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Meta-analysis of the effects of supplemental leucine alone or in combination with other branched-chain amino acids on lactational performance in dairy cows and the associated influencing factors

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Journal of dairy science 2025年

作者： Xiaowen Wang Mengxu Sun Zhisheng Hu Hengrui Zhan Dengpan Bu Lianbin Xu College of Animal Science and Technology Qingdao Agricultural University Qingdao 266109 China. Shandong Provincial Animal Husbandry Station Jinan 250100 China. College of Animal Science and Technology Qingdao Agricultural University Qingdao 266109 China State Key Laboratory of Animal Nutrition Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 China. College of Animal Science and Technology Qingdao Agricultural University Qingdao 266109 China. Electronic address: xulianbin@***.

Effects of Leu or in combination with Ile and Val (ILV) supplementation on lactational performance in dairy cows as well as the potential interfering factors need to be systematically investigated. PubMed, scienceDirect, Web of science and Google Scholar databases were searched for peer-reviewed papers published by August 31, 2024 to explore the factors influencng the effects of branched-chain amino acid (BCAA) supplementation in dairy cows. Weighted mean difference (WMD) with confidence interval (CI) of continuous variables from 17 studies were pooled using a hierarchical 3-level meta-analysis with a random-effect model. Moderator analyses were performed to evaluate the effects of different cow breed, lactational stage, dietary MP supply, basal diet type, supplementation method, and supplementation dosage and duration on the heterogeneity of outcomes. Results showed that Leu supplementation increased the milk protein concentration, and ILV supplementation tended to increase milk protein yield in dairy cows. The positive effect of Leu supplementation on milk protein concentration was more prominent in dairy cows fed a MP-adequate or corn silage based diet. Moreover, the milk protein concentration of cows had a tendency to increase when Leu was supplemented via infusion rather than feeding a rumen-protected Leu. Further analysis showed that total digestible Leu should be supplied at 266 g/d (or 11.2% of MP) or supplementation with a duration of 7 d, and total digestible ILV should be supplied at 620 g/d (or 24.2% of MP), to achieve the optimal performances in dairy cows. These findings indicated the benifical effects of supplemental Leu and ILV on milk protein output in dairy cows.

关键词： branched-chain AA supplementation dairy cows lactational performance leucine supplementation

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PANCAKE: Python bAsed Numerical Color-magnitude-diagram analysis pacKagE

arXiv

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arXiv 2025年

作者： Zheng, Yun Yang, Yujiao Zhang, Yong-Kun Zheng, Zheng Wang, Jing Staveley-Smith, Lister Tsai, Chao-Wei Li, Di Liu, Chao Hu, Jingjing Chen, Huaxi Quan, Donghui Zheng, Yinghui Li, Hangyuan Beijing 21st Century School Beijing100142 China Zhejiang Lab Zhejiang Hangzhou311121 China Kavli Institute for Astronomy and Astrophysics Peking University Beijing100871 China School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing100049 China National Astronomical Observatories Chinese Academy of Sciences Beijing100101 China Key Laboratory of Radio Astronomy and Technology Chinese Academy of Sciences Beijing100101 China International Centre for Radio Astronomy Research University of Western Australia 35 Stirling Highway CrawleyWA6009 Australia Australia Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Beijing102206 China University of Chinese Academy of Sciences Beijing100049 China New Cornerstone Science Laboratory Department of Astronomy Tsinghua University Beijing100084 China

Stellar populations serve as a fossil record of galaxy formation and evolution, providing crucial information about the history of star formation and galaxy evolution. The color-magnitude diagram (CMD) stands out as the most accurate tool currently available for inferring the star formation histories (SFHs) of nearby galaxies with stellar-resolved multiband data. The launch of new space telescopes, including JWST, EUCLID, and the upcoming CSST and Roman, will significantly increase the number of stellar-resolved galaxies over the next decade. A user-friendly and customizable CMD fitting package would be valuable for galaxy evolution studies with these data. We develop an open-source Python-based package named pancake, which is fast and accurate in determining SFHs and stellar population parameters in nearby galaxies. We have validated our method via a series of comprehensive tests. First, pancake performs well on mock data, meanwhile the random and systematic uncertainties are quantified. Second, pancake performs well on observational data containing a star cluster and 38 dwarf galaxies (50 fields). Third, the star formation rate (SFR) from pancake is consistent with the SFR from FUV photometry. To ensure compatibility and accuracy, we have included isochrone libraries generated using PARSEC for most of the optical and near-infrared filters used in space telescopes such as HST, JWST, and the upcoming CSST. Copyright © 2025, The Authors. All rights reserved.

