检索结果-内蒙古大学图书馆

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023年第4期17卷 714-728页

作者： Tianzhuo Wang Huiying Guo Lei Zhang Miao Yu Qianchen Li Jing Zhang Yan Tang Hongquan Zhang Jun Zhan Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesBeijing 100191China Peking University International Cancer Institute Beijing 100191China MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science CenterBeijing 100191China

FRMD6,a member of the 4.1 ezrin-radixin-moesin domain-containing protein family,has been reported to inhibit tumor progression in multiple ***,we demonstrate the involvement of FRMD6 in lung cancer *** find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung *** addition,the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma(n=75,P=0.0054)and lung adenocarcinoma(n=94,P=0.0330).Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of ***,FRMD6 interacts and colocalizes with mTOR and S6K,which are the key molecules of the mTOR signaling ***6 markedly enhances the interaction between mTOR and S6K,subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer ***,knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6^(−/−)gene KO MEFs and ***,our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6 lung cancer mTOR pathway

来源：评论

学校读者我要写书评

暂无评论

Protein neddylation and its role in health and diseases

引用

Signal Transduction and Targeted Therapy 2024年第5期9卷 1869-1904页

作者： Shizhen Zhang Qing Yu Zhijian Li Yongchao Zhao Yi Sun Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Thyroid Surgery Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Key Laboratory of Head&Neck Cancer Translational Research of Zhejiang Province Hangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of MedicineHangzhou 310029China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Hangzhou 310024China Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

NEDD8(Neural precursor cell expressed developmentally downregulated protein 8)is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process known as neddylation,catalyzed by the enzyme cascade,namely NEDD8 activating enzyme(E1),NEDD8 conjugating enzyme(E2),and NEDD8 ligase(E3).The substrates of neddylation are categorized into cullins and non-cullin *** of cullins activates CRLs(cullin RING ligases),the largest family of E3 ligases,whereas neddylation of non-cullin substrates alters their stability and activity,as well as subcellular ***,the neddylation pathway and/or many neddylation substrates are abnormally activated or over-expressed in various human diseases,such as metabolic disorders,liver dysfunction,neurodegenerative disorders,and cancers,among ***,targeting neddylation becomes an attractive strategy for the treatment of these *** this review,we first provide a general introduction on the neddylation cascade,its biochemical process and regulation,and the crystal structures of neddylation enzymes in complex with cullin substrates;then discuss how neddylation governs various key biological processes via the modification of cullins and non-cullin *** further review the literature data on dysregulated neddylation in several human diseases,particularly cancer,followed by an outline of current efforts in the discovery of small molecule inhibitors of neddylation as a promising therapeutic ***,few perspectives were proposed for extensive future investigations.

关键词： NEDD8 attached attractive

来源：评论

学校读者我要写书评

暂无评论

The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis

引用

Signal Transduction and Targeted Therapy 2022年第4期7卷 1311-1321页

作者： Yenan Fu Xi Zhang Xiao Liu Peng Wang Wenhui Chu Wei Zhao Yunling Wang Guangbiao Zhou Yu Yu Hongquan Zhang Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesPKU International Cancer InstituteMOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China Department of Orthopedics Peking University Third HospitalBeijing 100191China Institute for Cardiovascular Research Peking UniversityBeijing 100191China State Key Laboratory of Molecular Oncology National Cancer CenterNational Clinical Research Center for CancerCancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor *** of DNA methyltransferases(DNMTs)leads to elevated hyaluronan levels;however,whether DNMT inhibitors control PH20 remains ***,we report that the DNMT1 inhibitor,decitabine,suppresses PH20 expression by activating the long non-coding RNA PHACTR2-AS1(PAS1).PAS1 forms a tripartite complex with the RNA-binding protein vigilin and histone methyltransferase *** interaction between PAS1 and vigilin maintains the stability of ***,PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20,resulting in its ***,PAS1 inhibits breast cancer growth and metastasis,at least partially,by suppressing *** therapy of decitabine and PAS1-30nt-RNA,which directly binds to SUV39H1,effectively blocked breast cancer growth and metastasis in *** together,DNMT1,PAS1,and PH20 comprise a regulatory axis to control breast cancer growth and *** findings reveal that the DNMT1-PAS1-PH20 axis is a potential therapeutic target for breast cancer.

