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Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese Frailty

BIOSCIENCE REPORTS 2024年第11期44卷 BSR20240784页

作者： Ji, Fujue Park, Ji Hyun Rheem, Hyeonseung Kim, Jong-Hee Hanyang Univ Coll Performing Arts & Sport Div Sport Ind & Sci Major Sport Sci 222 Wangsimni Ro Seoul South Korea Hanyang Univ BK21 FOUR Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea

Background: Pure frailty and obese frailty are common types of frailty syndrome. However, the overlapping and distinct characteristics between pure frailty and obese frailty remain unclear. This study aims to reveal the overlapping/distinct physical and biological phenotypes of pure frailty and obese frailty, providing theoretical support for their prevention, diagnosis, and treatment. Method: Mice were fed either a normal or high-fat diet and assessed at 20 months of age. They were assigned to one of the four groups: control, obesity, pure frailty, and obese frailty. Grip strength, walking speed, physical activity, endurance, and body weight were measured to determine pure frailty and obese frailty. Physical and biological phenotypes were assessed. Results: Distinct physical phenotypes were observed between pure frailty and obese frailty in terms of body weight, lean mass, fat mass, fat mass in tissue, grip strength, endurance, and physical activity, while walking speed overlapped. In biological phenotypes, levels of Smad2/3, FoxO3a, P62, LAMP-2, and cathepsin L expression were distinct, while AKT, p-AKT, mTOR, p-mTOR, p-Smad2/3, p-FoxO3a, Beclin-1, ATG7, and LC3 overlapped. Conclusion: Distinct physical phenotypes observed in obese frailty are primarily attributable to the effect of obesity, with further impairment of muscle function resulting from the combined effects of frailty syndromes and obesity. Pure frailty and obese frailty share overlapping biological phenotypes, particularly in the regulation of muscle protein synthesis. Moreover, the interaction between obesity and frailty syndromes gives rise to both overlapping and distinct biological phenotypes, especially in the regulation of specific degradation signaling proteins.

关键词： frailty obesity phenotype

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Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace

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JOURNAL OF MULTIDISCIPLINARY HEALTHCARE 2025年 18卷 505-529页

作者： Han, Qifeng Kim, Sung Min Hanyang Univ Dept Phys Educ Seoul South Korea Hanyang Univ Dept Sport Sci 222 Wangsimni ro Seoul South Korea Hanyang Univ Human Tech Convergence Program BK21 FOUR Seoul South Korea Hanyang Univ Ctr Artificial Intelligence Muscle Seoul South Korea

Purpose: With the increasing global aging population, exercise interventions for mild cognitive impairment (MCI) have gained significant research attention. This study uses CiteSpace6.3R2 to systematically analyze the research progress and emerging trends in this field. Methods: A comprehensive literature search in the Web of Science Core Collection focused on exercise interventions for MCI. After screening, 420 relevant publications were imported into CiteSpace6.3R2 for bibliometric analysis, generating visual maps of keywords, authors, institutions, and other key indicators. Results: Publications on exercise interventions for MCI have shown steady growth, with Journal of Alzheimers' Disease leading in volume, and Geriatrics & Gerontology as the dominant subject area. The USA ranks highest in collaborative output, with the Chinese University of Hong Kong as the top institution. Among authors, Shimada Hiroyuki and three Japanese colleagues are key contributors, while Neurology is the most frequently co-cited journal. The most frequently co-cited author, Petersen, R.C. has his 2018 work as the top reference. High co-occurrence keywords include "mild cognitive impairment", "dementia", and "Alzheimer's disease". The primary keyword clusters are #0 Cognitive training, #1 Cognitive impairment, and #2 Mild Cognitive impairment, while newly burst keywords "systematic review", "recommendations", and "depression". Conclusion: Research on exercise interventions for MCI has been steadily gaining attention, becoming an interdisciplinary research area in fields such as geriatrics and neuroscience, with relevant findings concentrated in specific journals. In the collaboration network, developed countries dominate, showing systematic patterns of inter-institutional collaboration, while author collaborations are primarily focused within institutions. Current research is centered on the design and mechanisms of exercise intervention programs. Future studies will prioritize integrate

