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Metabolomics reveals that PS-NPs promote lung injury by regulating prostaglandin B1 through the cGAS-STING pathway

Chemosphere 2023年 342卷 140108页

作者： Xuan, Lihui Wang, Yin Qu, Can Yan, Yuhui Yi, Wensen Yang, Jingjing Skonieczna, Magdalena Chen, Cuimei Miszczyk, Justyna Ivanov, Dmitry S. Zakaly, Hesham M.H. Markovic, Vladimir Huang, Ruixue Department of Occupational and Environmental Health Xiangya School of Public Health Central South University Hunan Province Changsha410078 China Department of Systems Biology and Engineering Silesian University of Technology Institute of Automatic Control Akademicka 16 Gliwice44-100 Poland Biotechnology Centre Silesian University of Technology Krzywoustego 8 Gliwice44-100 Poland School of Public Health Xiang Nan University Hunan Chenzhou423000 China Department of Medical Physics Cyclotron Centre Bronowice Institute of Nuclear Physics Polish Academy of Sciences KrakowPL-31342 Poland Quantum Electronics Division Lebedev Physical Institute Moscow119991 Russia Institute of Physics and Technology Ural Federal University Yekaterinburg620002 Russia Physics Department Faculty of Science Al-Azhar University Assuit71524 Egypt Faculty of Sciences University of Kragujevac Kragujevac34000 Serbia

Nanoplastics have been widely studied as environmental pollutants, which can accumulate in the human body through the food chain or direct contact. Research has shown that nanoplastics can affect the immune system and mitochondrial function, but the underlying mechanisms are unclear. Lungs and macrophages have important immune and metabolic functions. This study explored the effects of 100 nm PS-NPs on innate immunity, mitochondrial function, and cellular metabolism-related pathways in lung (BEAS-2B) cells and macrophages (RAW264.7). The results had shown that PS-NPs exposure caused a decrease in mitochondrial membrane potential, intracellular ROS accumulation, and Ca2+ overload, and activated the cGAS-STING signaling pathway related to innate immunity. These changes had been observed at concentrations of PS-NPs as low as 60 μg/mL, which might have been comparable to environmental levels. Non-target metabolomics and Western Blotting results confirmed that PS-NPs regulated prostaglandin B1 and other metabolites to cause cell damage through the cGAS-STING pathway. Supplementation of prostaglandin B1 alleviated the immune activation and metabolic disturbance caused by PS-NPs exposure. This study identified PS-NPs-induced innate immune activation, mitochondrial dysfunction, and metabolic toxicity pathways, providing new insights into the potential for adverse outcomes of NPs in human life. © 2023 Elsevier Ltd

关键词： Toxicity

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Physico-chemical and biological evaluation of doxycycline loaded into hybrid oxide-polymer layer on Ti-Mo alloy

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Bioactive Materials 2020年第3期5卷 553-563页

作者： Alicja Kazek-Kęsik Agnieszka Nosol Joanna Płonka MonikaŚmiga-Matuszowicz Sebastian Student Monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła Wojciech Simka Faculty of Chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Biotechnology Centre Silesian University of TechnologyKrzywoustego 8 Street44-100GliwicePoland Faculty of Chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and Ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

Oxide-polymer coatings were formed on the surface of the vanadium-free Ti–15Mo titanium *** Ti alloy surface was modified by the plasma electrolytic oxidation process,and then,the polymer layer of a poly(D,Llactide-co-glycolide)with doxycycline was *** polymer evenly covered the porous oxide layer and filled some of the ***,the microstructure of the polymer surface was completely different from that of the PEO *** surface morphology,roughness and microstructure of the polymer layer were examined by scanning electron microscopy(SEM)and a confocal *** results confirmed the effectiveness of polymer and doxycycline deposition in their stable chemical *** drug analysis was performed by highperformance liquid *** 1H NMR technique was used to monitor the course of hydrolytic degradation of *** was shown that the PLGA layer is hydrolysed within a few weeks,and the polyglycolidyl part of the copolymer is hydrolysed to glycolic acid as first and much faster than the polylactide one to lactic *** paper presents influence of different microstructures on the biological properties of modified titanium *** and bacterial adhesion tests were evaluated using osteoblast-like MG-63 cells and using the reference *** and *** *** results showed that the optimum concentration of doxycycline was found to inhibit the growth of the bacteria and that the layer is still cytocompatible.