关键词： metastasis breast DNMT1

来源：评论

学校读者我要写书评

暂无评论

Derivation of totipotent-like stem cells with blastocyst-like structure forming potential

引用

细胞研究（英文版） 2022年第6期32卷 513-529页

作者： Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng MOE Engineering Research Center of Regenerative Medicine School of Basic Medical SciencesState Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and DifferentiationCollege of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijingChina School of Life Sciences Center for BioinformaticsCenter for Statistical SciencePeking UniversityBeijingChina Department of Rheumatology and Immunology Peking University Third HospitalBeijingChina Beijing Vitalstar Biotechnology Co. LtdBeijingChina Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesPKU International Cancer Institute MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science CenterBeijingChina Department of Cell Biology School of Basic Medical SciencesPeking University Stem Cell Research CenterPeking University Health Science CenterPeking UniversityBeijingChina

It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent ***,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in *** cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation *** vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell ***,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse ***,inhibition of HDAC1/2 and DOT1L activity and activation of RARγ signaling are important for inducing and maintaining totipotent features of TPS *** study opens up a new path toward fully capturing totipotent stem cells in vitro.

关键词： Self-renewal Totipotent stem cells

来源：评论

学校读者我要写书评

暂无评论

Brainstem opioid peptidergic neurons regulate cough reflexes in mice

引用

The Innovation 2024年第6期5卷 50-61页

作者： Haicheng Lu Guoqing Chen Miao Zhao Huating Gu Wenxuan Zheng Xiating Li Meizhu Huang Dandan Geng Minhui Yu Xuyan Guan Li Zhang Huimeng Song Yaning Li Menghua Wu Fan Zhang Dapeng Li Qingfeng Wu Congping Shang Zhiyong Xie Peng Cao National Institute of Biological Sciences Beijing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 100084China Peking University-Tsinghua University-NIBS Joint Graduate Program School of Life SciencesTsinghua UniversityBeijing 100084China Department of Neurobiology School of Basic Medical SciencesBeijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100069China Key Laboratory of Neural and Vascular Biology Ministry of EducationDepartment of Biochemistry and Molecular BiologyHebei Medical UniversityShijiazhuang 050011China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100005China State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Basic Medical Sciences Guangzhou National LaboratoryFifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510799China Department of Psychological Medicine Zhongshan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 200433China

Cough is a vital defensive reflex for expelling harmful substances from the *** sensory afferents for the cough reflex have been intensively ***,the brain mechanisms underlying the cough reflex remain poorly ***,we developed a paradigm to quantitatively measure cough-like reflexes in *** this paradigm,we found that prodynorphin-expressing(Pdyn+)neurons in the nucleus of the solitary tract(NTS)are critical for capsaicin-induced cough-like *** neurons receive cough-related neural signals from Trpv1+vagal sensory *** activation of Pdyn+NTS neurons triggered respiratory responses resembling cough-like *** the divergent projections of Pdyn+NTS neurons,a glutamatergic pathway projecting to the caudal ventral respiratory group(cVRG),the canonical cough center,was necessary and sufficient for capsaicin-induced cough-like *** results reveal that Pdyn+NTS neurons,as a key neuronal population at the entry point of the vagus nerve to the brainstem,initiate cough-like reflexes in mice.

