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Integrated transcriptomics and metabolomics analysis provide insights into the alleviation of waterlogging stress in maize by exogenous spermidine application

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Journal of Integrative Agriculture 2024年

作者： Xiuling Wang Li Niu Huaipan Liu Xucun Jia Yulong Zhao Qun Wang Yali Zhao Pengfei Dong Moubiao Zhang Hongping Li Panpan An Zhi Li Xiaohuan Mu Yongen Zhang Chaohai Li State Key Laboratory of Wheat and Maize Crop Science Collaborative Innovation Center of Henan Grain Crops College of Agronomy Henan Agricultural University Zhengzhou 450046 China Beijing Changping Agricultural Technology Extension Station Beijing 102200 China College of Life Science and Agronomy/Key Laboratory of Plant Genetics and Molecular Breeding Zhoukou Normal University Zhoukou 466001 China College of forestry of Henan Agriculture University Henan Agricultural University Zhengzhou 450046 China Agricultural Information Institute of CAAS Chinese Academy of Agricultural Sciences Beijing 100081 China

Waterlogging stress has been found to have adverse impacts on plant growth, subsequently reducing crop yields. Spermidine (Spd), a second messenger, positively affects the growth of plants under waterlogging stress. However, the molecular mechanisms of exogenous Spd application alleviating waterlogging stress remained unclear. In this study, we performed physiological analysis and multi-omics to underlying the effect of Spd application on waterlogging stress. Spd application increased genes expression level of light-harvesting complex (LHC) and photosynthesis-related and starch-related pathway, inhibited chlorophyll degradation and maintained higher photosynthetic rate, thus increased biomass accumulation under waterlogging stress. The activation of genes related trehalose and Spd biosynthesis would result in high accumulation of trehalose and endogenous Spd. Inhibiting 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase (ACO,) expression contributed to reduced ethylene emission. All those changes increased maize resistance to waterlogging. After Spd sparying, auxin-related genes up-regulated and IAA content was increased, those favor cell elongation in maize and thus keep normal growth after Spd application under waterlogging stress. Most of genes involved in lipids were up-regulated and thus increased lipids content and protected cell membranes in maize after Spd application under waterlogging conditions. All those changes contributed to increasing the resistance to waterlogging stress. These findings broaden our understanding of the regulatory roles of Spd in alleviating waterlogging damage and will provide evidence for breeding waterlogging-tolerant maize varieties.

关键词： maize spermidine waterlogging stress transcriptome metabolome 1

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Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy

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中国药理学报（英文版） 2019年第10期40卷 1364-1372页

作者： Yi Shi Ting Wang X.Edward Zhou Qiu-feng Liu Yi Jiang H.Eric Xu The CAS Key Laboratory of Receptor Research VARI-SIMM Center Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China The CAS Key Laboratory of Receptor Research VARI-SIMM Center Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China University of Chinese Academy of Sciences Beijing 100049 China School of Life Science and Technology ShanghaiTech UniversityShanghai 201213 China Laboratory of Structural Sciences Van Andel Research Institute Grand Rapids MI 49503 USA The CAS Key Laboratory of Receptor Research VARI-SIMM Center Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China University of Chinese Academy of Sciences Beijing 100049 China The CAS Key Laboratory of Receptor Research VARI-SIMM Center Center for Structure and Function of Drug Targets Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China University of Chinese Academy of Sciences Beijing 100049 China School of Life Science and Technology ShanghaiTech UniversityShanghai 201213 China Laboratory of Structural Sciences Van Andel Research Institute Grand Rapids MI 49503 USA