关键词： exercise intervention exercise therapy mild cognitive impairment cognitive dysfunction bibliometric visualization analysis CiteSpace

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Biomimetic cell-actuated artificial muscle with nanofibrous bundles

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Microsystems & Nanoengineering 2021年第5期7卷 205-211页

作者： Yongwoo Jang Sung Min Kim Eunyoung Kim Dong Yeop Lee Tong Mook Kang Seon Jeong Kim Center for Self-Powered Actuation Department of Biomedical EngineeringHanyang UniversitySeoul 04763South Korea Department of Physical Education and Human-Tech Convergence Program(BK21 Four) Hanyang UniversitySeoul 04763South Korea Department of Physiology Sungkyunkwan University School of MedicineSuwon 16419South Korea

Biohybrid artificial muscle produced by integrating living muscle cells and their scaffolds with free movement in vivo is promising for advanced biomedical applications,including cell-based microrobotic systems and therapeutic drug delivery ***,we provide a biohybrid artificial muscle constructed by integrating living muscle cells and their scaffolds,inspired by bundled myofilaments in skeletal ***,a bundled biohybrid artificial muscle was fabricated by the integration of skeletal muscle cells and hydrophilic polyurethane(HPU)/carbon nanotube(CNT)nanofibers into a fiber shape similar to that of natural skeletal *** HPU/CNT nanofibers provided a stretchable basic backbone of the 3-dimensional fiber structure,which is similar to aain-myosin *** incorporated skeletal muscle fibers contribute to the actuation of biohybrid artificial *** fact,electrical field stimulation reversibly leads to the contraction of biohybrid artificial ***,the current development of cell-actuated artificial muscle provides great potential for energy delivery systems as actuators for implantable medibot movement and drug delivery ***,the innervation of the biohybrid artificial muscle with motor neurons is of great interest for human-machine interfaces.

关键词： artificial fibers integrating

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Biofabrication of 3D adipose tissue via assembly of composite stem cell spheroids containing adipo-inductive dual-signal delivery nanofibers

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BIOFABRICATION 2024年第3期16卷 2024 May 13页

作者： Lee, Sangmin Lee, Jeongbok Choi, Soomi Kim, Eunhyung Kwon, Hyunseok Lee, Jinkyu Kim, Sung Min Shin, Heungsoo Hanyang Univ Dept Bioengn 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Human Tech Convergence Program BK21 FOUR Seoul 04763 South Korea Hanyang Univ Educ & Res Grp Biopharmaceut Innovat BK21 FOUR Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol Seoul 04763 South Korea Hanyang Univ Sports Sci Collage Performing Arts & Sport Seoul 04763 South Korea Hanyang Univ Ctr Artificial Intelligence Muscle Seoul 04763 South Korea

Reconstruction of large 3D tissues based on assembly of micro-sized multi-cellular spheroids has gained attention in tissue engineering. However, formation of 3D adipose tissue from spheroids has been challenging due to the limited adhesion capability and restricted cell mobility of adipocytes in culture media. In this study, we addressed this problem by developing adipo-inductive nanofibers enabling dual delivery of indomethacin and insulin. These nanofibers were introduced into composite spheroids comprising human adipose-derived stem cells (hADSCs). This approach led to a significant enhancement in the formation of uniform lipid droplets, as evidenced by the significantly increased Oil red O-stained area in spheroids incorporating indomethacin and insulin dual delivery nanofibers (56.9 +/- 4.6%) compared to the control (15.6 +/- 3.5%) with significantly greater gene expression associated with adipogenesis (C/EBPA, PPARG, FABP4, and adiponectin) of hADSCs. Furthermore, we investigated the influence of culture media on the migration and merging of spheroids and observed significant decrease in migration and merging of spheroids in adipogenic differentiation media. Conversely, the presence of adipo-inductive nanofibers promoted spheroid fusion, allowing the formation of macroscopic 3D adipose tissue in the absence of adipogenic supplements while facilitating homogeneous adipogenesis of hADSCs. The approach described here holds promise for the generation of 3D adipose tissue constructs by scaffold-free assembly of stem cell spheroids with potential applications in clinical and organ models.