关键词： Biomaterials Titanium alloy Plasma electrolytic oxidation Oxide-polymer hybrid coatings Doxycycline

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Antibacterial and cytocompatible coatings based on poly(adipic anhydride) for a Ti alloy surface

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Bioactive Materials 2020年第3期5卷 709-720页

作者： Katarzyna Leśniak-Ziółkowska MonikaŚmiga-Matuszowicz Agata Blacha-Grzechnik Sebastian Student Monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła Wojciech Simka Alicja Kazek-Kęsik Faculty of Chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Faculty of Chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Biotechnology Centre Silesian University of TechnologyB.Krzywoustego 8 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and Ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb *** is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride)((C6H8O3)n)that is loaded with drugs:amoxicillin(C16H19N3O5S),cefazolin(C14H14N8O4S3)or vancomycin(C66H75Cl2N9O24·xHCl).The characteristic microstructure of the polymer was evaluated using scanning electron microscopy and confocal *** on the surface treatment,the surface roughness varied(between 1.53μm and 2.06μm),and the wettability was change with the over of time.X-ray photoelectron spectroscopy analysis showed that the oxide layer did not affect the polymer layer or loaded ***,the drugs lose their stability in a phosphate-buffered saline solution after 6.5 h of exposure,and its decrease was greater than 7%(HPLC analysis).The stability,drug release and concentration of the drug loaded into the material were precisely analyzed by high-performance liquid *** results correlated with the degradation of the polymer in which the addition of drugs caused the percent of degraded polymer to be between 35.5%and 49.4%after 1 h of material immersion,depending on the mass of the loaded drug and various biological responses that were ***,all of the coatings were cytocompatible with MG-63 osteoblast-like *** drug concentrations released from the coatings were sufficient to inhibit adhesion of reference and clinical bacterial strains(***).The coatings with amoxicillin showed the best results in the bacterial inhibition zone,whereas coatings with cefazolin inhibited adhesion of the above bacteria on the surface.

关键词： Titanium alloy poly(adipic anhydride) Antibacterial coatings Cytocompatible Dental implants

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Classical and Advanced control Methods Applied to an Anaerobic Digestion Reactor Model

Classical and Advanced Control Methods Applied to an Anaerob...

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CHILEAN Conference on Electrical, Electronics engineering, Information and Communication Technologies (CHILECON)

作者： E. Fernandez W. Ipanaque R. Cajo R. De Keyser Automatic and Control Systems laboratory Piura University Piura Perú Automatic and Control Systems lab Piura University Piura Peru Faculty of Engineering and Architecture Research group on Dynamical Systems and Control Ghent University Gent Belgium Faculty of Engineering and Architecture Research group on Dynamical Systems and Control Ghent University Ghent Belgium

ISBN: (纸本)9781728131863

In this work, advanced method of process control as Extended Prediction Self-Adaptive control (EPSAC) and Nonlinear Extended Prediction Self-Adaptive control (NEPSAC) are implemented and compared with the traditional PID controller tuned by a novel KC autotuning method and a classical FRtool method. The controllers are designed based on a linear and non-linear reactor model of the Anaerobic digestion pilot plant located in Peru. The performance evaluation of the controllers is realized through MATLAB environment with model parameters obtained experimentally. Also, a linear model has been developed using a novel estimation method of a Second Order Plus Dead-Time models (SOPDT). The results show that NEPSAC outperforms the other controllers.

