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Chinese registry of rheumatoid arthritis: IV. Correlation and consistency of rheumatoid arthritis disease activity indices in China

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Chinese Medical Journal 2021年第12期134卷 1465-1470页

作者： Xing Song Yan-Hong Wang Meng-Tao Li Xin-Wang Duan Hong-Bin Li Xiao-Feng Zeng the Co-authors of CREDIT Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730China Department of Epidemiology and Bio-statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China Department of Rheumatology Peking Union Medical College Hospital(PUMCH)Peking Union Medical College&Chinese Academy of Medical SciencesNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Ministry of Science&TechnologyKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationState Key Laboratory of Complex Severe and Rare DiseasesMinistry of Science&TechnologyBeijing 100730China Department of Rheumatology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Rheumatology The Affiliated Hospital of Inner Mongolia Medical CollegeHohhotInner Mongolia 010050China 不详

Background:Disease activity indices(DAIs)including disease activity score 28(DAS28),simplified disease activity index(SDAI),and clinical disease activity index(CDAI)have been widely used in clinical practice and research studies of rheumatoid arthritis(RA).The objective of our study was to evaluate the correlation and concordance among different DAIs in Chinese patients with ***:A cross-sectional study,including patients enrolled in the Chinese registry of rheumatoid arthritis from November 2016 to August 2018,was *** correlations were evaluated using Spearman correlation coefficient and concordance with Bland-Altman plots,quadratic weighted kappa,and discordance rates in the *** other indices,the optimal cutoff points corresponding to SDAI remission were explored through receiver operating characteristic curve ***:A total of 30,501 patients were included,of whom 80.46%were *** individuals were with moderate disease activity or high disease *** correlations among DAS28-erythrocyte sedimentation rate(ESR)and DAS28-C-reactive protein(CRP),SDAI and CDAI were ***,the weighted kappa value among the indices was *** Bland-Altman plots,a positive difference between DAS28-ESR and DAS28-CRP was observed,with an absolute difference of>1.2 in 3079(10.09%)*** crosstab,approximately 30%of the patients were classified into different *** values between SDAI remission and the optimal cutoff points of DAS28-ESR,DAS28-CRP,and CDAI were 3.06,2.37,and 3.20,***:Although DAIs had high correlations and weighted kappa values,the discordance between DAIs was significant in Chinese patients with *** four DAIs are not interchangeable.

关键词： Disease activity indices Rheumatoid arthritis Chinese registry of rheumatoid arthritis

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Propagation Characteristics of Lightning-Generated Whistlers in the Ionosphere: Statistical and Simulation-Based analysis

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Journal of Geophysical Research: Space Physics 2025年第6期130卷

作者： Tian Xiang Moran Liu Shimin He Xiang Xu Shufan Zhao Chen Zhou Department of Space Physics School of Electronic Information Wuhan University Wuhan China Hubei Provincial Key Laboratory for Low-Frequency Electromagnetic Communication Technology Wuhan China State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences Beijing China

Lightning-generated whistlers (LGWs) are electromagnetic waves in the very-low-frequency band generated by lightning and propagate in the ionosphere. LGWs are an inexpensive ionospheric detection medium that can be used to reconstruct ionospheric electron density based on their dispersion characteristics. The propagation characteristics of LGWs determine their propagation paths in the ionosphere, and the correct calculation of these paths is a prerequisite for electron density inversion. Here the observations from the China Seismo-Electromagnetic Satellite in broad areas at about 500 km altitude are used to perform wave vector direction statistics and propagation characteristics analysis for fractional-hop whistlers that propagate from the Earth to the spacecraft. The propagation characteristics of whistlers are analyzed and distinguished using observational statistics of wave vector directions and simulation based on the finite difference time domain model. The results indicate that the wave normal angles of whistlers in low latitudes are significantly larger than those in mid latitudes. Low-latitude whistlers preferentially propagate obliquely outward in the magnetic meridian plane in a nonducted mode in the ionosphere. Mid-latitude whistlers may still propagate in a nonducted mode, even when their wave normal angles are relatively small. The wave normal angles of LGWs in the ionosphere show no significant longitudinal dependence and exhibit a clear latitudinal distribution pattern. The LGWs wave vector exhibits minimal vertical deviation at low and high latitudes, with significantly larger deviations near 30°N mid-latitudes. This paper reveals the propagation characteristics of LGWs in the ionosphere through observations, statistics, and simulation. Most lightning-generated whistlers (LGWs) propagate obliquely outward in the magnetic meridian plane in a nonducted mode in the ionosphere The wave normal angles of LGWs in the ionosphere exhibit a clear latitudinal d