关键词： adipose tissue engineering adipogenesis bottom-up strategy spheroid fusion electrospinning nanofibers

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A sustainable synthesis and applications of biomass waste-derived tunable fluorescent carbon dots: In vitro and in vivo fluorescent imaging

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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 2025年 458卷

作者： Krishnaiah, Prakash Atchudan, Raji Gangadaran, Prakash Perumal, Suguna Rajendran, Ramya Lakshmi Sundramoorthy, Ashok K. Kumar, Raju Suresh Ramalingam, Srinivasan Ahn, Byeong-Cheol Lee, Seung Woo Lee, Yong Rok Octo Biosci Pvt Ltd Dept Res & Dev Bangalore India Yeungnam Univ Sch Chem Engn Gyongsan 38541 South Korea Kyungpook Natl Univ Sch Med Dept Biomed Sci BK21 FOUR KNU Convergence Educ Program Biomed Sci Daegu 41944 South Korea Kyungpook Natl Univ Kyungpook Natl Univ Hosp Sch Med Dept Nucl Med Daegu 41944 South Korea Sejong Univ Dept Chem Seoul 143747 South Korea Saveetha Inst Med & Tech Sci Saveetha Dent Coll & Hosp Dept Prosthodont Poonamallee High Rd Chennai 600077 Tamil Nadu India King Saud Univ Coll Sci Dept Chem POB 2455 Riyadh 11451 Saudi Arabia Yeungnam Univ Dept Hort & Life Sci Gyongsan 38541 South Korea

Different heteroatoms introduced to carbon dots (CDs) have been used extensively owing to their excellent optical properties, simple synthesis method, and multifunctional applications such as environmental detection, multicolor cell imaging, and gene therapy/delivery. Nitrogen and sulfur codoped carbon dots (PSNCDs) were prepared using persimmon fruit (Diospyros kaki) peel biomass waste and sodium thiosulphate by the straight route, showing excellent optical properties. The resulting PSNCDs exhibit consistent fluorescence emission at 440 nm under excitation at 360 nm, with a high quantum yield (approximately 16%), making them suitable for a range of applications, including bioimaging, drug delivery, sensing, catalysts, and so on. The as-synthesized PSNCDs were subjected to various analytical methods to confirm their morphology and surface functionalization. High-resolution transmission electron microscopy displayed that the PSNCDs are predominately 2-4 nm with an average size of around 3 nm. fourier-transform infrared and X-ray photoelectron spectroscopy analysis confirmed the amine and sulfur functional moieties on the outer surfaces and edges of the PSNCDs. The uniform particle size distribution and structural morphology were confirmed by transmission electron microscopy analysis. The Raman and X-ray diffraction investigation reveals that the as-synthesized PSNCDs appeared to be defective graphite-like structures with an intensity ratio of D to G is 0.65. Furthermore, PSNCDs were also utilized as fluorescent probes for cellular imaging. PSNCDs exhibited enhanced biocompatibility (cell viability 98 %) with regular fibroblast cells;in both in vitro and in vivo scenarios, they exhibited robust fluorescence signals upon fluorescent imaging of cultured fibroblast cells. These characteristics collectively validate the potential of PSNCDs for cell imaging without the need for supplementary modifications.

关键词： Persimmon fruit Carbon dots Biocompatibility Fibroblast cells Cellular imaging

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Association between the appendicular skeletal muscle mass-to-visceral fat area ratio and bone mineral density and osteoporosis: A cross-sectional study

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EXPERIMENTAL GERONTOLOGY 2025年 206卷 112772页

作者： Liu, Jiao Ji, Fujue Lee, Haesung Kim, Jong-Hee Hanyang Univ Coll Performing Arts & Sport Div Sport Ind & Sci Major Sport Sci 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Human Tech Convergence Program BK21 4 222 Wangsimni Ro Seoul 004763 South Korea