Arthrobacter globiformis Uricase (AgUricase) is a homotetrameric uricase with the potential for therapeutic use in treating hyperuricemia-related *** achieve sufficient therapeutic effects,it is essential for this enzyme to have high thermostability and long half-life in physiological *** improve the thermostability of this enzyme,we introduced a series of cysteine pair mutations into the AgUricase subunits based on its structural model and studied the thermostability of the mutant enzymes with introduced disulfide *** intersubunit cysteine pair mutations,K12C-E286C and S296C-S296C,were found to markedly increase the melting temperatures of the corresponding mutant enzymes compared with WT *** crystal structure of the K12C-E286C mutant at 1.99 (A) resolution confirmed the formation of a distinct disulfide bond between the two subunits in the *** analysis and biochemical data revealed that the C-terminal loop of AgUricase was flexible,and its interaction with neighboring subunits was required for the stability of the *** introduced an additional intersubunit K244C-C302 disulfide bond based on the crystal structure of the K12C-E286C mutant and confirmed that this additional disulfide bond further stabilized the flexible C-terminal loop and improved the thermostability of the *** cross-linking also protected AgUricase from protease *** studies suggest that the introduction of disulfide bonds into proteins is a potential strategy for enhancing the thermostability of multimeric proteins for medical applications.

关键词： uricase thermostability disulfide cross-linking crystal structure

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Design of Target Behavior Intelligent analysis System Based on Distributed Computing

Design of Target Behavior Intelligent Analysis System Based ...

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2019 IEEE International Conference on Signal, Information and Data Processing, ICSIDP 2019

作者： Pan, Xinlong Cheng, Xueqi Yao, Libo Zhu, Zhenqiu DIng, Biao Tang, Tiantian Li, Minbo Liu, Chuanhui Institute of Information Fusion Naval Aviation University Yantai China CAS Key Laboratory of Network Data Science Technology Inistitute of Computing Technology Chinese Academy of Sciences Beijing China School of Software Fudan University Shanghai China

ISBN: (纸本)9781728123455

Through the fusion processing of target data obtained by radar, electronic reconnaissance, space reconnaissance, technical reconnaissance and civil cooperative system in early warning and surveillance system, multidimensional target data including explicit state information such as target attributes, type, position, speed and course could be obtained. The latent potential information, such as regular behavior, intention and threat degree, need to be mastered by human intelligence and experience analysis. It is urgent to use big data mining technology to realize intelligent analysis of target behavior. Based on the analysis of big data related technologies, this paper designs an intelligent target behavior analysis system based on distributed computing, which provides theoretical and technical support for intelligent upgrading of intelligence processing systems and command decision systems. © 2019 IEEE.

关键词： Data mining

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Evolution of interface character distribution in duplex stainless steel processed by cross-rolling and annealing

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Journal of Materials science & technology 2018年第11期34卷 2160-2166页

作者： Ming Wang Ting Xu Yanli Zhu Wenhong Yin Hong Guo Ertuan Zhao Xiaoying Fang Weiguo Wang School of Mechanical Engineering Shandong University of Technology Zibo 255000 China Key Laboratory of Liaoning Advancecl Welding and Joining Technology Dalian University of Technology Dalian 716024 China Center of Testing and Analysis Shandong University of Technology Zibo 255000 China School of Materials Science and Engineering Fujian University of Technology Fuzhou 350118 China

Duplex stainless steel UNS S31803 samples were cross-rolled with a true strain of ε = 2 followed by annealing at 1323 K for 2 min and 240 min, respectively. The distributions of intervariant boundary planes in the precipitated austenite（A） from ferrite（F） and phase boundary planes conforming to Kurdjumov-Sache（K-S） orientation relationship（OR） were characterized by electron backscatter diffraction（EBSD） and the five-para me ter analysis（FPA） method, respectively. The intervariant boundary planes with misorientation angle of 60° around 〈111 〉 and 〈011 〉 occur frequently and tend to terminate on the {111} plane. At the grain size level of 4 μm, the phase boundary appears to be connected with the K-S OR terminating on{110}F ｜｜ {111}A at the early stage of annealing. When the grain size reaches approximately 20 μm, phase boundary was modified into {541}F｜｜{533}A due to twinning in austenite during annealing.