关键词： respiratory opioid cough

来源：评论

学校读者我要写书评

暂无评论

Tumor molecular signatures: bridging the bench and the operating room

引用

American Journal of Surgery 2025年 246卷 116393-116393页

作者： Nomikos, Iakovos N. Kosmas, Christos Gkretsi, Vasiliki Rea Maternity Hospital Athens Greece School of Medicine European University Cyprus Nicosia Cyprus Metaxa Cancer Memorial Hospital Piraeus Greece Biomedical Sciences Program Department of Life Sciences School of Sciences European University Cyprus Nicosia Cyprus Cancer Metastasis and Adhesion Group Basic and Translational Cancer Research Center (BTCRC) Nicosia Cyprus

Contemporary diagnostic and therapeutic strategies for many solid tumors rely on understanding the Mismatch Repair (MMR) system, a fundamental DNA repair mechanism responsible for correcting errors introduced during DNA replication. Pathology reports written for tumors excised in surgery, often indicate the expression status of MMR proteins. This is of significant clinical value, as loss of MMR protein expression is associated with the accumulation of DNA replication errors. The MMR system recognizes and replaces mismatched nucleotides, particularly in microsatellite regions. These are short, repetitive non-coding DNA sequences prone to replication errors. When MMR proteins are inactivated by genetic or epigenetic alterations, MMR deficiency (dMMR) occurs, preventing repair and leading to microsatellite instability (MSI). MSI is a hallmark of Lynch syndrome, which is commonly associated with colorectal cancer (CRC) and endometrial cancer. This work highlights the clinical utility of MMR protein and MSI status as molecular signatures and discusses diagnostic, prognostic, and therapeutic implications. Understanding these molecular changes supports clinicians in making informed therapeutic decisions and may improve patient outcomes by providing personalized treatments to fit individual tumor profiles. © 2025 Elsevier Inc.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Time-Restricted Feeding Improves Aortic Endothelial Relaxation by Enhancing Mitochondrial Function and Attenuating Oxidative Stress in Aged Mice

SSRN

引用

SSRN 2024年

作者： Milan, Madison Brown, Jacob O’Reilly, Colleen Bubak, Matthew Negri, Sharon Balasubramanian, Priya Dhanekula, Arjune S. Pharaoh, Gavin Reyff, Zeke Ballard, Cade Shi, Helen Yabluchanskiy, Andriy Rudolph, Mike C. Ungvari, Zoltan Marcinek, David Miller, Benjamin F. Van Remmen, Holly Tarantini, Stefano Department of Physiology Oklahoma Medical Research Foundation United States Vascular Cognitive Impairment Neurodegeneration and Healthy Brain Aging Program Department of Neurosurgery University of Oklahoma Health Sciences Center Oklahoma CityOK United States Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center Oklahoma CityOK United States Stephenson Cancer Center University of Oklahoma Oklahoma CityOK United States Oklahoma City VA Oklahoma CityOK United States Aging and Metabolism Research Program Oklahoma Medical Research Foundation Oklahoma CityOK73104 United States Division of Cardiothoracic Surgery University of Washington School of Medicine SeattleWA United States Department of Radiology University of Washington School of Medicine SeattleWA United States International Training Program in Geroscience Doctoral School of Basic and Translational Medicine Department of Public Health Semmelweis University Budapest Hungary

Age-related endothelial dysfunction is a pivotal factor in the development of cardiovascular diseases, stemming, at least in part, from mitochondrial dysfunction and a consequential increase in oxidative stress. These alterations are central to the decline in vascular health seen with aging, underscoring the urgent need for interventions capable of restoring endothelial function for preventing cardiovascular diseases. Dietary interventions, notably time-restricted feeding (TRF), have been identified for their anti-aging effects on mitochondria, offering protection against age-associated declines in skeletal muscle and other organs. Motivated by these findings, our study aimed to investigate whether TRF could similarly exert protective effects on endothelial health in the vasculature, enhancing mitochondrial function and reducing oxidative stress. To explore this, 12-month-old C57BL/6 mice were placed on a TRF diet, with food access limited to a 6-hour window daily for 12 months. For comparison, we included groups of young mice and age-matched controls with unrestricted feeding. We evaluated the impact of TRF on endothelial function by measuring acetylcholine-induced vasorelaxation of the aorta. Mitochondrial health was assessed using fluororespirometry, and vascular reactive oxygen species (ROS) production was quantified with the redox-sensitive dye dihydroethidium. We also quantified 4-hydroxynonenal (4-HNE) levels, a stable marker of lipid peroxidation, in the aorta using ELISA. Our findings demonstrated that aged mice on a standard diet exhibited significant impairments in aortic endothelial relaxation and mitochondrial function, associated with elevated vascular oxidative stress. Remarkably, the TRF regimen led to substantial improvements in these parameters, indicating enhanced endothelial vasorelaxation, better mitochondrial function, and reduced oxidative stress in the aortas of aged mice. This investigation establishes a vital foundation, paving the way for