Objective: This cross-sectional study investigated the association between appendicular skeletal muscle mass-to-visceral fat area ratio (SVR), bone mineral density (BMD), and osteoporosis in U.S. adults using NHANES data. Methods: Data from the 2013-2014 and 2017-2018 NHANES cycles were analyzed. Multivariable regression models assessed associations between SVR, BMD, and osteoporosis, adjusting for demographic, lifestyle, metabolic, and comorbidity variables. Generalized Additive Models with smooth curve fitting and likelihood ratio tests evaluated model fit. Subgroup analyses explored effect modifications. Results: The study included 2325 individuals with a mean age of 50.66 +/- 5.55 years. In fully adjusted models, the highest SVR tertile was associated with a 0.05 g/cm(2) higher BMD (beta = 0.05, 95 % CI: 0.03-0.08, P = 0.002) and 57 % lower odds of osteoporosis (OR = 0.43, 95 % CI: 0.24-0.78, P = 0.028) than the lowest tertile. As a continuous variable, SVR remained significantly associated with BMD (beta = 0.03, 95 % CI: 0.02-0.04, P = 0.002) and osteoporosis (OR = 0.67, 95 % CI: 0.50-0.91, P = 0.033). Stronger associations were found in individuals with diabetes (beta = 0.09, 95 % CI: 0.06-0.12, P < 0.01) and BMI >= 30 (beta = 0.07, 95 % CI: 0.05-0.09, P < 0.01). Conclusion: Higher SVR was significantly associated with increased BMD and lower odds of osteoporosis, suggesting its potential as a marker for bone health assessment. However, the cross-sectional design limits causal inference. Further longitudinal and mechanistic studies are warranted to confirm these findings and explore clinical applicability.

关键词： Bone mineral density Osteoporosis Appendicular skeletal muscle mass-to-visceral fat area ratio Visceral fat area ratio Cross-sectional study

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Directed Regeneration of Osteochondral Tissue by Hierarchical Assembly of Spatially Organized Composite Spheroids

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ADVANCED SCIENCE 2022年第3期9卷 e2103525页

作者： Lee, Jinkyu Lee, Seoyun Huh, Seung Jae Kang, Byung-Jae Shin, Heungsoo Hanyang Univ Inst Bioengn & Biopharmaceut Res Dept Bioengn 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ BK21 FOUR Human Tech Convergence Program 222 Wangsimni Ro Seoul 04763 South Korea Seoul Natl Univ Dept Vet Clin Sci Coll Vet Med & Res Inst Vet SciBK21 FOUR Future Vet Med Leading Edu 1 Gwanak Ro Seoul 08826 South Korea Hanyang Univ BK21 FOUR Educ & Res Grp Biopharmaceut Innovat Le 222 Wangsimni Ro Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol 222 Wangsimni Ro Seoul 04763 South Korea

The use of engineered scaffolds or stem cells is investigated widely in the repair of injured musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral tissue remains a challenge due to delamination between cartilage and subchondral bone or difficulty in spatial control over differentiation of transplanted stem cells. Here, two types of composite spheroids are prepared using adipose-derived stem cells (hADSCs) and nanofibers coated with either transforming growth factor-beta 3 or bone morphogenetic growth factor-2 for chondrogenesis or osteogenesis, respectively. Each type of spheroid is then cultured within a 3D-printed microchamber in a spatially arranged manner to recapitulate the bilayer structure of osteochondral tissue. The presence of inductive factors regionally modulates in vitro chondrogenic or osteogenic differentiation of hADSCs within the biphasic construct without dedifferentiation. Furthermore, hADSCs from each spheroid proliferate and sprout and successfully connect the two layers mimicking the osteochondral interface without apertures. In vivo transplantation of the biphasic construct onto a femoral trochlear groove defect in rabbit knee joint results in 21.2 +/- 2.8% subchondral bone volume/total volume and a cartilage score of 25.0 +/- 3.7. The present approach can be an effective therapeutic platform to engineer complex tissue.