关键词： ionosphere whistlers propagation modes wave vector

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Data-driven evaluation of fatigue performance of additive manufactured parts using miniature specimens

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Journal of Materials science & technology 2019年第6期35卷 1137-1146页

作者： H.Y. Wan G.F. Chen C.P. Li X.B. Qi G.P. Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences 72 Wenhua Road Shenyang 110016 China School of Materials Science and Engineering University of Science and Technology of China Shenyang 110016 China Materials Manufacturing Qualification Group Corporate Technology Siemens Ltd. China Beijing 100102 China State Key Laboratory of Tribology Tsinghua University Beijing J00084 China

This overview firstly introduces the state-of-the-art research progress in length scale-related fatigue performance of conventionally-fabricated metals evaluated by miniature specimens. Some key factors for size effects sensitive to microstructures including the specimen thickness, grain size and a ratio between them are highlighted to summarize some general rules for size effects. Then, ongoing research progress and new challenges in evaluating the fatigue performance of additive manufactured parts controlled by location-specific defects, microstructure heterogeneities as well as mechanical anisotropy using miniature specimen testing technique are discussed and addressed. Finally, a potential roadmap to establish a data-driven evaluation platform based on a large number of miniature specimen-based experiment data,theoretical computations and the ’big data’ analysis with machine learning is proposed. It is expected that this overview would provide a novel strategy for the realistic evaluation and fast qualification of fatigue properties of additive manufactured parts we have been facing to.

关键词： Additive manufacturing Miniature specimen Fatigue Size effect Location-specific Data analysis

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An investigation into the origins of atmospheric ammonia and ammonium in beijing — Nitrogen stable isotope ratios as a basis

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Environmental Pollution 2025年 382卷

作者： Shaosong Zhen Min Luo Yang Shao Diandou Xu Qian Sun Yuepeng Pan Lingling Ma Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China School of Nuclear Science and Technology University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry (LAPC) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

Ammonia (NH 3 ) serves a pivotal role in the atmosphere as an alkaline gas, significantly impacting the formation of atmospheric particulate matter. This research employed nitrogen isotope (δ 15 N) tracer methodologies and a Bayesian mixing model (Mix SIAR) to examine representative PM 2.5 and PM 10 samples gathered in beijing in 2022. The objective was to discern the concentration, sources, and seasonal fluctuations of NH 3 and ammonium (NH 4 + ). This study analyzed the concentrations of NH 4 + and δ 15 N-NH 4 + values in PM 2.5 and PM 10 across the four seasons. The results indicated that winter had the highest concentrations, yet the lowest δ 15 N values. In spring, there was a notable increase in concentrations, accompanied by a significant rise in δ 15 N values. During summer, concentrations declined, but δ 15 N values remained elevated. By autumn, both concentrations and δ 15 N values peaked. Following this, an analysis of the contributions from different sources to NH 3 was undertaken. Notably, the contributions from NH 3 slip and coal combustion surged during winter, accounting for 34.2 % and 29.3 % respectively in PM 2.5 and 27.7 % and 23.6 % in PM 10 . Biomass burning contributes more prominently in spring and summer, while fertilizer application shows notably increased contributions in autumn, reflecting the significant role of agricultural-related sources. These results underscore the critical importance of non-agricultural sources in urban NH 3 emissions and provide a scientific basis for developing targeted seasonal emission reduction measures, aiming to effectively improve air quality in the beijing area.