关键词： Space telescopes

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AutoHR: A strong end-To-end baseline for remote heart rate measurement with neural searching

arXiv

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arXiv 2020年

作者： Yu, Zitong Li, Xiaobai Niu, Xuesong Shi, Jingang Zhao, Guoying Center for Machine Vision and Signal Analysis University of Oulu Oulu90014 Finland Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing100190 China University of Chinese Academy of Sciences Beijing100049 China

Remote photoplethysmography (rPPG), which aims at measuring heart activities without any contact, has great potential in many applications (e.g., remote healthcare). Existing end-To-end rPPG and heart rate (HR) measurement methods from facial videos are vulnerable to the less-constrained scenarios (e.g., with head movement and bad illumination). In this letter, we explore the reason why existing end-To-end networks perform poorly in challenging conditions and establish a strong end-Toend baseline (AutoHR) for remote HR measurement with neural architecture search (NAS). The proposed method includes three parts: 1) a powerful searched backbone with novel Temporal Difference Convolution (TDC), intending to capture intrinsic rPPGaware clues between frames;2) a hybrid loss function considering constraints from both time and frequency domains;and 3) spatiotemporal data augmentation strategies for better representation learning. Comprehensive experiments are performed on three benchmark datasets to show our superior performance on both intra-and cross-dataset testing. Copyright © 2020, The Authors. All rights reserved.

关键词： Convolution

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Two long-period giant planets around two giant stars: HD 112570 and HD 154391

arXiv

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arXiv 2023年

作者： Xiao, Guang-Yao Teng, Huan-Yu Zhou, Jianzhao Sato, Bunei Liu, Yu-Juan Bi, Shaolan Takarada, Takuya Kuzuhara, Masayuki Hon, Marc Wang, Liang Omiya, Masashi Harakawa, Hiroki Zhao, Fei Zhao, Gang Kambe, Eiji Izumiura, Hideyuki Ando, Hiroyasu Noguchi, Kunio Wang, Wei Zhai, Meng Song, Nan Yang, Chengqun Li, Tanda Brandt, Timothy D. Yoshida, Michitoshi Itoh, Yoichi Kokubo, Eiichiro CAS Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing100101 China Department of Earth and Planetary Sciences School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8551 Japan Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Beijing102206 China Department of Astronomy Beijing Normal University Beijing100875 China Astrobiology Center National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Institute for Astronomy University of Hawai’i 2680 Woodlawn Drive HonoluluHI96822 United States National Astronomical Observatories Nanjing Institute of Astronomical Optics & Technology Chinese Academy of Sciences Nanjing210042 China CAS Key Laboratory of Astronomical Optics & Technology Nanjing Institute of Astronomical Optics & Technology Chinese Academy of Sciences Nanjing210042 China National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Subaru Telescope National Astronomical Observatory of Japan National Institutes of Natural Sciences 650 North A’ohoku Pl. HiloHI96720 United States Okayama Branch Office Subaru Telescope National Astronomical Observatory of Japan National Institutes of Natural Sciences Asakuchi Kamogata719-0232 Japan China Science and Technology Museum Beijing100101 China Shanghai Astronomical Observatory 80 Nandan Road Shanghai200030 China School of Physics and Astronomy University of Birmingham Edgbaston BirminghamB15 2TT United Kingdom Department of Physics University of California Santa Barbara Santa BarbaraCA93106 United States Nishi-Harima Astronomical Observatory Center for Astronomy University of Hyogo 407-2 Sayo Nishigaichi Hyogo679-5313 Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan

