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NATURE REVIEWS METHODS PRIMERS 2025年第1期5卷 1页

作者： [Anonymous] Human Microbiome Research Program Department of Bacteriology and Immunology Faculty of Medicine University of Helsinki Helsinki Finland European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Non-traditional Antibacterial Therapy (ESGNTA) Basel Switzerland Institute of Biomedical and Oral Research (IBOR) Faculty of Dental Medicine Hebrew University of Jerusaleum Jerusalem Israel The Israeli Phage Center (IPTC) of the Hebrew University and Hadassah Medical Center Jerusalem Israel Department of Clinical Microbiology and Infectious Diseases Hadassah–Hebrew University Medical Center Jerusalem Jerusalem Israel Laboratory of Gene Technology Department of Biosystems KU Leuven Leuven Belgium Leicester Centre for Phage Research Department of Genetics and Genome Biology University of Leicester Leicester UK Center for Evolutionary Hologenomics Globe Institute University of Copenhagen Copenhagen Denmark Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) AIMST University Bedong Kedah Malaysia Laboratory of Phage Molecular Biology Institute of Immunology and Experimental Therapy Wrocław Poland Wrocław University of Science and Technology Faculty of Medicine Wrocław Poland Department of Biological Sciences University of Pittsburgh Pittsburgh PA USA Laboratory for Molecular and Cellular Technology Queen Astrid Military Hospital Brussels Belgium Department of Biological and Environmental Science Nanoscience Center University of Jyväskylä Jyväskylä Finland Chemical Engineering Department Loughborough University Loughborough UK

Bacteriophage (phages) are viruses that exclusively use bacterial cells for propagation, killing the bacterial host in the process. In phage therapy, phages are used to reduce bacterial numbers, thereby curing bacterial infections. Although this principle is conceptually straightforward, its practical application faces several hurdles. In this Primer, the practical aspects of phage therapy are outlined. We introduce the microbiological methods used to prepare and characterize phages and elucidate their interactions with bacteria. The discussion covers how the information in complete phage genome sequences is used, along with how RNA sequencing can enhance our understanding of phage biology. Selection parameters for therapeutic phages for clinical applications and key elements in industrial-scale phage production are provided. A summary of clinical trials both past and present, phage administration and dosing issues is analysed, as well as limitations associated with phage therapy and mitigation strategies. Finally, we speculate on the future of phage therapy.

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Interior design study of lecturer rooms at E12 building 2nd floor UNNES – learn from COVID-19 pandemic

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IOP Conference Series: Earth and Environmental science 2021年第1期700卷

作者： A Purnomo Study Program of Architecture Department of Civil Engineering Faculty of Engineering Universitas Negeri Semarang Building E4 Kampus Sekaran Gunungpati Semarang 50229 Indonesia

The covid-19 pandemic case has changed the structure of life in all aspects throughout the world. The field of man-made environment or architecture is no exception. The interior arrangement of a building, as part of the man-made environment, is also affected. The interior design of a building today seems to be obliged to participate in following the standards of new health-protocols in the new normal *** about the interior of the building that has already been utilized? Of course it requires further study to find out whether the interior of a building can be said to be healthy or not. This study aims to examine the interior design of the lecturer room E12 building 2nd floor UNNES in terms of health that is emphasized from the behavior of its users by referring to the situation of the covid-19 pandemic and its future prospects. The research method used is by field observations to search visual data, observing user behavior and textual data. Those who are categorized as users of the lecturer room E12 building 2nd floor UNNES are lecturers from the Department of architecture, students, administrators and guests. The results of this study indicate that based on the pattern of user behavior and associated with the standard requirements of space, area, volume of space, material and infrastructure conditions, interior design of lecturer room E12 building 2nd floor UNNES, is included in healthy category, although there are several minor corrections that can be included as suggestions for improvement in order to adjust to the new normal era during the covid-19 pandemic period and thereafter.

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Patchouli oil analysis of chemical components using FT-IR and GCMS method

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AIP Conference Proceedings 2023年第1期2738卷

作者： Hermin Pancasakti Kusumaningrum Rizqi Sa’adatun Ni’mah Yunita Nurlindasari Annisa Imrani Sadam Arrois Eko Purnomo Fa’ireza Rafli Arfiansyah Erni Setyowati Bambang Dwi Loka Biotechnology Study Program Biology Department Faculty of Science and Mathematics Diponegoro University Jl. Prof. Soedharto SH. Tembalang Semarang 50275 Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Jl. Prof. Soedharto SH. Tembalang Semarang 50275 Indonesia Architecture Department Faculty of Engineering Diponegoro University Jl. Prof. Soedharto SH. Tembalang Semarang 50275 Indonesia Food Technology Department Faculty of Animal and Agricultural Sciences Diponegoro University Jl. Prof. Soedharto SH. Tembalang Semarang 50275 Indonesia