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Dynamic Landscape of Multi-Elements in Pm2.5 Revealed by Real-Time analysis

SSRN

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SSRN 2022年

作者： Ji, Xiaomeng Qin, Ruiliang Shi, Chunzhen Yang, Lin Yao, Linlin Deng, Shenxi Qu, Guangbo Yin, Yongguang Hu, Ligang Shi, Jianbo Jiang, Guibin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing100085 China School of Environmental Science and Engineering Shandong University Qingdao266237 China School of Water Resources and Environment China University of Geosciences Beijing100083 China College of Ecology and Environment Beijing Technology and Business University Beijing100048 China School of Environment Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou310000 China State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution School of Environmental Studies China University of Geosciences Wuhan430074 China

Metal components in fine particulate matter (PM 2.5 ) are closely associated with many adverse health outcomes. Dynamic changes of metals in PM 2.5 are critical for risk assessment due to their temporal variations. Herein, an online method for real-time determination of multi-elements (As, Cd, Cs, Cu, Fe, Mg, Mn, Pb, Rb, Sn, Tl, and V) in PM 2.5 was established by directly introducing air samples into inductively coupled plasma mass spectrometry (ICPMS). Meanwhile, a quantified method using metal standard aerosols (Cr, Mo, and W) and high time-resolution for 3.3 min online measurement was developed and validated. The limits of detection were in range of 0.001–6.30 ng/m 3 for different metals. Subsequently, the real-time contents of multi-elements in PM 2.5 for 12 h over 33 days were measured at different air qualities. Temporal variations of crustal elements like Fe, Mg are similar as PM 2.5 , whereas toxic elements (Pb, As and Cd) have upward trends at dusk. This denoted the association with various emission sources and different exposure concentrations of metals. In addition to the acquisition of real-time information, online analysis of multi-elements in PM 2.5 is beneficial for atmospheric monitoring and provides critical insights for the different exposure risks of metals in PM 2.5 at varying times. © 2022, The Authors. All rights reserved.

关键词： Metals

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Linkage between the Nao and Siberian High Events on the Intraseasonal Timescale

SSRN

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SSRN 2022年

作者： Zhou, Fang Shi, Jian Liu, Ming-Hong Ren, Hong-Chang Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Key Laboratory of Meteorological Disaster Ministry of Education Joint International Research Laboratory of Climate and Environment Change Nanjing University of Information Science and Technology Nanjing China Laboratory for Climate Studies & CMA-NJU Joint Laboratory for Climate Prediction Studies China Meteorological Administration Beijing China Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Bremerhaven Germany State Key Laboratory of Severe Weather Institute of Tibetan Plateau & Polar Meteorology Chinese Academy of Meteorological Sciences Beijing China National Meteorological Center China Meteorological Administration Beijing China

The Siberian high (SH) is a dominant component of the boreal winter circulation, and it significantly controls the climate of almost the entirety of continental Asia. Inspired by a case study of the boss level cold wave in 2016, intraseasonal SH events are classified into two types: positive-North Atlantic Oscillation (NAO)-related and negative-NAO-related SH events. Composite analysis shows that the SH events associated with the positive NAO often occur west of Eurasia and gradually amplify to the entirety of northern Asia, which leads to a weak East Asian winter monsoon and warm Arctic-cold Eurasian surface temperature anomalies. The negative-NAO-related SH events often occur east of Eurasia and lead to a strong East Asian winter monsoon and almost all of the Eurasian negative surface temperature anomalies. Before the peaks of the positive-NAO-related SH events, an upper tropospheric Rossby wave train originates from the North Atlantic, propagates across northern Eurasia, and interacts with preexisting cold surface anomalies over central Siberia, which is particularly crucial for the development and eastward amplification of the positive-NAO-related SH events. In addition, the synoptic eddy-induced feedback originating from the North Pacific is the key factor in the development and westward amplification of the negative-NAO-related SH events. © 2022, The Authors. All rights reserved.