关键词： lntervariant boundary plane Phase boundary Duplex stainless steel Five-parameter analysis

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Organo-Ptⁱⁱ Complexes for Potent Photodynamic Inactivation of Multi-Drug Resistant Bacteria and the Influence of Configuration

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Advanced science 2024年第14期11卷 e2306936页

作者： Chong, Hui Liu, Xuanwei Fang, Siyu Yang, Xiaofei Zhang, Yuefei Wang, Tianyi Liu, Lin Kan, Yinshi Zhao, Yueqi Fan, Hongying Zhang, Jingqi Wang, Xiaoyu Yao, Hang Yang, Yi Gao, Yijian Zhao, Qi Li, Shengliang Plymoth, Martin Xi, Juqun Zhang, Yu Wang, Chengyin Pang, Huan Department of Chemical and Chemical Engineering Yangzhou University No. 180 Si-Wang-Ting Rd. Jiangsu Yangzhou 225009 China Department of Emergency Affiliated Hospital of Yangzhou University Jiangsu Yangzhou 225000 China School of Nursing Yangzhou University Yangzhou 225009 China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases No. 88 South University Rd. Yangzhou 225009 China Testing Center of Yangzhou University No. 48 Wenhui East Rd. Yangzhou 225009 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Center Laboratory Affiliated Hospital of Yangzhou University Yangzhou 225009 China College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Westmead hospital Sydney 2145 NSW Australia Department of Clinical Microbiology Umeå University Umeå 90187 Sweden Department of Pharmacology Institute of Translational Medicine School of Medicine Yangzhou University Yangzhou 225009 China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou 225009 China

PtII based organometallic photosensitizers (PSs) have emerged as novel potent photodynamic inactivation (PDI) reagents through their enhanced intersystem crossing (ISC) processes. Currently, few PtII PSs have been inv... 详细信息

Pt^II based organometallic photosensitizers (PSs) have emerged as novel potent photodynamic inactivation (PDI) reagents through their enhanced intersystem crossing (ISC) processes. Currently, few Pt^II PSs have been investigated as antibacterial materials, with relatively poor performances reported and with structure-activity relationships not well described. Herein, a pair of configurational isomers are reported of Bis-BODIPY (4,4-difluoro-boradizaindacene) embedded Pt^II PSs. The cis-isomer (cis-BBP) displayed enhanced ¹O₂ generation and better bacterial membrane anchoring capability as compared to the trans-isomer (trans-BBP). The effective PDI concentrations (efficiency > 99.9%) for cis-BBP in Acinetobacter baumannii (multi-drug resistant (MDR)) and Staphylococcus aureus are 400 nM (12 J cm⁻²) and 100 nM (18 J cm⁻²), respectively;corresponding concentrations and light doses for trans-BBP in the two bacteria are 2.50 µM (30 J cm⁻²) and 1.50 µM (18 J cm⁻²), respectively. The 50% and 90% minimum inhibitory concentration (MIC₅₀ and MIC₉₀) ratio of trans-BBP to cis-BBP is 22.22 and 24.02 in A. baumannii (MDR);21.29 and 22.36 in methicillin resistant S. aureus (MRSA), respectively. Furthermore, cis-BBP displays superior in vivo antibacterial performance, with acceptable dark and photoinduced cytotoxicity. These results demonstrate cis-BBP is a robust light-assisted antibacterial reagent at sub-micromolecular concentrations. More importantly, configuration of Pt^II PSs should be an important issue to be considered in further PDI reagents design. © 2023 The Authors. Advanced science published by Wiley-VCH GmbH.

关键词： antibacterial agents drug resistance membrane anchoring photosensitizers PtII reactive oxygen species structure-activity relationship

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Physical components and influence factors of municipal solid waste(MSW) in the residential area of beijing

Physical components and influence factors of municipal solid...

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第四届能源与环境研究进展国际学术会议（ICAEER 2019）

作者： Zhang Hongyu Wang Guiqin Bai Yaxuan Chen Rihui Zhang Li Beijing Municipal Institute of City Management/Beijing Key Laboratory of Municipal Solid Wastes Testing Analysis and Evaluation Beijing Institute of Petrochemical Technology

The treatment, disposal and management of municipal solid waste strongly depend on the composition and characteristics of municipal solid waste. The Physical composition of MSW and its influencing factors were investigated and analyzed in the residential of beijing area. The result showed that the composition of MSW in four seasons was similar, and the kitchen was the main composition of MSW, accounting for 69-74% of the total amount of MSW. The average age of families, educational backgrounds, family income and building area have a great influence on the physical proportion of MSW. As the average age of the family increases, the proportion of other wastes was gradually reduced, the proportion of the harmful waste was increased. With the increase of educational backgrounds and family income, the content of kitchen waste decreased, while the content of recyclable waste increased obviously. The 50 square meters was used as a dividing point for the residential area of the family, the kitchen waste decreased at first and then increased, while the proportion of disposable packaging and other waste increases at first and then decreases with the increase of building area.