关键词： Oxidative stress

来源：评论

学校读者我要写书评

暂无评论

SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests (vol 54, pg 1446, 2022)

引用

NATURE GENETICS 2022年第11期54卷 1755-1755页

作者： Zhou, Wei Bi, Wenjian Zhao, Zhangchen Dey, Kushal K. Jagadeesh, Karthik A. Karczewski, Konrad J. Daly, Mark J. Neale, Benjamin M. Lee, Seunggeun Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA USA Department of Medical Genetics School of Basic Medical Sciences Peking University Beijing China Center for Statistical Genetics University of Michigan School of Public Health Ann Arbor MI USA Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USA Department of Epidemiology Harvard T. H. Chan School of Public Health Boston MA USA Institute for Molecular Medicine Finland Helsinki Institute of Life Sciences University of Helsinki Helsinki Finland Graduate School of Data Science Seoul National University Seoul Korea

Several biobanks, including UK Biobank (UKBB), are generating large-scale sequencing data. An existing method, SAIGE-GENE, performs well when testing variants with minor allele frequency (MAF) ≤ 1%, but inflation is observed in variance component set-based tests when restricting to variants with MAF ≤ 0.1% or 0.01%. Here, we propose SAIGE-GENE+ with greatly improved type I error control and computational efficiency to facilitate rare variant tests in large-scale data. We further show that incorporating multiple MAF cutoffs and functional annotations can improve power and thus uncover new gene–phenotype associations. In the analysis of UKBB whole exome sequencing data for 30 quantitative and 141 binary traits, SAIGE-GENE+ identified 551 gene–phenotype associations.

关键词： Genome-wide association studies Software

来源：评论

学校读者我要写书评

暂无评论

Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study

引用

Cancer Gene Therapy 2024年第6期31卷 894-903页

作者： Huang, Yu-Fen Chiao, Ming-Tsang Hsiao, Tzu-Hung Zhan, Yong-Xiang Chen, Tse-Yu Lee, Chung-Hsin Liu, Szu-Yuan Liao, Chih-Hsiang Cheng, Wen-Yu Yen, Chun-Ming Lai, Chih-Ming Chen, Jun-Peng Shen, Chiung-Chyi Yang, Meng-Yin Department of Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Medical Research Taichung Veterans General Hospital Taichung 40705 Taiwan Precision Medicine Center Taichung Veterans General Hospital Taichung 40705 Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Translational Medicine Research Center National Chung Hsing University Taichung Taiwan Institute of Medicine Chung Shan Medical University Taichung 402 Taiwan Graduate Institute of Life Science Department of Life Science College of Life Science National Chung Hsing University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan School of Medicine Taipei Medical University Taipei Taiwan Department of Minimally Invasive Skull Base Neurosurgery Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Department of Physical Therapy Hung Kuang University Taichung Taiwan Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan School of Medicine National Defense Medical Center Taipei Taiwan Department of Critical Care Medicine Taichung Veterans General Hospital Taichung Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung Taiwan Institute of Molecular Biology College of Life Science National Chung Hsing University Taichung Taiwan Biostatistics Task Force Taichung Veterans General Hospital Taichung Taiwan Basic Medical Education Center Central Taiwan University of Science and Technology Taichung Taiwan

