kranzl, Lukas Ansbach University of Applied Sciences Germany Vienna University of Technology Austria Fraunhofer Institute for Systems and Innovation Research Breslauer Str. 48 Karlsruhe76139 Germany Technische Universität Wien Energy Economics Group Gusshausstrasse 25-29/370-3 Wien1040 Austria Copernicus Institute of Sustainable Development Utrecht University Heidelberglaan 8 Utrecht3584 CS Netherlands Heidelberg University Grabengasse 1 Heidelberg69117 Germany Research and Innovation Centre Pro-Akademia 9/11 Innowacyjna street Konstantynów Lódzki95-050 Poland

This paper introduces FLEX, an open-source modeling suite designed to analyze the behavior,energy system operation, and interactions of households within energy communities. FLEXconsists of three interconnected models: FLEX-Behavior, which utilizes a time-dependentMarkov core to simulate hourly behavior and energy demands based on Time-use Survey data;FLEX-Operation, which allows hourly consumption calculation of household with technologyconfigurations such as heating systems, photovoltaics, storage solutions, and smart energymanagement;and FLEX-Community, which models peer-to-peer electricity trading and batteryoperation optimization by aggregators. This suite enables the examination of technologicaland behavioral impacts on energy systems, supporting broader power system analysis. Resultsdemonstrating FLEX’s capabilities and limitations are also presented, highlighting its potentialto address complexities introduced by societal shifts such as increased teleworking and theevolution from "prosumers" to "prosumagers" who actively manage their energy consumption. © 2024, The Authors. All rights reserved.

关键词： Energy utilization

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Optimal Reordering Trace Files for Improving Software Testing Suitcase

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Computers, Materials & Continua 2021年第4期67卷 1225-1239页

作者： Yingfu Cai Sultan Noman Qasem Harish Garg Hamïd Parvïn Kim-Hung Pho Zulkefli Mansor School of Measurement and Communication Harbin University of Science&TechnologyHarbinChina Computer Science Department College of Computer and Information SciencesAl Imam Mohammad Ibn Saud Islamic University(IMSIU)RiyadhSaudi Arabia Department of Computer Science Faculty of Applied ScienceTaiz UniversityTaizYemen School of Mathematics Thapar Institute of Engineering and TechnologyDeemed UniversityPatiala147004India Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam Department of Computer Science Nourabad Mamasani BranchIslamic Azad UniversityMamasaniIran Fractional Calculus Optimization and Algebra Research GroupFaculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam Fakulti Teknologi dan Sains Maklumat Universiti Kebangsan MalaysiaUKM BangiSelangor43600Malaysia

An invariant can be described as an essential relationship between program *** invariants are very useful in software checking and *** tools that are used to detect invariants are invariant *** are two types of invariant detectors:dynamic invariant detectors and static invariant *** software is an available computer program that implements a special case of a dynamic invariant detection *** proposes a dynamic invariant detection algorithm based on several runs of the tested program;then,it gathers the values of its variables,and finally,it detects relationships between the variables based on a simple statistical *** method has some *** of its biggest drawbacks is its overwhelming time *** is observed that the runtime for the Daikon invariant detection tool is dependent on the ordering of traces in the trace file.A mechanism is proposed in order to reduce differences in adjacent trace *** is done by applying some special techniques of mutation/crossover in genetic algorithm(GA).An experiment is run to assess the benefits of this *** findings reveal that the runtime of the proposed dynamic invariant detection algorithm is superior to the main approach with respect to these improvements.

关键词： Dynamic invariant detection software testing genetic algorithm

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Watt-level all polarization-maintaining femtosecond fiber laser source at 1100 nm for multicolor two-photon fluorescence excitation of fluorescent proteins

arXiv

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arXiv 2024年

作者： Wen, Junpeng Pilger, Christian Wang, Wenlong Erapaneedi, Raghu Xiu, Hao Fan, Yiheng Hu, Xu Huser, Thomas Kiefer, Friedemann Wei, Xiaoming Yang, Zhongmin School of Physics and Optoelectronics South China University of Technology Guangzhou510640 China State Key Laboratory of Luminescent Materials and Devices Institute of Optical Communication Materials South China University of Technology Guangzhou510640 China Biomolecular Photonics Research Group Faculty of Physics Bielefeld University BielefeldD-33615 Germany European Institute for Molecular Imaging University of Münster Röntgenstraße 16 MünsterD-48149 Germany Max Planck Institute for Molecular Biomedicine Röntgenstraße 20 MünsterD-48149 Germany Guangdong Engineering Technology Research Development Center of Special Optical Fiber Materials and Devices South China University of Technology Guangzhou510640 China Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques South China University of Technology Guangzhou510640 China Research Institute of Future Technology South China Normal University Guangdong Guangzhou510006 China