Patchouli (Pogostemon cablin Benth.) is a plant that produces essential oils to be used for cosmetics, soap, antiseptic, perfume, pharmaceutical, insecticide and aromatherapy industries. One of the products produced from the patchouli plant is patchouli oil. This study aims to determine the content of chemical compounds contained in the essential oil of patchouli using the GC-MS analysis method to determine the molecular structure of the compound and separate the fractions in patchouli oil. Another method is the FT-IR analysis method to identify the functional groups contained in patchouli oil. The chemical properties of patchouli oil from the Blado area, Batang Indonesia, are traditionally distilled from fresh patchouli leaves and stems. The results of the GCMS analysis showed that there were 10 compounds with 4 peaks of dominant components which were the constituents of patchouli essential oil, namely Patchouli Alcohol (39.46 %), Delta-Guaiene (21.51%), Alpha Guaiene (20.13%), Alpha-patchoulena (9.01%). In the FTIR results carried out in the range of 4000-450 cm-1, various functional groups such as C=C, –CH2, C-H, C=O, O-H, C-O, =C-H, and N-H. This shows that patchouli oil is rich in alcohol, aromatics, and aldehydes.

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Rule of thumb for the calculation of overall transfer thermal value in Bandung

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IOP Conference Series: Earth and Environmental science 2021年第1期780卷

作者： L Kusumawati E Setyowati A B Purnomo Lecturer at Department of Architecture Faculty of Civil Engineering and Planning Trisakti University Jakarta Indonesia Student of Doctoral Program in Architecture and Urban Science Diponegoro University Semarang Indonesia Lecturer at Departement of Architecture Faculty of Engineering Diponegoro University Semarang Indonesia

The rule of thumb for heat transfer in building envelopes is made to make it easier to calculate heat transfer using the OTTV formula from SNI. Using this formula, it often makes it difficult for architects to quickly estimate the heat transfer value of a building. The OTTV formula variable issued by SNI is not an architectural design variable. Only one variable that is in accordance with the field of architecture is the window to wall ratio (WWR). The use of the OTTV formula is very dependent on the location of the building and solar radiation. So to overcome this difficulty, the researcher tries to offer a rule of thumb formula for calculating heat transfer. To get the OTTV formula by rule of thumb by means of design variable regression. With the rule of thumb formula for calculating OTTV, it is hoped that it can make it easier for architects to consider designs that are adapted to local conditions.

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Antioxidant compounds of leaves and seeds extracts of Parkia Speciosa overcome ferroptosis

Food Chemistry Advances

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Food Chemistry Advances 2025年 7卷

作者： Nopiyanti, Elsa Safithri, Mega Trivadila Sahidin Kuspradini, Harlinda Earnestly, Femi Hirata, Yoko Takemori, Hiroshi Batubara, Irmanida Department of Chemistry Chemistry Post-graduate Program Bogor Agricultural University West Java Bogor Indonesia Department of Biochemistry Chemistry Post-graduate Program Bogor Agricultural University West Java Bogor Indonesia Department of Pharmacy Faculty of Pharmacy Universitas Halu Oleo Kendari Indonesia Faculty of Forestry Universitas Mulawarman Samarinda East Kalimantan Indonesia Faculty of Pharmacy Muhammadiyah University of Sumatera Barat West Sumatera Padang Indonesia Life Science Research Center Institute for Advanced Study Gifu University Gifu Japan Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University Gifu Japan Tropical Biopharmaca Research Center IPB University West Java Bogor Indonesia

Parkia speciosa seeds, a widely consumed plant in Southeast Asia, are known for their rich bioactive compounds with potential health benefits. This study investigates the antioxidant properties of ethanol extracts from P. speciosa leaves (PSL) and seeds (PSS) to combat oxidative stress. Antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays, revealing that PSL exhibited higher antioxidant potential than PSS, with values of 14.34 ± 0.02 and 19.39 ± 0.04 μg ascorbic acid equivalent (AAE)/g extract, respectively. The ethanol extracts of PSL and PSS significantly protected HT22 cells from erastin-induced ferroptotic cell death and activated the antioxidant response element (ARE) pathway, enhancing endogenous antioxidant defense mechanisms. Furthermore, in silico molecular docking analysis identified 7,7′-Dihydroxy-5′‑methoxy-2′,2′-dimethyl-4-oxo-3′,4′-dihydro-2′H,4H-3,6′-bichromen-5-yl hexopyranosiduronic acid as a promising bioactive compound with strong binding affinities to oxidative stress-related receptors (5i6x, 6cm4, 2f8a, 8bxn, and 8ivr). These findings suggest that P. speciosa ethanol extract, particularly from its leaves, exhibits strong antioxidant and neuroprotective properties, supporting its potential application as a natural therapeutic agent for oxidative stress-related disorders. © 2025 The Authors

