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SSRN 2023年

作者： Liu, Juanjuan Yang, Yue Lu, Xiaolong Zheng, Shuyun Ma, Ronghua Shu, Guiming Li, Ke State Key Laboratory of Separation Membrane and Membrane Processes School of Material Science and Engineering Institute of Biological and Chemical Engineering Tiangong University Tianjin300387 China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin Artificial cell engineering technology research center Institute of Hepatobiliary Disease The Third Central Hospital Affiliated to Nankai University Tianjin Third Central Hospital 300170 China State Key Laboratory of Membrane Materials and Membrane Applications Tianjin Motimo Membrane Tech Co. Ltd No.60.11th Street Teda Tianjin300457 China Clinical Laboratory Tianjin Children’s Hospital 300074 China

It is necessary to inject anticoagulants continuously during plasma exchange therapy due to the poor anticoagulant property of the plasma separation membrane. However, it can easily lead to a risk of bleeding or thrombosis. Herein, a novel anticoagulation-separation dual functional polyvinyl chloride (PVC) plasma separation membrane structure is proposed. The small molecular itaconic acid was grafted onto the PVC plasma separation membrane, which can bind Ca2+ in blood to block the anticoagulant pathway. When blood flows through the membrane, the blood coagulation time will be prolonged. Meanwhile, plasma containing toxins can be filtrated from the inside of the membrane to the outside. Toxins are removed from human blood effectively. The results proved that itaconic acid was grafted on the PVC plasma separation membrane without reducing membrane pores successfully. The maximum pores of the adopted "anticoagulant-separation" dual function PVC plasma separation membrane is 0.30 µm. The sieving coefficients of BSA reached 95 %, which can meet the requirements of the plasma separation membrane. Meanwhile, it exhibited excellent hemocompatibility by suppressed bovine serum albumin adsorption, platelets adsorption, erythrocyte adsorption, hemolysis, and strengthened anticoagulant activity. Thus, the anticoagulation-separation dual functional PVC plasma separation membrane designed in this work may have a great clinical application prospect. © 2023, The Authors. All rights reserved.

关键词： Adsorption

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Neural-activity-regulated and glia-mediated control of brain lymphatic development

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Cell 2025年

作者： Li, Jia Liu, Ming-Jian Du, Wen-Jie Peng, Xiao-Lan Deng, Hao Zi, Hua-Xing Shang, Han-Bing Du, Jiu-Lin Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100049 China Department of Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Anesthesiology Huashan Hospital Fudan University Shanghai 200040 China Emergency Medicine Center Shanghai Institute of Aviation Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China School of Life Science and Technology ShanghaiTech University Shanghai 200031 China Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China

The nervous system regulates peripheral immune responses under physiological and pathological conditions, but the brain's impact on immune system development remains unknown. Meningeal mural lymphatic endothelial cells (muLECs), embedded in the leptomeninges, form an immune niche surrounding the brain that contributes to brain immunosurveillance. Here, we report that the brain controls the development of muLECs via a specialized glial subpopulation, slc6a11b+ radial astrocytes (RAs), a process modulated by neural activity in zebrafish. slc6a11b+ RAs, with processes extending to the meninges, govern muLEC formation by expressing vascular endothelial growth factor C (vegfc). Moreover, neural activity regulates muLEC development, and this regulation requires Vegfc in slc6a11b+ RAs. Intriguingly, slc6a11b+ RAs cooperate with calcium-binding EGF domain 1 (ccbe1)+ fibroblasts to restrict muLEC growth on the brain surface via controlling mature Vegfc distribution. Thus, our study uncovers a glia-mediated and neural-activity-regulated control of brain lymphatic development and highlights the importance of inter-tissue cellular cooperation in development. © 2025 Elsevier Inc.

关键词： development fibroblast immune system leptomeninges meningeal mural lymphatic endothelial cells nervous system neural activity radial astrocyte VEGFC

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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3124-3138页

作者： Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao Department of Pharmacy Naval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China Centre for Biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage Cancer therapy

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A Novel Petal-Type Battery Thermal Management System with Dual Phase Change Materials

SSRN

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SSRN 2022年

作者： Li, Yonghao Chen, Zhaolin Feng, Yi Liu, Meinan Kang, Chuanzhi Yang, Kaijie Yuan, Jie Qiu, Chenghui Shi, Hong Jiang, Yanlong Key Laboratory of Aircraft environment control and life support MIIT Nanjing University of Aeronautics & Astronautics 29 Yudao Street Nanjing210016 China College of Energy & Power Engineering Jiangsu University of Science and Technology 2 Mengxi Jingkou Zhenjiang212003 China China Ship Development and Design Center 268 Zhangzhidong Road Wuchang Wuhan430064 China