关键词： 3D printing composite spheroid microchamber osteochondral tissue regeneration tissue engineering

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Green Synthesis of Multicolor Emissive Nitrogen-Doped Carbon Dots for Bioimaging of human Cancer Cells

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JOURNAL OF CLUSTER SCIENCE 2023年第3期34卷 1583-1594页

作者： Atchudan, Raji Gangadaran, Prakash Perumal, Suguna Edison, Thomas Nesakumar Jebakumar Immanuel Sundramoorthy, Ashok K. Rajendran, Ramya Lakshmi Ahn, Byeong-Cheol Lee, Yong Rok Yeungnam Univ Sch Chem Engn Gyongsan 38541 South Korea Kyungpook Natl Univ Sch Med Dept Biomed Sci BK21 Four KNU Convergence Educ Program Biomed Sci Daegu 41944 South Korea Kyungpook Natl Univ Kyungpook Natl Univ Hosp Sch Med Dept Nucl Med Daegu 41944 South Korea Sejong Univ Dept Chem Seoul 143747 South Korea Saveetha Inst Med & Tech Sci Saveetha Sch Engn Dept Chem Chennai 602105 Tamil Nadu India Saveetha Inst Med & Tech Sci Saveetha Dent Coll & Hosp Dept Prosthodont Poonamallee High Rd Chennai 600077 Tamil Nadu India

In this work, banana peel (BP) was utilized as a green carbon precursor to synthesize carbon dots (CDs) through the single-step hydrothermal-carbonization method. The structural and optical properties of the resulting BP-CDs were investigated by various techniques. The transmission electron microscopy measurement of BP-CDs displayed uniform morphology with a quasi-spherical shape of 5 nm in size. The optical studies of BP-CDs revealed that BP-CDs emit excitation-dependent fluorescence emission behaviors (redshift) without any capping or passivation agent. The maximum emission was observed at an excitation wavelength of 340 nm, showing an acceptable quantum yield of 19%. The abundant functional groups such as nitrogen- (amine and amide) and oxygen-containing (carbonyl and hydroxyl) groups on the surface of the BP-CDs were confirmed from X-ray photoelectron spectroscopy, and Attenuated total reflection-fourier transform infrared studies. These functional groups in BP-CDs are responsible for the negative zeta potential. Since the BP-CDs showed excellent long-term stability (120 days) and photostability (120 min). The biocompatibility of BP-CDs was examined by cytotoxicity studies on cancer cells and utilized as a multi-colored nano-probe for imaging human cancer cells. The aforesaid properties demonstrate that the BP-CDs can be applied to imaging human cells without further modifications.

关键词： Banana peel Hydrothermal Carbon dots Fluorescent probe Bioimaging Cancer cells

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Size-controlled human adipose-derived stem cell spheroids hybridized with singlesegmented nanofibers and their effect on viability and stem cell differentiation

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BIOMATERIALS RESEARCH 2021年第1期25卷 1页

作者： Lee, Jinkyu Lee, Sangmin Kim, Sung Min Shin, Heungsoo Hanyang Univ Dept Bioengn Seoul 04763 South Korea Hanyang Univ Human Tech Convergence Program BK21 4 Seoul 04763 South Korea Hanyang Univ Educ & Res Grp Biopharmaceut Innovat Leader BK21 4 Seoul 04763 South Korea Hanyang Univ Dept Phys Educ & Act Aging Ind Seoul 04763 South Korea Hanyang Univ Ctr Artificial Intelligence Muscle Seoul 04763 South Korea Hanyang Univ Inst Nano Sci & Technol Seoul 04763 South Korea