关键词： adaptive control bioreactors linear systems nonlinear control systems predictive control process control temperature control three-term control Process control Three term control systems Nonlinear control systems Predictive control Temperature control adaptive control Bioreactors Linear system Proportional Integral Derivative control controllers control Methods DEAD TIME Anaerobic digestion anaerobic treatment Advanced controls

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Author Correction: H∞ observer-based control for fuzzy Hadamard fractional-order systems

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Computational and Applied Mathematics 2025年第5期44卷 1-1页

作者： Rhaima, Mohamed Gassara, Hamdi Mchiri, Lassaad Hajjaji, Ahmed El Makhlouf, Abdellatif Ben Department of Statistics and Operations Research College of Science King Saud University Riyadh Saudi Arabia Laboratory of Sciences Techniques of Automatic Control and Computer Engineering National School of Engineering of Sfax University of Sfax Sfax Tunisia Panthéon-Assas University Paris II Paris France Modeling Information and Systems Laboratory University of Picardie Jules Verne UFR of Sciences Amiens France Department of Mathematics Faculty of Sciences Sfax University Sfax Tunisia

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Chattering-free fixed-time sliding mode control for bilateral teleoperation under unknown time-varying delay via disturbance and state observers

Advanced Control for Applications: Engineering and Industria...

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Advanced control for Applications: engineering and Industrial systems 2020年第4期2卷

作者： Abadi, Ali Soltani Sharif Hosseinabadi, Pooyan Alinaghi Mekhilef, Saad Ordys, Andrzej Department of Electrical Engineering Faculty of Engineering Yazd University Yazd Iran Faculty of Engineering University of Malaya Kuala Lumpur Malaysia School of Software and Electrical Engineering Faculty of Science Engineering and Technology Swinburne University of Technology Melbourne Australia Center of Research Excellence in Renewable Energy and Power Systems King Abdulaziz University Jeddah Saudi Arabia The Institute of Automatic Control and Robotics Faculty of Mechatronics Warsaw University of Technology Warsaw Poland

This paper proposes a new chattering-free Fixed-time Observer-Based Sliding Mode control (FOBSMC) scheme for synchronization of two bilateral teleoperations under unknown time-varying delay. The system is subjected to unknown disturbances which are estimated in a fixed time by utilizing the Disturbance Observer-based SMC scheme. The fixed-time State Observer-based SMC is designed to estimate the unmeasured velocity state, while the position state is assumed to be available. Fixed-time stability method is used to provide the system convergence time independently of initial states. A FOBSMC scheme is first designed for master system of bilateral teleoperation under unknown time-varying delay to track the environmental torque by the human operating torque in the presence of time delay in the communication channel, as well as estimating the unknown disturbances and unmeasured states. A FOBSMC scheme is designed to synchronize slave system to master system in the presence of time delay in the communication channel, as well as estimating disturbances and states. The stability analysis is performed for closed-loop system of combined controller-observer by using Lyapunov theory. The efficacy of the proposed method to fulfill a good transparency and stability under time-varying communication delays is tested by performing numerical simulation in Simulink/MATLAB. © 2020 John Wiley & Sons Ltd.

关键词： Time delay

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Reconstruction of photospheric velocity fields from highly corrupted data

arXiv

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arXiv 2022年

作者： Rempel, Erico L. Chertovskih, Roman Davletshina, Kamilla R. Silva, Suzana S.A. Welsch, Brian T. Chian, Abraham C.-L. SP São José dos Campos12228–900 Brazil P.O. Box 515 SP São José dos Campos12227-010 Brazil Electrical and Computer Engineering Department Faculty of Engineering University of Porto Rua Dr. Roberto Frias s/n Porto4200-465 Portugal Yandex Lva Tolstogo street 16 Moscow119021 Russia Plasma Dynamics Group Department of Automatic Control and Systems Engineering University of Sheffield Sheffield United Kingdom University of Wisconsin Green BayWI54311 United States University of Adelaide School of Mathematical Sciences AdelaideSA5005 Australia

The analysis of the photospheric velocity field is essential for understanding plasma turbulence in the solar surface, which may be responsible for driving processes such as magnetic reconnection, flares, wave propagation, particle acceleration, and coronal heating. Currently, the only available methods to estimate velocities at the solar photosphere transverse to an observer’s line of sight infer flows from differences in image structure in successive observations. Due to data noise, algorithms such as local correlation tracking (LCT) may lead to a vector field with wide gaps where no velocity vectors are provided. In this letter, a novel method for image inpainting of highly corrupted data is proposed and applied to the restoration of horizontal velocity fields in the solar photosphere. The restored velocity field preserves all the vector field components present in the original field. The method shows robustness when applied to both simulated and observational data. Copyright © 2022, The Authors. All rights reserved.