关键词： Feedback

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Creation of a Chiral Bobber Lattice in Helimagnet-Multilayer Heterostructures

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Physical Review Letters 2021年第1期126卷 017204-017204页

作者： Kejing Ran Yizhou Liu Yao Guang David M. Burn Gerrit van der Laan Thorsten Hesjedal Haifeng Du Guoqiang Yu Shilei Zhang School of Physical Science and Technology ShanghaiTech University Shanghai 200031 China ShanghaiTech Laboratory for Topological Physics ShanghaiTech University Shanghai 200031 China RIKEN Center for Emergent Matter Science (CEMS) Wako 351-0198 Japan Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Diamond Light Source Harwell Science and Innovation Campus Didcot Oxfordshire OX11 0DE United Kingdom Clarendon Laboratory Department of Physics University of Oxford Parks Road Oxford OX1 3PU United Kingdom The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory and University of Science and Technology of China Chinese Academy of Science (CAS) Hefei Anhui 230031 China

A chiral bobber is a localized three-dimensional magnetization configuration, terminated by a singularity. Chiral bobbers coexist with magnetic skyrmions in chiral magnets, lending themselves to new types of skyrmion-complementary bits of information. However, the on-demand creation of bobbers, as well as their direct observation remained elusive. Here, we introduce a new mechanism for creating a stable chiral bobber lattice state via the proximity of two skyrmion species with comparable size. This effect is experimentally demonstrated in a Cu2OSeO3/[Ta/CoFeB/MgO]4 heterostructure in which an exotic bobber lattice state emerges in the phase diagram of Cu2OSeO3. To unambiguously reveal the existence of the chiral bobber lattice state, we have developed a novel characterization technique, magnetic truncation rod analysis, which is based on resonant elastic x-ray scattering.

关键词： Magnetic coupling Magnetic texture Skyrmions Micromagnetic modeling Resonant elastic x-ray scattering

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A new subclass of gamma-ray burst originating from compact binary merger

arXiv

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arXiv 2024年

作者： Wang, Chen-Wei Tan, Wen-Jun Xiong, Shao-Lin Yi, Shu-Xu Moradi, Rahim Li, Bing Zhang, Zhen Wang, Yu Meng, Yan-Zhi Liu, Jia-Cong Wang, Yue Xie, Sheng-Lun Xue, Wang-Chen Yu, Zheng-Hang Zhang, Peng Zhang, Wen-Long Zhang, Yan-Qiu Zheng, Chao Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China ICRANet Piazza della Repubblica 10 PescaraI-65122 Italy ICRA Dipartamento di Fisica Sapienza Università di Roma Piazzale Aldo Moro 5 RomeI-00185 Italy INAF Osservatorio Astronomico d'Abruzzo Via M. Maggini snc TeramoI-64100 Italy School of Science Guangxi University of Science and Technology Liuzhou545006 China Institute of Astrophysics Central China Normal University Wuhan430079 China College of Electronic and Information Engineering Tongji University Shanghai201804 China Qufu Normal University Qufu273165 China

Type I gamma-ray bursts (GRBs) are believed to originate from compact binary merger usually with duration less than 2 seconds for the main emission. However, recent observations of GRB 211211A and GRB 230307A indicate that some merger-origin GRBs could last much longer. Since they show strikingly similar properties (indicating a common mechanism) which are different from the classic "long"-short burst (e.g. GRB 060614), forming an interesting subclass of type I GRBs, we suggest to name them as type IL GRBs. By identifying the first peak of GRB 230307A as a quasithermal precursor, we find that the prompt emission of type IL GRB is composed of three episodes: (1) a precursor followed by a short quiescent (or weak emission) period, (2) a long-duration main emission, and (3) an extended emission. With this burst pattern, a good candidate, GRB 170228A, was found in the Fermi/GBM archive data, and subsequent temporal and spectral analyses indeed show that GRB 170228A falls in the same cluster with GRB 211211A and GRB 230307A in many diagnostic figures. Thus this burst pattern could be a good reference for rapidly identifying type IL GRB and conducting low-latency follow-up observation. We estimated the occurrence rate and discussed the physical origins and implications for the three emission episodes of type IL GRBs. Our analysis suggests the pre-merger precursor model, especially the super flare model, is more favored for type IL GRBs. More observations in multi-wavelength and multi-messenger are required to deepen our understanding of this subclass of GRBs. © 2024, CC BY.