关键词： MSW Physical components and influence factors of municipal solid waste in the residential area of beijing

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Intelligent Nowcasting of Convection Initiation Using a Special Ring-Like Warmer Environment Implied in Fengyun-4B AGRI Data

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Journal of Geophysical Research: Atmospheres 2025年第12期130卷

作者： Jinqing Liu Yunying Li Suling Ren Yaqiang Wang Danyu Qin Ziliang Li Chengzhi Ye Bowei Han College of Meteorology and Oceanography National University of Defense Technology Changsha China College of Oceanic and Atmospheric Science State Key Laboratory of Physical Oceanography Ocean University of China Qingdao China Key Laboratory of High Impact Weather (special) China Meteorological Administration Changsha China National Satellite Meteorological Centre China Meteorological Administration Beijing China Institute of Artificial Intelligence for Meteorology Chinese Academy of Meteorological Sciences Beijing China Hunan Meteorological Research Institute Hunan Meteorological Bureau Changsha China

Based on the neighborhood matching of the satellite Fengyun-4B and radar observations made during the warm seasons of 2022–2023, a small convection initiation (CI) data set was constructed. Further analyses showed that CI clouds are immersed in an obviously warmer environment (≥290 K) in a “ring-like” appearance relative to non-CI clouds. Following this ring-like feature, an intelligent CI nowcasting method is proposed, the Time-Space Transformer-Azimuth Feature Fusion Network (TimeSformer-AFNet), which is enhanced by an innovative azimuthal patch transformation and high-level feature fusion. The results show that this novel approach provides highly accurate CI predictions, achieving a threat score (TS) of 0.342, a false alarm ratio (FAR) of 0.529, and a significant lead time of 18 min—an improvement of 59.8%, 31.7%, and 5 min, respectively, over the traditional thresholding method, and an improvement of 13.6%, 12.6%, and 4 min, respectively, over a common machine learning-based method, called LightGBM. These results highlight the effectiveness of the TimeSformer-AFNet in CI nowcasting and its potential for broader applications to feature learning in various tasks. A “ring-like” area of warmer environment is found in areas likely to undergo convection initiation (CI) An intelligent nowcasting model (called TimeSformer-AFNet), including “ring-like” patch transformation, is constructed for CI prediction TimeSformer-AFNet model enhances CI prediction accuracy, with an improvement of 59.8% for threat score and 5 min for lead time over traditional thresholding algorithm A convective initiation (CI) event marks the newborn of a moist convective cell. As a precursor to the occurrence of convective weather, CI is the most crucial aspect of the subsequent convection predicting and disaster preparedness. Based the satellite Fengyun-4B and radar observations made during the warm seasons of 2022–2023, a CI data set was constructed. Further analysis found that CI clouds are imme

关键词： convective initiation Fengyun-4B TimeSformer-AFNet

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Land Use and Land Cover Change of Ghana

Land Use and Land Cover Change of Ghana

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IEEE International Symposium on Geoscience and Remote Sensing (IGARSS)

作者： Ankai Hou Abrado Blankson Samuel Mujie Li Zezhong Zheng Jun Xia Xiang Zhang Guoqing Zhou State Key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and the Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences Beijing PRC School of Resources and Environment University of Electronic Science and Technology of China Chengdu Sichuan PRC Guangxi Key Laboratory for Spatial Information and Geomatics Guilin University of Technology Guilin Guangxi PRC State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan Hubei PRC

ISBN: (数字)9781728163741

ISBN: (纸本)9781728163758

Land use and cover change (LUCC) is a central component in current strategies for managing natural resources and monitoring environmental change. In this paper, we used maximum likelihood classification algorithm to obtain the supervised land use and cover classification. Four major land use and cover classes are identified and mapped from 2000 to 2015. The changes of land use and cover using Landsat images of the study area were analyzed. The results showed that: From 2005 to 2015, closed forest has increased and the annual rate of change was (+)3.3%. Open forest has an annual rate of change of (+)1.21%. Water bodies had an annual rate of change of (+)0.81%. While the settlements and bare lands had a decrease of 52.93 km 2 and the annual rate of change was (-)5.3%.