关键词： 7,7′-Dihydroxy-5′-methoxy-2′2′-dimethyl-4-oxo-3′4′-dihydro-2′H 4H-3 6′-bichromen-5-yl hexopyranosiduronic acid antioxidant response element Ferroptosis, P. speciosa HT22 cells

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Baseline waste management data in North Lombok District

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IOP Conference Series: Earth and Environmental science 2021年第1期802卷

作者： A Simorangkir N Citrasari S Hariyanto A Widyastuti Undergraduate Environmental Engineering Department of Biology Faculty of Science and Technology Universitas Airlangga Indonesia Study of Biology Program Department of Biology Faculty of Science and Technology Universitas Airlangga Indonesia

An integrated waste management system requires baseline data, including waste generation analysis, composition density, and waste characteristics. Baseline data is needed to determine the proper waste management strategy. This research was conducted by measuring directly from the source of waste carried out by stratified sampling following SNI 19-3964-1994. The location of the study was carried out in Tanjung and Gangga districts because this location is considered to represent North Lombok Regency. The research was conducted using 100 samples of household waste. The study results on the composition of waste in the North Lombok Regency consisted of organic waste, plastic waste, paper, cloth, wood, glass, metal, and rubber waste. The dominant composition is organic waste. The characteristics of waste in the North Lombok Regency have a higher water content than the water content of waste in general. All the characteristics tested indicate that the waste in North Lombok Regency requires several treatments before processing waste, such as reducing the water content and increasing the C/N ratio. Based on the characteristics and composition of the waste, composting or incineration is the suitable waste management method in North Lombok Regency.

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Increasing accuracy of classification physical activity based on smartphone using ensemble logistic regression with boosting method 3

Increasing accuracy of classification physical activity base...

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3rd International Conference on science, ICOS 2019

作者： Lawi, A. Aziz, F. Wungo, S.L. Department of Computer Science Universitas Hasanuddin Makassar90245 Indonesia Faculty of Mathematics and Natural Sciences Universitas Pancasakti Makassar90132 Indonesia Program Study Informatics Engineering STMIK Kreatindo Monokwari98300 Indonesia

At present, the smartphone is equipped with several sensors such as Accelerometer, Gravity sensor, and Gyroscope which can be used to recognize human physical activities such as walking upstair and walking downstairs etc. Machine learning is needed to group data and get information. Statistical methods have poor performance in classifying because procedures must be met. To overcome this, an ensemble technique was used. This study proposes the application of the gradientboost ensemble method to classify walking upstair and walking downstairs. The *** system is designed for data retrieval using a smartphone. Then, the dataset will be partitioned into 70% training data and 30% test data. The results show that the performance of the ensemble boosting method produces 81.82% accuracy, 86.11% sensitivity and 77.50% specificity. © Published under licence by IOP Publishing Ltd.

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Designing louvers toward optimum daylight performance in Indonesia: a parametric study

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IOP Conference Series: Earth and Environmental science 2021年第1期907卷

作者： R P Khidmat H Fukuda Kustiani A P Wibowo Graduate School of Environmental Engineering The University of Kitakyushu Japan Architecture Study Program Institut Teknologi Sumatera Indonesia Department of Architecture Faculty of Environmental Engineering The University of Kitakyushu Japan Department of Architecture Universitas Bandar Lampung Indonesia Department of Architecture Universitas Atma Jaya Yogyakarta Indonesia

architecture has a strong relationship with the daylight universe. It implicates further occupants' behaviour toward visual comforts, healthiness, and energy consumption. The daylight simulation in the early phase of design benefits the architect in predicting the possibilities of daylight-related target goals during the design process. A shading system is one of the strategies in approaching passive design to prevent an excessive amount of undesirable daylight intensity. This paper investigates different sun louvers shading patterns and their relation to the Useful Daylight Illuminance (UDI) in the context of Indonesia, presented by incorporating the EPW file of Jakarta. Parametric and multi-objective optimization has been used to optimize, explore, and map the design possibilities based on the louver shading component as dynamic parameters. Rhinoceros and Grasshopper, as parametric-based modelling software, were used as the primary modelling platform, while the Honeybee and Ladybug plugin were used to undergo the daylight-related environmental analysis. The design exploration iterates 2.160 design solutions with a value of dynamic parameters and the targeted UDI value embedded in each. The results show that the solution founded from iteration process has more areas of illuminance within 300 lx to 500 lx by about 15%.