关键词： Velocity

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Adaptive neural network based dynamic surface control for uncertain dual arm robots

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International Journal of Dynamics and control 2020年第3期8卷 824-834页

作者： Pham, Dung Tien Nguyen, Thai Van Le, Hai Xuan Nguyen, Linh Thai, Nguyen Huu Phan, Tuan Anh Pham, Hai Tuan Duong, Anh Hoai Bui, Lam Thanh Centre for Autonomous Systems University of Technology SydneyNSW2007 Australia Department of Automatic Control Hanoi University of Science and Technology Hanoi10000 Viet Nam University of Paris Saclay Espace Technologique Bat. Discovery - RD 128 - 2e ét Saint-Aubin91190 France School of Electrical and Electronics Engineering College of Urban Works Construction Hanoi10000 Viet Nam Vinh University of Technology Education VinhNghe An Viet Nam School of Electrical and Electronics Engineering Military Industrial College Hanoi10000 Viet Nam University of Lorraine 34 Cours Léopold Nancy54000 France Faculty of Electrical Engineering Hanoi University of Industry Hanoi10000 Viet Nam

The paper discusses an adaptive strategy to effectively control nonlinear manipulation motions of a dual arm robot (DAR) under system uncertainties including parameter variations, actuator nonlinearities and external disturbances. It is proposed that the control scheme is first derived from the dynamic surface control (DSC) method, which allows the robot’s end-effectors to robustly track the desired trajectories. Moreover, since exactly determining the DAR system’s dynamics is impractical due to the system uncertainties, the uncertain system parameters are then proposed to be adaptively estimated by the use of the radial basis function network (RBFN). The adaptation mechanism is derived from the Lyapunov theory, which theoretically guarantees stability of the closed-loop control system. The effectiveness of the proposed RBFN-DSC approach is demonstrated by implementing the algorithm in a synthetic environment with realistic parameters, where the obtained results are highly promising. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Radial basis function networks

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A spectral small-gain condition for input-to-state stability of infinite networks

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IFAC-PapersOnLine 2020年第2期53卷 5303-5308页

作者： Christoph Kawan Andrii Mironchenko Abdalla Swikir Navid Noroozi Majid Zamani Institute of Informatics Ludwig Maximilian University Munich Germany Faculty of Computer Science and Mathematics University of Passau Germany Department of Electrical and Computer Engineering Technical University of Munich Germany Otto-von-Guericke University Magdeburg Laboratory for Systems Theory and Automatic Control Germany Computer Science Department University of Colorado Boulder USA

This paper presents a tight small-gain theorem for networks composed of infinitely many finite-dimensional subsystems. Assuming that each subsystem is exponentially input-to-state stable, we show that if the gain operator, collecting all the information about the internal Lyapunov gains, has a spectral radius less than one, the overall infinite network is exponentially input-to-state stable. We illustrate the effectiveness of our result by applying it to traffic networks.

关键词： Nonlinear systems small-gain theorems infinite-dimensional systems input-to-state stability Lyapunov methods large-scale systems

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On an IFAC online pilot survey for a first course on control 5

On an IFAC online pilot survey for a first course on control

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5th Experiment at International Conference, exp.at 2019

作者： Huba, Mikulas Anthony Rossiter, J. Zakova, Katarina Serbezov, Atanas Visioli, Antonio Institute of Automotive Mechatronics Faculty of Electrical Engineering and Information Technology Slovak University of Technology Bratislava Slovakia Department of Automatic Control and Systems Engineering University of Sheffield Sheffield United Kingdom Rose-Hulman Institute of Technology Terre Haute United States Department of Mechanical and Industrial Engineering University of Brescia Brescia Italy

ISBN: (纸本)9781728136370

关键词： engineering education

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