We present the discoveries of two giant planets orbiting the red giant branch (RGB) star HD 112570 and the red clump (RC) star HD 154391, based on the radial velocity (RV) measurements from Xinglong station and Okayama Astrophysical Observatory (OAO). Spectroscopic and asteroseismic analyses suggest that HD 112570 has a mass of 1.15 ± 0.12 M☉, a radius of 9.85 ± 0.23 R☉, a metallicity [Fe/H] of −0.46 ± 0.1 and a log g of 2.47 ± 0.1. With the joint analysis of RV and Hipparcos-Gaia astrometry, we obtain a dynamical mass of Mp = 3.42+1.4−0.84 MJup, a period of P = 2615+85−77 days and a moderate eccentricity of e = 0.20+0.16−0.14 for the Jovian planet HD 112570 b. For HD 154391, it has a mass of 2.07 ± 0.03 M☉, a radius of 8.56 ± 0.05 R☉, a metallicity [Fe/H] of 0.07 ± 0.1 and a log g of 2.86 ± 0.1. The super-Jupiter HD 154391 b has a mass of Mp = 9.1+2.8−1.9 MJup, a period of P = 5163+60−57 days and an eccentricity of e = 0.20−0.04+0.04. We found HD 154391 b has one of the longest orbital period among those ever discovered orbiting evolved stars, which may provide a valuable case in our understanding of planetary formation at wider orbits. Moreover, while a mass gap at 4 MJup seems to be present in the population of giant stars, there appears to be no significant differences in the distribution of metallicity among giant planets with masses above or below this threshold. Finally, The origin of the abnormal accumulation near 2 au for planets around large evolved stars (R* > 21 R☉), remains unclear. © 2023, CC BY.

关键词： Giant stars

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Can the nature of a0(980) be tested in the Ds+ → π+π0η decay?

arXiv

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arXiv 2021年

作者： Ling, Xi-Zhe Liu, Ming-Zhu Lu, Jun-Xu Geng, Li-Sheng Xie, Ju-Jun School of Physics Beihang University Beijing100191 China School of Space and Environment Beihang University Beijing100191 China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing100191 China School of Physics and Microelectronics Zhengzhou University ZhengzhouHenan450001 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou730000 China School of Nuclear Science and Technology University of Chinese Academy of Sciences Beijing101408 China

From the amplitude analysis of the Ds+ → π+π0η decay, the BESIII Collaboration firstly observed the Ds+ → a0(980)+π0 and Ds+ → a0(980)0π+ decay modes, which are expected to occur through the pure W-annihilation processes. The measured branching fraction B[Ds+ → a0(980)+(0)π0(+),a0(980)+(0) → π+(0)η] is, however, found to be larger than those of known W-annihilation decays by one order of magnitude. This apparent contradiction can be reconciled if the two decays are induced by internal W-conversion or external W-emission mechanisms instead of W-annihilation mechanism. In this work, we propose that the Ds+ decay proceeds via both the external and internal W-emission instead of W-annihilation mechanisms. In such a scenario, we perform a study of the Ds+ → π+π0η decay by taking into account the contributions from the tree diagram Ds+ → ρ+η → π+π0η and the intermediate ρ+η and K∗K/K¯ K¯∗ triangle diagrams. The intermediate a0(980) state can be dynamically generated from the final state interactions of coupled KK¯ and πη channels, and it is shown that the experimental data can be described fairly well, which supports the interpretation of a0(980) as a molecular state. © 2021, CC BY-SA.

关键词： Decay (organic)

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Hybrid optimization algorithm of particle swarm optimization with lagrangian relaxation for solving the multidimensional knapsack problem 2nd

Hybrid optimization algorithm of particle swarm optimization...

引用

2nd International Conference on Smart Vehicular technology, Transportation, Communication and Applications, VTCA 2018

作者： Luo, Jinyan Lin, Geng Zhang, Fuquan Xu, Lin Department of Mathematics Minjiang University Fuzhou350108 China Fujian Provincial Key Laboratory of Information Processing and Intelligent Control Minjiang University Fuzhou350121 China Digital Performance and Simulation Technology Laboratory School of Computer Science and Technology Beijing Institute of Technology Beijing100081 China Key Laboratory of Nondestructive Testing Fuqing Branch of Fujian Normal University Fuzhou350300 China

ISBN: (纸本)9783030045845

A hybrid algorithm that integrates PSO with Lagrangian relaxation is proposed for solving the multidimensional knapsack problem (MKP). An efficiency measure for MKP based on the LR dual information is defined to combine the object function and the constraints of the MKP together. The efficiency measure is used to determine the core problem for MKP with the aim of reducing the problem scale. Then a hybrid algorithm combines the Quantum Particle Swarm Optimization with a local search method is presented to solve the core problem. Numerical experiments are made on certain knapsack problems and computational results show that the proposed algorithm is very promising. © Springer Nature Switzerland AG 2019.