Phase change material (PCM) cooling is a promising approach to battery thermal management, but its wide application is limited by the narrow phase change temperature range. When the PCM temperature is below the melting point, PCM is equivalent to a purely thermally conductive material. When the ambient temperature exceeds the phase change temperature of PCM, PCM melts completely and cannot play the role of battery thermal management. Therefore, a novel petal-type battery thermal management system (BTMS) with dual PCMs is proposed in this paper to solve the environmental adaptability problem of PCM cooling. The thermal performance of the system at different ambient temperatures and different discharge rates is investigated by numerical simulation methods. The results show that the maximum temperature of battery at 2 C discharge rate is 30.49 ℃, 34.16 ℃ and 43.70 ℃ at ambient temperatures of 20 ℃, 30 ℃ and 40 ℃, respectively. Compared with the BTMS filled with a single PCM, the thermal performance of the proposed BTMS is particularly good at the high operating temperature represented by 40 ℃. At lower ambient temperatures such as 20 ℃ and 30 ℃, the thermal performance is not the best, but it fully meets the requirements of battery thermal management. Furthermore, the above BTMS is optimized using fin-reinforced heat transfer technology in this paper. The solution with the optimal fin arrangement can reduce the maximum temperature difference by 36.2% and 42.8% and the maximum temperature rise by 5.53% and 29.19% at 30 ℃ and 40 ℃, respectively. © 2022, The Authors. All rights reserved.

关键词： Phase change materials

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A Novel Petal-Type Battery Thermal Management System with Dual Phase Change Materials

SSRN

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SSRN 2022年

Phase change material (PCM) cooling is a prominent approach for battery thermal management. However, its wide application is limited by the narrow range of phase change temperature. When the temperature of PCM does not reach the phase change temperature range, it is either a pure thermal conductive material or a completely molten liquid material, neither of which can take effect in battery thermal management. The present study provides a novel petal-type battery thermal management system (BTMS) with dual PCMs, which has greatly enhanced environmental adaptability compared to other PCM-based BTMS. The thermal performance of the BTMS at different ambient temperatures and discharge rates is investigated by numerical simulation methods. The results show that when the ambient temperature is 20 °C, 30 °C and 40 °C, the maximum temperature of battery ( [[EQUATION]] ) at 2 C discharge rate is 30.49 °C, 34.16 °C and 43.7 °C, respectively. Considering the three common ambient temperature conditions comprehensively, the thermal performance and environmental adaptability of the proposed BTMS is the best compared to the other two conventional BTMS with a single filled PCM. Furthermore, the above BTMS is optimized using fin-reinforced heat transfer technology in this paper. At an ambient temperature of 30 °C, the solution with a better fin arrangement can reduce the maximum temperature difference ( [[EQUATION]] ) by 42.8% and the maximum temperature rise ( [[EQUATION]] ) by 29.19% compared to the system without fins, respectively. © 2022, The Authors. All rights reserved.

关键词： Lithium-ion batteries

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Embedding narrative medicine in primary healthcare:Exploration and practice from a medical humanities perspective

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World Journal of Clinical Cases 2025年第22期13卷 6-24页

作者： Ning-Jia Lei Deep K Vaishnani Mohmmad Shaheen Haniah Pisheh Jing Zeng Fu-Rong Ying Qiu-Qin Yang Cong-Ying Wang Jun Ma Jing-Ye Pan Ning-Jian Hou College of Pharmacy Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina School of International Studies Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Medicine Misr University for Science and TechnologyCairo 3237101Al QahirahEgypt School of Clinical Medicine Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Clinical Laboratory First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina School of Medical Technology and Pharmacy Renji College of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Pathology First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Key Laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Province Wenzhou Key Laboratory of Critical Care and Artificial IntelligenceZhejiang Engineering Research Center for Hospital Emergency and Process DigitizationThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of International Cooperation and Exchange Wencheng Branch of the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

This study examines the integration of narrative medicine(NM)into primary healthcare(PHC)settings,evaluating its role in enhancing medical humanities education within grassroots healthcare *** a comprehensive literature review and case analysis,the research investigates the current state,challenges,and practical barriers to embedding NM into PHC systems,while proposing targeted strategies for *** findings suggest that NM fosters stronger doctor-patient trust,enhances healthcare quality,and promotes humanistic ***,primary hospitals face numerous challenges in advancing medical humanities,including a lack of trust between doctors and patients,tensions arising from the commercialization of healthcare,institutional limitations,unequal distribution of resources,and issues related to physicians'professional competencies and stress *** interrelated obstacles detract from the quality of PHC services and the overall patient *** on successful case studies from primary hospitals,the paper outlines effective strategies for overcoming these *** study provides both theoretical and practical insights for advancing medical humanities in PHC,contributing to improvements in healthcare service quality and supporting the development of high standards in the healthcare ***,the findings aim to promote the broader adoption and ongoing refinement of NM within PHC institutions.