关键词： Spectrum analysis

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The genome and transcriptome analysis of snake gourd provide insights into its evolution and fruit development and ripening

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Horticulture Research 2020年第1期7卷 204-218页

作者： Lili Ma Qing Wang Jianlou Mu Anzhen Fu Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuewen Zhang Xuechuan Zhang Zhangjun Fei Donald Grierson Jinhua Zuo Key Laboratory of Vegetable Postharvest Processing Ministry of AgricultureBeijing Key Laboratory of Fruits and Vegetable Storage and ProcessingKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(North China)of Ministry of AgricultureKey Laboratory of Urban Agriculture(North)of Ministry of AgricultureThe Collaborative Innovation Center of Cucurbit CropsBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Food Science and Technology Hebei Agricultural UniversityBaoding 071001China Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 100048China Department of Horticulture Zhejiang UniversityHangzhou 310058China Biomarker Technologies Corporation Beijing 101300China Boyce Thompson Institute for Plant Research Cornell UniversityIthacaNY 14853USA U.S.Department of Agriculture-Agricultural Research Service Robert W.Holley Center for Agriculture and HealthIthacaNY 14853USA School of Biosciences University of NottinghamSutton Bonington CampusLoughboroughLeicestershire LE125RDUK

Snake gourd(Trichosanthes anguina L.),which belongs to the Cucurbitaceae family,is a popular ornamental and food crop species with medicinal value and is grown in many parts of the *** progress has been made in its genetic improvement,the organization,composition,and evolution of the snake gourd genome remain largely ***,we report a high-quality genome assembly for snake gourd,comprising 202 contigs,with a total size of 919.8 Mb and an N50 size of 20.1 *** findings indicate that snake gourd has one of the largest genomes of Cucurbitaceae species sequenced to *** snake gourd genome assembly harbors 22,874 protein-coding genes and 80.0%of the genome consists of repetitive *** analysis reveals that snake gourd is closely related to sponge gourd but diverged from their common ancestor~33–47 million years *** genome sequence reported here serves as a valuable resource for snake gourd genetic research and comparative genomic studies in Cucurbitaceae and other plant *** addition,fruit transcriptome analysis reveals the candidate genes related to quality traits during snake gourd fruit development and provides a basis for future research on snake gourd fruit development and ripening at the transcript level.

关键词： Snake evolution snake

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How to unravel the nature of the Σ*(1430)(1/2−) state from correlation functions

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Physical Review D 2024年第11期110卷 114018-114018页

作者： Hai-Peng Li Chu-Wen Xiao Wei-Hong Liang Jia-Jun Wu En Wang Eulogio Oset Department of Physics Guangxi Normal University Guilin 541004 China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal University Guilin 541004 China School of Physics Central South University Changsha 410083 China School of Physics University of Chinese Academy of Sciences Beijing 100049 China Southern Center for Nuclear-Science Theory (SCNT) Institute of Modern Physics Chinese Academy of Sciences Huizhou 516000 China School of Physics Zhengzhou University Zhengzhou 450001 China Departamento de Física Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de Paterna Apartado 22085 46071 Valencia Spain

We calculate the correlation functions for the K¯0p,π+Σ0,π0Σ+,π+Λ, and ηΣ+ states, which in the chiral unitary approach predict an excited Σ*(1/2−) state at the K¯N threshold, recently observed by the Belle Collaboration. Once this is done, we tackle the inverse problem of seeing how much information one can obtain from these correlation functions. With the resampling method, one can determine the scattering parameters of all the channels with relative precision, by means of the analysis in a general framework, and find a clear cusplike structure corresponding to the Σ*(1/2−) in the different amplitudes at the K¯N threshold.

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