关键词： Efficiency

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Graphdiyne oxide enhances the stability of solid contact-based ion-selective electrodes for excellent in vivo analysis

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中国科学：信息科学（英文版） 2019年第10期62卷 1414-1420页

作者： Lijun Zhao Ying Jiang Jie Hao Huan Wei Wei Zheng Lanqun Mao Institute of Surface/Interface Science and Technology Key Laboratory of Superlight Material and Surface Technology of Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistrythe Chinese Academy of Sciences Beijing 100190 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistrythe Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Quantitively and stably tracking ion dynamics in the living brain of animals is essential to understanding many physiological and pathological ***-state ion-selective electrodes (ISEs) are powerful tools for monitoring the dynamic change of ions at physiological concentration range;however,the unintentional accumulation of an aqueous layer at the ion selective membrane/solid contact interface compromises the electrode potential stability,limiting its in vivo ***,using manganese dioxide (MnO2) and potassium ISE (K+-ISE) as model solid contact and ISEs,we demonstrate for the first time that graphdiyne oxide (GDYO) can enhance the potential stability of solid contact-based *** results suggest that the intrinsic structural and hydrophobic features of GDYO,plays a key role in impeding and stabilizing the formation of water *** GDYO-MnO2 acting as the solid contact,the K+-ISE displays an excellent short-term potential stability and maintains great selectivity,achieving reliable K+ sensing at the animal *** GDYO-based strategy is generalizable to different ISEs and does not require complicated processing steps,paving an exciting opportunity for in vivo ion recognition and sensing.

关键词： in vivo analysis graphdiyne oxide solid-state ion selective electrodes water layer

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Recurring tidal disruption events a decade apart in IRAS F01004-2237

arXiv

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arXiv 2024年

作者： Sun, Luming Jiang, Ning Dou, Liming Shu, Xinwen Zhu, Jiazheng Dong, Subo Buckley, David Cenko, S. Bradley Fan, Xiaohui Gromadzki, Mariusz Liu, Zhu Wang, Jianguo Wang, Tinggui Wang, Yibo Wu, Tao Yang, Lei Zhang, Fabao Zhang, Wenjie Zhang, Xiaer Department of Physics Anhui Normal University Anhui Wuhu241002 China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of China Anhui Hefei230026 China School of Astronomy and Space Sciences University of Science and Technology of China Hefei230026 China Center for Astrophysics Guangzhou University Guangzhou510006 China Department of Astronomy School of Physics Peking University 5 Yiheyuan Road Haidian District Beijing100871 China Kavli Institute of Astronomy and Astrophysics Peking University 5 Yiheyuan Road Haidian District Beijing100871 China National Astronomical Observatories Chinese Academy of Science 20A Datun Road Chaoyang District Beijing100101 China South African Astronomical Observatory P.O. Box 9 Observatory Cape Town7935 South Africa Astrophysics Science Division NASA Goddard Space Flight Center MC 661 GreenbeltMD20771 United States Steward Observatory University of Arizona 933 North Cherry Avenue Rm. N204 TucsonAZ85721-0065 United States Astronomical Observatory University of Warsaw Al. Ujazdowskie 4 Warszawa00-478 Poland Max-Planck-Institut für Extraterrestrische Physik Gießenbachstraße 1 Garching85748 Germany Key Laboratory for the Structure and Evolution of Celestial Objects Yunnan Observatories Kunming650011 China

Context. In theory, recurring tidal disruption events (TDEs) may occur when a close stellar binary encounters a supermassive black hole, if one star is captured and undergoes repeating partial TDEs, or if both stars are tidally disrupted (double TDEs). In addition, independent TDEs may be observed over decades in some special galaxies where the TDE rate is extremely high. Exploring the diversity of recurring TDEs and probing their natures with rich observational data help to understand these mechanisms. Aims. We report the discovery of a second optical flare that occurred in September 2021 in IRAS F01004-2237, where the first flare occurred in 2010 has been reported, and present a detailed analysis of multi-band data. We aim to understand the nature of the flare and explore the possible causes of the recurring flares. Methods. We describe our analysis of the position of the flare, the multi-band light curves (LCs), the optical and ultraviolet (UV) spectra, and the X-ray LC and spectra. Results. The position of the flare coincides with the galaxy centre with a precision of 650 pc. The flare peaks in ∼ 50 days with an absolute magnitude of ∼ −21 and fades in two years roughly following L ∝ t−5/3. It maintains a nearly constant blackbody temperature of ∼22,000 K in the late time. Its optical and UV spectra show hydrogen and helium broad emission lines with full width at half maxima of 7,000–21,000 km s−1 and He II/Hα ratio of 0.3–2.3. It shows weak X-ray emission relative to UV emission, with X-ray flares lasting for +1.4. These characters are consistent with a TDE, ruling out the possibilities of a supernova or an active galactic nuclei flare. With a TDE model, we infer a peak UV luminosity of 3.3 ± 0.2 × 1044 erg s−1 and an energy budget of 4.5 ± 0.2 × 1051 erg. Conclusions. A TDE caused the flare that occurred in 2021. The two optical flares separated by 10.3 ± 0.3 years can be interpreted as repeating partial TDEs, double TDEs, or two independent TDEs. Although no