We demonstrate a compact watt-level all polarization-maintaining (PM) femtosecond fiber laser source at 1100 nm. The fiber laser source is seeded by an all PM fiber mode-locked laser employing a nonlinear amplifying loop mirror. The seed laser can generate stable pulses at a fundamental repetition rate of 40.71 MHz with a signal-to-noise rate of >100 dB and an integrated relative intensity noise of only ~0.061%. After two-stage external amplification and pulse compression, an output power of ~1.47 W (corresponding to a pulse energy of ~36.1 nJ) and a pulse duration of ~251 fs are obtained. The 1100 nm femtosecond fiber laser is then employed as the excitation light source for multicolor multi-photon fluorescence microscopy of Chinese hamster ovary (CHO) cells stably expressing red fluorescent proteins. Copyright © 2024, The Authors. All rights reserved.

关键词： Proteins

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Existence and regularity of inverse problem for the nonlinear fractional Rayleigh-Stokes equations

Existence and regularity of inverse problem for the nonlinea...

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作者： Tran Bao, Ngoc Nguyen Hoang, Luc Vo Van, Au Nguyen, Huy Tuan Zhou, Yong Institute of Research Development Duy Tan University Da Nang550000 Viet Nam Department of Mathematics and Computer Science University of Science Ho Chi Minh City Viet Nam Vietnam National University Ho Chi Minh City Viet Nam Applied Analysis Research Group Faculty of Mathematics Statistics Ton Duc Thang University Ho Chi Minh City Viet Nam Faculty of Information Technology Macau University of Science Technology 999078 China Faculty of Mathematics Computational Science Xiangtan University Hunan411105 China

This paper investigates an inverse problem for fractional Rayleigh-Stokes equations with nonlinear source. The fractional derivative in time is taken in the sense of Riemann-Liouville. The proposed problem has many applications in some non-Newtonian fluids. We obtain some results on the existence and regularity of mild solutions. © 2020 John Wiley & Sons, Ltd.

关键词： Inverse problems

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Unveiling the Conditioning Correlation in Ex-Situ Catalytic Pyrolysis of Waste Polyolefins Towards Designated Conversion into Valuable Products

SSRN

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SSRN 2024年

作者： Xiang, Huan Wang, Jiawei Ma, Peng Cheng, Yi Yildiz, Güray College of Chemistry and Chemical Engineering Southwest Petroleum University Chengdu610500 China Bioenergy Research Group EBRI Aston University Aston Triangle BirminghamB4 7ET United Kingdom Department of Chemical Engineering and Applied Chemistry Aston University Aston Triangle BirminghamB4 7ET United Kingdom Research and Development Centre of High Value Utilization of Biomass Zhengzhou University of Technology Zhengzhou450044 China Department of Energy Systems Engineering Faculty of Engineering Izmir Institute of Technology Urla Izmir35430 Turkey Department of Materials Engineering and Production Faculty of Mechanical Engineering Bialystok University of Technology Wiejska 45C Bialystok15-351 Poland

The ex-situ catalytic pyrolysis of waste polyolefin plastics holds promise for producing aromatics and light olefins, with potential integrations in the low-carbon olefin processing industry for producing ethylene, propylene, butadiene, or aromatic hydrocarbons. Employing ZSM-5(50) zeolite, selected for its substantial specific surface area and total pore volume, facilitated the catalytic pyrolysis of household plastic waste through an ex-situ pyrolysis-catalysis approach. This study explored the impact of operating parameters, namely pyrolysis temperature (T1), catalytic vapor upgrading temperature (T2), and the catalyst/plastic (C/P) mass ratio, on pyrolysis product yields and distributions. Higher catalytic vapor upgrading temperatures benefited gas production, accompanied by a notable decrease in C4 content in gaseous products. A larger C/P mass ratio provided more active sites for pyrolysis reactions, but higher reaction temperatures induced coke formation on the catalyst, leading to ZSM-5(50) deactivation and inhibiting further gas production. Positive effects of catalytic vapor upgrading temperature and the C/P mass ratio were observed for the concentration of BTX in the produced oil. The quadratic fitting was engaged in characterising the reaction conditions. Specifically, the 500-550-0.25 run achieved the maximum C2 yield of 30.3 wt.%, the 500-350-0.4 run obtained the highest yield of C3 and C4 of 75.4 wt.%, and the run of 575-450-0.25 yielded the highest amount of BTX of 17.2 wt.%. These findings provide valuable insights into the designated conditioning of catalytic pyrolysis for plastic waste valorisation. © 2024, The Authors. All rights reserved.

关键词： Ethylene

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