Background: Fabrication of three-dimensional stem cell spheroids have been studied to improve stem cell function, but the hypoxic core and limited penetration of nutrients and signaling cues to the interior of the spheroid were challenges. The incorporation of polymers such as silica and gelatin in spheroids resulted in relatively relaxed assembly of composite spheroids, and enhancing transport of nutrient and biological gas. However, because of the low surface area between cells and since the polymers were heterogeneously distributed throughout the spheroid, these polymers cannot increase the cell to extracellular matrix interactions needed to support differentiation. Methods: We developed the stem cell spheroids that incorporate poly(iota-lactic acid) single-segmented fibers synthesized by electrospinning and physical and chemical fragmentation. The proper mixing ratio was 2000 cells/ mu g fibers (average length of the fibers was 50 mu m - 100 mu m). The SFs were coated with polydopamine to increase cell binding affinity and to synthesize various-sized spheroids. The function of spheroids was investigated by in vitro analysis depending on their sizes. For statistical analysis, Graphpad Prism 5 software (San Diego, CA, USA) was used to perform one-way analysis of variance ANOVA with Tukey's honest significant difference test and a Student's t-test (for two variables) (P < 0.05). Results: Spheroids of different sizes were created by modulating the amount of cells and fibers (0.063mm(2)-0.322 mm(2)). The fibers in the spheroid were homogenously distributed and increased cell viability, while cell-only spheroids showed a loss of DNA contents, internal degradation, and many apoptotic signals. Furthermore, we investigated stemness and various functions of various-sized fiber-incorporated spheroids. In conclusion, the spheroid with the largest size showed the greatest release of angiogenic factors (released VEGF: 0.111 +/- 0.004 pg/ng DNA), while the smallest size showed

关键词： Single segmented fibers Spheroid Stem cell Angiogenic factor Differentiation

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Multifunctional carbon dots originated from waste garlic peel for rapid sensing of heavy metals and fluorescent imaging of 2D and 3D spheroids cultured fibroblast cells

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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2024年 304卷 123422页

作者： Krishnaiah, Prakash Atchudan, Raji Perumal, Suguna Gangadaran, Prakash Manoj, Devaraj Ahn, Byeong-Cheol Kumar, Raju Suresh Almansour, Abdulrahman I. Lee, Yong Rok Jeon, Byong-Hun Hanyang Univ Dept Earth Resources & Environm Engn 222 Wangsimni Ro Seoul 04763 South Korea Yeungnam Univ Sch Chem Engn Gyongsan 38541 South Korea Saveetha Inst Med & Tech Sci Saveetha Sch Engn Dept Chem Chennai 602105 Tamil Nadu India Sejong Univ Dept Chem Seoul 143747 South Korea Kyungpook Natl Univ Sch Med Dept Biomed Sci BK21 FOUR KNU Convergence Educ Program Biomed Sci Daegu 41944 South Korea Kyungpook Natl Univ Kyungpook Natl Univ Hosp Sch Med Dept Nucl Med Daegu 41944 South Korea Karpagam Acad Higher Educ Dept Chem Coimbatore 641021 Tamil Nadu India Karpagam Acad Higher Educ Ctr Mat Chem Coimbatore 641021 Tamil Nadu India King Saud Univ Coll Sci Dept Chem Riyadh 11451 Saudi Arabia

Here, we prepared sulfur and nitrogen self-doped carbon dots derived from garlic peel extract (GPSNCDs) using a hydrothermal method. The as-synthesized GPSNCDs were confirmed using fourier-transform infrared spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. The analytical techniques indicate that the resulting GPSNCDs exhibit distinct emissive carbon-core with functionalities (owing to various ligands in the GPSNCDs). These functionalities are responsible for excellent hydrophilic and optical properties, including excitation-dependent emission and anti-photobleaching. Fluorescence intensities of GPSNCDs were quenched in the existence of Mn2+ and Fe3+ ions. This indicates that the GPSNCDs were sensitive to Fe3+ and Mn2+ ions with a limited range from 5 to 50 mu M and showed lower recognition at similar to 0.75 and 0.95 mu M, respectively. In addition, the sensing results were generated in a short time (20 s). The cytotoxicity of GPSNCDs was tested to demonstrate that they are sufficiently safe to use for cellular imaging. The novel fluorescent GPSNCDs-based sensor can be used as a high-performance sensor for environmental monitoring. Further, GPSNCDs showed greater biocompatibility with normal fibroblast cells, and In Vitro fluorescent imaging of GPSNCDs revealed strong fluorescence signals in the two-dimensional (2D) and threedimensional (3D) spheroids cultured fibroblast cells. The properties mentioned above demonstrate that the GPSNCDs can be applied to imaging normal cells without further modifications.

关键词： Garlic peel Carbon dots Fluorescence sensor Detection of metal ions Cellular imaging

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