关键词： Budget control

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A single-cell transcriptomic atlas of severe intrauterine adhesion

MedComm - Future Medicine

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MedComm - Future Medicine 2024年第4期3卷

作者： Xia, Siyu Ye, Wenting Zeng, Jiajun Song, Ge Sun, Yan Zhang, Yongmei Luo, Xiaoqing Cai, Jing Yu, Hongjin Pan, Wenwei Chen, Jiayun Yang, Chuanbin Luo, Qingming Wang, Jigang Song, Yali Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Dongguan China Department of Nephrology Guangdong Provincial Clinical Research Center for Geriatrics Shenzhen Clinical Research Center for Geriatric Shenzhen People's Hospital (The First Affiliated Hospital School of Medicine Southern University of Science and Technology) Guangdong Shenzhen China Reproductive Medicine Center of Foshan Women and Childen Hospital Foshan China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Center and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China State Key Laboratory of Antiviral Drugs School of Pharmacy Henan University Kaifeng China

Intrauterine adhesion (IUA) is a common endometrial disease caused by injury, leading to reproductive health issues. Current treatments have limited effectiveness, side effects, and high recurrence rates, especially, in severe cases. However, the underlying molecular and cellular mechanisms are largely unknown. Here we performed a comprehensive analysis by profiling integrated single-cell transcriptomes of over 72,000 individual endometrial cells, encompassing samples from both patients with IUA and those with normal endometrium. We identified changes in cell type-specific molecular signatures, including the inflammatory activation in immune cells, extensive damage in epithelial subpopulations, and the deposition of collagen secreted by fibroblasts subpopulations. Our results demonstrated activation of the TREM2⁺ macrophages, which displayed properties of inflammatory regulation. Annexin A1⁺ NK subpopulations exhibited the highest susceptibility among NK subtypes, displaying decreased cellular density and the most pronounced differential gene expression. Furthermore, we identified the matrix metallopeptidase 7 (MMP7⁺) and C-C motif chemokine ligand 5 (CCL5⁺) unciliated epithelial subtype originated from pituitary tumor-transforming gene 1 (PTTG1⁺) unciliated epithelium as the most vulnerable subpopulations to epithelial injury. Collectively, our study offers integrated resources of the cellular microenvironment of IUA, serving as a comprehensive cellular map of the disease in affected individuals. The insights gained from this study are expected to provide valuable resources for future diagnostic and therapeutic approaches. © 2024 The Author(s). MedComm - Future Medicine published by John Wiley & Sons Australia, Ltd on behalf of Sichuan International Medical Exchange & Promotion Association (SCIMEA).

关键词： cellular microenvironment intrauterine adhesion single-cell sequence

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Advances in the Application of Radiomics in Colorectal Cancer

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Chinese Journal of Biomedical Engineering(English Edition) 2021年第1期30卷 1-12页

作者： ZHOU Xue-zhi WEI Wei LIU Zhen-yu WANG Shuo TIAN Jie Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education School of Life Science and TechnologyXidian UniversityXi'an 710126China School of Electronics and Information Xi'an Polytechnic UniversityXi'an 710048China CAS Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100191China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China

Medical images contain a great deal of information that cannot be recognized by the human *** may not only fully express the heterogeneity of the tumor,but also reflect important information such as prognosis information of *** the development of image processing and artificial intelligence technology,an emerging field called"radiomics"has become a research hotspot,aiming to assist doctors to make decisions or to solve the thorny problems in clinical practice by advanced image analysis *** this paper,taking applications of radiomics in colorectal cancer as an example,we introduced the basic principle and technology of radiomics followed by studies focusing on different clinical questions during treatment cycle,including assessment and prediction of the pathological response status after neoadjuvant chemoradiotherapy,the decision of operative plan and the survival analysis after *** believe that advances in medical image analysis will promote the development of precision medicine.

关键词： radiomics colorectal cancer precision medicine artificial intelligence

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