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Prediction of the activity of carbohydrate moiety of bromelain as immunomodulator using an in silico approach

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AIP Conference Proceedings 2023年第1期2480卷

作者： Trina Ekawati Tallei Fatimawali Afriza Yelnetty Nurdjannah Jane Niode Diah Kusumawaty Billy Johnson Kepel Souvia Rahimah Yunus Effendi Rinaldi Idroes Sefren Geiner Tumilaar Shafi Mahmud Talha Bin Emran Department of Biology Faculty of Mathematics and Natural Sciences Sam Ratulangi University Manado 95115 North Sulawesi Indonesia Pharmacy Study Program Faculty of Mathematics and Natural Sciences Sam Ratulangi University Manado 95115 North Sulawesi Indonesia Animal Products Technology Study Program Faculty of Animal Husbandry Sam Ratulangi University Manado 95115 North Sulawesi Indonesia Department of Dermatology and Venereology Faculty of Medicine University of Sam Ratulangi RD Kandou Hospital Manado 95163 North Sulawesi Indonesia Department of Biology Education Faculty of Mathematics and Science Education Universitas Pendidikan Indonesia Bandung 40154 Jawa Barat Indonesia Department of Chemistry Faculty of Medicine Sam Ratulangi University Manado 95115 North Sulawesi Indonesia Food Technology Study Program Department of Food Industrial Technology Faculty of Agroindustrial Technology Universitas Padjadjaran Jatinangor 45363 West Java Indonesia Biology Study Program Faculty of Science and Technology Universitas Al Azhar Jakarta 12110 Indonesia Department of Pharmacy Faculty of Mathematics and Natural Sciences Universitas Syiah Kuala Kopelma Darussalam Banda Aceh 23111 Indonesia Microbiology Laboratory Department of Genetic Engineering and Biotechnology University of Rajshahi Rajshahi 6205 Bangladesh Department of Pharmacy BGC Trust University Bangladesh Chittagong 4381 Bangladesh

Bromelain is a glycoprotein that contains a single carbohydrate moiety group and displays proteolytic activity. Bromelain has long been known to act as an immunomodulator; however, the immunomodulatory activity of its carbohydrate moiety has been very rarely studied and is not well understood. This study aimed to predict the immunomodulatory activity of the carbohydrate moiety of bromelain (CMB) by evaluating it using the PASS server, and the binding affinities between CMB and various pro-inflammatory cytokines were analyzed using a molecular docking approach. This research was conducted by docking the CMB ligand to the following receptor proteins: interleukin-6 (IL-6), IκBβ/nuclear factor (NF)-κB p65 homodimer complex (IκBα/NF-κB p65), tumor necrosis factor-alpha (TNF-α), and IL-1β. The biological potential of CMB was predicted using the online PASS server. The results of the computational analysis indicated that the highest binding energy was identified between CMB and IκBβ/NF-κB p65 (−10.3 kcal/mol), followed by TNF-α (−9.7 kcal/mol), and IL-6 and IL-1β, with values of −8.2 kcal/mol for both. The CMB activity predicted by the Way2Drug PASS server indicated that this molecule is likely to display significant immunostimulant activity. These findings suggested that CMB can be considered a potential lead molecule for further drug development to identify agent that can prevent or cure inflammation and restore balance to the immune system. However, the predictions determined in this study remain to be validated in future in vitro and in vivo studies.

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Correction: Optimized framework for evaluating F3 transgressive segregants in cayenne pepper

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BMC plant biology 2025年第1期25卷 300页

作者： Ifayanti Ridwan Muh Farid Feranita Haring Nuniek Widiayani Ahmad Yani Nirwansyah Amier Muhammad Alfan Ikhlasul Amal Jekvy Hendra Nawab Ali Mekhled M Alenazi Mahmoud F Seleiman Willy Bayuardi Suwarno Muhammad Fuad Anshori Department of Agronomy Faculty of Agriculture Hasanuddin University Makassar 90245 Indonesia. Agrotechnology Bachelor Study Program Faculty of Agriculture Hasanuddin University Makassar 90245 Indonesia. Agrotechnology Master Study Program Faculty of Agriculture Hasanuddin University Makassar 90245 Indonesia. Agricultural Science Doctoral Program Graduate School Hasanuddin University Makassar 90245 Indonesia. Directorate of Horticultural Protection Agricultural Ministry Jakarta 12520 Indonesia. Department of Biosystems and Agricultural Engineering (BAE) College of Agriculture and Natural Resources Michigan State University East Lansing USA. Department of Plant Production College of Food and Agriculture Sciences King Saud University Riyadh Saudi Arabia. Department of Agronomy and Horticulture Faculty of Agriculture IPB University Bogor 11680 Indonesia. Department of Agronomy Faculty of Agriculture Hasanuddin University Makassar 90245 Indonesia. fuad.anshori@unhas.ac.id.

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