This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based on their survival periods: extended survival (over two years, N = 17) and abbreviated survival (under two years, N = 13). For identifying pathogenic or likely pathogenic variants, we leveraged the ClinVar database. The cohort, aged 23 to 66 (median: 53), included 17 patients in Group A (survival >2 years, 10 males, 7 females), and 13 patients in Group B (survival <2 years, 8 males, 5 females), with a 60% to 40% male-to-female ratio. Identified mutations included CHEK2 (c.1477 G > A, p.E493K), IDH1 (c.395 G > A, p.R132H), and TP53 mutations. Non-coding regions exhibited variants in the TERT promoter (c.-146C > T, c.-124C > T) and TP53 RNA splicing site (c.376-2 A > C, c.376-2 A > G). While Group A had more mutations, statistical significance wasn’t reached, likely due to sample size. Notably, TP53, and ATR displayed a trend toward significance. Surprisingly, TP53 mutations were more prevalent in Group A, contradicting Western findings on poorer GBM prognosis. In Taiwanese GBM patients, bevacizumab usage is linked to improved survival rates, affirming its safety and effectiveness. EGFR mutations are infrequent, suggesting potential distinctions in carcinogenic pathways. Further research on EGFR mutations and amplifications is essential for refining therapeutic approaches. TP53 mutations are associated with enhanced survival, but their functional implications necessitate detailed exploration. This study pioneers genetic analysis in Taiwanese GBM patients using NGS, advancing our understanding of their genetic landscape. © The Author(s) 2024.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Tumor microenvironment responsive nano-PROTAC for BRD4 degradation enhanced cancer photo-immunotherapy

引用

Biomaterials 2025年 322卷 123387-123387页

作者： Li, Zheng Ren, Guodong Wang, Xuewei Li, Xiaowan Ding, Lingwen Zhu, Jianwei Zhang, Yajie Zhang, Chengwu Zou, Jianhua Chen, Xiaoyuan Departments of Diagnostic Radiology Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore School of Basic Medical Sciences Shanxi Medical University Taiyuan030001 China Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Yong Loo Lin School of Medicine National University of Singapore 11 Biopolis Way Helios Singapore 138667 Singapore 61 Biopolis Drive Proteos Singapore 138673 Singapore Department of Pharmacy and Pharmaceutical Sciences National University of Singapore Lower Kent Ridge Road 4 Science Drive 2 117544 Singapore

Proteolysis Targeting Chimeras (PROTAC) technology has garnered great attention due to its advantages in targeted protein degradation, promising its potential for treating malignant cancer. Nevertheless, the inherent drawbacks of PROTAC technology hinder its clinical translation. The integration of nanotechnology with PROTAC molecules to create nano-PROTACs for combined therapy offers a promising solution. Among the various cancer treatment methods, phototherapy is considered the optimal choice to integrate with specific PROTACs due to its proven effectiveness and non-invasive nature. Herein, a nano-PROTAC formulation (ARV@PEG-ICG) consisting of a phototherapeutic agent named indocyanine green functionalized polyethylene glycol (PEG-ICG) and a BRD4 degrader (ARV-825) was fabricated for cancer photo-immunotherapy. Activated by acidic tumor microenvironment (TME), ARV@PEG-ICG nanoparticles (NPs) will decompose rapidly for ARV delivery. PEG-ICG generated abundant ROS with laser irradiation, downregulating the expression of Bcl-xL and inducing the cleavage of PARP to stimulate cell apoptosis. Furthermore, the degradation of BRD4, a transcriptional cofactor, inhibited nitric oxide synthase (iNOS) generation to improve phototherapeutic efficacy. In a 4T1 breast tumor model, dying 4T1 cells released tumor associated antigens (TAAs) to serve as the immunogenic cell death (ICD) inducer, facilitating DC maturation and T cell activation and amplifying systemic immune response. The distant tumor growth can also be inhibited due to the activation of long-term immune response. Overall, the current study aims to combine typical PROTAC with functional nanomaterials to form nano-PROTAC with high performance for PROTAC delivery mediated cancer treatment. © 2025 Elsevier Ltd

关键词： Nanocomposites

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：