关键词： Remote sensing Earth Forestry Artificial satellites Image color analysis Water resources Laboratories

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Optical colorimetric sensor arrays for chemical and biological analysis

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science China Chemistry 2018年第6期61卷 643-655页

作者： Yufan Ma Yawen Li Kun Ma Zhuo Wang Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Chemical Resource EngineeringCollege of Science Beijing University of Chemical Technology Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

In recent years, the sensor array has attracted much attention in the field of complex system analysis on the basis of its good selectivity and easy operation. Many optical colorimetric sensor arrays are designed to analyze multi-target analytes due to the good sensitivity of optical signal. In this review, we introduce the targeting analytes, sensing mechanisms and data processing methods of the optical colorimetric sensor array based on optical probes(including organic molecular probes, polymer materials and nanomaterials). The research progress in the detection of metal ions, anions, toxic gases, organic compounds, biomolecules and living organisms(such as DNA, amino acids, proteins, microbes and cells) and actual sample mixtures are summarized *** review illustrates the types, application advantages and development prospects of the optical colorimetric sensor array to help broad readers to understand the research progress in the application of chemical sensor array.

关键词： sensor array optical colorimetric chemical analysis biological analysis

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FoodMicroDB: A microbiome database for composition and time-series research in food

iMetaOmics

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iMetaOmics 2024年第2期1卷

作者： Yahui Li Hujie Lyu Haifei Yang Zhicheng Ju Chuang Ma Huiyu Hou Yao Wang Yuanping Zhou Yunyun Gao Junbo Yang Shanshan Xu Defeng Bai Hao Luo Salsabeel Yousuf Tianyuan Zhang Jiani Xun Meiyin Zeng Heyuan Qi Tong Chen Yong-Xin Liu Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China Department of Life Sciences Imperial College of London London UK College of Life Sciences Qingdao Agricultural University Qingdao China Department of Ocean Science The Hong Kong University of Science and Technology Hong Kong SAR China Anhui Agricultural University Hefei China Zhanjiang Key Laboratory of Human Microecology and Clinical Translation Research The Marine Biomedical Research Institute College of Basic Medicine Guangdong Medical University Zhanjiang Guangdong China School of Food and Biological Engineering Hefei University of Technology Hefei China Institute of Microbiology Chinese Academy of Sciences Beijing China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Science Beijing China

Microorganisms are crucial for food fermentation, preservation, and safety, directly impacting human health. The number of studies on the food microbiome has surged recently, along with a substantial increase in data. However, there is a notable lack of databases specialized for this field. To address this gap, we developed Food Microbiome Database (FoodMicroDB), a platform aimed at enhancing the reusability and accessibility of food microbiome data through comprehensive data management and data visualization tools. FoodMicroDB aggregates 6358 amplicon data from 108 meta-taxonomic projects covering 62 foods, and harbors 4710 taxa of bacteria, archaea, and fungi. The collected data were consistently analyzed and curated, then visualized using versatile utilities, including unique tools for visualizing microbial composition and time-series microbiome data. It also includes advanced modules for microbial abundance analysis, cross-host abundance comparison, and cross-food analysis. FoodMicroDB will be a valuable resource platform for the food microbiome research field. The database is freely accessible at: https://***/FoodMicro/ . FoodMicroDB is a freely accessible database specialized for food microbiome research, organizing microbiome data by project and food/organism. The platform ensures consistent data analysis and metadata curation, facilitating cross-host comparisons. It provides versatile data visualization modules, including unique tools for visualizing composition and time-series microbiome data.

关键词： database food microbiome fermented food microbial composition microbiome analysis time-series

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