关键词： Narrative medicine Primary healthcare Medical humanities Doctor-patient relationship Healthcare quality

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Improving Session-to-session Transfer Performance of Emotion Recognition Using Adaptive support Vector Machine

Improving Session-to-session Transfer Performance of Emotion...

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作者： Kai Yang Guangcheng Bao Ying Zeng Li Tong Jun Shu Bin Yan Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering University Key Laboratory for Neuro Information of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China

The non-stationarity of electroencephalograph(EEG) signals has been a barrier in real-life application of EEG-based emotion recognition. The features extracted from emotional EEG vary from one session to another and a model trained on a temporally-limited EEG dataset may generalize poorly to data recorded at a different time for the same individual. In this study, the EEG features that stably characterize the differences between emotions are firstly explored. Then the classic progressive transductive support vector machine(PTSVM) is extended to three-classes classifications by a new region labelling rule, furthermore K-nearest neighbour algorithm and iterative process are utilized to improve the confidence of the predicted labels. Experimental results indicate that high gamma band local activation difference features and network features derived from prefrontal lobe, the temporal lobe on both sides, the left occipital-parietal lobe, the right occipital lobe and the posterior occipital lobe are temporally stable features for distinguishing different emotions(positive, neutral and negative). And the proposed session-to-session transfer model achieves an averaged classification accuracy 63.56% for three emotions classification on our dataset recorded from 23 subjects in three different days, which is 4% higher than the existing best adaptive classification model. Hence, the proposed classification model can effectively improve the performance of EEG-based session-to-session emotion recognition.

关键词： session Improving Session-to-session Transfer Performance of Emotion Recognition Using Adaptive support Vector Machine Vector

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Performance comparation of two kinds of aircraft ram air outlet

Performance comparation of two kinds of aircraft ram air out...

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CSAA/IET International Conference on Aircraft Utility Systems 2020, AUS 2020

作者： Zhimao, Li Xinlong, Zhu Boyu, Wu Houju, Pei Wenbing, Xu Hong, Shi Environment Control and Oxygen System Department Shanghai Aircraft Design and Research Institute Shanghai201210 China College of Energy and Power Jiangsu University of Science and Technology Zhenjiang212003 China Key Laboratory of Aircraft Environment Control and Life Support MIT Nanjing University of Aeronautics and Astronautics Nanjing210016 China

ISBN: (纸本)9781839535635

With the development of electronic equipment integration technology, the air demand for cooling in cabin and electronic system is increasing continuously. The ram air outlet plays an important role in the airflow system. In this paper, the three-dimensional modeling of the door-type ram air outlet and the grille-type ram air outlet is carried out. Then, the flow characteristics and resistance characteristics of ram air outlet are analyzed based on structured grid technology. The results show that the flow rate of the door panel ram air outlet is greater than that of the grille-type ram air outlet in the same size, the discharge rate of the door panel outlet is 0.3kg/s more than that of the grille-type outlet under the design condition, and the skin surface temperature at the back of the door panel outlet is 13.5K lower than that of the grille outlet. Therefore, the door-type ram air outlet has better emission characteristics and flow characteristics, which is more suitable for the aircraft in this research. This study provides a technical reference for the design of the civil aircraft. © 2020 Institution of Engineering and technology. All rights reserved.

关键词： Aircraft

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Reliability Analysis of Certain Rocket Engine Based on Fault Tree

Reliability Analysis of Certain Rocket Engine Based on Fault...

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作者： Wensheng Wang Liying Jin Xi Sun Jing Liu Aviation Key Laboratory Science and Technology on Life-Support Technology Aerospace Life-Support Industries Ltd. School of Mechanical Engineering Xi'an Jiaotong University

In this paper, a fault tree model of certain rocket engine is established according to its structure and working principle. Through qualitative analysis and quantitative calculation, the factors affecting the reliability of a certain type of rocket engine are obtained, and the corresponding improvement measures are put forward to improve the reliability and safety of a certain type of rocket engine.

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Correction to: Bacillus licheniformis prevents and reduces anxiety‑like and depression‑like behaviours

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Applied microbiology and biotechnology 2023年第15期107卷 4989页

作者： Siyuan Feng Chen Meng Yiyuan Liu Yue Yi Axin Liang Yingyu Zhang Zikai Hao Institute of Environmental Biology and Life Support Technology School of Biological Science and Medical Engineering Beihang University Beijing 100083 China. Beijing Institute of Otolaryngology Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing 100730 China. Key Laboratory of Molecular Medicine and Biotherapy the Ministry of Industry and Information Technology School of Life Science Beijing Institute of Technology Beijing 100081 China. Henan Key Laboratory of Rare Diseases Endocrinology and Metabolism Center The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003 China. zhangyingyu0613@***. Key Laboratory of Molecular Medicine and Biotherapy the Ministry of Industry and Information Technology School of Life Science Beijing Institute of Technology Beijing 100081 China. by1510111@***.

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